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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC9A5


Basic description
Gene Name SLC9A5
Protein Name Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)
Family SLC9
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 8 2 0 8 3 0 8 4 0 8 5 0 8 6 0 8 7 0 8 8 0 8 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890 
MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV ALWILVASLA KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY QLEPGTFFLF LLPPIVLDSG YFMPSRLFFD NLGAILTYAV VGTLWNAFTT GAALWGLQQA GLVAPRVQAG LLDFLLFGSL ISAVDPVAVL AVFEEVHVNE TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY LKGVASLFVV SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS AVDSSKWAWD SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV VMSYGGLRGA VAFALVILLD RTKVPAKDYF VATTIVVVFF TVIVQGLTIK PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI LAAVEDVVGH HGYHYWRDRW EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV DQGGHVLSST GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS TKHNICFTKS KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV ESEEEEEESD SSETEKEDDE GIIFVARATS EVLQEGKVSG SLEVCPSPRI IPPSPTCAEK ELPWKSGQGD LAVYVSSETT KIVPVDMQTG WNQSISSLES LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA FPPSLAKAGR SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL 
CHHHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCEECCC HHHCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHCCCCCC CCCHHHHHHH CCHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC HHHCHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHCCCCC CHHHHHHCCC CCCHHHHHHH HHHHHHHHHC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCHHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCHHHCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHCCCHHHH HHHHHHHHCC CCCCCHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHCCHHHCCC CHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHC CCCHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHCCCC CCCCHHCCCC CCCCCCCCCC CCEEECCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCC
[Overview] SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9B1 SLC9B2 SLC9C1 SLC9C2 
SLC9A1    --------MVLRS------GICGLSPHR---------------------IFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRP--VNHS--VTDHGMKPRKA-FPVLGIDYTHVRTPFEISLWILLACL--------------------MKIGFHVI-PTISSIVPESCLLIVVGLLVGGLI-KGVGE-TP----------------------------------------------------PFLQSDVFFLFLLPPIILDAGYFLPLRQFTE--------NLGTILIFAVVGTLWNAFFLGGLMY----------------AVCLVGGEQ-INNIGLLDNLLFGSIISAVDPVAVLAVFEEIH-----INELLHILVFGESLLNDAVTVVLYHLFEEFANY---EHVGIVDIF------LGF-LSFFVVALGGVLVGVVYGVIAAFTSRFTS-----HIRVIEPLFVFLYSYMAYLSAELFHL---SGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HHWNW---TFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSL--GYLLDKKHF--------PMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVK-------------------------------------------------------------KKQETKRS----------INEEIHTQFL----DHLLTGIEDICGHYGHHHWK--D----KLNRFNKKYVKKCLIAG---------------------------------------------------ERSKEPQ----LIAFYH--------------------------------KMEM-------------------------------------------------------------KQAIELVESG--------------GMG----KIPSAVS----------------------------TVSMQNIHPKSLPSERILPALSKDKEEEI-------------------RKILRNNLQKTRQRLR-SYNRHTLVADPYEEAWNQMLLRRQKARQLEQKIN-------------------N-------------------------YLTVPAHK------------------LDSPTMSRARIG------SDPLA---------------------------------------------YEPKEDL---------------PV-----------------I-TID--------------PASPQS---------------------------------PESVDLVNEE-L--------KG-KVLGLSRD-------PAKVAEEDEDDDGGIMMRSKETSS---------------PGTDDVFTPA------------PSDSPSSQRIQRCLSDPGP-HPEPGE-----------GEPF----FPKGQ---
SLC9A2    MEPLGNW-RSLR------------AP------------------------LPPMLLLLL------------LQVAGPVGALAETLLNAPRAMGTSSSPPSP----------ASV--VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASL--------------------AKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVDEKSP----------------------------------------------------PAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE--------NIGTIFWYAVVGTLWNSIGIGVSLF----------------GICQIEAFG-LSDITLLQNLLFGSLISAVDPVAVLAVFENIH-----VNEQLYILVFGESLLNDAVTVVLYNLFKSFCQM---KTIETIDVF------AGI-ANFFVVGIGGVLIGIFLGFIAAFTTRFTH-----NIRVIEPLFVFLYSYLSYITAEMFHL---SGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFAL--VFLLPAAVF--------PRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-------------------------------------------------------------RSNKKQQA----------VSEEIYCRLF----DHVKTGIEDVCGHWGHNFWR--D----KFKKFDDKYLRKLLI------------------------------------------------------RENQPKS--SIVSLYK--------------------------------KLEI-------------------------------------------------------------KHAIEMAETG--------------MIS----TVPTFASL--------------------------NDCREEKIR-----------KVTSSETDEI-------------------RELLSRNLYQIRQRTL-SYNRHSLTADTSERQAKEILIRRRHS--LRESIR-------------------KDSSLNREH---------RASTSTSRYLSLPKNT----------------KLPEKL-QKRRTISIADGNSSDSDA--------------DAGTT--------------------VLNLQPR-ARRFL---------------PEQFSKKSPQSYKMEWKNEV-DVDS---------GRDMPSTPPT---------------------------------PHS----REK-----------GTQTSGLLQQ-------PLL-SKDQSG-------------S---------------EREDSLTEGI------------PPKPP--PRLVWRASEPGSRKARFGS-----------EKP-------------
SLC9A3    MWGLGA-----------------RGP------------------------DRGLLLALALGG---------LARA-----------------GGVEVEPGGAHGESG-------------------G-FQVVTFEWAHVQDPYVIALWILVASL--------------------AKIGFHLS-HKVTSVVPESALLIVLGLVLGGIV-WAADHIAS----------------------------------------------------FTLTPTVFFFYLLPPIVLDAGYFMPNRLFFG--------NLGTILLYAVVGTVWNAATTGLSLY----------------GVFLSGLMG-DLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVH-----VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGG-DNVTGVDCV------KGI-VSFFVVSLGGTLVGVVFAFLLSLVTRFTK-----HVRIIEPGFVFIISYLSYLTSEMLSL---SAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAV-NP-FIWTWN-TAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFAL--VVLLDGDKV--------KEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVK-------------------------------------------------------------RSEHREPR----------LNEKLHGRAF----DHILSAIEDISGQIGHNYLR--D----KWSHFDRKFLSRVLM------------------------------------------------------RRSAQKSRDRILNVFH--------------------------------ELNL-------------------------------------------------------------KDAISYVAEGE------------RRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRR--------RSIRDAEDMV------------------THHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR-LESFKS-------------------TKLGLNQNKKAAKLYKRERAQKR--RNSSIPNGK----------------LPMESP-AQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDT-----ASDSPAGIDNP-VFSPDEALDRSLLAR-----------LPPWLS-PGETVVPSQRARTQI---------------------------------------------------------PYS--------------------PGTFCRLM-------PFR------------------LSS---------------KSVDSFL---------------QADGPEE---RPPAALPESTHM-------------------------------
SLC9A4    --------MALQM------FVT-YSP------------------------WNCLLLLVA------------LECSEASSDLNES--------ANSTAQYAS----------NAW--FAAASSEPEEG-ISVFELDYDYVQIPYEVTLWILLASL--------------------AKIGFHLY-HRLPGLMPESCLLILVGALVGGII-FGTDHKSP----------------------------------------------------PVMDSSIYFLYLLPPIVLEGGYFMPTRPFFE--------NIGSILWWAVLGALINALGIGLSLY----------------LICQVKAFG-LGDVNLLQNLLFGSLISAVDPVAVLAVFEEAR-----VNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDIL------AGC-ARFIVVGLGGVLFGIVFGFISAFITRFTQ-----NISAIEPLIVFMFSYLSYLAAETLYL---SGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSL--AFLLPLSLF--------PRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-------------------------------------------------------------KTNKK-ES----------INEELHIRLM----DHLKAGIEDVCGHWSHYQVR--D----KFKKFDHRYLRKILI------------------------------------------------------RKNLPKS--SIVSLYK--------------------------------KLEM-------------------------------------------------------------KQAIEMVETG--------------ILSSTAFSIPHQAQ------------------------------RIQGIK-----------RLSPEDVESI-------------------RDILTSNMYQVRQRTL-SYNKYNLKPQTSEKQAKEILIRRQNT--LRESMR-------------------KGHSLPWGK---------PAGTKNIRYLSYPYGN------------------PQSAGRDTRAAGFSDDDSSDPGSP---------SITFSACSR--------------------IGSLQKQEAQEII---------------PMKSLHRGRKAFSFGYQRNT-----------------------------------------------------------S----QEEYL--------GGVRRVALRPK-------PLFHAVDEEGESGG--------ES---------------EGKASLVE---------------------VRSRWTADH-GHGRDHHRS-----------HSPL----LQKK----
SLC9A5    ----------------------------------------------------MLRAALSLLA---------LPLA-----------------GAAE-EPTQKPESPG---------------EPPPG-LELFRWQWHEVEAPYLVALWILVASL--------------------AKIVFHLS-RKVTSLVPESCLLILLGLVLGGIV-LAVAKKAE----------------------------------------------------YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFD--------NLGAILTYAVVGTLWNAFTTGAALW----------------GLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVH-----VNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS-ANVQATDYL------KGV-ASLFVVSLGGAAVGLVFAFLLALTTRFTK-----RVRIIEPLLVFLLAYAAYLTAEMASL---SAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAV-DS-SKWAWD-SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFAL--VILLDRTKV--------PAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVK-------------------------------------------------------------RSEHHKPT----------LNQELHEHTF----DHILAAVEDVVGHHGYHYWR--D----RWEQFDKKYLSQLLM------------------------------------------------------RRSAYRIRDQIWDVYY--------------------------------RLNI-------------------------------------------------------------RDAISFVDQGG------------HVLSSTGLTLPSMPS--------RNSVAETSVTNLLRESGSGACLDLQVIDT-V--------RSGRDREDAV------------------MHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRR-LESFKS-------------------TKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKH---RGLGFQDTAAVILTVES---------EEEEEESDSSETEKEDDE---GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKEL---------------PWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQA-----------------------PILTCLPPHP--------------------RGTEEPQV-------PLH------------------LPS---------------DPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGT-----------ATSHWCIQFNRGSRL-
SLC9A6    --------MARR--------GWRRAP--------------LRRGVGSSPRARRLMRPLWLLL--------AVGVFDWAGA----------SDGGGG--EARAMDEEI--------------VSEKQA-------EESHRQDSANLLIFILLLTL--------------------TILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFR--------NLGSILAYAFLGTAISCFVIGSIMY------------GCVTLMKVTGQLA--GDFYFTDCLLFGAIVSATDPVTVLAIFHELQ-----VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG--DNSHTFDVT---AMFKSI-GIFLGIFSGSFAMGAATGVVTALVTKFTKL---REFQLLETGLFFLMSWSTFLLAEAWGF---TGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP---TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFAL--AIR-DTAT---------YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGV--------DSDQ----------EH-----------LGV--------------------PENER-RT----------TKAE------------------------SAWLFR-------MWYNFDHNYLKPLLT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPACCGP-------------------------------------------------------I------------------ARCLTSPQAYENQEQLK-------------DDDSDLILNDGDIS--LT-------------------------------------------------YGDSTVNT-----------------------------------EPATSS--------------------------------------------------------------------------------------------------------APRRFMG---------------------------------NSSEDALDRELA--------FGDHELVIRGTR---LVLPMD-------------------DS---------------EPPLNLLD-------------NTRHGPA-----------------------------------------------
SLC9A7    ---MEPGDAARP--------GSGRA--------------------TGAPPPRLLLLPLLLGW--------GLRVAAAASA----------SSSGAAAEDSSAM-EEL--------------ATEKEA-------EESHRQDSVSLLTFILLLTL--------------------TILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSG-RDKSL-SCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFR--------NLGSILAYAFLGTAVSCFIIGNLMY------------GVVKLMKIMGQLS--DKFYYTDCLFFGAIISATDPVTVLAIFNELH-----ADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAG--LNTHAFDAA---AFFKSV-GIFLGIFSGSFTMGAVTG-VNANVTKFTKL---HCFPLLETALFFLMSWSTFLLAEACGF---TGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP---IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFAL--AIR-DTAS---------YARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVE--EPSEEDQNE----------HHWQYF------RVGVDPDQDPPPNNDSFQVLQGDGPDSARGNR----------TKQE------------------------SAWIFR-------LWYSFDHNYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPAWCGL-------------------------------------------------------L------------------ARCLTSPQVYDNQEPLR-------------EEDSDFILTEGDLT--LT-------------------------------------------------YGDSTVTA-----------------------------------NGSSSSH------------------------------------------------------------------TAST------------------------------SLEGSRR-TK---------------------------------SSSEEVLERDLG--------MGDQKVSSRGTR---LVFPLE-------------------DN---------------A--------------------------------------------------------------------------
SLC9A8    ---MGEK-MAE----------EERFPNT----THEGFNVTLH---TTLVVTTKLVLPT----------------------------------------PGKPI-LPV--------------QTGEQA-------QQEEQSSGMTIFFSLLVLAI--------------------CIILVHLLIRYRLHFLPESVAVVSLGILMGAVI----------------------------------KIIEFK--------KLANWKEEEM-----FRPNMFFLLLLPPIIFESGYSLHKGNFFQ--------NIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFILQADVIS---KLNMTDSFAFGSLISAVDPVATIAIFNALH-----VDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK------NMSDVSGWQTFLQAL-DYFLKMFFGSAALGTLTGLISALVLKHIDL---RKTPSLEFGMMIIFAYLPYGLAEGISL---SGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEI---SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYAL--SLHLDLEPM--------EKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI-----------EDAKA----------HR----------------------------------RNKKDVNL----------SKTEKMGNTVE--SEHLSELTEE---EYEAHYIRRQDLKGFVW--LDAKYLNPFFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRLTQEDLHHGRIQMK--------------------------T--LTNK----------------------------------------------WYEEVR---------------------------------------------------------------------------------------------------------------------------------------------------------QG---------------------------------PSGSEDDEQELL--------------------------------------------------------------------------------------------------------------------------------------------
SLC9A9    --------MER---------------------------------------------------------------------------------------QSRVM-------------------SEKDE-------YQFQHQGAVELLVFNFLLIL--------------------TILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ--------NLGSILTYAFLGTAISCIVIGLIMY------------GFVKAMIHAGQLK-NGDFHFTDCLFFGSLMSATDPVTVLAIFHELH-----VDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK---ENPNAFDAA---AFFQSV-GNFLGIFAGSFAMGSAYAIITALLTKFTKL---CEFPMLETGLFFLLSWSAFLSAEAAGL---TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA---LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFAL--AIR-NTES---------QPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSS----------QHQE--------------------------------ANNLDKNM----------TKAE------------------------SARLFR-------MWYSFDHKYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPEWCGP-------------------------------------------------------I------------------SRLLTSPQAYG--EQLK-------------EDDVECIVNQDELA--IN-------------------------------------------------YQEQA---------------------------------------SSPCSP------------------------------------------------------------------PARL------------------------------GLDQKASPQT---------------------------------PGKENIYEGDLG--------LGGYELKLEQT--------LG-------------------QS---------------Q--LN----------------------------------------------------------------------
SLC9B1    --MHTTESKNEHLEDENFQTST--TPQSLIDPNNTAHEETKT----------------------------VLS--DTEE-----------------IKPQTKK--ET------------YISCPLRG-----VLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPP--LPPLLGMLLAGFTIRNVPFINE-------------------HVHV-----------------------------PNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWA---------------------------------FLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFS---SGGILNNAI------ASI---------RNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQE------KMKVQKIITTVWDIFQPLLFGLVGAEVSVSS-LESNI--VGISVATLSLALCVRILTTYLLMCF------AGFSFKEKIFIALAWMPKATVQAVLGPLALETARV------SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPK------------------------------------------------------------------------------------------------------------------------------------MLT------------------------------------------------------RHYDPSKI----------------------------------------KLQL---ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC9B2    ---MGDEDKRITYEDSEPSTGMNYTPSM----HQEAQEETVM----------------------------KLKGIDANEP----------TEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHG-----LLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPP--LPSLLGMLLAGFLIRNIPVIND-------------------NVQI-----------------------------KHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWG---------------------------------FILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFS---TGSTVFNVL------RGV---------LEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSE------KAEVEKIIAVAWDIFQPLLFGLIGAEVSIAS-LRPET--VGLCVATVGIAVLIRILTTFLMVCF------AGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS-----HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPR------------------------------------------------------------------------------------------------------------------------------------LLQ------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEHQNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEE-------------------------------------------------VQG---------------ETSVQV---------------------------------------------------------------------
SLC9C1    --------MAGIF-------------------------------------------------------------------------------------------------------------------------KEFFFSTEDLPEVILTLSLI--------------------SSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLS-FTSSQVQR---------------------------YANAI--------------------QWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK--------LFWQILLISIPGF-----LVNYILV-----------------LWHLASVN-QLLLKPTQWLLFSAILVSSDPMLTAAAIRDLG-----LSRSLISLINGESLMTSVISLITFTSIMDFDQRLQ-SKRNH-TLA--EEIVGGI-CSY-II--ASFLFGILSSKLIQFWMSTVF-----GDDVNHISLIFSILYLIFYICELVGM---SGIFTLAIVGLLLNSTSFK--AAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVG-HEFSWRWIFIMVCSEMKGMPNINM--ALLLAYSDLYFGSDK--EKSQI-LFHGVLVCLITLVVNRFILPVAVTILG-----------LRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDL----ANADWNMI----EKAITLEN-PYM------LNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANR-RLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIIS-W--ISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEI-----DTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMS-HQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILK-AFGLKGIISKTEGAGINKLIMAKKKE--VLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKV-VTFDCGNDIFEEGDEPKGIYIIISGM---------VKLEKS---KPGLGI--DQMVESKEKDFP------IIDTDYMLSGE------------------IIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKM--------WL----KLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPM-----STKTDIYDENLI--YVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVI---IQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTL----EEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR--INLRKVRKE-
SLC9C2    --------MSSYFW----AQNESNRP--------------------------------------------DLLCG----------------------QPADYL------------------------------VEEKHFTT--------LVCFI--------------------VVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMA-YNSVEVHQ---------------------------IVYPL--------------------LRTSSFSLYSYFSPLIIFMVALDVEFYTLKK--------MFWQVLLTGLISFSTASIIIGYVVI------------KFNKDSWDLQSC-----------LLFSITLGIIDPLRSVNSLKTIG-----ISKIYIDLIRGESLIICSIASIFFGN-------FR-GNRIHFSIF--RDLHVGIELSYDIL--GSIIFGYWCAKIIQCILADVF-----SNMLTNIILCFSMVYMTFYIVEFLGM---SGTLALAAVGLNLDSLTFK--PKI-ELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN-YEYNWRWGVVITWSGIKGVFN-------LLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNAT-----------QHIQEIVQNTITLFKTEKIL----TNVNWTLV----EDKTRIEYIPFSHVSHNDMKTESTT--------------DEAL----MEEARL-HVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNV---SALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI----QLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIK-KRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLT-FLCSRGIIDKHEVIEINKVLLKKLKA--LNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKL-ACFDSGDTICKGGEMPQGIYLIISGM---------AILHSL---SPTFGIESNQRCDRGSRD---------MFTEFCTTGD------------------IIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKI--------WL----KLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE--TL-----SSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLI---IQA-------------------SELT--------------------QRNSNTNVMASVNTVF---------------EQPG--KNINGRQKMS

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC9A5 206 V/I 0.000681532 rs200636776
-- SLC9A5 225 N/T 0.000132652 rs549199804
-- SLC9A5 328 V/A 0.000140301 rs755852418
-- SLC9A5 352 V/M 0.000108214 rs542721154
-- SLC9A5 444 V/M 0.00014463 rs75549387
-- SLC9A5 530 R/K 0.000593339 rs199753728
-- SLC9A5 636 V/G 0.000971199 rs757169178
-- SLC9A5 736 G/R 0.000435205 rs201718658
-- SLC9A5 738 V/F 0.00132967 rs75080122
-- SLC9A5 749 R/Q 0.000105384 rs756654496
-- SLC9A5 823 E/D 0.000489288 rs55690921
-- SLC9A5 867 P/S 0.000129208 rs529471266

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC9A5 SLC9A5 [plasma membrane] Sodium/Proton exchangers

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data