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Detail Data SLC7A6
Basic description
Gene Name | SLC7A6 |
---|---|
Protein Name | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) |
Family | SLC7 |
Category | Transport of inorganic cations/anions and amino acids/oligopeptides |
Reaction name | - |
Reaction | - |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG VSLVVGNMIG SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLVVEPTGQ AIIAITFANY IIQPSFPSCD PPYLACRLLA AACICLLTFV NCAYVKWGTR VQDTFTYAKV VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL YSALFSYSGW DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG HLPDLLSMIH IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF VGLSVVGQLY LRWKEPKRPR PLKLSVFFPI VFCICSVFLV IVPLFTDTIN SLIGIGIALS GVPFYFMGVY LPESRRPLFI RNVLAAITRG TQQLCFCVLT ELDVAEEKKD ERKTD CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHC CCCHHCHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCH HHHHHHHHHC CHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCH HCCCCCCCCC CHHHHHHHHH HHHHHHHCCC CHHHHHHHHH CCCCCCCCCC HHCCHHHHHH HHHHHHHHHH HCCCHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCHHHHHCC CCCCCCCCHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH CCHHHCCHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHCC HHCCC
[Overview]
SLC7A1 -----------------------------------------MGCKVL-LNIGQQMLRRKVVD-CSRE--------ETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAREN---AGPAIVISFLIAALASVLAGLCYGEFGARVPK-TGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHM-TLNAPGVLAE-NPD---------IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSG---FVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKP-GVGGFMPFGFSG--------VLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQ-PEQPNL---------------------------------------------VYQMASTSDELDPADQNELASTN------------------DSQLGFLPEAEMFSLKTILSP-------------KNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----------GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVW-------------MLIGFIIYFGYGLWHSEE------------------------------------------------------------------------ASLDADQA-------RTPDG-------------------NLDQCK--------- SLC7A10 ----MAGH--------------------TQ------------------QPSGRGNPR-PAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHS-GSVGLALFV-WVLGGGVTALGSLCYAELGVAIPK-SGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVI---SMTFSNYVLQPV--------------------FPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRP------------------------------SNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALH-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVNL--LIPVAYLVFWAFLLV---------FSFISEPM-VCGVGVIIILTGVPIFFLGVFW--RSKPKCVHRLTESMTHWGQELCFVVYP--------QDAP----------------------------------EEEENGPCP---PSLLPATDK-----------------PSKPQ------------ SLC7A11 M---VRKP-------------VVSTISKGG------------------YLQGNVNGRLPSLGNKEPPGQ-----EKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNT-GSVGMSLTI-WTVCGVLSLFGALSYAELGTTIKK-SGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVI---SLAFGRYILEPF--------------------FIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFK--------------------------------DAFSG-RDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMH-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------FKVPL--FIPALFSFTCLFMVA---------LSLYSDPF-STGIGFVITLTGVPAYYLFIIW--DKKPRWFRIMSEKITRTLQIILEVV----------------------------------------------------------------PEEDKL--------------------------------- SLC7A13 MD------------------------------------------------RG----------------------EKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCV-WAGCAILAMTSTLCSAEISISFPC-SGAQYYFLKRYFGSTVAFLNLWTSLFL----GSGVVAGQALLLAEYSIQPF--------------------FPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVER-----------------------------FQNAFDA-ELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLN-SHSSPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLS-----------------------------------------------------------------------------------------------------------IP-------------------------------------------------------------------------------------------------YKVFL--SFPLATIVIDVGLVV---------IPLVKSPNVHYVYVLLLVLSGLLFYIPLIHF--KIRLAWF----EKMTCYLQLLFNICLPDVS-----EE------------------------------------------------------------------------------------------- SLC7A14 ----MSGFFT-------------------------SLDPRRVQWGAAWYAMHSRILRTKPVE-SMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEM---AGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPD---------LLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGL-FFING--KYW--------------------------AEGQFLPHGWSG--------VLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQ-PESD-IDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYL-----IKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVV----------LMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVW-------------CFVGLLIYFGYGIWNSTLEISAREEALHQSTYQ----RYDVDDPFSV----EEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKS-------KHKQN-------SEALIAND----ELDYSPE-------- SLC7A2 MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAA-LTFARCLIRRKIVTLDSLE--------DTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKAD---SGPSIVVSFLIAALASVMAGLCYAEFGARVPK-TGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYF-RMNYTG-LAE-YPD---------FFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAG---FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTG--------TLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ-PGLS------------------------------------------------YDQPKCSPEKDGLGSSPRVTSK-----------------SESQVTML-QRQGFSMRTLFCP--------------SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLA----------LFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIW-------------MAIGFLIYFSYGIRHSLEGH---------------------------------------------------------------------LRDENNEED-------AYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF SLC7A3 -----------------------------------------MPWQAF-RRFGQKLVRRRTLE-SGMA--------ETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDK---AGPSIVICFLVAALSSVLAGLCYAEFGARVPR-SGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSI-ALHVPHVLAE-YPD---------FFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISG---FVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFVPFGFEG--------ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ-PDQE---------------------------------------------------TKTGEEVEL--QEEAITT---------------------------ESEKLTLWGLFFP-------------LNSIPTPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVW-------------MLIGFAIYFGYGIQHSLEEI---------------------------------------------------------------------KSNQPSRKS-------RAKTV-------------------DLDPGTLYVHSV--- SLC7A4 -------------------------------------MARGLPTIASLARLCQKLNRLKPLEDSTME---------TSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEV---AGPAVLLSFGVAAVASLLAALCYAEFGARVPR-TGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPL-LGH-YPD---------FLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILG---FILAQPHNWSA------------------------DEGGFAPFGFSG--------VMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQ-KSSP------------------------------PSSPGPASPGPLT-----KQQSSFSDHLQLVGTVHASVPE---PG--------------------------ELKPALRPY------------LGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTL-HLPHWGYILLL---LLTSVMFLLSLLVLGA-----HQQQYREDL-FQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIW-------------LLMGLAVYFGYGIRHSKENQ--RELPGLNSTH------YVVFPRGSL----EETV----------------------------------QAMQPPSQA-------PAQDP------------------GHME------------ SLC7A5 MA--GAGPKRRAL--------AAPAAEEKE------------------EAREKMLAA-KSADGSAPAGEGEG----VTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEA-GSPGLALVV-WAACGVFSIVGALCYAELGTTISK-SGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIV---ALVFATYLLKPL--------------------FPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDP------------------------------NFSFEG-TKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELE-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVNL--ALPVFFILACLFLIA---------VSFWKTPV-ECGIGFTIILSGLPVYFFGVWW--KNKPKWLLQGIFSTTVLCQKLMQVV-P--------QET------------------------------------------------------------------------------------------ SLC7A6 ME--AREPGRPTPTY-----HLVPNT-----------------------SQSQVEE-----DVSSPPQRSSET---MQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHT-ASYGMSLIV-WAIGGLFSVVGALCYAELGTTITK-SGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAII---AITFANYIIQPS--------------------FPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQ--------------------------------DAFEG-SSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------LKLSV--FFPIVFCICSVFLVI---------VPLFTDTI-NSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDV----AEEK----------------------------------KDERKTD------------------------------------------------ SLC7A7 ---------------------MVDSTEYEV------------------ASQPEVETS-PLGDGASP---GPEQ---VKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYS-ASFGLSLVI-WAVGGLFSVFGALCYAELGTTIKK-SGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAII---AITFANYMVQPL--------------------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFE--------------------------------NSFEG-SSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------LKLSV--FFPIVFCLCTIFLVA---------VPLYSDTI-NSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDL----EDGG----------------------------------EMPKQRD---------PKSN----------------------------------- SLC7A8 ME-EGARHRNNT---------------EKK------------------HPGG------GESDASPEAGSGGGG---VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENA-GSVGLALIV-WIVTGFITVVGALCYAELGVTIPK-SGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVI---ALTFSNYVLQPL--------------------FPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEP------------------------------KNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKINL--LFPIIYLLFWAFLLV---------FSLWSEPV-VCGIGLAIMLTGVPVYFLGVYW--QHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEAN----------------------------------EDMEEQQQPMYQPT--PTKDKDV---------------AGQPQP----------- SLC7A9 --------------------------------------------------MGDTGLRKRREDEKSIQSQEPKT---TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNT-EAVGPCLII-WAACGVLATLGALCFAELGTMITK-SGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAII---CLSFSEYVCAPF--------------------YVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFD--------------------------------NSFEG-AQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELE-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVPV--VIPVLMTLISVFLVL---------APIISKPTWEYLYCVLFILSGLLFYFLFVHY----KFGWAQKISKPITMHLQMLMEVVPPE-------ED----------------------------------------------------PE-------------------------------------
Variant
check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
---|---|---|---|---|---|
-- | SLC7A6 | 7 | G/R | 0.000246786 | rs541318131 |
-- | SLC7A6 | 26 | E/D | 0.0103671 | rs62636644 |
-- | SLC7A6 | 60 | S/L | 0.000210759 | rs140250756 |
-- | SLC7A6 | 82 | I/M | 0.000151109 | rs199740573 |
-- | SLC7A6 | 84 | V/I | 0.000135709 | rs143818486 |
-- | SLC7A6 | 89 | L/F | 0.000232204 | rs201303478 |
-- | SLC7A6 | 167 | R/H | 0.000135709 | rs143818486 |
-- | SLC7A6 | 172 | A/V | 0.000232204 | rs201303478 |
-- | SLC7A6 | 190 | R/H | 0.000210767 | rs574384727 |
-- | SLC7A6 | 236 | L/F | 0.000135194 | rs150246220 |
-- | SLC7A6 | 296 | S/T | 0.00577927 | rs62636648 |
-- | SLC7A6 | 417 | K/R | 0.00163861 | rs79087422 |
-- | SLC7A6 | 426 | V/M | 0.000234708 | rs576161347 |
-- | SLC7A6 | 456 | G/E | 0.000151107 | rs759798067 |
-- | SLC7A6 | 457 | I/T | 0.00114527 | rs116107120 |
-- | SLC7A6 | 475 | R/Q | 0.000107482 | rs181995623 |
-- | SLC7A6 | 504 | V/A | 0.00275412 | rs62636646 |
Phylogenetic tree
Pathway
Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
---|---|---|---|
main | SLC7A6 | SLC7A6 [plasma membrane] | Amino acid transport across the plasma membrane |
SLC7A6 | SLC7A6 [plasma membrane] | Basigin interactions |
Disease
Gene Name | Reactome (Gene) | Reactome (Pathway) |
---|---|---|
No data |