Detail Data SLCO1B1

Basic description

Gene Name	SLCO1B1
Protein Name	Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Family	SLCO
Category	Transport of vitamins, nucleosides, and related molecules
Reaction name	SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol SLCO1B1 transports T3,T4 from extracellular region to cytosol SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol
Reaction	1 ALB:(GCCA, TCCA) [extracellular region] --> 1 GCCA, TCCA [cytosol] + 1 ALB [extracellular region] 1 T3,T4 [extracellular region] --> 1 T3,T4 [cytosol] 1 ALB:(GCCA, TCCA) [extracellular region] --> 1 GCCA, TCCA [cytosol] + 1 ALB [extracellular region]

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690 
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C 
CCCCCCCCCC CCCCCCCCHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHC HHHCCCCCCC CCCCCCCCCC HHHHHCHHHC CCCCHHHCCC CCCCCCCCHH HHHHHHHHHH HHCCCCCCCC CCCCCHHHHH HHCCCCHHHH HHHHHHHHCC CHHHHHHHHH HHCCCCCCCC CCCCEEECCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCHHC CCCCCCCCCC CCCCCCCCHH HHHCCHHHHH HHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHCCEEEEE CCHHHHHHCH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCCE EECCCCCCCC CCCCCCCCEE EEECCEEEEC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCHHHHHH HHHHHHHHHH HHHCCCCCEE EEEECCCCEE EEECCCCCCC CEEEECCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCH HCCCCCCCCC CCCCCCHHHH HHHCCCCCCC CCCCCCCCCC C

Family alignment

[Overview]

SLCO1A2   MGETEKRI-------------------ETH------------------RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL----------------CMENGTQIL-------RPTQDPS--ECTKEVKS---LMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP---------KEGLETNADIIKNENE--DKQK-EEVKKEKYG---------ITK---DFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY----FLSFLMTCENSSVVGINTSYEGIPQDLYVEND-IFADCNVDCNCPSKIWDPVCG-NNGLSYLSACLAGCET----SIGTGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSS--FVPALIILILLR----KCHLPGENASS-----------------GTELIETKVKGKENECKDIYQKSTVLKDD--ELKTKL----------------------------
SLCO1B1   MDQNQHLN-------------------KTA----------EAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI--NSSENSTSTL------------STCLINQI----LSLNRASPEIVGK--GCLKESGS---YMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT-PNK-----PQKERKASLSLHVLETNDEKDQTA-NLTNQGKN----------ITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY----LLYFFILCENKSVAGLTMTYDGNNPVTSHRDV-PLSYCNSDCNCDESQWEPVCG-NNGITYISPCLAGCKS----SSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSS--LVLYIILIYAMK---KKYQEKDINASEN-GSVMDEANLESLNK-NKHFVPSAGADSETHC-------------------------------------------------
SLCO1B3   MDQHQHLN-------------------KTA----------ESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHI--NPSENSTSSL------------STCLINQT----LSFNGTSPEIVEK--DCVKESGS---HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKN-PNK-----PQKERKISLSLHVLKTNDDRNQTA-NLTNQGKN----------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQ----LLYFPLICESKSVAGLTLTYDGNNSVASHVDV-PLSYCNSECNCDESQWEPVCG-NNGITYLSPCLAGCKS----SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPA--LVLYIVFIFAMK---KKFQGKDTKASDNERKVMDEANLEFLNN-GEHFVPSAGTDSKT-CNLDMQDNAAAN--------------------------------------
SLCO1C1   MDTSSKEN--------------IQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYS-----PSSNSTLSI------------SPCLLESSSQLPVSVMEKSKSKISN--ECEVDTSS---SMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRS-----QSREDSNSSSEKSKFIID--DHTD-YQTPQGENA--------KIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLF----LSLFALGCENSDVAGLTVSYQGTKPVSYHERA-LFSDCNSRCKCSETKWEPMCG-ENGITYVSACLAGCQT----SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF---------------------------------RYQIKSIPASHC-YSIPDLHNATDTNKFSCHFTACKTYISGTNCDTGHSVNSPKHCSTFHFKEKLCFKTQKFYNQERKNNGVYKIPKGKLHYK
SLCO2A1   MGLLPKLG--------------ASQGSDTSTSRAGR----CA-------RSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLAS-----TGNNSRLQAELCQKHWQDLPPSKCHSTTQ----------NPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILC----VPLFFMGCSTPTVAEV---YPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCV-TGG----SASAKTGSCPV--PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI-----------SWRVKKNKEYNV-------------QK-AAGLI------------------------------------------------------------
SLCO2B1   MG--PRIGPAGEVPQVPDKETKATMG--TENTPGGK----ASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTS-----PEDMP-----------QDFKASLCLPTTS----------APASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGI------THQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCV-VEG----N-PVLAGSCDS--TCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICFALVLAVLRQQDKEARTKESRSSPA-------------VE-QQLLVSGPGKKPED--------------------SRV----------------------------

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLCO1B1	51	S/F	0.000111493	rs769900186
--	SLCO1B1	57	R/Q	0.00039841	rs61760182
--	SLCO1B1	106	I/T	0.000704904	rs200227560
--	SLCO1B1	130	N/D	0.473714	rs2306283
--	SLCO1B1	151	N/S	0.000323402	rs2306282
--	SLCO1B1	155	P/T	0.114208	rs11045819
--	SLCO1B1	174	V/A	0.132876	rs4149056
--	SLCO1B1	211	I/M	0.00357899	rs201722521
--	SLCO1B1	222	I/V	0.000765593	rs79135870
--	SLCO1B1	245	I/V	0.00617382	rs11045852
--	SLCO1B1	253	R/Q	0.000290677	rs11045853
--	SLCO1B1	345	T/M	0.000384961	rs61760243
--	SLCO1B1	400	F/L	0.00346598	rs59113707
--	SLCO1B1	432	N/K	0.000127672	rs534931824
--	SLCO1B1	437	G/R	0.000171724	rs142965323
--	SLCO1B1	441	T/N	0.000163872	rs141779296
--	SLCO1B1	488	G/A	0.00259131	rs59502379
--	SLCO1B1	492	S/T	0.000207168	rs568173893
--	SLCO1B1	541	Q/L	0.000159141	rs71581988
--	SLCO1B1	643	L/F	0.0452999	rs34671512
--	SLCO1B1	678	H/Y	0.0002195	rs200995543
--	SLCO1B1	682	S/F	0.000139723	rs140790673

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLCO1B1	SLCO1B1 [plasma membrane]	Transport of organic anions
	SLCO1B1	SLCO1B1 [plasma membrane]	Recycling of bile acids and salts

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
SLCO1B1	SLCO1B1 R580* [plasma membrane]	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
SLCO1B1	SLCO1B1 R580* [plasma membrane]	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
SLCO1B1	SLCO1B1 R253* [plasma membrane]	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
SLCO1B1	SLCO1B1 R253* [plasma membrane]	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)