Detail Data SLC9C2

Basic description

Gene Name	SLC9C2
Protein Name	Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2)
Family	SLC9
Category	-
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

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MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK NCEVIVLTIL SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI IFMVALDVEF YTLKKMFWQV LLTGLISFST ASIIIGYVVI KFNKDSWDLQ SCLLFSITLG IIDPLRSVNS LKTIGISKIY IDLIRGESLI ICSIASIFFG NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ CILADVFSNM LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL LTILLVSPIL MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV EVPQMFILYV QVISLLTMGI NSYVMTQSAR KLDLCVLSLP RQMILQNATQ HIQEIVQNTI TLFKTEKILT NVNWTLVEDK TRIEYIPFSH VSHNDMKTES TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI GAAKCYYSIQ GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL YVLESTLKII ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA LIQLTVIMGY LRIIRFLPLF KIIVPILIRI ADVQIKKRLS LMYSITKGYI KSQEDAKLLI KQIAVCESIY QKLCEILETN KQDAVKELVL MEHEGRDVVI ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL LKKLKALNNF PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL SCLLKREIEY TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS TAYQYFESSL IDEDLRFQNC VMFNQAYVET LSSYSDMIID NMTMKFVIIV YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS DLSKLLIIQA SELTQRNSNT NVMASVNTVF EQPGKNINGR QKMS 
CCCCCCCCCC CCCCCCCCCC CCHHHHCHHH HHHHHHHHHH HHHHHHHHHH CCCCCHHHHH HHHHHHHHHH HCCCCHHHHC HHHHHCCCHH HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH CCCHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HEEEEEECCH HHHHHHHHHH HHHCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHHCCHHH CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHHHHC CCCCCHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHCCC CCCHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHCC CCCCCCCCHH HHHHCCHHHC CCHHHHHHHH HHCEEEEECC CCEEEECCCC CCEEEEEEEC EEEEEECCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHCCCCEEE EEEECCCEEE EEEEHHHHHH HHHHHCHHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHCCEEECC CCCCCEEEEE CCCCEEEEEE EEEEEECCCC CEEECCEECC CCCEECCCCC CCCEEEEEEC HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCC

Family alignment

[Overview]

SLC9A1    --------MVLRS------GICGLSPHR---------------------IFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRP--VNHS--VTDHGMKPRKA-FPVLGIDYTHVRTPFEISLWILLACL--------------------MKIGFHVI-PTISSIVPESCLLIVVGLLVGGLI-KGVGE-TP----------------------------------------------------PFLQSDVFFLFLLPPIILDAGYFLPLRQFTE--------NLGTILIFAVVGTLWNAFFLGGLMY----------------AVCLVGGEQ-INNIGLLDNLLFGSIISAVDPVAVLAVFEEIH-----INELLHILVFGESLLNDAVTVVLYHLFEEFANY---EHVGIVDIF------LGF-LSFFVVALGGVLVGVVYGVIAAFTSRFTS-----HIRVIEPLFVFLYSYMAYLSAELFHL---SGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HHWNW---TFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSL--GYLLDKKHF--------PMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVK-------------------------------------------------------------KKQETKRS----------INEEIHTQFL----DHLLTGIEDICGHYGHHHWK--D----KLNRFNKKYVKKCLIAG---------------------------------------------------ERSKEPQ----LIAFYH--------------------------------KMEM-------------------------------------------------------------KQAIELVESG--------------GMG----KIPSAVS----------------------------TVSMQNIHPKSLPSERILPALSKDKEEEI-------------------RKILRNNLQKTRQRLR-SYNRHTLVADPYEEAWNQMLLRRQKARQLEQKIN-------------------N-------------------------YLTVPAHK------------------LDSPTMSRARIG------SDPLA---------------------------------------------YEPKEDL---------------PV-----------------I-TID--------------PASPQS---------------------------------PESVDLVNEE-L--------KG-KVLGLSRD-------PAKVAEEDEDDDGGIMMRSKETSS---------------PGTDDVFTPA------------PSDSPSSQRIQRCLSDPGP-HPEPGE-----------GEPF----FPKGQ---
SLC9A2    MEPLGNW-RSLR------------AP------------------------LPPMLLLLL------------LQVAGPVGALAETLLNAPRAMGTSSSPPSP----------ASV--VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASL--------------------AKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVDEKSP----------------------------------------------------PAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE--------NIGTIFWYAVVGTLWNSIGIGVSLF----------------GICQIEAFG-LSDITLLQNLLFGSLISAVDPVAVLAVFENIH-----VNEQLYILVFGESLLNDAVTVVLYNLFKSFCQM---KTIETIDVF------AGI-ANFFVVGIGGVLIGIFLGFIAAFTTRFTH-----NIRVIEPLFVFLYSYLSYITAEMFHL---SGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFAL--VFLLPAAVF--------PRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-------------------------------------------------------------RSNKKQQA----------VSEEIYCRLF----DHVKTGIEDVCGHWGHNFWR--D----KFKKFDDKYLRKLLI------------------------------------------------------RENQPKS--SIVSLYK--------------------------------KLEI-------------------------------------------------------------KHAIEMAETG--------------MIS----TVPTFASL--------------------------NDCREEKIR-----------KVTSSETDEI-------------------RELLSRNLYQIRQRTL-SYNRHSLTADTSERQAKEILIRRRHS--LRESIR-------------------KDSSLNREH---------RASTSTSRYLSLPKNT----------------KLPEKL-QKRRTISIADGNSSDSDA--------------DAGTT--------------------VLNLQPR-ARRFL---------------PEQFSKKSPQSYKMEWKNEV-DVDS---------GRDMPSTPPT---------------------------------PHS----REK-----------GTQTSGLLQQ-------PLL-SKDQSG-------------S---------------EREDSLTEGI------------PPKPP--PRLVWRASEPGSRKARFGS-----------EKP-------------
SLC9A3    MWGLGA-----------------RGP------------------------DRGLLLALALGG---------LARA-----------------GGVEVEPGGAHGESG-------------------G-FQVVTFEWAHVQDPYVIALWILVASL--------------------AKIGFHLS-HKVTSVVPESALLIVLGLVLGGIV-WAADHIAS----------------------------------------------------FTLTPTVFFFYLLPPIVLDAGYFMPNRLFFG--------NLGTILLYAVVGTVWNAATTGLSLY----------------GVFLSGLMG-DLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVH-----VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGG-DNVTGVDCV------KGI-VSFFVVSLGGTLVGVVFAFLLSLVTRFTK-----HVRIIEPGFVFIISYLSYLTSEMLSL---SAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAV-NP-FIWTWN-TAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFAL--VVLLDGDKV--------KEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVK-------------------------------------------------------------RSEHREPR----------LNEKLHGRAF----DHILSAIEDISGQIGHNYLR--D----KWSHFDRKFLSRVLM------------------------------------------------------RRSAQKSRDRILNVFH--------------------------------ELNL-------------------------------------------------------------KDAISYVAEGE------------RRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRR--------RSIRDAEDMV------------------THHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR-LESFKS-------------------TKLGLNQNKKAAKLYKRERAQKR--RNSSIPNGK----------------LPMESP-AQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDT-----ASDSPAGIDNP-VFSPDEALDRSLLAR-----------LPPWLS-PGETVVPSQRARTQI---------------------------------------------------------PYS--------------------PGTFCRLM-------PFR------------------LSS---------------KSVDSFL---------------QADGPEE---RPPAALPESTHM-------------------------------
SLC9A4    --------MALQM------FVT-YSP------------------------WNCLLLLVA------------LECSEASSDLNES--------ANSTAQYAS----------NAW--FAAASSEPEEG-ISVFELDYDYVQIPYEVTLWILLASL--------------------AKIGFHLY-HRLPGLMPESCLLILVGALVGGII-FGTDHKSP----------------------------------------------------PVMDSSIYFLYLLPPIVLEGGYFMPTRPFFE--------NIGSILWWAVLGALINALGIGLSLY----------------LICQVKAFG-LGDVNLLQNLLFGSLISAVDPVAVLAVFEEAR-----VNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDIL------AGC-ARFIVVGLGGVLFGIVFGFISAFITRFTQ-----NISAIEPLIVFMFSYLSYLAAETLYL---SGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSL--AFLLPLSLF--------PRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-------------------------------------------------------------KTNKK-ES----------INEELHIRLM----DHLKAGIEDVCGHWSHYQVR--D----KFKKFDHRYLRKILI------------------------------------------------------RKNLPKS--SIVSLYK--------------------------------KLEM-------------------------------------------------------------KQAIEMVETG--------------ILSSTAFSIPHQAQ------------------------------RIQGIK-----------RLSPEDVESI-------------------RDILTSNMYQVRQRTL-SYNKYNLKPQTSEKQAKEILIRRQNT--LRESMR-------------------KGHSLPWGK---------PAGTKNIRYLSYPYGN------------------PQSAGRDTRAAGFSDDDSSDPGSP---------SITFSACSR--------------------IGSLQKQEAQEII---------------PMKSLHRGRKAFSFGYQRNT-----------------------------------------------------------S----QEEYL--------GGVRRVALRPK-------PLFHAVDEEGESGG--------ES---------------EGKASLVE---------------------VRSRWTADH-GHGRDHHRS-----------HSPL----LQKK----
SLC9A5    ----------------------------------------------------MLRAALSLLA---------LPLA-----------------GAAE-EPTQKPESPG---------------EPPPG-LELFRWQWHEVEAPYLVALWILVASL--------------------AKIVFHLS-RKVTSLVPESCLLILLGLVLGGIV-LAVAKKAE----------------------------------------------------YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFD--------NLGAILTYAVVGTLWNAFTTGAALW----------------GLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVH-----VNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS-ANVQATDYL------KGV-ASLFVVSLGGAAVGLVFAFLLALTTRFTK-----RVRIIEPLLVFLLAYAAYLTAEMASL---SAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAV-DS-SKWAWD-SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFAL--VILLDRTKV--------PAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVK-------------------------------------------------------------RSEHHKPT----------LNQELHEHTF----DHILAAVEDVVGHHGYHYWR--D----RWEQFDKKYLSQLLM------------------------------------------------------RRSAYRIRDQIWDVYY--------------------------------RLNI-------------------------------------------------------------RDAISFVDQGG------------HVLSSTGLTLPSMPS--------RNSVAETSVTNLLRESGSGACLDLQVIDT-V--------RSGRDREDAV------------------MHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRR-LESFKS-------------------TKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKH---RGLGFQDTAAVILTVES---------EEEEEESDSSETEKEDDE---GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKEL---------------PWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQA-----------------------PILTCLPPHP--------------------RGTEEPQV-------PLH------------------LPS---------------DPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGT-----------ATSHWCIQFNRGSRL-
SLC9A6    --------MARR--------GWRRAP--------------LRRGVGSSPRARRLMRPLWLLL--------AVGVFDWAGA----------SDGGGG--EARAMDEEI--------------VSEKQA-------EESHRQDSANLLIFILLLTL--------------------TILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFR--------NLGSILAYAFLGTAISCFVIGSIMY------------GCVTLMKVTGQLA--GDFYFTDCLLFGAIVSATDPVTVLAIFHELQ-----VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG--DNSHTFDVT---AMFKSI-GIFLGIFSGSFAMGAATGVVTALVTKFTKL---REFQLLETGLFFLMSWSTFLLAEAWGF---TGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP---TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFAL--AIR-DTAT---------YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGV--------DSDQ----------EH-----------LGV--------------------PENER-RT----------TKAE------------------------SAWLFR-------MWYNFDHNYLKPLLT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPACCGP-------------------------------------------------------I------------------ARCLTSPQAYENQEQLK-------------DDDSDLILNDGDIS--LT-------------------------------------------------YGDSTVNT-----------------------------------EPATSS--------------------------------------------------------------------------------------------------------APRRFMG---------------------------------NSSEDALDRELA--------FGDHELVIRGTR---LVLPMD-------------------DS---------------EPPLNLLD-------------NTRHGPA-----------------------------------------------
SLC9A7    ---MEPGDAARP--------GSGRA--------------------TGAPPPRLLLLPLLLGW--------GLRVAAAASA----------SSSGAAAEDSSAM-EEL--------------ATEKEA-------EESHRQDSVSLLTFILLLTL--------------------TILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSG-RDKSL-SCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFR--------NLGSILAYAFLGTAVSCFIIGNLMY------------GVVKLMKIMGQLS--DKFYYTDCLFFGAIISATDPVTVLAIFNELH-----ADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAG--LNTHAFDAA---AFFKSV-GIFLGIFSGSFTMGAVTG-VNANVTKFTKL---HCFPLLETALFFLMSWSTFLLAEACGF---TGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP---IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFAL--AIR-DTAS---------YARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVE--EPSEEDQNE----------HHWQYF------RVGVDPDQDPPPNNDSFQVLQGDGPDSARGNR----------TKQE------------------------SAWIFR-------LWYSFDHNYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPAWCGL-------------------------------------------------------L------------------ARCLTSPQVYDNQEPLR-------------EEDSDFILTEGDLT--LT-------------------------------------------------YGDSTVTA-----------------------------------NGSSSSH------------------------------------------------------------------TAST------------------------------SLEGSRR-TK---------------------------------SSSEEVLERDLG--------MGDQKVSSRGTR---LVFPLE-------------------DN---------------A--------------------------------------------------------------------------
SLC9A8    ---MGEK-MAE----------EERFPNT----THEGFNVTLH---TTLVVTTKLVLPT----------------------------------------PGKPI-LPV--------------QTGEQA-------QQEEQSSGMTIFFSLLVLAI--------------------CIILVHLLIRYRLHFLPESVAVVSLGILMGAVI----------------------------------KIIEFK--------KLANWKEEEM-----FRPNMFFLLLLPPIIFESGYSLHKGNFFQ--------NIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFILQADVIS---KLNMTDSFAFGSLISAVDPVATIAIFNALH-----VDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK------NMSDVSGWQTFLQAL-DYFLKMFFGSAALGTLTGLISALVLKHIDL---RKTPSLEFGMMIIFAYLPYGLAEGISL---SGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEI---SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYAL--SLHLDLEPM--------EKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI-----------EDAKA----------HR----------------------------------RNKKDVNL----------SKTEKMGNTVE--SEHLSELTEE---EYEAHYIRRQDLKGFVW--LDAKYLNPFFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRLTQEDLHHGRIQMK--------------------------T--LTNK----------------------------------------------WYEEVR---------------------------------------------------------------------------------------------------------------------------------------------------------QG---------------------------------PSGSEDDEQELL--------------------------------------------------------------------------------------------------------------------------------------------
SLC9A9    --------MER---------------------------------------------------------------------------------------QSRVM-------------------SEKDE-------YQFQHQGAVELLVFNFLLIL--------------------TILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ--------NLGSILTYAFLGTAISCIVIGLIMY------------GFVKAMIHAGQLK-NGDFHFTDCLFFGSLMSATDPVTVLAIFHELH-----VDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK---ENPNAFDAA---AFFQSV-GNFLGIFAGSFAMGSAYAIITALLTKFTKL---CEFPMLETGLFFLLSWSAFLSAEAAGL---TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA---LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFAL--AIR-NTES---------QPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSS----------QHQE--------------------------------ANNLDKNM----------TKAE------------------------SARLFR-------MWYSFDHKYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPEWCGP-------------------------------------------------------I------------------SRLLTSPQAYG--EQLK-------------EDDVECIVNQDELA--IN-------------------------------------------------YQEQA---------------------------------------SSPCSP------------------------------------------------------------------PARL------------------------------GLDQKASPQT---------------------------------PGKENIYEGDLG--------LGGYELKLEQT--------LG-------------------QS---------------Q--LN----------------------------------------------------------------------
SLC9B1    --MHTTESKNEHLEDENFQTST--TPQSLIDPNNTAHEETKT----------------------------VLS--DTEE-----------------IKPQTKK--ET------------YISCPLRG-----VLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPP--LPPLLGMLLAGFTIRNVPFINE-------------------HVHV-----------------------------PNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWA---------------------------------FLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFS---SGGILNNAI------ASI---------RNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQE------KMKVQKIITTVWDIFQPLLFGLVGAEVSVSS-LESNI--VGISVATLSLALCVRILTTYLLMCF------AGFSFKEKIFIALAWMPKATVQAVLGPLALETARV------SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPK------------------------------------------------------------------------------------------------------------------------------------MLT------------------------------------------------------RHYDPSKI----------------------------------------KLQL---ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC9B2    ---MGDEDKRITYEDSEPSTGMNYTPSM----HQEAQEETVM----------------------------KLKGIDANEP----------TEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHG-----LLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPP--LPSLLGMLLAGFLIRNIPVIND-------------------NVQI-----------------------------KHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWG---------------------------------FILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFS---TGSTVFNVL------RGV---------LEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSE------KAEVEKIIAVAWDIFQPLLFGLIGAEVSIAS-LRPET--VGLCVATVGIAVLIRILTTFLMVCF------AGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS-----HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPR------------------------------------------------------------------------------------------------------------------------------------LLQ------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEHQNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEE-------------------------------------------------VQG---------------ETSVQV---------------------------------------------------------------------
SLC9C1    --------MAGIF-------------------------------------------------------------------------------------------------------------------------KEFFFSTEDLPEVILTLSLI--------------------SSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLS-FTSSQVQR---------------------------YANAI--------------------QWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK--------LFWQILLISIPGF-----LVNYILV-----------------LWHLASVN-QLLLKPTQWLLFSAILVSSDPMLTAAAIRDLG-----LSRSLISLINGESLMTSVISLITFTSIMDFDQRLQ-SKRNH-TLA--EEIVGGI-CSY-II--ASFLFGILSSKLIQFWMSTVF-----GDDVNHISLIFSILYLIFYICELVGM---SGIFTLAIVGLLLNSTSFK--AAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVG-HEFSWRWIFIMVCSEMKGMPNINM--ALLLAYSDLYFGSDK--EKSQI-LFHGVLVCLITLVVNRFILPVAVTILG-----------LRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDL----ANADWNMI----EKAITLEN-PYM------LNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANR-RLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIIS-W--ISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEI-----DTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMS-HQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILK-AFGLKGIISKTEGAGINKLIMAKKKE--VLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKV-VTFDCGNDIFEEGDEPKGIYIIISGM---------VKLEKS---KPGLGI--DQMVESKEKDFP------IIDTDYMLSGE------------------IIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKM--------WL----KLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPM-----STKTDIYDENLI--YVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVI---IQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTL----EEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR--INLRKVRKE-
SLC9C2    --------MSSYFW----AQNESNRP--------------------------------------------DLLCG----------------------QPADYL------------------------------VEEKHFTT--------LVCFI--------------------VVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMA-YNSVEVHQ---------------------------IVYPL--------------------LRTSSFSLYSYFSPLIIFMVALDVEFYTLKK--------MFWQVLLTGLISFSTASIIIGYVVI------------KFNKDSWDLQSC-----------LLFSITLGIIDPLRSVNSLKTIG-----ISKIYIDLIRGESLIICSIASIFFGN-------FR-GNRIHFSIF--RDLHVGIELSYDIL--GSIIFGYWCAKIIQCILADVF-----SNMLTNIILCFSMVYMTFYIVEFLGM---SGTLALAAVGLNLDSLTFK--PKI-ELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN-YEYNWRWGVVITWSGIKGVFN-------LLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNAT-----------QHIQEIVQNTITLFKTEKIL----TNVNWTLV----EDKTRIEYIPFSHVSHNDMKTESTT--------------DEAL----MEEARL-HVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNV---SALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI----QLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIK-KRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLT-FLCSRGIIDKHEVIEINKVLLKKLKA--LNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKL-ACFDSGDTICKGGEMPQGIYLIISGM---------AILHSL---SPTFGIESNQRCDRGSRD---------MFTEFCTTGD------------------IIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKI--------WL----KLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE--TL-----SSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLI---IQA-------------------SELT--------------------QRNSNTNVMASVNTVF---------------EQPG--KNINGRQKMS

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC9C2	33	T/M	0.00410645	rs77489322
--	SLC9C2	33	T/A	0.000111402	rs780322544
--	SLC9C2	118	W/C	0.00104224	rs78264456
--	SLC9C2	139	V/I	0.000362558	rs147559775
--	SLC9C2	168	V/L	0.000112109	rs190106261
--	SLC9C2	211	I/V	0.000762284	rs538125592
--	SLC9C2	219	I/V	0.000353547	rs150906421
--	SLC9C2	233	Y/H	0.000323896	rs114531453
--	SLC9C2	281	A/T	0.000259456	rs200329765
--	SLC9C2	310	Y/F	0.000138801	rs114076888
--	SLC9C2	392	V/I	0.00255285	rs116588526
--	SLC9C2	404	Q/K	0.00120975	rs145922237
--	SLC9C2	468	I/N	0.000111614	rs765481351
--	SLC9C2	481	T/M	0.0129529	rs7551131
--	SLC9C2	505	A/G	0.283062	rs16846206
--	SLC9C2	738	R/H	0.00017977	rs535826422
--	SLC9C2	759	L/P	0.000152924	rs770269569
--	SLC9C2	791	M/I	0.000438474	rs41265230
--	SLC9C2	796	R/H	0.000115477	rs148203526
--	SLC9C2	805	K/Q	0.000413812	rs146458684
--	SLC9C2	856	P/S	0.000354717	rs551848802
--	SLC9C2	941	C/S	0.000218857	rs374880612
--	SLC9C2	956	R/H	0.000227949	rs147272652
--	SLC9C2	973	I/V	0.00039778	rs138661865
--	SLC9C2	1043	T/N	0.00267412	rs114102564
--	SLC9C2	1108	T/M	0.000295058	rs558671181

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
	SLC9C2	SLC9C2 [plasma membrane]	Stimuli-sensing channels

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data