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Basic
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Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC5A5


Basic description
Gene Name SLC5A5
Protein Name Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5)
Family SLC5
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name Iodide is taken up by thyroid epithelial cells
SLC5A5 cotransports Na+ with I- from extracellular region to cytosol
Reaction 1 I- [extracellular region] + 2 Na+ [extracellular region] --> 1 I- [cytosol] + 2 Na+ [cytosol]
1 I- [extracellular region] + 1 Na+ [extracellular region] --> 1 I- [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG GRRLAALPVG LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL TALLFMPVFY RLGLTSTYEY LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTFYTA VGGMKAVVWT DVFQVVVMLS GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS RYTFWTFVVG GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT VAALSSLLGG GVLQGSFTVM GVISGPLLGA FILGMFLPAC NTPGVLAGLG AGLALSLWVA LGATLYPPSE QTMRVLPSSA ARCVALSVNA SGLLDPALLP ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV LCGALISCLT GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL 
CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCHHHHHCC CCCCCHHHHH HHHHHHHCCH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHCCCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHC CCHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHCCCCCC CCCCCCHHHH HHHCCCCCHH HHHHHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHCCCCCH HHCCCCCCCC CHHCHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHCCC CCCHHHHHHH CCCCCCHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCC
[Overview] SLC5A1 SLC5A10 SLC5A11 SLC5A12 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 
SLC5A1    -----------MDSSTWSPKTTAVT---RPVETHELIRNAADISIIVIYFVVVMAVGLWAMFST-NRGTVGG----FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN-------------------------ALVLVVVLGWLFVPIYIKAGVVTMPEYLR----KRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIF------INLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVG----GYDAFMEKYMKAIPTIVS-------DGNT---TFQEKCYT-PRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIM----VMPGMISRILYT----------------EKIACVVPSECEKYCGTKVGCTNIAYPTLVVEL---MPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYA-KVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGI-----SRMITEFA------YGTGS------------CME----------------------PS-------NCPTIIC---GVHYLYFAIILFAISFITIVVISLL--------TKPIPDVH-------------------------------------------------------LYRLCWSLRNSKEERIDLDAEEEN---------------------IQEGPKETIEIETQVPEK-----------------------------------------------KKGIFRRAYDLFCGLEQHG---APKM-----TEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA-
SLC5A10   -------MAANSTSDLHTPGTQLSVA---------------DIIVITVYFALNVAVGIWSSCRA-SRNTVNG----YFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN-------------------------ATYVLLALAWVFVPIYISSEIVTLPEYIQ----KRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALF------VHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIG----GYGQLEAAYAQAIPSRTI-------ANTT--------CHL-PRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLI----IMPGMISRALFPGAHVYEERHQVSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMEL---MPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWR-RLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGA-----TRLVLEFL------NPAPP------------CGE----------------------PD-------TRPAVLG---SIHYLHFAVALFALSGAVVVAGSLL--------TPPPQSVQ-------------------------------------------------------IENLTWWTL-------------------------------AQDVPLGTKAGD----GQ--------------------------------------------------------------------------TPQK----------------------HAFWARVCGFNAILLMCVNIFFYAYFA-
SLC5A11   --------MESGTSSPQPPQLDPLDAF-PQKGLE-----PGDIAVLVLYFLFVLAVGLWSTVKT-KRDTVKG----YFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELN-------------------------GLFSVLMLAWIFLPIYIAGQVTTMPEYLR----KRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIF------IQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVG----GMEGLKEKYFLALASNRS-------ENSS--------CGL-PREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIM----VFPGMVSRILFP----------------DQVACADPEICQKICSNPSGCSDIAYPKLVLEL---LPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWN-HLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGL-----VRLVLDFI------YVQPR------------CDQ----------------------PD-------ERPVLVK---SIHYLYFSMILSTVTLITVSTVSWF--------TEPPSKEM-------------------------------------------------------VSHLTWFTRHDPVVQ-----KEQAPPAA-----------PLSLTLSQNGMPEASSSSSVQFEMVQ------------------------ENTSKTHSCDM--------TPKQSKVVKAILWLCGIQEKG------------KEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA-
SLC5A12   ---------ME---------------------VK--NFAVWDYVVFAALFFISSGIGVFFAIKERKKATSRE----FLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIA-------------------------YLFVILLTSELFLPVFYRSGITSTYEYLQ----LRFN--KPVRYAATVIYIVQTILYTGVVVYAPALA------LNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAG----GFHNVLEQ-----------------STNG------------SRLHIFDFDVDPLRRHTFWT-ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALY----FNLLGLWIILVCAVFSGLIMYSHFK----------------D---------CDPWTSGIISAPDQLMPYFVMEIFATMP-GLPGLFVACAFSGTLSTVASSINALATVTFEDFVK-SCFPHLSDKLSTWISKGLCLLFGVMCTS-MAVAASVM-GGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSF-----WVAIGAFI------YPAPASKTWPLPLSTDQCIK-SN-----VTATGPPVLSS-------------RPGIADTWYSISYLYYSAVGCLGCIVAGVIISLI--------T-GRQRGE-------------------------------------------DIQPLLIRP---VCNLFCFWSKK--------------------------YKTLCWCGVQH---DS-GTEQ---ENLEN------------------------------------------GSARKQGAESVL-QNGLRRESLVHVPGY--------DPKDKSYNNMAFETTHF-------------------------
SLC5A2    --------MEEHTEAGSAPEMGAQKA---------LIDNPADILVIAAYFLLVIGVGLWSMCRT-NRGTVGG----YFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN-------------------------ALFVVLLLGWLFAPVYLTAGVITMPQYLR----KRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVF------IQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVG----GYSGLFDKYLGAATSLTV-------SEDPAVGNISSFCYR-PRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLM----VMPGMISRILYP----------------DEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKL---MPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYT-RLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGL-----ARLIPEFS------FGSGS------------CVQ----------------------PS-------ACPAFLC---GVHYLYFAIVLFFCSGLLTLTVSLC--------TAPIPRKH-------------------------------------------------------LHRLVFSLRHSKEEREDLDADEQQ----------------GSSLPVQNGCPES-AMEMNEPQA----------------------------------------------PAPSLFRQCLLWFCGMSRGGVGSPPPL-----TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA-
SLC5A3    -----------------------MRA----------VLDTADIAIVALYFILVMCIGFFAMWKS-NRSTVSG----YFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN-------------------------ALLLLQLLGWVFIPIYIRSGVYTMPEYLS----KRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALF------IQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIG----GFEEVKRRYMLASPDVTSILLTYNLSNTNS-------CNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFII----VVPGMISRILFT----------------DDIACINPEHCMLVCGSRAGCSNIAYPRLVMKL---VPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYK-LIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGA-----VRLILAFA------YRAPE------------CDQ----------------------PD-------NRPGFIK---DIHYMYVATGLFWVTGLITVIVSLL--------TPPPTKEQ-------------------------------------------------------IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSED-SIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKS---LSKRSLRDLMEEEAVCLQM----LEETRQVKVILNIGLFAVCSLGIFMFVYFSL
SLC5A4    ------------MASTVSPSTIAETPEPPPLSDH--IRNAADISVIVIYFLVVMAVGLWAMLKT-NRGTIGG----FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT-------------------------SSVMLLILGWIFVPIYIKSGVMTMPEYLK----KRFGGERLQVYLSILSLFICVVLLISADIFAGAIF------IKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVG----GYESFTEKYVNATPSVVE-------GDNL---TISASCYT-PRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLM----VMPGMISRILYT----------------DMVACVVPSECVKHCGVDVGCTNYAYPTMVLEL---MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT-KMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL-----IRMITEFA------YGTGS------------CLA----------------------PS-------NCPKIIC---GVHYLYFSIVLFFGSMLVTLGISLL--------TKPIPDVH-------------------------------------------------------LYRLCWVLRNSTEERIDIDAEEKS---------------------QEETDD---GVEEDYPEK-----------------------------------------------SRGCLKKAYDLFCGLQK-----GPKL-----TKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA-
SLC5A5    ---------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAED----FFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLG-------------------------QLLNSVLTALLFMPVFYRLGLTSTYEYLE----MRFS--RAVRLCGTLQYIVATMLYTGIVIYAPALI------LNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVG----GPRQVLTL-----------------AQNH------------SRINLMDFNPDPRSRYTFWT-FVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALL----INQVGLFLIVSSAACCGIVMFVFYT----------------D---------CDPLLLGRISAPDQYMPLLVLDIFEDLP-GVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK-PRLRSLAPRKLVIISKGLSLIYGSACLT-VAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSL-----WVALGATL------YPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSS--GMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCL--------TGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNED-RL----FFLGQKEL----------------------EGAGSWTPC-VGH---DG-GRDQQE-TNL--------------------------------------------------------------------------------------------------------------------------
SLC5A6    ---------MSVGVSTSAPLSPTSGT---SVGMS--TFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGE----LLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCC-------------------------YFLGLLIPAHIFIPVFYRLHLTSAYEYLE----LRFN--KTVRVCGTVTFIFQMVIYMGVVLYAPSLA------LNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVG----GLGRVWAV-----------------ASQH------------GRISGFELDPDPFVRHTFWT-LAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCV----GCLIGLVMFAYYQ----------------E---------YPMSIQQAQAAPDQFVLYFVMDLLKGLP-GLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIR-PWFPEFSEARAIMLSRGLAFGYGLLCLG-MAYISSQM-GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAF-----WIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVA--------TVTTLMPLTTF------------SKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLL--------T-GRMRGR----------SLNPATIYPV----------------LPK----------------LLSLLPLSCQKRLH--------------------CRSYGQ------DH--LDT-GLFPEKPRNGVL------------------------------------------GDSRDKEAMAL---DGTAYQG--------------------SSSTCILQETSL-------------------------
SLC5A7    -----------------------------------MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAP-------------------IG----YSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGG------------LLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVD-------SSEVY-----------SWLDSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSF----LAAFGCLVMAIPAILIGAIGASTDW----------------NQTAYGLPD------PKTTEEADMILPIVLQYL---CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATA-MALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIF-----YPGYY-------------------------------------PDDNGIYNQKFP-------------FKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDV-------FD-----AVVARHSE-----ENM-------------DKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEA-------------FLDVDSSPEGSGTEDN------------------------------------------------------------------------------------------------------LQ-----------------------------
SLC5A8    ---------MDT------PR-----------GIG--TFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKD----FLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFT-------------------------YFFVVVISAEVFLPVFYKLGITSTYEYLE----LRFN--KCVRLCGTVLFIVQTILYTGIVIYAPALA------LNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQG----GISTILND-----------------AYDG------------GRLNFWNFNPNPLQRHTFWT-IIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLY----INLVGLWAILTCSVFCGLALYSRYH----------------D---------CDPWTAKKVSAPDQLMPYLVLDILQDYP-GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK-PYFRSLSERSLSWISQGMSVVYGALCIG-MAALASLM-GALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISL-----WVGIGAQI------YPPLPERTLPLHLDIQGCNS-TYNETNLMTTTEMPFTTSVFQI-----YNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLS--------TGGRKQNL-------------------------------------------DPRYILTKED-FLSNFDIFKKKKHV----------------------LSYKS-------HPVEDG-GTDNPAFNHIEL------------------------------------------NS--DQSGKS----NGTRL-----------------------------------------------------------
SLC5A9    MSKELAAMGPGASGDGVRTETAPHIALDSRVGLH-----AYDISVVVIYFVFVIAVGIWSSIRA-SRGTIGG----YFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLK----KRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALF------IQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG----WYPGLEQRYRQAIPNVTV-------PNTT--------CHL-PRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFI----VMPGMISRALFP----------------DEVGCVDPDVCQRICGARVGCSNIAYPKLVMAL---MPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQ-RFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGL-----LRMILEFS------YPAPA------------CGE----------------------VD-------RRPAVLK---DFHYLYFAILLCGLTAIVIVIVSLC--------TTPIPEEQ-------------------------------------------------------LTRLTWWTRNCPLSELEKEAHESTPEISE---------RPAGECPAGGGAAENSSLGQEQPEA----------------------------------------------PSRSWGKLLWSWFCGLSG-----TPEQA---LSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC5A5 53 R/H 0.000401307 rs541775288
-- SLC5A5 248 V/A 0.000127276 rs545753923
-- SLC5A5 288 G/S 0.000510245 rs142014480
-- SLC5A5 298 C/G 0.000470419 rs8108188
-- SLC5A5 473 M/T 0.000121033 rs559355247
-- SLC5A5 503 D/N 0.00380797 rs73520745
-- SLC5A5 506 R/T 0.000132879 rs199838566
-- SLC5A5 536 T/M 0.000111388 rs368563694
-- SLC5A5 569 R/W 0.000244131 rs201835225
-- SLC5A5 594 L/F 0.000294696 rs140990171
-- SLC5A5 608 N/S 0.000191372 rs370808239

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC5A5 SLC5A5 [plasma membrane] Organic anion transporters
SLC5A5 SLC5A5 [plasma membrane] Thyroxine biosynthesis

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC5A5 SLC5A5 T354P [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SLC5A5 SLC5A5 V59E [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SLC5A5 SLC5A5 G395R [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SLC5A5 SLC5A5 C272* [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SLC5A5 SLC5A5 G93R [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
SLC5A5 SLC5A5 R124H [plasma membrane] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)