Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLCO1B3


Basic description
Gene Name SLCO1B3
Protein Name Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
Family SLCO
Category Transport of vitamins, nucleosides, and related molecules
Reaction name SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol
Defective SLCO1B3 does not transport ALB:(GCCA, TCCA) from extracellular region to cytosol
Reaction 1 ALB:(GCCA, TCCA) [extracellular region] --> 1 GCCA, TCCA [cytosol] + 1 ALB [extracellular region]
1 ALB:(GCCA, TCCA) [extracellular region] -->

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700 
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA AN 
CCCCCCCCCC CCCCCCCCHH CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCEEHHH HHHHHHHHHH HHCHHHHHCC CCCCCCEECC CCCCCCCCCH HHHHCCCCCC CCCCHHHHHC HHHHCCCCHH HHHHHHHHHH HHHCCCCCCC CCCCHHHHHH HHCCCCHHHH HCCHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHCCC CCCCCCHHHC CCCCCHHHHC CCCCCCHHHH HCCCCCCCCC CHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHCCHHHHHH HHHHHHHCCC HHHHHHHCCC CCCCHHHHHH HHHCHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCEE ECCCCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCEE EEECCCCCCC CCCCCCCEEE EEECCCCEEC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHCC CCCCHHHHEE EEECHHHHHH HHHHHHHHHH HHHCCCHHHH HCHHHHCCCC CCCCCCCCCC CCEEEECCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCHH HCCCCCCCCH HHCCCCCHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CC
[Overview] SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2A1 SLCO2B1 
SLCO1A2   MGETEKRI-------------------ETH------------------RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL----------------CMENGTQIL-------RPTQDPS--ECTKEVKS---LMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP---------KEGLETNADIIKNENE--DKQK-EEVKKEKYG---------ITK---DFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY----FLSFLMTCENSSVVGINTSYEGIPQDLYVEND-IFADCNVDCNCPSKIWDPVCG-NNGLSYLSACLAGCET----SIGTGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSS--FVPALIILILLR----KCHLPGENASS-----------------GTELIETKVKGKENECKDIYQKSTVLKDD--ELKTKL----------------------------
SLCO1B1   MDQNQHLN-------------------KTA----------EAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI--NSSENSTSTL------------STCLINQI----LSLNRASPEIVGK--GCLKESGS---YMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT-PNK-----PQKERKASLSLHVLETNDEKDQTA-NLTNQGKN----------ITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY----LLYFFILCENKSVAGLTMTYDGNNPVTSHRDV-PLSYCNSDCNCDESQWEPVCG-NNGITYISPCLAGCKS----SSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSS--LVLYIILIYAMK---KKYQEKDINASEN-GSVMDEANLESLNK-NKHFVPSAGADSETHC-------------------------------------------------
SLCO1B3   MDQHQHLN-------------------KTA----------ESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHI--NPSENSTSSL------------STCLINQT----LSFNGTSPEIVEK--DCVKESGS---HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKN-PNK-----PQKERKISLSLHVLKTNDDRNQTA-NLTNQGKN----------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQ----LLYFPLICESKSVAGLTLTYDGNNSVASHVDV-PLSYCNSECNCDESQWEPVCG-NNGITYLSPCLAGCKS----SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPA--LVLYIVFIFAMK---KKFQGKDTKASDNERKVMDEANLEFLNN-GEHFVPSAGTDSKT-CNLDMQDNAAAN--------------------------------------
SLCO1C1   MDTSSKEN--------------IQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYS-----PSSNSTLSI------------SPCLLESSSQLPVSVMEKSKSKISN--ECEVDTSS---SMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRS-----QSREDSNSSSEKSKFIID--DHTD-YQTPQGENA--------KIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLF----LSLFALGCENSDVAGLTVSYQGTKPVSYHERA-LFSDCNSRCKCSETKWEPMCG-ENGITYVSACLAGCQT----SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF---------------------------------RYQIKSIPASHC-YSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
SLCO2A1   MGLLPKLG--------------ASQGSDTSTSRAGR----CA-------RSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLAS-----TGNNSRLQAELCQKHWQDLPPSKCHSTTQ----------NPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILC----VPLFFMGCSTPTVAEV---YPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCV-TGG----SASAKTGSCPV--PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI-----------SWRVKKNKEYNV-------------QK-AAGLI------------------------------------------------------------
SLCO2B1   MG--PRIGPAGEVPQVPDKETKATMG--TENTPGGK----ASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTS-----PEDMP-----------QDFKASLCLPTTS----------APASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGI------THQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCV-VEG----N-PVLAGSCDS--TCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICFALVLAVLRQQDKEARTKESRSSPA-------------VE-QQLLVSGPGKKPED--------------------SRV----------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLCO1B3 4 H/R 0.00165531 rs61612406
-- SLCO1B3 36 F/L 0.00149253 rs79042365
-- SLCO1B3 52 I/V 0.000557991 rs57325543
-- SLCO1B3 92 H/R 0.000597139 rs144099822
-- SLCO1B3 112 S/Y 0.00103959 rs145334570
-- SLCO1B3 112 S/A 0.808213 rs4149117
-- SLCO1B3 135 S/L 0.000159072 rs150039066
-- SLCO1B3 138 S/I 0.000110077 rs369529563
-- SLCO1B3 145 N/S 0.00158134 rs146623116
-- SLCO1B3 147 T/A 0.00223548 rs57585902
-- SLCO1B3 170 M/V 0.000107512 rs752206814
-- SLCO1B3 181 R/H 0.000302584 rs180875376
-- SLCO1B3 198 D/N 0.000120259 rs368649517
-- SLCO1B3 215 I/M 0.000151819 rs142673817
-- SLCO1B3 226 L/V 0.00100725 rs115227445
-- SLCO1B3 233 M/I 0.808279 rs7311358
-- SLCO1B3 247 I/K 0.000236498 rs764151105
-- SLCO1B3 256 G/A 0.112233 rs60140950
-- SLCO1B3 330 K/E 0.0001191 rs146780296
-- SLCO1B3 414 T/I 0.000618437 rs146940490
-- SLCO1B3 420 L/V 0.000147602 rs201866779
-- SLCO1B3 437 G/S 0.000280036 rs61673910
-- SLCO1B3 438 L/P 0.000832633 rs189943255
-- SLCO1B3 456 L/F 0.000646696 rs61736817
-- SLCO1B3 465 K/E 0.0391001 rs75072111
-- SLCO1B3 476 S/N 0.000469704 rs544671592
-- SLCO1B3 489 C/Y 0.000104259 rs762055285
-- SLCO1B3 530 C/R 0.000184829 rs188500840
-- SLCO1B3 537 Y/C 0.000305243 rs150998576
-- SLCO1B3 550 T/A 0.000202008 rs144378120
-- SLCO1B3 560 V/A 0.00159203 rs12299012
-- SLCO1B3 571 A/G 0.000348642 rs76963574
-- SLCO1B3 572 M/V 0.000825301 rs564235948
-- SLCO1B3 619 V/I 0.00103983 rs202234562
-- SLCO1B3 653 G/E 0.00741265 rs188817665
-- SLCO1B3 661 M/R 0.000126487 rs201268097
-- SLCO1B3 663 R/K 0.000111636 rs371725645
-- SLCO1B3 680 T/I 0.000529863 rs138097461
-- SLCO1B3 688 G/S 0.000224671 rs112108376
-- SLCO1B3 706 F/L 0.000185242 rs200519879
-- SLCO1B3 742 V/I 0.000101643 rs200355373
-- SLCO1B3 744 S/T 0.000171215 rs200074074
-- SLCO1B3 748 Q/K 0.00539371 rs73241802

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLCO1B3 SLCO1B3 [plasma membrane] Transport of organic anions
SLCO1B3 SLCO1B3 [plasma membrane] Recycling of bile acids and salts

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLCO1B3 SLCO1B3 I562* [plasma membrane] Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)