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Detail Data SLCO2A1


Basic description
Gene Name SLCO2A1
Protein Name Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)
Family SLCO
Category Transport of vitamins, nucleosides, and related molecules
Reaction name SLCO2A1 transports PGT substrates from extracellular region to cytosol
Reaction 1 PGT substrates [extracellular region] --> 1 PGT substrates [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI 
CCCCCCCCCC CCCCCCCCCC CCCHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHHHH HHHHHHCHHH CCCCCCCEEC CCCCCCCHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHCCCCCCCC CCCCHHCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHCHHHHCCC CCCCCCCCCC CCCCHHHHHH HHHCCCCHHH HHHHCCHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HCCCCCHHHH HHCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCHHHHCCC CCCCCCCCCC CHHHCCCCCC CCCCCCCCCC CCCCEECCCC CCCCCCCCCC CCCCCEEEEE ECCCCCCCCC CCCCCCCCCC HHCCCHHHHH HHHHHHHHHH HCCCHHHCCE EECCCHHHHH HHHHHHHHHH HHHHCCCCCE EEEECCCCCH HHHCCCCCCC CCCEECCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC HHHHCHHHHC CCC
[Overview] SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 
SLCO1A2   MGETEKRI-------------------ETH------------------RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL----------------CMENGTQIL-------RPTQDPS--ECTKEVKS---LMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP---------KEGLETNADIIKNENE--DKQK-EEVKKEKYG---------ITK---DFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY----FLSFLMTCENSSVVGINTSYEGIPQDLYVEND-IFADCNVDCNCPSKIWDPVCG-NNGLSYLSACLAGCET----SIGTGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSS--FVPALIILILLR----KCHLPGENASS-----------------GTELIETKVKGKENECKDIYQKSTVLKDD--ELKTKL----------------------------
SLCO1B1   MDQNQHLN-------------------KTA----------EAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI--NSSENSTSTL------------STCLINQI----LSLNRASPEIVGK--GCLKESGS---YMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT-PNK-----PQKERKASLSLHVLETNDEKDQTA-NLTNQGKN----------ITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY----LLYFFILCENKSVAGLTMTYDGNNPVTSHRDV-PLSYCNSDCNCDESQWEPVCG-NNGITYISPCLAGCKS----SSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSS--LVLYIILIYAMK---KKYQEKDINASEN-GSVMDEANLESLNK-NKHFVPSAGADSETHC-------------------------------------------------
SLCO1B3   MDQHQHLN-------------------KTA----------ESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHI--NPSENSTSSL------------STCLINQT----LSFNGTSPEIVEK--DCVKESGS---HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKN-PNK-----PQKERKISLSLHVLKTNDDRNQTA-NLTNQGKN----------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQ----LLYFPLICESKSVAGLTLTYDGNNSVASHVDV-PLSYCNSECNCDESQWEPVCG-NNGITYLSPCLAGCKS----SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPA--LVLYIVFIFAMK---KKFQGKDTKASDNERKVMDEANLEFLNN-GEHFVPSAGTDSKT-CNLDMQDNAAAN--------------------------------------
SLCO1C1   MDTSSKEN--------------IQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYS-----PSSNSTLSI------------SPCLLESSSQLPVSVMEKSKSKISN--ECEVDTSS---SMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRS-----QSREDSNSSSEKSKFIID--DHTD-YQTPQGENA--------KIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLF----LSLFALGCENSDVAGLTVSYQGTKPVSYHERA-LFSDCNSRCKCSETKWEPMCG-ENGITYVSACLAGCQT----SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF---------------------------------RYQIKSIPASHC-YSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
SLCO2A1   MGLLPKLG--------------ASQGSDTSTSRAGR----CA-------RSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLAS-----TGNNSRLQAELCQKHWQDLPPSKCHSTTQ----------NPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILC----VPLFFMGCSTPTVAEV---YPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCV-TGG----SASAKTGSCPV--PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI-----------SWRVKKNKEYNV-------------QK-AAGLI------------------------------------------------------------
SLCO2B1   MG--PRIGPAGEVPQVPDKETKATMG--TENTPGGK----ASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTS-----PEDMP-----------QDFKASLCLPTTS----------APASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGI------THQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCV-VEG----N-PVLAGSCDS--TCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICFALVLAVLRQQDKEARTKESRSSPA-------------VE-QQLLVSGPGKKPED--------------------SRV----------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLCO2A1 26 S/L 0.00252026 rs201797879
-- SLCO2A1 62 R/H 0.000353984 rs200980092
-- SLCO2A1 70 S/L 0.00017102 rs184853591
-- SLCO2A1 99 R/C 0.000203161 rs144748248
-- SLCO2A1 99 R/H 0.000167292 rs192851611
-- SLCO2A1 123 E/K 0.000231057 rs142920472
-- SLCO2A1 162 P/A 0.000250595 rs140769111
-- SLCO2A1 165 E/D 0.000628406 rs142215026
-- SLCO2A1 228 V/I 0.000330086 rs141676845
-- SLCO2A1 248 P/L 0.000190922 rs200824486
-- SLCO2A1 283 P/S 0.0014437 rs79619371
-- SLCO2A1 302 A/P 0.000318134 rs142480645
-- SLCO2A1 330 L/P 0.00011541 rs1415094638
-- SLCO2A1 362 A/P 0.000319611 rs556819076
-- SLCO2A1 389 R/H 0.00330309 rs201539847
-- SLCO2A1 396 A/T 0.238241 rs34550074
-- SLCO2A1 430 P/S 0.000653059 rs530021473
-- SLCO2A1 431 P/T 0.000211182 rs146195307
-- SLCO2A1 439 P/L 0.000142011 rs147644142
-- SLCO2A1 445 R/C 0.00214844 rs146970901
-- SLCO2A1 462 N/S 0.00124911 rs150345667
-- SLCO2A1 477 I/V 0.000155325 rs368928185
-- SLCO2A1 478 N/K 0.00020715 rs375938553
-- SLCO2A1 500 A/T 0.000174682 rs138923414
-- SLCO2A1 539 M/V 0.000317091 rs140206661
-- SLCO2A1 553 I/V 0.000345941 rs199895359
-- SLCO2A1 582 R/Q 0.000637689 rs144464929

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLCO2A1 SLCO2A1 [plasma membrane] Transport of organic anions

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLCO2A1 SLCO2A1 C420F [plasma membrane] Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
SLCO2A1 SLCO2A1 G222R [plasma membrane] Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
SLCO2A1 SLCO2A1 F276Lfs*18 [plasma membrane] Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
SLCO2A1 SLCO2A1 N545Tfs*15 [plasma membrane] Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
SLCO2A1 SLCO2A1 G255E [plasma membrane] Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)