Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC7A11


Basic description
Gene Name SLC7A11
Protein Name Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Family SLC7
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500 
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK L 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHCC CCHHCHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCH HHHHHHHHCC HHHHHHHHHH HHCHHHHHHH HHHHHHHHHH HHHHHCCCCC HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHCCCH HHHHCCCCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHE ECCHHHHHCC HHHHHHHHHH HCCCCHHHHH HHHHHHHHCC CCCCHHHCHH HHHHHHCCCC CCHHHHHCCC CCCCCHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHCCCCCC C
[Overview] SLC7A1 SLC7A10 SLC7A11 SLC7A13 SLC7A14 SLC7A2 SLC7A3 SLC7A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 
SLC7A1    -----------------------------------------MGCKVL-LNIGQQMLRRKVVD-CSRE--------ETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAREN---AGPAIVISFLIAALASVLAGLCYGEFGARVPK-TGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHM-TLNAPGVLAE-NPD---------IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSG---FVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKP-GVGGFMPFGFSG--------VLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQ-PEQPNL---------------------------------------------VYQMASTSDELDPADQNELASTN------------------DSQLGFLPEAEMFSLKTILSP-------------KNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----------GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVW-------------MLIGFIIYFGYGLWHSEE------------------------------------------------------------------------ASLDADQA-------RTPDG-------------------NLDQCK---------
SLC7A10   ----MAGH--------------------TQ------------------QPSGRGNPR-PAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHS-GSVGLALFV-WVLGGGVTALGSLCYAELGVAIPK-SGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVI---SMTFSNYVLQPV--------------------FPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRP------------------------------SNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALH-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVNL--LIPVAYLVFWAFLLV---------FSFISEPM-VCGVGVIIILTGVPIFFLGVFW--RSKPKCVHRLTESMTHWGQELCFVVYP--------QDAP----------------------------------EEEENGPCP---PSLLPATDK-----------------PSKPQ------------
SLC7A11   M---VRKP-------------VVSTISKGG------------------YLQGNVNGRLPSLGNKEPPGQ-----EKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNT-GSVGMSLTI-WTVCGVLSLFGALSYAELGTTIKK-SGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVI---SLAFGRYILEPF--------------------FIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFK--------------------------------DAFSG-RDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMH-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------FKVPL--FIPALFSFTCLFMVA---------LSLYSDPF-STGIGFVITLTGVPAYYLFIIW--DKKPRWFRIMSEKITRTLQIILEVV----------------------------------------------------------------PEEDKL---------------------------------
SLC7A13   MD------------------------------------------------RG----------------------EKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCV-WAGCAILAMTSTLCSAEISISFPC-SGAQYYFLKRYFGSTVAFLNLWTSLFL----GSGVVAGQALLLAEYSIQPF--------------------FPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVER-----------------------------FQNAFDA-ELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLN-SHSSPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLS-----------------------------------------------------------------------------------------------------------IP-------------------------------------------------------------------------------------------------YKVFL--SFPLATIVIDVGLVV---------IPLVKSPNVHYVYVLLLVLSGLLFYIPLIHF--KIRLAWF----EKMTCYLQLLFNICLPDVS-----EE-------------------------------------------------------------------------------------------
SLC7A14   ----MSGFFT-------------------------SLDPRRVQWGAAWYAMHSRILRTKPVE-SMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEM---AGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPD---------LLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGL-FFING--KYW--------------------------AEGQFLPHGWSG--------VLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQ-PESD-IDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYL-----IKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVV----------LMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVW-------------CFVGLLIYFGYGIWNSTLEISAREEALHQSTYQ----RYDVDDPFSV----EEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKS-------KHKQN-------SEALIAND----ELDYSPE--------
SLC7A2    MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAA-LTFARCLIRRKIVTLDSLE--------DTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKAD---SGPSIVVSFLIAALASVMAGLCYAEFGARVPK-TGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYF-RMNYTG-LAE-YPD---------FFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAG---FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTG--------TLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ-PGLS------------------------------------------------YDQPKCSPEKDGLGSSPRVTSK-----------------SESQVTML-QRQGFSMRTLFCP--------------SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLA----------LFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIW-------------MAIGFLIYFSYGIRHSLEGH---------------------------------------------------------------------LRDENNEED-------AYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
SLC7A3    -----------------------------------------MPWQAF-RRFGQKLVRRRTLE-SGMA--------ETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDK---AGPSIVICFLVAALSSVLAGLCYAEFGARVPR-SGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSI-ALHVPHVLAE-YPD---------FFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISG---FVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFVPFGFEG--------ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ-PDQE---------------------------------------------------TKTGEEVEL--QEEAITT---------------------------ESEKLTLWGLFFP-------------LNSIPTPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVW-------------MLIGFAIYFGYGIQHSLEEI---------------------------------------------------------------------KSNQPSRKS-------RAKTV-------------------DLDPGTLYVHSV---
SLC7A4    -------------------------------------MARGLPTIASLARLCQKLNRLKPLEDSTME---------TSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEV---AGPAVLLSFGVAAVASLLAALCYAEFGARVPR-TGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPL-LGH-YPD---------FLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILG---FILAQPHNWSA------------------------DEGGFAPFGFSG--------VMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQ-KSSP------------------------------PSSPGPASPGPLT-----KQQSSFSDHLQLVGTVHASVPE---PG--------------------------ELKPALRPY------------LGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTL-HLPHWGYILLL---LLTSVMFLLSLLVLGA-----HQQQYREDL-FQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIW-------------LLMGLAVYFGYGIRHSKENQ--RELPGLNSTH------YVVFPRGSL----EETV----------------------------------QAMQPPSQA-------PAQDP------------------GHME------------
SLC7A5    MA--GAGPKRRAL--------AAPAAEEKE------------------EAREKMLAA-KSADGSAPAGEGEG----VTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEA-GSPGLALVV-WAACGVFSIVGALCYAELGTTISK-SGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIV---ALVFATYLLKPL--------------------FPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDP------------------------------NFSFEG-TKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELE-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVNL--ALPVFFILACLFLIA---------VSFWKTPV-ECGIGFTIILSGLPVYFFGVWW--KNKPKWLLQGIFSTTVLCQKLMQVV-P--------QET------------------------------------------------------------------------------------------
SLC7A6    ME--AREPGRPTPTY-----HLVPNT-----------------------SQSQVEE-----DVSSPPQRSSET---MQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHT-ASYGMSLIV-WAIGGLFSVVGALCYAELGTTITK-SGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAII---AITFANYIIQPS--------------------FPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQ--------------------------------DAFEG-SSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------LKLSV--FFPIVFCICSVFLVI---------VPLFTDTI-NSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDV----AEEK----------------------------------KDERKTD------------------------------------------------
SLC7A7    ---------------------MVDSTEYEV------------------ASQPEVETS-PLGDGASP---GPEQ---VKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYS-ASFGLSLVI-WAVGGLFSVFGALCYAELGTTIKK-SGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAII---AITFANYMVQPL--------------------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFE--------------------------------NSFEG-SSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------LKLSV--FFPIVFCLCTIFLVA---------VPLYSDTI-NSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDL----EDGG----------------------------------EMPKQRD---------PKSN-----------------------------------
SLC7A8    ME-EGARHRNNT---------------EKK------------------HPGG------GESDASPEAGSGGGG---VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENA-GSVGLALIV-WIVTGFITVVGALCYAELGVTIPK-SGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVI---ALTFSNYVLQPL--------------------FPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEP------------------------------KNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIP-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKINL--LFPIIYLLFWAFLLV---------FSLWSEPV-VCGIGLAIMLTGVPVYFLGVYW--QHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEAN----------------------------------EDMEEQQQPMYQPT--PTKDKDV---------------AGQPQP-----------
SLC7A9    --------------------------------------------------MGDTGLRKRREDEKSIQSQEPKT---TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNT-EAVGPCLII-WAACGVLATLGALCFAELGTMITK-SGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAII---CLSFSEYVCAPF--------------------YVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFD--------------------------------NSFEG-AQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELE-----------------------------------------------------------------------------------------------------------RP-------------------------------------------------------------------------------------------------IKVPV--VIPVLMTLISVFLVL---------APIISKPTWEYLYCVLFILSGLLFYFLFVHY----KFGWAQKISKPITMHLQMLMEVVPPE-------ED----------------------------------------------------PE-------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC7A11 84 T/M 0.000155221 rs199779027
SLC7A11 148 R/C 0.000111474 rs145016189
SLC7A11 163 L/F 0.000151208 rs768658328
SLC7A11 202 I/V 0.00872063 rs111500641
SLC7A11 228 R/K 0.000131724 rs372955852
SLC7A11 284 T/A 0.00178322 rs546073661
SLC7A11 292 I/T 0.00147971 rs144628608
SLC7A11 321 I/V 0.00533233 rs76702927
SLC7A11 378 I/T 0.000497548 rs146944326
SLC7A11 411 R/Q 0.000263652 rs140100905
SLC7A11 470 W/R 0.000128033 rs748428954
SLC7A11 493 E/K 0.000128575 rs146095038
SLC7A11 499 D/E 0.00133876 rs141122045

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC7A11 SLC7A11 [plasma membrane] Amino acid transport across the plasma membrane
SLC7A11 SLC7A11 [plasma membrane] Basigin interactions

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data