Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC8A2


Basic description
Gene Name SLC8A2
Protein Name Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)
Family SLC8
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 8 2 0 8 3 0 8 4 0 8 5 0 8 6 0 8 7 0 8 8 0 8 9 0 9 0 0 9 1 0 9 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890        900        910        920 
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ PGVLLPVWEP DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC IYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR AFYRIQATRL MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP SLYHCLENCG SVLLSVTCQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK PVLGENCRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT VSAGDEEEEE DGSREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFGVSILVIG LLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL GLWLLYILFA SLEAYCHIRG F 
CHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCEECCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HCCCEEEEEE CCCCCEEEEE EEECCHHHHH HHHHHHHCCC HHHHHHHHHH HCCCCCCCCC CCCCCCCHHH CHHHHHHHHE EEEECCCCCC CCCCCCEEEE HHHHHHHHHH HHHHHHHHCC CCCEEHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCEE CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHCHHC CHHHHHHHHH HHCCCCCCCC HHHHHHHHHH HHHHHHCHHH HHHHHHHHHC CCCCCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCEEECCC CHHCCCCCCC CEEEEEEECC CCCCCEEEEE EEECCCCCCC CCCCEECEEE EEECCCCCEE EEEEEECCCC CCCCCCEEEE EEECCCCCCC CCCCCCCCCC CCCCEECCCC CCEEEECCCC CCCEEEECCE EEEECCCCCE EEEEEEECCC CCCEEEEEEE ECCCCCCCCC CCCHHCCCCE ECCCCCCCCE EEEEEECCCC CCCCCCEEEE CCCCHHHHCC HHHHHHCCCC CCCCCCHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHCCCCCCCC HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC HHCHHHHHHH HHHHHHHHCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC HHCHHHHHHH HCCCCCHHHH HHHEECCCCC CHHHCHHCHH HHHHHHHHHC CHHHHHHHHH HHHCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHCHH CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC C
[Overview] SLC8A1 SLC8A2 SLC8A3 SLC8B1 
SLC8A1    MYNMRRLSLSPTFSMGFHL-LVTVSLLFSHVDHVIAETEMEGEG---------------NETGE------------------CTG------SYYCK------------------KGV-------ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYII------LSVISPGVVEVWE-GLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALV--LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFK-PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACL---GSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAG-EDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIG------VAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAY--CHIKGF
SLC8A2    --------MAPLA-------LVGVTLLL-------AAPPCSGAATPTPSLPPPPANDSDTSTGG------------------CQG------SYRCQ------------------PGV-------LLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLI------LAVFSPGVVQVWE-ALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGAEAPGELGGLGPGPAEARELD----ASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFK-PGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQ---GMFEPDGGG--RPKGRL---VAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGI-SALLLNQ----------------------------------GD--GDRK-LTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLG------VAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAY--CHIRGF
SLC8A3    ---MAWLRLQPLTSAFLHFGLVTFVLFLNGLR---AEAGGSGDV---------------PSTGQN----------NE----SCSG------SSDCK------------------EGV-------ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMI------LAVFSPGVVQVWE-GLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH---FLDGNLV-PLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLK-PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVL---ASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLS---------------------------------------PDRK-LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAA-GDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIG------LAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAY--CYIKGF
SLC8B1    ---MAGRRLN------LRWALSVLCVLL-------MAETVSGTR--------------GSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPL-------------AVTLYVSWLLYLFLILGVTAAKFFC----------------PNLSAISTTLKL-SHNVAGVTFLAFGNGAPDIFSALVAFSDPH-TAG-LALGALFGAGVLVTTVVAGGITILHP-------------FMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTV---------ILCTWIYQRQRR-------------------------------------GSLFCPMPV-------------TPEILSDSEE-------DRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLD------------------------------------------------------------YMKWRRKSA---------YWKALKVFKLPVEFLLLLTVPVVDPD--KDDQNW--------------------------KRPLNCLHLVISPLVV-----------VLTLQSGTYGVYEIGGLVPVWVV-------------VVIAGTA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LASVTFFAT-SDSQ---------PPRLHWLFAFLGFLTSALWINAAATE-------------VVNILRSL--------GVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQG-YPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL----VFSLVSVPLQCFQLSRVYG--------------FCLLLFYLNFLVVALLTEFGVIHLKSM

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC8A2 14 A/V 0.000126626 rs1056315157
-- SLC8A2 29 P/L 0.00105431 rs201723439
-- SLC8A2 32 P/L 0.000152958 rs543995307
-- SLC8A2 65 L/P 0.000156097 rs201007458
-- SLC8A2 69 A/V 0.000103831 rs746692355
-- SLC8A2 499 G/S 0.000223979 rs748638430

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC8A2 SLC8A2 [plasma membrane] Sodium/Calcium exchangers
SLC8A2 SLC8A2 [plasma membrane] Reduction of cytosolic Ca++ levels
SLC8A2 SLC8A2 [plasma membrane] Ion homeostasis

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data