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Variant
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Detail Data SLC9A1


Basic description
Gene Name SLC9A1
Protein Name Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
Family SLC9
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810 
MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE PPRERSIGDV TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR TPFEISLWIL LACLMKIGFH VIPTISSIVP ESCLLIVVGL LVGGLIKGVG ETPPFLQSDV FFLFLLPPII LDAGYFLPLR QFTENLGTIL IFAVVGTLWN AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV AVLAVFEEIH INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL SGIMALIASG VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV STVAGSHHWN WTFVISTLLF CLIARVLGVL GLTWFINKFR IVKLTPKDQF IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF LTAIITVIFF TVFVQGMTIR PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH YGHHHWKDKL NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN RHTLVADPYE EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR IGSDPLAYEP KEDLPVITID PASPQSPESV DLVNEELKGK VLGLSRDPAK VAEEDEDDDG GIMMRSKETS SPGTDDVFTP APSDSPSSQR IQRCLSDPGP HPEPGEGEPF FPKGQ 
CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC EECCCHHHHC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHHHHHH HHHHHCCCHH HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHCCCCHH HHHHHHCCCC CCHHHHHHHH CCCCCCHHHH HHHHHHHHHH HCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHC CCHHHHHHHH HHHHHHHHHH CCHHHHHCCC CCCCCCHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCHHHHH HHHHCCHHHH HHHHHHHHCC CCCCHHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHCCCCCCC HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCCEEECC CCCCCCCCCC CCCCHHHCCC CCCCCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HCHHCCCCCC CCCCCCCCCC CCCCC
[Overview] SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9B1 SLC9B2 SLC9C1 SLC9C2 
SLC9A1    --------MVLRS------GICGLSPHR---------------------IFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRP--VNHS--VTDHGMKPRKA-FPVLGIDYTHVRTPFEISLWILLACL--------------------MKIGFHVI-PTISSIVPESCLLIVVGLLVGGLI-KGVGE-TP----------------------------------------------------PFLQSDVFFLFLLPPIILDAGYFLPLRQFTE--------NLGTILIFAVVGTLWNAFFLGGLMY----------------AVCLVGGEQ-INNIGLLDNLLFGSIISAVDPVAVLAVFEEIH-----INELLHILVFGESLLNDAVTVVLYHLFEEFANY---EHVGIVDIF------LGF-LSFFVVALGGVLVGVVYGVIAAFTSRFTS-----HIRVIEPLFVFLYSYMAYLSAELFHL---SGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HHWNW---TFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSL--GYLLDKKHF--------PMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVK-------------------------------------------------------------KKQETKRS----------INEEIHTQFL----DHLLTGIEDICGHYGHHHWK--D----KLNRFNKKYVKKCLIAG---------------------------------------------------ERSKEPQ----LIAFYH--------------------------------KMEM-------------------------------------------------------------KQAIELVESG--------------GMG----KIPSAVS----------------------------TVSMQNIHPKSLPSERILPALSKDKEEEI-------------------RKILRNNLQKTRQRLR-SYNRHTLVADPYEEAWNQMLLRRQKARQLEQKIN-------------------N-------------------------YLTVPAHK------------------LDSPTMSRARIG------SDPLA---------------------------------------------YEPKEDL---------------PV-----------------I-TID--------------PASPQS---------------------------------PESVDLVNEE-L--------KG-KVLGLSRD-------PAKVAEEDEDDDGGIMMRSKETSS---------------PGTDDVFTPA------------PSDSPSSQRIQRCLSDPGP-HPEPGE-----------GEPF----FPKGQ---
SLC9A2    MEPLGNW-RSLR------------AP------------------------LPPMLLLLL------------LQVAGPVGALAETLLNAPRAMGTSSSPPSP----------ASV--VAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASL--------------------AKIGFHLY-HKLPTIVPESCLLIMVGLLLGGII-FGVDEKSP----------------------------------------------------PAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE--------NIGTIFWYAVVGTLWNSIGIGVSLF----------------GICQIEAFG-LSDITLLQNLLFGSLISAVDPVAVLAVFENIH-----VNEQLYILVFGESLLNDAVTVVLYNLFKSFCQM---KTIETIDVF------AGI-ANFFVVGIGGVLIGIFLGFIAAFTTRFTH-----NIRVIEPLFVFLYSYLSYITAEMFHL---SGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFAL--VFLLPAAVF--------PRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-------------------------------------------------------------RSNKKQQA----------VSEEIYCRLF----DHVKTGIEDVCGHWGHNFWR--D----KFKKFDDKYLRKLLI------------------------------------------------------RENQPKS--SIVSLYK--------------------------------KLEI-------------------------------------------------------------KHAIEMAETG--------------MIS----TVPTFASL--------------------------NDCREEKIR-----------KVTSSETDEI-------------------RELLSRNLYQIRQRTL-SYNRHSLTADTSERQAKEILIRRRHS--LRESIR-------------------KDSSLNREH---------RASTSTSRYLSLPKNT----------------KLPEKL-QKRRTISIADGNSSDSDA--------------DAGTT--------------------VLNLQPR-ARRFL---------------PEQFSKKSPQSYKMEWKNEV-DVDS---------GRDMPSTPPT---------------------------------PHS----REK-----------GTQTSGLLQQ-------PLL-SKDQSG-------------S---------------EREDSLTEGI------------PPKPP--PRLVWRASEPGSRKARFGS-----------EKP-------------
SLC9A3    MWGLGA-----------------RGP------------------------DRGLLLALALGG---------LARA-----------------GGVEVEPGGAHGESG-------------------G-FQVVTFEWAHVQDPYVIALWILVASL--------------------AKIGFHLS-HKVTSVVPESALLIVLGLVLGGIV-WAADHIAS----------------------------------------------------FTLTPTVFFFYLLPPIVLDAGYFMPNRLFFG--------NLGTILLYAVVGTVWNAATTGLSLY----------------GVFLSGLMG-DLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVH-----VNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGG-DNVTGVDCV------KGI-VSFFVVSLGGTLVGVVFAFLLSLVTRFTK-----HVRIIEPGFVFIISYLSYLTSEMLSL---SAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAV-NP-FIWTWN-TAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFAL--VVLLDGDKV--------KEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVK-------------------------------------------------------------RSEHREPR----------LNEKLHGRAF----DHILSAIEDISGQIGHNYLR--D----KWSHFDRKFLSRVLM------------------------------------------------------RRSAQKSRDRILNVFH--------------------------------ELNL-------------------------------------------------------------KDAISYVAEGE------------RRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRR--------RSIRDAEDMV------------------THHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR-LESFKS-------------------TKLGLNQNKKAAKLYKRERAQKR--RNSSIPNGK----------------LPMESP-AQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDT-----ASDSPAGIDNP-VFSPDEALDRSLLAR-----------LPPWLS-PGETVVPSQRARTQI---------------------------------------------------------PYS--------------------PGTFCRLM-------PFR------------------LSS---------------KSVDSFL---------------QADGPEE---RPPAALPESTHM-------------------------------
SLC9A4    --------MALQM------FVT-YSP------------------------WNCLLLLVA------------LECSEASSDLNES--------ANSTAQYAS----------NAW--FAAASSEPEEG-ISVFELDYDYVQIPYEVTLWILLASL--------------------AKIGFHLY-HRLPGLMPESCLLILVGALVGGII-FGTDHKSP----------------------------------------------------PVMDSSIYFLYLLPPIVLEGGYFMPTRPFFE--------NIGSILWWAVLGALINALGIGLSLY----------------LICQVKAFG-LGDVNLLQNLLFGSLISAVDPVAVLAVFEEAR-----VNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDIL------AGC-ARFIVVGLGGVLFGIVFGFISAFITRFTQ-----NISAIEPLIVFMFSYLSYLAAETLYL---SGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKN-HEWNW---AFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSL--AFLLPLSLF--------PRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-------------------------------------------------------------KTNKK-ES----------INEELHIRLM----DHLKAGIEDVCGHWSHYQVR--D----KFKKFDHRYLRKILI------------------------------------------------------RKNLPKS--SIVSLYK--------------------------------KLEM-------------------------------------------------------------KQAIEMVETG--------------ILSSTAFSIPHQAQ------------------------------RIQGIK-----------RLSPEDVESI-------------------RDILTSNMYQVRQRTL-SYNKYNLKPQTSEKQAKEILIRRQNT--LRESMR-------------------KGHSLPWGK---------PAGTKNIRYLSYPYGN------------------PQSAGRDTRAAGFSDDDSSDPGSP---------SITFSACSR--------------------IGSLQKQEAQEII---------------PMKSLHRGRKAFSFGYQRNT-----------------------------------------------------------S----QEEYL--------GGVRRVALRPK-------PLFHAVDEEGESGG--------ES---------------EGKASLVE---------------------VRSRWTADH-GHGRDHHRS-----------HSPL----LQKK----
SLC9A5    ----------------------------------------------------MLRAALSLLA---------LPLA-----------------GAAE-EPTQKPESPG---------------EPPPG-LELFRWQWHEVEAPYLVALWILVASL--------------------AKIVFHLS-RKVTSLVPESCLLILLGLVLGGIV-LAVAKKAE----------------------------------------------------YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFD--------NLGAILTYAVVGTLWNAFTTGAALW----------------GLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVH-----VNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS-ANVQATDYL------KGV-ASLFVVSLGGAAVGLVFAFLLALTTRFTK-----RVRIIEPLLVFLLAYAAYLTAEMASL---SAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAV-DS-SKWAWD-SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFAL--VILLDRTKV--------PAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVK-------------------------------------------------------------RSEHHKPT----------LNQELHEHTF----DHILAAVEDVVGHHGYHYWR--D----RWEQFDKKYLSQLLM------------------------------------------------------RRSAYRIRDQIWDVYY--------------------------------RLNI-------------------------------------------------------------RDAISFVDQGG------------HVLSSTGLTLPSMPS--------RNSVAETSVTNLLRESGSGACLDLQVIDT-V--------RSGRDREDAV------------------MHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRR-LESFKS-------------------TKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKH---RGLGFQDTAAVILTVES---------EEEEEESDSSETEKEDDE---GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKEL---------------PWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQA-----------------------PILTCLPPHP--------------------RGTEEPQV-------PLH------------------LPS---------------DPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGT-----------ATSHWCIQFNRGSRL-
SLC9A6    --------MARR--------GWRRAP--------------LRRGVGSSPRARRLMRPLWLLL--------AVGVFDWAGA----------SDGGGG--EARAMDEEI--------------VSEKQA-------EESHRQDSANLLIFILLLTL--------------------TILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFR--------NLGSILAYAFLGTAISCFVIGSIMY------------GCVTLMKVTGQLA--GDFYFTDCLLFGAIVSATDPVTVLAIFHELQ-----VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG--DNSHTFDVT---AMFKSI-GIFLGIFSGSFAMGAATGVVTALVTKFTKL---REFQLLETGLFFLMSWSTFLLAEAWGF---TGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP---TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFAL--AIR-DTAT---------YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGV--------DSDQ----------EH-----------LGV--------------------PENER-RT----------TKAE------------------------SAWLFR-------MWYNFDHNYLKPLLT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPACCGP-------------------------------------------------------I------------------ARCLTSPQAYENQEQLK-------------DDDSDLILNDGDIS--LT-------------------------------------------------YGDSTVNT-----------------------------------EPATSS--------------------------------------------------------------------------------------------------------APRRFMG---------------------------------NSSEDALDRELA--------FGDHELVIRGTR---LVLPMD-------------------DS---------------EPPLNLLD-------------NTRHGPA-----------------------------------------------
SLC9A7    ---MEPGDAARP--------GSGRA--------------------TGAPPPRLLLLPLLLGW--------GLRVAAAASA----------SSSGAAAEDSSAM-EEL--------------ATEKEA-------EESHRQDSVSLLTFILLLTL--------------------TILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSG-RDKSL-SCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFR--------NLGSILAYAFLGTAVSCFIIGNLMY------------GVVKLMKIMGQLS--DKFYYTDCLFFGAIISATDPVTVLAIFNELH-----ADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAG--LNTHAFDAA---AFFKSV-GIFLGIFSGSFTMGAVTG-VNANVTKFTKL---HCFPLLETALFFLMSWSTFLLAEACGF---TGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP---IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFAL--AIR-DTAS---------YARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVE--EPSEEDQNE----------HHWQYF------RVGVDPDQDPPPNNDSFQVLQGDGPDSARGNR----------TKQE------------------------SAWIFR-------LWYSFDHNYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPAWCGL-------------------------------------------------------L------------------ARCLTSPQVYDNQEPLR-------------EEDSDFILTEGDLT--LT-------------------------------------------------YGDSTVTA-----------------------------------NGSSSSH------------------------------------------------------------------TAST------------------------------SLEGSRR-TK---------------------------------SSSEEVLERDLG--------MGDQKVSSRGTR---LVFPLE-------------------DN---------------A--------------------------------------------------------------------------
SLC9A8    ---MGEK-MAE----------EERFPNT----THEGFNVTLH---TTLVVTTKLVLPT----------------------------------------PGKPI-LPV--------------QTGEQA-------QQEEQSSGMTIFFSLLVLAI--------------------CIILVHLLIRYRLHFLPESVAVVSLGILMGAVI----------------------------------KIIEFK--------KLANWKEEEM-----FRPNMFFLLLLPPIIFESGYSLHKGNFFQ--------NIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFVCFILQADVIS---KLNMTDSFAFGSLISAVDPVATIAIFNALH-----VDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK------NMSDVSGWQTFLQAL-DYFLKMFFGSAALGTLTGLISALVLKHIDL---RKTPSLEFGMMIIFAYLPYGLAEGISL---SGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEI---SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYAL--SLHLDLEPM--------EKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI-----------EDAKA----------HR----------------------------------RNKKDVNL----------SKTEKMGNTVE--SEHLSELTEE---EYEAHYIRRQDLKGFVW--LDAKYLNPFFT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRLTQEDLHHGRIQMK--------------------------T--LTNK----------------------------------------------WYEEVR---------------------------------------------------------------------------------------------------------------------------------------------------------QG---------------------------------PSGSEDDEQELL--------------------------------------------------------------------------------------------------------------------------------------------
SLC9A9    --------MER---------------------------------------------------------------------------------------QSRVM-------------------SEKDE-------YQFQHQGAVELLVFNFLLIL--------------------TILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ--------NLGSILTYAFLGTAISCIVIGLIMY------------GFVKAMIHAGQLK-NGDFHFTDCLFFGSLMSATDPVTVLAIFHELH-----VDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK---ENPNAFDAA---AFFQSV-GNFLGIFAGSFAMGSAYAIITALLTKFTKL---CEFPMLETGLFFLLSWSAFLSAEAAGL---TGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA---LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFAL--AIR-NTES---------QPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSS----------QHQE--------------------------------ANNLDKNM----------TKAE------------------------SARLFR-------MWYSFDHKYLKPILT------------------------------------------------------HSGPPLTT----------------------------------------------------------------------------------------------------------------------------------------TLPEWCGP-------------------------------------------------------I------------------SRLLTSPQAYG--EQLK-------------EDDVECIVNQDELA--IN-------------------------------------------------YQEQA---------------------------------------SSPCSP------------------------------------------------------------------PARL------------------------------GLDQKASPQT---------------------------------PGKENIYEGDLG--------LGGYELKLEQT--------LG-------------------QS---------------Q--LN----------------------------------------------------------------------
SLC9B1    --MHTTESKNEHLEDENFQTST--TPQSLIDPNNTAHEETKT----------------------------VLS--DTEE-----------------IKPQTKK--ET------------YISCPLRG-----VLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPP--LPPLLGMLLAGFTIRNVPFINE-------------------HVHV-----------------------------PNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWA---------------------------------FLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFS---SGGILNNAI------ASI---------RNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQE------KMKVQKIITTVWDIFQPLLFGLVGAEVSVSS-LESNI--VGISVATLSLALCVRILTTYLLMCF------AGFSFKEKIFIALAWMPKATVQAVLGPLALETARV------SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPK------------------------------------------------------------------------------------------------------------------------------------MLT------------------------------------------------------RHYDPSKI----------------------------------------KLQL---ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC9B2    ---MGDEDKRITYEDSEPSTGMNYTPSM----HQEAQEETVM----------------------------KLKGIDANEP----------TEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHG-----LLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPP--LPSLLGMLLAGFLIRNIPVIND-------------------NVQI-----------------------------KHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWG---------------------------------FILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFS---TGSTVFNVL------RGV---------LEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSE------KAEVEKIIAVAWDIFQPLLFGLIGAEVSIAS-LRPET--VGLCVATVGIAVLIRILTTFLMVCF------AGFNLKEKIFISFAWLPKATVQAAIGSVALDTARS-----HGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPR------------------------------------------------------------------------------------------------------------------------------------LLQ------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEHQNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEE-------------------------------------------------VQG---------------ETSVQV---------------------------------------------------------------------
SLC9C1    --------MAGIF-------------------------------------------------------------------------------------------------------------------------KEFFFSTEDLPEVILTLSLI--------------------SSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLS-FTSSQVQR---------------------------YANAI--------------------QWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK--------LFWQILLISIPGF-----LVNYILV-----------------LWHLASVN-QLLLKPTQWLLFSAILVSSDPMLTAAAIRDLG-----LSRSLISLINGESLMTSVISLITFTSIMDFDQRLQ-SKRNH-TLA--EEIVGGI-CSY-II--ASFLFGILSSKLIQFWMSTVF-----GDDVNHISLIFSILYLIFYICELVGM---SGIFTLAIVGLLLNSTSFK--AAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVG-HEFSWRWIFIMVCSEMKGMPNINM--ALLLAYSDLYFGSDK--EKSQI-LFHGVLVCLITLVVNRFILPVAVTILG-----------LRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDL----ANADWNMI----EKAITLEN-PYM------LNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANR-RLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIIS-W--ISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAITLIGILHVILIEI-----DTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMS-HQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILK-AFGLKGIISKTEGAGINKLIMAKKKE--VLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKV-VTFDCGNDIFEEGDEPKGIYIIISGM---------VKLEKS---KPGLGI--DQMVESKEKDFP------IIDTDYMLSGE------------------IIGEINCLTNEPMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKM--------WL----KLGLAITARKIREHLSYEDWNYNMQLKLSNIYVVDIPM-----STKTDIYDENLI--YVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVI---IQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTL----EEGIQEERNVKEDGAHSAATARSPQPCSLLGTKFNCKESPR--INLRKVRKE-
SLC9C2    --------MSSYFW----AQNESNRP--------------------------------------------DLLCG----------------------QPADYL------------------------------VEEKHFTT--------LVCFI--------------------VVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMA-YNSVEVHQ---------------------------IVYPL--------------------LRTSSFSLYSYFSPLIIFMVALDVEFYTLKK--------MFWQVLLTGLISFSTASIIIGYVVI------------KFNKDSWDLQSC-----------LLFSITLGIIDPLRSVNSLKTIG-----ISKIYIDLIRGESLIICSIASIFFGN-------FR-GNRIHFSIF--RDLHVGIELSYDIL--GSIIFGYWCAKIIQCILADVF-----SNMLTNIILCFSMVYMTFYIVEFLGM---SGTLALAAVGLNLDSLTFK--PKI-ELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN-YEYNWRWGVVITWSGIKGVFN-------LLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNAT-----------QHIQEIVQNTITLFKTEKIL----TNVNWTLV----EDKTRIEYIPFSHVSHNDMKTESTT--------------DEAL----MEEARL-HVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNV---SALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI----QLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIK-KRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLT-FLCSRGIIDKHEVIEINKVLLKKLKA--LNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKL-ACFDSGDTICKGGEMPQGIYLIISGM---------AILHSL---SPTFGIESNQRCDRGSRD---------MFTEFCTTGD------------------IIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKI--------WL----KLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE--TL-----SSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLI---IQA-------------------SELT--------------------QRNSNTNVMASVNTVF---------------EQPG--KNINGRQKMS

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC9A1 54 E/Q 0.000318248 rs545434461
-- SLC9A1 76 H/Y 0.000879112 rs141715004
SLC9A1 287 G/S 0.0002552 rs145043085
SLC9A1 307 L/F 0.000135403 rs139348254
SLC9A1 323 T/P 0.000200528 rs764779520
-- SLC9A1 520 A/V 0.000411475 rs139228809
-- SLC9A1 523 L/F 0.000197415 rs552738912
-- SLC9A1 553 I/V 0.000228855 rs74650982
-- SLC9A1 553 I/L 0.0053175 rs74650982
-- SLC9A1 696 M/V 0.00181033 rs201372679
SLC9A1 721 P/L 0.000127947 rs745617798
-- SLC9A1 746 R/Q 0.000190913 rs141694580
-- SLC9A1 759 D/N 0.000270522 rs140504210

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC9A1 SLC9A1 [plasma membrane] Sodium/Proton exchangers
SLC9A1 SLC9A1 [plasma membrane] Hyaluronan uptake and degradation

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data