Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC8B1


Basic description
Gene Name SLC8B1
Protein Name Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)
Family SLC8
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
Reaction 3 Na+ [mitochondrial intermembrane space] + 1 Ca2+ [mitochondrial matrix] --> 1 Ca2+ [mitochondrial intermembrane space] + 3 Na+ [mitochondrial matrix]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580 
MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG APDIFSALVA FSDPHTAGLA LGALFGAGVL VTTVVAGGIT ILHPFMAASR PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY VVTVILCTWI YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD DQNWKRPLNC LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA LASVTFFATS DSQPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVV FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF SLVSVPLQCF QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM 
CCCCCCCHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHCCCC HHHCCHHHHH CCCCCCCCCC CCHHHHHHCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHCCCCHHHH HHHHHHHHCC CCHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCHHCCCCH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHC CCCHHHHHHC CCCCCCCCCC CCCCCCCCCC HHHHCCHHHH HHHCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHCHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHCCCC CCCHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCC
[Overview] SLC8A1 SLC8A2 SLC8A3 SLC8B1 
SLC8A1    MYNMRRLSLSPTFSMGFHL-LVTVSLLFSHVDHVIAETEMEGEG---------------NETGE------------------CTG------SYYCK------------------KGV-------ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYII------LSVISPGVVEVWE-GLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALV--LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFK-PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACL---GSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAG-EDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIG------VAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAY--CHIKGF
SLC8A2    --------MAPLA-------LVGVTLLL-------AAPPCSGAATPTPSLPPPPANDSDTSTGG------------------CQG------SYRCQ------------------PGV-------LLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLI------LAVFSPGVVQVWE-ALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGAEAPGELGGLGPGPAEARELD----ASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFK-PGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQ---GMFEPDGGG--RPKGRL---VAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGI-SALLLNQ----------------------------------GD--GDRK-LTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLG------VAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAY--CHIRGF
SLC8A3    ---MAWLRLQPLTSAFLHFGLVTFVLFLNGLR---AEAGGSGDV---------------PSTGQN----------NE----SCSG------SSDCK------------------EGV-------ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMI------LAVFSPGVVQVWE-GLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH---FLDGNLV-PLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLK-PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVL---ASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLS---------------------------------------PDRK-LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAA-GDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIG------LAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAY--CYIKGF
SLC8B1    ---MAGRRLN------LRWALSVLCVLL-------MAETVSGTR--------------GSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPL-------------AVTLYVSWLLYLFLILGVTAAKFFC----------------PNLSAISTTLKL-SHNVAGVTFLAFGNGAPDIFSALVAFSDPH-TAG-LALGALFGAGVLVTTVVAGGITILHP-------------FMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTV---------ILCTWIYQRQRR-------------------------------------GSLFCPMPV-------------TPEILSDSEE-------DRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLD------------------------------------------------------------YMKWRRKSA---------YWKALKVFKLPVEFLLLLTVPVVDPD--KDDQNW--------------------------KRPLNCLHLVISPLVV-----------VLTLQSGTYGVYEIGGLVPVWVV-------------VVIAGTA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LASVTFFAT-SDSQ---------PPRLHWLFAFLGFLTSALWINAAATE-------------VVNILRSL--------GVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQG-YPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL----VFSLVSVPLQCFQLSRVYG--------------FCLLLFYLNFLVVALLTEFGVIHLKSM

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC8B1 3 G/S 0.000167492 rs143332433
-- SLC8B1 9 V/M 0.00014637 rs554490304
-- SLC8B1 54 R/H 0.000107704 rs567764947
-- SLC8B1 56 V/L 0.00013155 rs546565755
-- SLC8B1 71 N/K 0.000111426 rs774251856
-- SLC8B1 168 G/S 0.000107588 rs577130341
-- SLC8B1 222 R/C 0.0561488 rs16942745
-- SLC8B1 222 R/H 0.000111401 rs200728763
-- SLC8B1 246 L/V 0.00148734 rs115521155
-- SLC8B1 278 V/L 0.000116108 rs200612695
-- SLC8B1 293 P/L 0.000282425 rs150909186
-- SLC8B1 294 L/V 0.000258538 rs189446912
-- SLC8B1 346 D/H 0.000143641 rs761721258
-- SLC8B1 358 L/F 0.00468603 rs3764034
-- SLC8B1 393 V/M 0.00010747 rs368819577
-- SLC8B1 404 V/A 0.000135316 rs778329829
-- SLC8B1 437 A/T 0.000120211 rs750401003
-- SLC8B1 460 L/F 0.000367242 rs146994195
-- SLC8B1 474 S/L 0.000139491 rs141329750
-- SLC8B1 480 R/C 0.00011554 rs538747610
-- SLC8B1 529 V/I 0.000394602 rs150843854

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC8B1 SLC24A6 [plasma membrane] Sodium/Calcium exchangers
SLC8B1 SLC8B1 [mitochondrial inner membrane] Mitochondrial calcium ion transport

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data