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Variant
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Disease

Detail Data SLCO1C1


Basic description
Gene Name SLCO1C1
Protein Name Solute carrier organic anion transporter family member 1C1 (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter)
Family SLCO
Category Transport of vitamins, nucleosides, and related molecules
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730 
MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS FVYFAKALAE GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCVIMG VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS ISPCLLESSS QLPVSVMEKS KSKISNECEV DTSSSMWIYV FLGNLLRGIG ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF LLGSLCAKLY VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF GNPVYFLYLC TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI PAVALGIFSG GIVMKKFRIS VCGAAKLYLG SSVFGYLLFL SLFALGCENS DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC KCSETKWEPM CGENGITYVS ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR CQKDNGCPQM FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRY QIKSIPASHC YSIPDLHNAT DTNKFSCHFT ACKTYISGTN CDTGHSVNSP KHCSTFHFKE KLCFKTQKFY NQERKNNGVY KIPKGKLHYK  
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHHCHH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHC CCCCCCCCCH HCCCCCCHHC CHHHHCCCCC CCCCCCCCCH HHHHHHHHCC CCCCCCCCCE EEECCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCHHC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHHH CHHHCCCCHH HHHHCCCHHH CCHHHCCCCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCEEEE CCCCCCCCCC CCCCCEEEEE CCCCEEECCC CCCCCEEEEE CCCCCCCHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHEEC CHHHHCHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHCC CCCCCCCCEE EEEECHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHCCCCEE ECCCCCEECC
[Overview] SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 
SLCO1A2   MGETEKRI-------------------ETH------------------RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL----------------CMENGTQIL-------RPTQDPS--ECTKEVKS---LMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP---------KEGLETNADIIKNENE--DKQK-EEVKKEKYG---------ITK---DFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY----FLSFLMTCENSSVVGINTSYEGIPQDLYVEND-IFADCNVDCNCPSKIWDPVCG-NNGLSYLSACLAGCET----SIGTGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSS--FVPALIILILLR----KCHLPGENASS-----------------GTELIETKVKGKENECKDIYQKSTVLKDD--ELKTKL----------------------------
SLCO1B1   MDQNQHLN-------------------KTA----------EAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI--NSSENSTSTL------------STCLINQI----LSLNRASPEIVGK--GCLKESGS---YMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT-PNK-----PQKERKASLSLHVLETNDEKDQTA-NLTNQGKN----------ITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY----LLYFFILCENKSVAGLTMTYDGNNPVTSHRDV-PLSYCNSDCNCDESQWEPVCG-NNGITYISPCLAGCKS----SSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSS--LVLYIILIYAMK---KKYQEKDINASEN-GSVMDEANLESLNK-NKHFVPSAGADSETHC-------------------------------------------------
SLCO1B3   MDQHQHLN-------------------KTA----------ESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHI--NPSENSTSSL------------STCLINQT----LSFNGTSPEIVEK--DCVKESGS---HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKN-PNK-----PQKERKISLSLHVLKTNDDRNQTA-NLTNQGKN----------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQ----LLYFPLICESKSVAGLTLTYDGNNSVASHVDV-PLSYCNSECNCDESQWEPVCG-NNGITYLSPCLAGCKS----SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPA--LVLYIVFIFAMK---KKFQGKDTKASDNERKVMDEANLEFLNN-GEHFVPSAGTDSKT-CNLDMQDNAAAN--------------------------------------
SLCO1C1   MDTSSKEN--------------IQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYS-----PSSNSTLSI------------SPCLLESSSQLPVSVMEKSKSKISN--ECEVDTSS---SMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRS-----QSREDSNSSSEKSKFIID--DHTD-YQTPQGENA--------KIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLF----LSLFALGCENSDVAGLTVSYQGTKPVSYHERA-LFSDCNSRCKCSETKWEPMCG-ENGITYVSACLAGCQT----SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF---------------------------------RYQIKSIPASHC-YSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
SLCO2A1   MGLLPKLG--------------ASQGSDTSTSRAGR----CA-------RSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLAS-----TGNNSRLQAELCQKHWQDLPPSKCHSTTQ----------NPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILC----VPLFFMGCSTPTVAEV---YPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCV-TGG----SASAKTGSCPV--PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI-----------SWRVKKNKEYNV-------------QK-AAGLI------------------------------------------------------------
SLCO2B1   MG--PRIGPAGEVPQVPDKETKATMG--TENTPGGK----ASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTS-----PEDMP-----------QDFKASLCLPTTS----------APASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGI------THQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCV-VEG----N-PVLAGSCDS--TCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICFALVLAVLRQQDKEARTKESRSSPA-------------VE-QQLLVSGPGKKPED--------------------SRV----------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLCO1C1 13 C/R 0.000215781 rs778959818
-- SLCO1C1 117 V/G 0.000513551 rs538277486
-- SLCO1C1 143 P/T 0.0339936 rs36010656
-- SLCO1C1 230 T/M 0.000134134 rs142645342
-- SLCO1C1 309 N/K 0.00118608 rs75171154
-- SLCO1C1 389 S/F 0.00749438 rs144285413
-- SLCO1C1 425 A/T 0.000139372 rs541289271
-- SLCO1C1 532 G/R 0.000103788 rs149798560
-- SLCO1C1 536 G/D 0.000171218 rs145739313
-- SLCO1C1 564 T/A 0.0103657 rs147735206
-- SLCO1C1 672 C/R 0.000184882 rs772559363
-- SLCO1C1 677 S/F 0.535308 rs6487138
-- SLCO1C1 687 V/F 0.0165433 rs111796962
-- SLCO1C1 725 G/R 0.000155639 rs772956609

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLCO1C1 SLCO1C1 [plasma membrane] Transport of organic anions

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data