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Basic
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Variant
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Pathway
Disease

Detail Data SLC9B1


Basic description
Gene Name SLC9B1
Protein Name Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9, subfamily B member 1)
Family SLC9
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510 
MHTTESKNEH LEDENFQTST TPQSLIDPNN TAHEETKTVL SDTEEIKPQT KKETYISCPL RGVLNVIITN GVILFVIWCM TWSILGSEAL PGGNLFGLFI IFYSAIIGGK ILQLIRIPLV PPLPPLLGML LAGFTIRNVP FINEHVHVPN TWSSILRSIA LTIILIRAGL GLDPQALRHL KVVCFRLAVG PCLMEASAAA VFSHFIMKFP WQWAFLLGFV LGAVSPAVVV PYMMVLQENG YGVEEGIPTL LMAASSMDDI LAITGFNTCL SIVFSSGGIL NNAIASIRNV CISLLAGIVL GFFVRYFPSE DQKKLTLKRG FLVLTMCVSA VLGSQRIGLH GSGGLCTLVL SFIAGTKWSQ EKMKVQKIIT TVWDIFQPLL FGLVGAEVSV SSLESNIVGI SVATLSLALC VRILTTYLLM CFAGFSFKEK IFIALAWMPK ATVQAVLGPL ALETARVSAP HLEPYAKDVM TVAFLAILIT APNGALLMGI LGPKMLTRHY DPSKIKLQLS TLEHH 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCEEEECCCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCHHHHH HHHCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHCCHHHHH HHHHHHHHCC CCCCCCHHHH HHHHHCCHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHCCCHH HHHHHHHHHH CHHHHHHHHH HHHHHHHHCH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHCCCCCC CCCCC
[Overview] SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9B1 SLC9B2 SLC9C1 SLC9C2 
SLC9A1    --------MVLRS------GICGLSPHR---------------------IFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRP--VNHS--VTDHGMKPRKA-FPVLGIDYTHVRTPFEISLWILLACL--------------------MKIGFHVI-PTISSIVPESCLLIVVGLLVGGLI-KGVGE-TP----------------------------------------------------PFLQSDVFFLFLLPPIILDAGYFLPLRQFTE--------NLGTILIFAVVGTLWNAFFLGGLMY----------------AVCLVGGEQ-INNIGLLDNLLFGSIISAVDPVAVLAVFEEIH-----INELLHILVFGESLLNDAVTVVLYHLFEEFANY---EHVGIVDIF------LGF-LSFFVVALGGVLVGVVYGVIAAFTSRFTS-----HIRVIEPLFVFLYSYMAYLSAELFHL---SGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HHWNW---TFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSL--GYLLDKKHF--------PMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVK-------------------------------------------------------------KKQETKRS----------INEEIHTQFL----DHLLTGIEDICGHYGHHHWK--D----KLNRFNKKYVKKCLIAG---------------------------------------------------ERSKEPQ----LIAFYH--------------------------------KMEM-------------------------------------------------------------KQAIELVESG--------------GMG----KIPSAVS----------------------------TVSMQNIHPKSLPSERILPALSKDKEEEI-------------------RKILRNNLQKTRQRLR-SYNRHTLVADPYEEAWNQMLLRRQKARQLEQKIN-------------------N-------------------------YLTVPAHK------------------LDSPTMSRARIG------SDPLA---------------------------------------------YEPKEDL---------------PV-----------------I-TID--------------PASPQS---------------------------------PESVDLVNEE-L--------KG-KVLGLSRD-------PAKVAEEDEDDDGGIMMRSKETSS---------------PGTDDVFTPA------------PSDSPSSQRIQRCLSDPGP-HPEPGE-----------GEPF----FPKGQ---
SLC9A2    MEPLGNW-RSLR------------AP------------------------LPPMLLLLL------------LQVAGPVGALAETLLNAPRAMGTSSSPPSP----------ASV--VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASL--------------------AKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVDEKSP----------------------------------------------------PAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE--------NIGTIFWYAVVGTLWNSIGIGVSLF----------------GICQIEAFG-LSDITLLQNLLFGSLISAVDPVAVLAVFENIH-----VNEQLYILVFGESLLNDAVTVVLYNLFKSFCQM---KTIETIDVF------AGI-ANFFVVGIGGVLIGIFLGFIAAFTTRFTH-----NIRVIEPLFVFLYSYLSYITAEMFHL---SGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFAL--VFLLPAAVF--------PRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-------------------------------------------------------------RSNKKQQA----------VSEEIYCRLF----DHVKTGIEDVCGHWGHNFWR--D----KFKKFDDKYLRKLLI------------------------------------------------------RENQPKS--SIVSLYK--------------------------------KLEI-------------------------------------------------------------KHAIEMAETG--------------MIS----TVPTFASL--------------------------NDCREEKIR-----------KVTSSETDEI-------------------RELLSRNLYQIRQRTL-SYNRHSLTADTSERQAKEILIRRRHS--LRESIR-------------------KDSSLNREH---------RASTSTSRYLSLPKNT----------------KLPEKL-QKRRTISIADGNSSDSDA--------------DAGTT--------------------VLNLQPR-ARRFL---------------PEQFSKKSPQSYKMEWKNEV-DVDS---------GRDMPSTPPT---------------------------------PHS----REK-----------GTQTSGLLQQ-------PLL-SKDQSG-------------S---------------EREDSLTEGI------------PPKPP--PRLVWRASEPGSRKARFGS-----------EKP-------------
SLC9A3    MWGLGA-----------------RGP------------------------DRGLLLALALGG---------LARA-----------------GGVEVEPGGAHGESG-------------------G-FQVVTFEWAHVQDPYVIALWILVASL--------------------AKIGFHLS-HKVTSVVPESALLIVLGLVLGGIV-WAADHIAS----------------------------------------------------FTLTPTVFFFYLLPPIVLDAGYFMPNRLFFG--------NLGTILLYAVVGTVWNAATTGLSLY----------------GVFLSGLMG-DLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVH-----VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGG-DNVTGVDCV------KGI-VSFFVVSLGGTLVGVVFAFLLSLVTRFTK-----HVRIIEPGFVFIISYLSYLTSEMLSL---SAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAV-NP-FIWTWN-TAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFAL--VVLLDGDKV--------KEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVK-------------------------------------------------------------RSEHREPR----------LNEKLHGRAF----DHILSAIEDISGQIGHNYLR--D----KWSHFDRKFLSRVLM------------------------------------------------------RRSAQKSRDRILNVFH--------------------------------ELNL-------------------------------------------------------------KDAISYVAEGE------------RRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRR--------RSIRDAEDMV------------------THHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR-LESFKS-------------------TKLGLNQNKKAAKLYKRERAQKR--RNSSIPNGK----------------LPMESP-AQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDT-----ASDSPAGIDNP-VFSPDEALDRSLLAR-----------LPPWLS-PGETVVPSQRARTQI---------------------------------------------------------PYS--------------------PGTFCRLM-------PFR------------------LSS---------------KSVDSFL---------------QADGPEE---RPPAALPESTHM-------------------------------
SLC9A4    --------MALQM------FVT-YSP------------------------WNCLLLLVA------------LECSEASSDLNES--------ANSTAQYAS----------NAW--FAAASSEPEEG-ISVFELDYDYVQIPYEVTLWILLASL--------------------AKIGFHLY-HRLPGLMPESCLLILVGALVGGII-FGTDHKSP----------------------------------------------------PVMDSSIYFLYLLPPIVLEGGYFMPTRPFFE--------NIGSILWWAVLGALINALGIGLSLY----------------LICQVKAFG-LGDVNLLQNLLFGSLISAVDPVAVLAVFEEAR-----VNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDIL------AGC-ARFIVVGLGGVLFGIVFGFISAFITRFTQ-----NISAIEPLIVFMFSYLSYLAAETLYL---SGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSL--AFLLPLSLF--------PRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-------------------------------------------------------------KTNKK-ES----------INEELHIRLM----DHLKAGIEDVCGHWSHYQVR--D----KFKKFDHRYLRKILI------------------------------------------------------RKNLPKS--SIVSLYK--------------------------------KLEM-------------------------------------------------------------KQAIEMVETG--------------ILSSTAFSIPHQAQ------------------------------RIQGIK-----------RLSPEDVESI-------------------RDILTSNMYQVRQRTL-SYNKYNLKPQTSEKQAKEILIRRQNT--LRESMR-------------------KGHSLPWGK---------PAGTKNIRYLSYPYGN------------------PQSAGRDTRAAGFSDDDSSDPGSP---------SITFSACSR--------------------IGSLQKQEAQEII---------------PMKSLHRGRKAFSFGYQRNT-----------------------------------------------------------S----QEEYL--------GGVRRVALRPK-------PLFHAVDEEGESGG--------ES---------------EGKASLVE---------------------VRSRWTADH-GHGRDHHRS-----------HSPL----LQKK----
SLC9A5    ----------------------------------------------------MLRAALSLLA---------LPLA-----------------GAAE-EPTQKPESPG---------------EPPPG-LELFRWQWHEVEAPYLVALWILVASL--------------------AKIVFHLS-RKVTSLVPESCLLILLGLVLGGIV-LAVAKKAE----------------------------------------------------YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFD--------NLGAILTYAVVGTLWNAFTTGAALW----------------GLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVH-----VNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS-ANVQATDYL------KGV-ASLFVVSLGGAAVGLVFAFLLALTTRFTK-----RVRIIEPLLVFLLAYAAYLTAEMASL---SAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAV-DS-SKWAWD-SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFAL--VILLDRTKV--------PAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVK-------------------------------------------------------------RSEHHKPT----------LNQELHEHTF----DHILAAVEDVVGHHGYHYWR--D----RWEQFDKKYLSQLLM------------------------------------------------------RRSAYRIRDQIWDVYY--------------------------------RLNI-------------------------------------------------------------RDAISFVDQGG------------HVLSSTGLTLPSMPS--------RNSVAETSVTNLLRESGSGACLDLQVIDT-V--------RSGRDREDAV------------------MHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRR-LESFKS-------------------TKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKH---RGLGFQDTAAVILTVES---------EEEEEESDSSETEKEDDE---GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKEL---------------PWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQA-----------------------PILTCLPPHP--------------------RGTEEPQV-------PLH------------------LPS---------------DPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGT-----------ATSHWCIQFNRGSRL-
SLC9A6    --------MARR--------GWRRAP--------------LRRGVGSSPRARRLMRPLWLLL--------AVGVFDWAGA----------SDGGGG--EARAMDEEI--------------VSEKQA-------EESHRQDSANLLIFILLLTL--------------------TILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFR--------NLGSILAYAFLGTAISCFVIGSIMY------------GCVTLMKVTGQLA--GDFYFTDCLLFGAIVSATDPVTVLAIFHELQ-----VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG--DNSHTFDVT---AMFKSI-GIFLGIFSGSFAMGAATGVVTALVTKFTKL---REFQLLETGLFFLMSWSTFLLAEAWGF---TGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP---TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFAL--AIR-DTAT---------YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGV--------DSDQ----------EH-----------LGV--------------------PENER-RT----------TKAE------------------------SAWLFR-------MWYNFDHNYLKPLLT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPACCGP-------------------------------------------------------I------------------ARCLTSPQAYENQEQLK-------------DDDSDLILNDGDIS--LT-------------------------------------------------YGDSTVNT-----------------------------------EPATSS--------------------------------------------------------------------------------------------------------APRRFMG---------------------------------NSSEDALDRELA--------FGDHELVIRGTR---LVLPMD-------------------DS---------------EPPLNLLD-------------NTRHGPA-----------------------------------------------
SLC9A7    ---MEPGDAARP--------GSGRA--------------------TGAPPPRLLLLPLLLGW--------GLRVAAAASA----------SSSGAAAEDSSAM-EEL--------------ATEKEA-------EESHRQDSVSLLTFILLLTL--------------------TILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSG-RDKSL-SCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFR--------NLGSILAYAFLGTAVSCFIIGNLMY------------GVVKLMKIMGQLS--DKFYYTDCLFFGAIISATDPVTVLAIFNELH-----ADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAG--LNTHAFDAA---AFFKSV-GIFLGIFSGSFTMGAVTG-VNANVTKFTKL---HCFPLLETALFFLMSWSTFLLAEACGF---TGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP---IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFAL--AIR-DTAS---------YARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVE--EPSEEDQNE----------HHWQYF------RVGVDPDQDPPPNNDSFQVLQGDGPDSARGNR----------TKQE------------------------SAWIFR-------LWYSFDHNYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPAWCGL-------------------------------------------------------L------------------ARCLTSPQVYDNQEPLR-------------EEDSDFILTEGDLT--LT-------------------------------------------------YGDSTVTA-----------------------------------NGSSSSH------------------------------------------------------------------TAST------------------------------SLEGSRR-TK---------------------------------SSSEEVLERDLG--------MGDQKVSSRGTR---LVFPLE-------------------DN---------------A--------------------------------------------------------------------------
SLC9A8    ---MGEK-MAE----------EERFPNT----THEGFNVTLH---TTLVVTTKLVLPT----------------------------------------PGKPI-LPV--------------QTGEQA-------QQEEQSSGMTIFFSLLVLAI--------------------CIILVHLLIRYRLHFLPESVAVVSLGILMGAVI----------------------------------KIIEFK--------KLANWKEEEM-----FRPNMFFLLLLPPIIFESGYSLHKGNFFQ--------NIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFILQADVIS---KLNMTDSFAFGSLISAVDPVATIAIFNALH-----VDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK------NMSDVSGWQTFLQAL-DYFLKMFFGSAALGTLTGLISALVLKHIDL---RKTPSLEFGMMIIFAYLPYGLAEGISL---SGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEI---SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYAL--SLHLDLEPM--------EKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI-----------EDAKA----------HR----------------------------------RNKKDVNL----------SKTEKMGNTVE--SEHLSELTEE---EYEAHYIRRQDLKGFVW--LDAKYLNPFFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRLTQEDLHHGRIQMK--------------------------T--LTNK----------------------------------------------WYEEVR---------------------------------------------------------------------------------------------------------------------------------------------------------QG---------------------------------PSGSEDDEQELL--------------------------------------------------------------------------------------------------------------------------------------------
SLC9A9    --------MER---------------------------------------------------------------------------------------QSRVM-------------------SEKDE-------YQFQHQGAVELLVFNFLLIL--------------------TILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ--------NLGSILTYAFLGTAISCIVIGLIMY------------GFVKAMIHAGQLK-NGDFHFTDCLFFGSLMSATDPVTVLAIFHELH-----VDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK---ENPNAFDAA---AFFQSV-GNFLGIFAGSFAMGSAYAIITALLTKFTKL---CEFPMLETGLFFLLSWSAFLSAEAAGL---TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA---LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFAL--AIR-NTES---------QPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSS----------QHQE--------------------------------ANNLDKNM----------TKAE------------------------SARLFR-------MWYSFDHKYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPEWCGP-------------------------------------------------------I------------------SRLLTSPQAYG--EQLK-------------EDDVECIVNQDELA--IN-------------------------------------------------YQEQA---------------------------------------SSPCSP------------------------------------------------------------------PARL------------------------------GLDQKASPQT---------------------------------PGKENIYEGDLG--------LGGYELKLEQT--------LG-------------------QS---------------Q--LN----------------------------------------------------------------------
SLC9B1    --MHTTESKNEHLEDENFQTST--TPQSLIDPNNTAHEETKT----------------------------VLS--DTEE-----------------IKPQTKK--ET------------YISCPLRG-----VLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPP--LPPLLGMLLAGFTIRNVPFINE-------------------HVHV-----------------------------PNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWA---------------------------------FLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFS---SGGILNNAI------ASI---------RNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQE------KMKVQKIITTVWDIFQPLLFGLVGAEVSVSS-LESNI--VGISVATLSLALCVRILTTYLLMCF------AGFSFKEKIFIALAWMPKATVQAVLGPLALETARV------SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPK------------------------------------------------------------------------------------------------------------------------------------MLT------------------------------------------------------RHYDPSKI----------------------------------------KLQL---ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC9B2    ---MGDEDKRITYEDSEPSTGMNYTPSM----HQEAQEETVM----------------------------KLKGIDANEP----------TEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHG-----LLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPP--LPSLLGMLLAGFLIRNIPVIND-------------------NVQI-----------------------------KHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWG---------------------------------FILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFS---TGSTVFNVL------RGV---------LEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSE------KAEVEKIIAVAWDIFQPLLFGLIGAEVSIAS-LRPET--VGLCVATVGIAVLIRILTTFLMVCF------AGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS-----HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPR------------------------------------------------------------------------------------------------------------------------------------LLQ------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEHQNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEE-------------------------------------------------VQG---------------ETSVQV---------------------------------------------------------------------
SLC9C1    --------MAGIF-------------------------------------------------------------------------------------------------------------------------KEFFFSTEDLPEVILTLSLI--------------------SSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLS-FTSSQVQR---------------------------YANAI--------------------QWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK--------LFWQILLISIPGF-----LVNYILV-----------------LWHLASVN-QLLLKPTQWLLFSAILVSSDPMLTAAAIRDLG-----LSRSLISLINGESLMTSVISLITFTSIMDFDQRLQ-SKRNH-TLA--EEIVGGI-CSY-II--ASFLFGILSSKLIQFWMSTVF-----GDDVNHISLIFSILYLIFYICELVGM---SGIFTLAIVGLLLNSTSFK--AAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVG-HEFSWRWIFIMVCSEMKGMPNINM--ALLLAYSDLYFGSDK--EKSQI-LFHGVLVCLITLVVNRFILPVAVTILG-----------LRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDL----ANADWNMI----EKAITLEN-PYM------LNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANR-RLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIIS-W--ISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEI-----DTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMS-HQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILK-AFGLKGIISKTEGAGINKLIMAKKKE--VLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKV-VTFDCGNDIFEEGDEPKGIYIIISGM---------VKLEKS---KPGLGI--DQMVESKEKDFP------IIDTDYMLSGE------------------IIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKM--------WL----KLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPM-----STKTDIYDENLI--YVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVI---IQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTL----EEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR--INLRKVRKE-
SLC9C2    --------MSSYFW----AQNESNRP--------------------------------------------DLLCG----------------------QPADYL------------------------------VEEKHFTT--------LVCFI--------------------VVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMA-YNSVEVHQ---------------------------IVYPL--------------------LRTSSFSLYSYFSPLIIFMVALDVEFYTLKK--------MFWQVLLTGLISFSTASIIIGYVVI------------KFNKDSWDLQSC-----------LLFSITLGIIDPLRSVNSLKTIG-----ISKIYIDLIRGESLIICSIASIFFGN-------FR-GNRIHFSIF--RDLHVGIELSYDIL--GSIIFGYWCAKIIQCILADVF-----SNMLTNIILCFSMVYMTFYIVEFLGM---SGTLALAAVGLNLDSLTFK--PKI-ELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN-YEYNWRWGVVITWSGIKGVFN-------LLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNAT-----------QHIQEIVQNTITLFKTEKIL----TNVNWTLV----EDKTRIEYIPFSHVSHNDMKTESTT--------------DEAL----MEEARL-HVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNV---SALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI----QLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIK-KRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLT-FLCSRGIIDKHEVIEINKVLLKKLKA--LNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKL-ACFDSGDTICKGGEMPQGIYLIISGM---------AILHSL---SPTFGIESNQRCDRGSRD---------MFTEFCTTGD------------------IIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKI--------WL----KLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE--TL-----SSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLI---IQA-------------------SELT--------------------QRNSNTNVMASVNTVF---------------EQPG--KNINGRQKMS

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC9B1 27 D/E 0.000368378 rs775009509
-- SLC9B1 33 Q/H 0.996538 rs2715591
-- SLC9B1 183 V/I 0.00174682 rs149874100
-- SLC9B1 234 M/T 0.000179306 rs141566610
-- SLC9B1 263 I/V 0.00216276 rs148380466
-- SLC9B1 302 F/I 0.000332591 rs201651247
-- SLC9B1 305 R/Q 0.000506029 rs200795458
-- SLC9B1 331 V/I 0.000104624 rs182377523
-- SLC9B1 336 R/C 0.000263559 rs540333209
-- SLC9B1 370 T/A 0.000109513 rs559867252
-- SLC9B1 374 D/G 0.000172901 rs140935768
-- SLC9B1 421 C/Y 0.000112748 rs201066131
-- SLC9B1 459 A/T 0.000345907 rs369335965
-- SLC9B1 466 A/V 0.000225301 rs763383035
-- SLC9B1 490 I/S 0.000314481 rs150354484

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC9B1 SLC9B1 [plasma membrane] Stimuli-sensing channels

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data