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Detail Data SLCO2B1


Basic description
Gene Name SLCO2B1
Protein Name Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9)
Family SLCO
Category Transport of vitamins, nucleosides, and related molecules
Reaction name SLCO2B1 has a narrow substrate specificity
Reaction 1 SLCO2B1 substrates [extracellular region] --> 1 SLCO2B1 substrates [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700 
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM ATFLPKFLER QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP GKKPEDSRV 
CCCCCCCCCC CCCCCCHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHCCCHH HHHHHHHHHH HHCCCCCCCC CCCEEEECCC CHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHCH HHHCCCHHHH HHHCCHHHHH HHHCCEECCC CCCCCCCCEE EHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCEECCCCC CCEEEECCCC CCCCCCCCCC CCCCCCHHHC HHHHHHHHHH HHHHHHHCCC HHHHHHHHHC CHHHCCHHHH HHHHHHHHHH CCCCCEEEEC CCCCCCHHCC CCCCCCCEEE ECCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHH HHHHHCCCHH HHHHHHCCCC CCCCCCCCC
[Overview] SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 
SLCO1A2   MGETEKRI-------------------ETH------------------RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL----------------CMENGTQIL-------RPTQDPS--ECTKEVKS---LMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP---------KEGLETNADIIKNENE--DKQK-EEVKKEKYG---------ITK---DFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY----FLSFLMTCENSSVVGINTSYEGIPQDLYVEND-IFADCNVDCNCPSKIWDPVCG-NNGLSYLSACLAGCET----SIGTGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSS--FVPALIILILLR----KCHLPGENASS-----------------GTELIETKVKGKENECKDIYQKSTVLKDD--ELKTKL----------------------------
SLCO1B1   MDQNQHLN-------------------KTA----------EAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI--NSSENSTSTL------------STCLINQI----LSLNRASPEIVGK--GCLKESGS---YMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT-PNK-----PQKERKASLSLHVLETNDEKDQTA-NLTNQGKN----------ITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY----LLYFFILCENKSVAGLTMTYDGNNPVTSHRDV-PLSYCNSDCNCDESQWEPVCG-NNGITYISPCLAGCKS----SSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSS--LVLYIILIYAMK---KKYQEKDINASEN-GSVMDEANLESLNK-NKHFVPSAGADSETHC-------------------------------------------------
SLCO1B3   MDQHQHLN-------------------KTA----------ESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHI--NPSENSTSSL------------STCLINQT----LSFNGTSPEIVEK--DCVKESGS---HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKN-PNK-----PQKERKISLSLHVLKTNDDRNQTA-NLTNQGKN----------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQ----LLYFPLICESKSVAGLTLTYDGNNSVASHVDV-PLSYCNSECNCDESQWEPVCG-NNGITYLSPCLAGCKS----SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPA--LVLYIVFIFAMK---KKFQGKDTKASDNERKVMDEANLEFLNN-GEHFVPSAGTDSKT-CNLDMQDNAAAN--------------------------------------
SLCO1C1   MDTSSKEN--------------IQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYS-----PSSNSTLSI------------SPCLLESSSQLPVSVMEKSKSKISN--ECEVDTSS---SMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRS-----QSREDSNSSSEKSKFIID--DHTD-YQTPQGENA--------KIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLF----LSLFALGCENSDVAGLTVSYQGTKPVSYHERA-LFSDCNSRCKCSETKWEPMCG-ENGITYVSACLAGCQT----SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF---------------------------------RYQIKSIPASHC-YSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
SLCO2A1   MGLLPKLG--------------ASQGSDTSTSRAGR----CA-------RSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLAS-----TGNNSRLQAELCQKHWQDLPPSKCHSTTQ----------NPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILC----VPLFFMGCSTPTVAEV---YPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCV-TGG----SASAKTGSCPV--PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI-----------SWRVKKNKEYNV-------------QK-AAGLI------------------------------------------------------------
SLCO2B1   MG--PRIGPAGEVPQVPDKETKATMG--TENTPGGK----ASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTS-----PEDMP-----------QDFKASLCLPTTS----------APASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGI------THQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCV-VEG----N-PVLAGSCDS--TCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICFALVLAVLRQQDKEARTKESRSSPA-------------VE-QQLLVSGPGKKPED--------------------SRV----------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLCO2B1 15 P/S 0.000457981 rs56837383
-- SLCO2B1 111 R/Q 0.00134811 rs142693902
-- SLCO2B1 115 P/S 0.000401645 rs148248368
-- SLCO2B1 143 R/H 0.000139345 rs78648789
-- SLCO2B1 201 V/M 0.0207955 rs35199625
-- SLCO2B1 240 L/V 0.000589421 rs140630595
-- SLCO2B1 285 G/S 0.000533147 rs150167315
-- SLCO2B1 306 R/H 0.0144884 rs78825186
-- SLCO2B1 312 R/Q 0.183525 rs12422149
-- SLCO2B1 340 K/N 0.000274539 rs555605508
-- SLCO2B1 350 N/T 0.000119376 rs147131265
-- SLCO2B1 392 I/T 0.999992 rs1621378
-- SLCO2B1 420 S/L 0.000103534 rs200453426
-- SLCO2B1 486 S/F 0.0775044 rs2306168
-- SLCO2B1 490 M/V 0.000135414 rs114413167
-- SLCO2B1 509 R/H 0.000441791 rs140407559
-- SLCO2B1 542 V/M 0.00138122 rs143480565
-- SLCO2B1 546 N/K 0.000243049 rs145875125
-- SLCO2B1 548 V/M 0.00029083 rs149242910
-- SLCO2B1 556 T/M 0.00010754 rs772552828
-- SLCO2B1 691 V/I 0.000191848 rs149765874
-- SLCO2B1 693 Q/E 0.000455876 rs140987364

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLCO2B1 SLCO2B1 [plasma membrane] Transport of organic anions

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data