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Detail Data SLC9A7


Basic description
Gene Name SLC9A7
Protein Name Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7)
Family SLC9
Category Transport of inorganic cations/anions and amino acids/oligopeptides|Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720 
MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED SSAMEELATE KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH ETGLAMIYGL IVGVILRYGT PATSGRDKSL SCTQEDRAFS TLLVNVSGKF FEYTLKGEIS PGKINSVEQN DMLRKVTFDP EVFFNILLPP IIFHAGYSLK KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM GQLSDKFYYT DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVNANVTKF TKLHCFPLLE TALFFLMSWS TFLLAEACGF TGVVAVLFCG ITQAHYTYNN LSVESRSRTK QLFEVLHFLA ENFIFSYMGL ALFTFQKHVF SPIFIIGAFV AIFLGRAAHI YPLSFFLNLG RRHKIGWNFQ HMMMFSGLRG AMAFALAIRD TASYARQMMF TTTLLIVFFT VWIIGGGTTP MLSWLNIRVG VEEPSEEDQN EHHWQYFRVG VDPDQDPPPN NDSFQVLQGD GPDSARGNRT KQESAWIFRL WYSFDHNYLK PILTHSGPPL TTTLPAWCGL LARCLTSPQV YDNQEPLREE DSDFILTEGD LTLTYGDSTV TANGSSSSHT ASTSLEGSRR TKSSSEEVLE RDLGMGDQKV SSRGTRLVFP LEDNA 
CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCHHHHHCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHCCCCC CCCHHHCCHH HHHCCCCCCH HHHHHHCCCH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHC CCCHHHHHHH HHHCCCCCCE EEEEHHHHHH CCHHHHHHHH HHHHHHHCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHCHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCE EEEECCCHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHCCCCCC CCCCCHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCCCHHHH HHHCCHHHHH HHHHCCCCCC CCCCCHHHHH HHHHCCCHHH HHCCCCCCCC HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHCCCCCCCC CCCCCCCCCC CCCCC
[Overview] SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9B1 SLC9B2 SLC9C1 SLC9C2 
SLC9A1    --------MVLRS------GICGLSPHR---------------------IFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRP--VNHS--VTDHGMKPRKA-FPVLGIDYTHVRTPFEISLWILLACL--------------------MKIGFHVI-PTISSIVPESCLLIVVGLLVGGLI-KGVGE-TP----------------------------------------------------PFLQSDVFFLFLLPPIILDAGYFLPLRQFTE--------NLGTILIFAVVGTLWNAFFLGGLMY----------------AVCLVGGEQ-INNIGLLDNLLFGSIISAVDPVAVLAVFEEIH-----INELLHILVFGESLLNDAVTVVLYHLFEEFANY---EHVGIVDIF------LGF-LSFFVVALGGVLVGVVYGVIAAFTSRFTS-----HIRVIEPLFVFLYSYMAYLSAELFHL---SGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HHWNW---TFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSL--GYLLDKKHF--------PMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVK-------------------------------------------------------------KKQETKRS----------INEEIHTQFL----DHLLTGIEDICGHYGHHHWK--D----KLNRFNKKYVKKCLIAG---------------------------------------------------ERSKEPQ----LIAFYH--------------------------------KMEM-------------------------------------------------------------KQAIELVESG--------------GMG----KIPSAVS----------------------------TVSMQNIHPKSLPSERILPALSKDKEEEI-------------------RKILRNNLQKTRQRLR-SYNRHTLVADPYEEAWNQMLLRRQKARQLEQKIN-------------------N-------------------------YLTVPAHK------------------LDSPTMSRARIG------SDPLA---------------------------------------------YEPKEDL---------------PV-----------------I-TID--------------PASPQS---------------------------------PESVDLVNEE-L--------KG-KVLGLSRD-------PAKVAEEDEDDDGGIMMRSKETSS---------------PGTDDVFTPA------------PSDSPSSQRIQRCLSDPGP-HPEPGE-----------GEPF----FPKGQ---
SLC9A2    MEPLGNW-RSLR------------AP------------------------LPPMLLLLL------------LQVAGPVGALAETLLNAPRAMGTSSSPPSP----------ASV--VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASL--------------------AKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVDEKSP----------------------------------------------------PAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE--------NIGTIFWYAVVGTLWNSIGIGVSLF----------------GICQIEAFG-LSDITLLQNLLFGSLISAVDPVAVLAVFENIH-----VNEQLYILVFGESLLNDAVTVVLYNLFKSFCQM---KTIETIDVF------AGI-ANFFVVGIGGVLIGIFLGFIAAFTTRFTH-----NIRVIEPLFVFLYSYLSYITAEMFHL---SGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFAL--VFLLPAAVF--------PRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-------------------------------------------------------------RSNKKQQA----------VSEEIYCRLF----DHVKTGIEDVCGHWGHNFWR--D----KFKKFDDKYLRKLLI------------------------------------------------------RENQPKS--SIVSLYK--------------------------------KLEI-------------------------------------------------------------KHAIEMAETG--------------MIS----TVPTFASL--------------------------NDCREEKIR-----------KVTSSETDEI-------------------RELLSRNLYQIRQRTL-SYNRHSLTADTSERQAKEILIRRRHS--LRESIR-------------------KDSSLNREH---------RASTSTSRYLSLPKNT----------------KLPEKL-QKRRTISIADGNSSDSDA--------------DAGTT--------------------VLNLQPR-ARRFL---------------PEQFSKKSPQSYKMEWKNEV-DVDS---------GRDMPSTPPT---------------------------------PHS----REK-----------GTQTSGLLQQ-------PLL-SKDQSG-------------S---------------EREDSLTEGI------------PPKPP--PRLVWRASEPGSRKARFGS-----------EKP-------------
SLC9A3    MWGLGA-----------------RGP------------------------DRGLLLALALGG---------LARA-----------------GGVEVEPGGAHGESG-------------------G-FQVVTFEWAHVQDPYVIALWILVASL--------------------AKIGFHLS-HKVTSVVPESALLIVLGLVLGGIV-WAADHIAS----------------------------------------------------FTLTPTVFFFYLLPPIVLDAGYFMPNRLFFG--------NLGTILLYAVVGTVWNAATTGLSLY----------------GVFLSGLMG-DLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVH-----VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGG-DNVTGVDCV------KGI-VSFFVVSLGGTLVGVVFAFLLSLVTRFTK-----HVRIIEPGFVFIISYLSYLTSEMLSL---SAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAV-NP-FIWTWN-TAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFAL--VVLLDGDKV--------KEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVK-------------------------------------------------------------RSEHREPR----------LNEKLHGRAF----DHILSAIEDISGQIGHNYLR--D----KWSHFDRKFLSRVLM------------------------------------------------------RRSAQKSRDRILNVFH--------------------------------ELNL-------------------------------------------------------------KDAISYVAEGE------------RRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRR--------RSIRDAEDMV------------------THHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR-LESFKS-------------------TKLGLNQNKKAAKLYKRERAQKR--RNSSIPNGK----------------LPMESP-AQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDT-----ASDSPAGIDNP-VFSPDEALDRSLLAR-----------LPPWLS-PGETVVPSQRARTQI---------------------------------------------------------PYS--------------------PGTFCRLM-------PFR------------------LSS---------------KSVDSFL---------------QADGPEE---RPPAALPESTHM-------------------------------
SLC9A4    --------MALQM------FVT-YSP------------------------WNCLLLLVA------------LECSEASSDLNES--------ANSTAQYAS----------NAW--FAAASSEPEEG-ISVFELDYDYVQIPYEVTLWILLASL--------------------AKIGFHLY-HRLPGLMPESCLLILVGALVGGII-FGTDHKSP----------------------------------------------------PVMDSSIYFLYLLPPIVLEGGYFMPTRPFFE--------NIGSILWWAVLGALINALGIGLSLY----------------LICQVKAFG-LGDVNLLQNLLFGSLISAVDPVAVLAVFEEAR-----VNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDIL------AGC-ARFIVVGLGGVLFGIVFGFISAFITRFTQ-----NISAIEPLIVFMFSYLSYLAAETLYL---SGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSL--AFLLPLSLF--------PRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-------------------------------------------------------------KTNKK-ES----------INEELHIRLM----DHLKAGIEDVCGHWSHYQVR--D----KFKKFDHRYLRKILI------------------------------------------------------RKNLPKS--SIVSLYK--------------------------------KLEM-------------------------------------------------------------KQAIEMVETG--------------ILSSTAFSIPHQAQ------------------------------RIQGIK-----------RLSPEDVESI-------------------RDILTSNMYQVRQRTL-SYNKYNLKPQTSEKQAKEILIRRQNT--LRESMR-------------------KGHSLPWGK---------PAGTKNIRYLSYPYGN------------------PQSAGRDTRAAGFSDDDSSDPGSP---------SITFSACSR--------------------IGSLQKQEAQEII---------------PMKSLHRGRKAFSFGYQRNT-----------------------------------------------------------S----QEEYL--------GGVRRVALRPK-------PLFHAVDEEGESGG--------ES---------------EGKASLVE---------------------VRSRWTADH-GHGRDHHRS-----------HSPL----LQKK----
SLC9A5    ----------------------------------------------------MLRAALSLLA---------LPLA-----------------GAAE-EPTQKPESPG---------------EPPPG-LELFRWQWHEVEAPYLVALWILVASL--------------------AKIVFHLS-RKVTSLVPESCLLILLGLVLGGIV-LAVAKKAE----------------------------------------------------YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFD--------NLGAILTYAVVGTLWNAFTTGAALW----------------GLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVH-----VNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS-ANVQATDYL------KGV-ASLFVVSLGGAAVGLVFAFLLALTTRFTK-----RVRIIEPLLVFLLAYAAYLTAEMASL---SAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAV-DS-SKWAWD-SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFAL--VILLDRTKV--------PAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVK-------------------------------------------------------------RSEHHKPT----------LNQELHEHTF----DHILAAVEDVVGHHGYHYWR--D----RWEQFDKKYLSQLLM------------------------------------------------------RRSAYRIRDQIWDVYY--------------------------------RLNI-------------------------------------------------------------RDAISFVDQGG------------HVLSSTGLTLPSMPS--------RNSVAETSVTNLLRESGSGACLDLQVIDT-V--------RSGRDREDAV------------------MHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRR-LESFKS-------------------TKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKH---RGLGFQDTAAVILTVES---------EEEEEESDSSETEKEDDE---GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKEL---------------PWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQA-----------------------PILTCLPPHP--------------------RGTEEPQV-------PLH------------------LPS---------------DPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGT-----------ATSHWCIQFNRGSRL-
SLC9A6    --------MARR--------GWRRAP--------------LRRGVGSSPRARRLMRPLWLLL--------AVGVFDWAGA----------SDGGGG--EARAMDEEI--------------VSEKQA-------EESHRQDSANLLIFILLLTL--------------------TILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFR--------NLGSILAYAFLGTAISCFVIGSIMY------------GCVTLMKVTGQLA--GDFYFTDCLLFGAIVSATDPVTVLAIFHELQ-----VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG--DNSHTFDVT---AMFKSI-GIFLGIFSGSFAMGAATGVVTALVTKFTKL---REFQLLETGLFFLMSWSTFLLAEAWGF---TGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP---TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFAL--AIR-DTAT---------YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGV--------DSDQ----------EH-----------LGV--------------------PENER-RT----------TKAE------------------------SAWLFR-------MWYNFDHNYLKPLLT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPACCGP-------------------------------------------------------I------------------ARCLTSPQAYENQEQLK-------------DDDSDLILNDGDIS--LT-------------------------------------------------YGDSTVNT-----------------------------------EPATSS--------------------------------------------------------------------------------------------------------APRRFMG---------------------------------NSSEDALDRELA--------FGDHELVIRGTR---LVLPMD-------------------DS---------------EPPLNLLD-------------NTRHGPA-----------------------------------------------
SLC9A7    ---MEPGDAARP--------GSGRA--------------------TGAPPPRLLLLPLLLGW--------GLRVAAAASA----------SSSGAAAEDSSAM-EEL--------------ATEKEA-------EESHRQDSVSLLTFILLLTL--------------------TILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSG-RDKSL-SCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFR--------NLGSILAYAFLGTAVSCFIIGNLMY------------GVVKLMKIMGQLS--DKFYYTDCLFFGAIISATDPVTVLAIFNELH-----ADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAG--LNTHAFDAA---AFFKSV-GIFLGIFSGSFTMGAVTG-VNANVTKFTKL---HCFPLLETALFFLMSWSTFLLAEACGF---TGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP---IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFAL--AIR-DTAS---------YARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVE--EPSEEDQNE----------HHWQYF------RVGVDPDQDPPPNNDSFQVLQGDGPDSARGNR----------TKQE------------------------SAWIFR-------LWYSFDHNYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPAWCGL-------------------------------------------------------L------------------ARCLTSPQVYDNQEPLR-------------EEDSDFILTEGDLT--LT-------------------------------------------------YGDSTVTA-----------------------------------NGSSSSH------------------------------------------------------------------TAST------------------------------SLEGSRR-TK---------------------------------SSSEEVLERDLG--------MGDQKVSSRGTR---LVFPLE-------------------DN---------------A--------------------------------------------------------------------------
SLC9A8    ---MGEK-MAE----------EERFPNT----THEGFNVTLH---TTLVVTTKLVLPT----------------------------------------PGKPI-LPV--------------QTGEQA-------QQEEQSSGMTIFFSLLVLAI--------------------CIILVHLLIRYRLHFLPESVAVVSLGILMGAVI----------------------------------KIIEFK--------KLANWKEEEM-----FRPNMFFLLLLPPIIFESGYSLHKGNFFQ--------NIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFILQADVIS---KLNMTDSFAFGSLISAVDPVATIAIFNALH-----VDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK------NMSDVSGWQTFLQAL-DYFLKMFFGSAALGTLTGLISALVLKHIDL---RKTPSLEFGMMIIFAYLPYGLAEGISL---SGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEI---SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYAL--SLHLDLEPM--------EKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI-----------EDAKA----------HR----------------------------------RNKKDVNL----------SKTEKMGNTVE--SEHLSELTEE---EYEAHYIRRQDLKGFVW--LDAKYLNPFFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRLTQEDLHHGRIQMK--------------------------T--LTNK----------------------------------------------WYEEVR---------------------------------------------------------------------------------------------------------------------------------------------------------QG---------------------------------PSGSEDDEQELL--------------------------------------------------------------------------------------------------------------------------------------------
SLC9A9    --------MER---------------------------------------------------------------------------------------QSRVM-------------------SEKDE-------YQFQHQGAVELLVFNFLLIL--------------------TILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ--------NLGSILTYAFLGTAISCIVIGLIMY------------GFVKAMIHAGQLK-NGDFHFTDCLFFGSLMSATDPVTVLAIFHELH-----VDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK---ENPNAFDAA---AFFQSV-GNFLGIFAGSFAMGSAYAIITALLTKFTKL---CEFPMLETGLFFLLSWSAFLSAEAAGL---TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA---LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFAL--AIR-NTES---------QPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSS----------QHQE--------------------------------ANNLDKNM----------TKAE------------------------SARLFR-------MWYSFDHKYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPEWCGP-------------------------------------------------------I------------------SRLLTSPQAYG--EQLK-------------EDDVECIVNQDELA--IN-------------------------------------------------YQEQA---------------------------------------SSPCSP------------------------------------------------------------------PARL------------------------------GLDQKASPQT---------------------------------PGKENIYEGDLG--------LGGYELKLEQT--------LG-------------------QS---------------Q--LN----------------------------------------------------------------------
SLC9B1    --MHTTESKNEHLEDENFQTST--TPQSLIDPNNTAHEETKT----------------------------VLS--DTEE-----------------IKPQTKK--ET------------YISCPLRG-----VLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPP--LPPLLGMLLAGFTIRNVPFINE-------------------HVHV-----------------------------PNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWA---------------------------------FLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFS---SGGILNNAI------ASI---------RNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQE------KMKVQKIITTVWDIFQPLLFGLVGAEVSVSS-LESNI--VGISVATLSLALCVRILTTYLLMCF------AGFSFKEKIFIALAWMPKATVQAVLGPLALETARV------SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPK------------------------------------------------------------------------------------------------------------------------------------MLT------------------------------------------------------RHYDPSKI----------------------------------------KLQL---ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC9B2    ---MGDEDKRITYEDSEPSTGMNYTPSM----HQEAQEETVM----------------------------KLKGIDANEP----------TEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHG-----LLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPP--LPSLLGMLLAGFLIRNIPVIND-------------------NVQI-----------------------------KHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWG---------------------------------FILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFS---TGSTVFNVL------RGV---------LEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSE------KAEVEKIIAVAWDIFQPLLFGLIGAEVSIAS-LRPET--VGLCVATVGIAVLIRILTTFLMVCF------AGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS-----HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPR------------------------------------------------------------------------------------------------------------------------------------LLQ------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEHQNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEE-------------------------------------------------VQG---------------ETSVQV---------------------------------------------------------------------
SLC9C1    --------MAGIF-------------------------------------------------------------------------------------------------------------------------KEFFFSTEDLPEVILTLSLI--------------------SSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLS-FTSSQVQR---------------------------YANAI--------------------QWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK--------LFWQILLISIPGF-----LVNYILV-----------------LWHLASVN-QLLLKPTQWLLFSAILVSSDPMLTAAAIRDLG-----LSRSLISLINGESLMTSVISLITFTSIMDFDQRLQ-SKRNH-TLA--EEIVGGI-CSY-II--ASFLFGILSSKLIQFWMSTVF-----GDDVNHISLIFSILYLIFYICELVGM---SGIFTLAIVGLLLNSTSFK--AAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVG-HEFSWRWIFIMVCSEMKGMPNINM--ALLLAYSDLYFGSDK--EKSQI-LFHGVLVCLITLVVNRFILPVAVTILG-----------LRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDL----ANADWNMI----EKAITLEN-PYM------LNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANR-RLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIIS-W--ISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEI-----DTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMS-HQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILK-AFGLKGIISKTEGAGINKLIMAKKKE--VLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKV-VTFDCGNDIFEEGDEPKGIYIIISGM---------VKLEKS---KPGLGI--DQMVESKEKDFP------IIDTDYMLSGE------------------IIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKM--------WL----KLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPM-----STKTDIYDENLI--YVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVI---IQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTL----EEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR--INLRKVRKE-
SLC9C2    --------MSSYFW----AQNESNRP--------------------------------------------DLLCG----------------------QPADYL------------------------------VEEKHFTT--------LVCFI--------------------VVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMA-YNSVEVHQ---------------------------IVYPL--------------------LRTSSFSLYSYFSPLIIFMVALDVEFYTLKK--------MFWQVLLTGLISFSTASIIIGYVVI------------KFNKDSWDLQSC-----------LLFSITLGIIDPLRSVNSLKTIG-----ISKIYIDLIRGESLIICSIASIFFGN-------FR-GNRIHFSIF--RDLHVGIELSYDIL--GSIIFGYWCAKIIQCILADVF-----SNMLTNIILCFSMVYMTFYIVEFLGM---SGTLALAAVGLNLDSLTFK--PKI-ELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN-YEYNWRWGVVITWSGIKGVFN-------LLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNAT-----------QHIQEIVQNTITLFKTEKIL----TNVNWTLV----EDKTRIEYIPFSHVSHNDMKTESTT--------------DEAL----MEEARL-HVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNV---SALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI----QLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIK-KRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLT-FLCSRGIIDKHEVIEINKVLLKKLKA--LNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKL-ACFDSGDTICKGGEMPQGIYLIISGM---------AILHSL---SPTFGIESNQRCDRGSRD---------MFTEFCTTGD------------------IIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKI--------WL----KLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE--TL-----SSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLI---IQA-------------------SELT--------------------QRNSNTNVMASVNTVF---------------EQPG--KNINGRQKMS

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC9A7 38 A/T 0.000298071 rs782799890
-- SLC9A7 211 I/V 0.000329234 rs139280673
-- SLC9A7 443 I/V 0.000192632 rs144546494
-- SLC9A7 534 W/R 0.000282234 rs138701264
-- SLC9A7 542 E/K 0.000400158 rs141987517
-- SLC9A7 589 R/W 0.000149243 rs774748269
-- SLC9A7 660 D/N 0.00102383 rs368880317

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC9A7 SLC9A7 [early endosome membrane] Sodium/Proton exchangers
main SLC9A7 SLC9A7 [Golgi membrane] Sodium/Proton exchangers

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data