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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC5A8


Basic description
Gene Name SLC5A8
Protein Name Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
Family SLC5
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC5A8 transports monocarboxylates from extracellular region to cytosol
Passive I- efflux mediated by SMCT1
Reaction 1 monocarboxylates transported by SLC5A8 [extracellular region] + 3 Na+ [extracellular region] --> 3 Na+ [cytosol] + 1 monocarboxylates transported by SLC5A8 [cytosol]
1 I- [cytosol] --> 1 I- [extracellular region]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610 
MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR RMTAVPVALS LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA EVFLPVFYKL GITSTYEYLE LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP ALALNQVTGF DLWGAVVATG VVCTFYCTLG GLKAVIWTDV FQVGIMVAGF ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH TFWTIIIGGT FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL STVSSSINAL AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA ALASLMGALL QAALSVFGMV GGPLMGLFAL GILVPFANSI GALVGLMAGF AISLWVGIGA QIYPPLPERT LPLHLDIQGC NSTYNETNLM TTTEMPFTTS VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS LSTGGRKQNL DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD QSGKSNGTRL  
CCCCCHHHCH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHCCCCCC CCCHHHHHHH HHHHHHCHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHC CCCCHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHCCC HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCHHHHHHHH HCCCCCHHHH HHHHHHHCHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHC CCCCEECCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CHHHCCCHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC
[Overview] SLC5A1 SLC5A10 SLC5A11 SLC5A12 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 
SLC5A1    -----------MDSSTWSPKTTAVT---RPVETHELIRNAADISIIVIYFVVVMAVGLWAMFST-NRGTVGG----FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN-------------------------ALVLVVVLGWLFVPIYIKAGVVTMPEYLR----KRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIF------INLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVG----GYDAFMEKYMKAIPTIVS-------DGNT---TFQEKCYT-PRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIM----VMPGMISRILYT----------------EKIACVVPSECEKYCGTKVGCTNIAYPTLVVEL---MPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYA-KVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGI-----SRMITEFA------YGTGS------------CME----------------------PS-------NCPTIIC---GVHYLYFAIILFAISFITIVVISLL--------TKPIPDVH-------------------------------------------------------LYRLCWSLRNSKEERIDLDAEEEN---------------------IQEGPKETIEIETQVPEK-----------------------------------------------KKGIFRRAYDLFCGLEQHG---APKM-----TEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA-
SLC5A10   -------MAANSTSDLHTPGTQLSVA---------------DIIVITVYFALNVAVGIWSSCRA-SRNTVNG----YFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN-------------------------ATYVLLALAWVFVPIYISSEIVTLPEYIQ----KRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALF------VHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIG----GYGQLEAAYAQAIPSRTI-------ANTT--------CHL-PRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLI----IMPGMISRALFPGAHVYEERHQVSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMEL---MPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWR-RLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGA-----TRLVLEFL------NPAPP------------CGE----------------------PD-------TRPAVLG---SIHYLHFAVALFALSGAVVVAGSLL--------TPPPQSVQ-------------------------------------------------------IENLTWWTL-------------------------------AQDVPLGTKAGD----GQ--------------------------------------------------------------------------TPQK----------------------HAFWARVCGFNAILLMCVNIFFYAYFA-
SLC5A11   --------MESGTSSPQPPQLDPLDAF-PQKGLE-----PGDIAVLVLYFLFVLAVGLWSTVKT-KRDTVKG----YFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELN-------------------------GLFSVLMLAWIFLPIYIAGQVTTMPEYLR----KRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIF------IQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVG----GMEGLKEKYFLALASNRS-------ENSS--------CGL-PREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIM----VFPGMVSRILFP----------------DQVACADPEICQKICSNPSGCSDIAYPKLVLEL---LPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWN-HLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGL-----VRLVLDFI------YVQPR------------CDQ----------------------PD-------ERPVLVK---SIHYLYFSMILSTVTLITVSTVSWF--------TEPPSKEM-------------------------------------------------------VSHLTWFTRHDPVVQ-----KEQAPPAA-----------PLSLTLSQNGMPEASSSSSVQFEMVQ------------------------ENTSKTHSCDM--------TPKQSKVVKAILWLCGIQEKG------------KEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA-
SLC5A12   ---------ME---------------------VK--NFAVWDYVVFAALFFISSGIGVFFAIKERKKATSRE----FLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIA-------------------------YLFVILLTSELFLPVFYRSGITSTYEYLQ----LRFN--KPVRYAATVIYIVQTILYTGVVVYAPALA------LNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAG----GFHNVLEQ-----------------STNG------------SRLHIFDFDVDPLRRHTFWT-ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALY----FNLLGLWIILVCAVFSGLIMYSHFK----------------D---------CDPWTSGIISAPDQLMPYFVMEIFATMP-GLPGLFVACAFSGTLSTVASSINALATVTFEDFVK-SCFPHLSDKLSTWISKGLCLLFGVMCTS-MAVAASVM-GGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSF-----WVAIGAFI------YPAPASKTWPLPLSTDQCIK-SN-----VTATGPPVLSS-------------RPGIADTWYSISYLYYSAVGCLGCIVAGVIISLI--------T-GRQRGE-------------------------------------------DIQPLLIRP---VCNLFCFWSKK--------------------------YKTLCWCGVQH---DS-GTEQ---ENLEN------------------------------------------GSARKQGAESVL-QNGLRRESLVHVPGY--------DPKDKSYNNMAFETTHF-------------------------
SLC5A2    --------MEEHTEAGSAPEMGAQKA---------LIDNPADILVIAAYFLLVIGVGLWSMCRT-NRGTVGG----YFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN-------------------------ALFVVLLLGWLFAPVYLTAGVITMPQYLR----KRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVF------IQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVG----GYSGLFDKYLGAATSLTV-------SEDPAVGNISSFCYR-PRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLM----VMPGMISRILYP----------------DEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKL---MPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYT-RLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGL-----ARLIPEFS------FGSGS------------CVQ----------------------PS-------ACPAFLC---GVHYLYFAIVLFFCSGLLTLTVSLC--------TAPIPRKH-------------------------------------------------------LHRLVFSLRHSKEEREDLDADEQQ----------------GSSLPVQNGCPES-AMEMNEPQA----------------------------------------------PAPSLFRQCLLWFCGMSRGGVGSPPPL-----TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA-
SLC5A3    -----------------------MRA----------VLDTADIAIVALYFILVMCIGFFAMWKS-NRSTVSG----YFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN-------------------------ALLLLQLLGWVFIPIYIRSGVYTMPEYLS----KRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALF------IQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIG----GFEEVKRRYMLASPDVTSILLTYNLSNTNS-------CNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFII----VVPGMISRILFT----------------DDIACINPEHCMLVCGSRAGCSNIAYPRLVMKL---VPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYK-LIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGA-----VRLILAFA------YRAPE------------CDQ----------------------PD-------NRPGFIK---DIHYMYVATGLFWVTGLITVIVSLL--------TPPPTKEQ-------------------------------------------------------IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSED-SIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKS---LSKRSLRDLMEEEAVCLQM----LEETRQVKVILNIGLFAVCSLGIFMFVYFSL
SLC5A4    ------------MASTVSPSTIAETPEPPPLSDH--IRNAADISVIVIYFLVVMAVGLWAMLKT-NRGTIGG----FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT-------------------------SSVMLLILGWIFVPIYIKSGVMTMPEYLK----KRFGGERLQVYLSILSLFICVVLLISADIFAGAIF------IKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVG----GYESFTEKYVNATPSVVE-------GDNL---TISASCYT-PRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLM----VMPGMISRILYT----------------DMVACVVPSECVKHCGVDVGCTNYAYPTMVLEL---MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT-KMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL-----IRMITEFA------YGTGS------------CLA----------------------PS-------NCPKIIC---GVHYLYFSIVLFFGSMLVTLGISLL--------TKPIPDVH-------------------------------------------------------LYRLCWVLRNSTEERIDIDAEEKS---------------------QEETDD---GVEEDYPEK-----------------------------------------------SRGCLKKAYDLFCGLQK-----GPKL-----TKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA-
SLC5A5    ---------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAED----FFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLG-------------------------QLLNSVLTALLFMPVFYRLGLTSTYEYLE----MRFS--RAVRLCGTLQYIVATMLYTGIVIYAPALI------LNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVG----GPRQVLTL-----------------AQNH------------SRINLMDFNPDPRSRYTFWT-FVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALL----INQVGLFLIVSSAACCGIVMFVFYT----------------D---------CDPLLLGRISAPDQYMPLLVLDIFEDLP-GVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK-PRLRSLAPRKLVIISKGLSLIYGSACLT-VAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSL-----WVALGATL------YPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSS--GMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCL--------TGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNED-RL----FFLGQKEL----------------------EGAGSWTPC-VGH---DG-GRDQQE-TNL--------------------------------------------------------------------------------------------------------------------------
SLC5A6    ---------MSVGVSTSAPLSPTSGT---SVGMS--TFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGE----LLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCC-------------------------YFLGLLIPAHIFIPVFYRLHLTSAYEYLE----LRFN--KTVRVCGTVTFIFQMVIYMGVVLYAPSLA------LNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVG----GLGRVWAV-----------------ASQH------------GRISGFELDPDPFVRHTFWT-LAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCV----GCLIGLVMFAYYQ----------------E---------YPMSIQQAQAAPDQFVLYFVMDLLKGLP-GLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIR-PWFPEFSEARAIMLSRGLAFGYGLLCLG-MAYISSQM-GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAF-----WIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVA--------TVTTLMPLTTF------------SKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLL--------T-GRMRGR----------SLNPATIYPV----------------LPK----------------LLSLLPLSCQKRLH--------------------CRSYGQ------DH--LDT-GLFPEKPRNGVL------------------------------------------GDSRDKEAMAL---DGTAYQG--------------------SSSTCILQETSL-------------------------
SLC5A7    -----------------------------------MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAP-------------------IG----YSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGG------------LLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVD-------SSEVY-----------SWLDSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSF----LAAFGCLVMAIPAILIGAIGASTDW----------------NQTAYGLPD------PKTTEEADMILPIVLQYL---CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATA-MALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIF-----YPGYY-------------------------------------PDDNGIYNQKFP-------------FKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDV-------FD-----AVVARHSE-----ENM-------------DKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEA-------------FLDVDSSPEGSGTEDN------------------------------------------------------------------------------------------------------LQ-----------------------------
SLC5A8    ---------MDT------PR-----------GIG--TFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKD----FLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFT-------------------------YFFVVVISAEVFLPVFYKLGITSTYEYLE----LRFN--KCVRLCGTVLFIVQTILYTGIVIYAPALA------LNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQG----GISTILND-----------------AYDG------------GRLNFWNFNPNPLQRHTFWT-IIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLY----INLVGLWAILTCSVFCGLALYSRYH----------------D---------CDPWTAKKVSAPDQLMPYLVLDILQDYP-GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK-PYFRSLSERSLSWISQGMSVVYGALCIG-MAALASLM-GALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISL-----WVGIGAQI------YPPLPERTLPLHLDIQGCNS-TYNETNLMTTTEMPFTTSVFQI-----YNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLS--------TGGRKQNL-------------------------------------------DPRYILTKED-FLSNFDIFKKKKHV----------------------LSYKS-------HPVEDG-GTDNPAFNHIEL------------------------------------------NS--DQSGKS----NGTRL-----------------------------------------------------------
SLC5A9    MSKELAAMGPGASGDGVRTETAPHIALDSRVGLH-----AYDISVVVIYFVFVIAVGIWSSIRA-SRGTIGG----YFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLK----KRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALF------IQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG----WYPGLEQRYRQAIPNVTV-------PNTT--------CHL-PRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFI----VMPGMISRALFP----------------DEVGCVDPDVCQRICGARVGCSNIAYPKLVMAL---MPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQ-RFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGL-----LRMILEFS------YPAPA------------CGE----------------------VD-------RRPAVLK---DFHYLYFAILLCGLTAIVIVIVSLC--------TTPIPEEQ-------------------------------------------------------LTRLTWWTRNCPLSELEKEAHESTPEISE---------RPAGECPAGGGAAENSSLGQEQPEA----------------------------------------------PSRSWGKLLWSWFCGLSG-----TPEQA---LSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC5A8 10 F/L 0.00185296 rs148314248
SLC5A8 35 A/S 0.0112018 rs117927891
SLC5A8 54 A/T 0.000528821 rs149707334
SLC5A8 78 V/A 0.000613209 rs545922954
SLC5A8 91 T/I 0.000127387 rs755904407
SLC5A8 111 G/R 0.000394043 rs142523691
SLC5A8 165 A/T 0.000127347 rs199610556
SLC5A8 175 F/C 0.000342207 rs547725023
SLC5A8 193 V/I 0.237935 rs1709189
SLC5A8 223 D/N 0.000115483 rs199742636
SLC5A8 251 F/V 0.00175092 rs11834933
SLC5A8 285 V/L 0.000163592 rs199644337
SLC5A8 314 K/N 0.000215203 rs116304556
SLC5A8 337 L/F 0.00427769 rs142175729
SLC5A8 416 V/I 0.000117468 rs369064667
-- SLC5A8 490 M/I 0.2335 rs164365
-- SLC5A8 557 T/N 0.00022581 rs138570903
-- SLC5A8 573 H/N 0.000109598 rs202098151
-- SLC5A8 609 R/C 0.00257317 rs113062899

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC5A8 SLC5A8 [plasma membrane] Organic anion transporters
SLC5A8 SLC5A8 [plasma membrane] Nicotinamide salvaging

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data