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Variant
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Pathway
Disease

Detail Data SLC5A12


Basic description
Gene Name SLC5A12
Protein Name Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)
Family SLC5
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
Reaction 1 LACT, PYR, NCA [extracellular region] + 1 Na+ [extracellular region] --> 1 Na+ [cytosol] + 1 LACT, PYR, NCA [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610 
MEVKNFAVWD YVVFAALFFI SSGIGVFFAI KERKKATSRE FLVGGRQMSF GPVGLSLTAS FMSAVTVLGT PSEVYRFGAS FLVFFIAYLF VILLTSELFL PVFYRSGITS TYEYLQLRFN KPVRYAATVI YIVQTILYTG VVVYAPALAL NQVTGFDLWG SVFATGIVCT FYCTLGGLKA VVWTDAFQMV VMIVGFLTVL IQGSTHAGGF HNVLEQSTNG SRLHIFDFDV DPLRRHTFWT ITVGGTFTWL GIYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIILVCA VFSGLIMYSH FKDCDPWTSG IISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA SSINALATVT FEDFVKSCFP HLSDKLSTWI SKGLCLLFGV MCTSMAVAAS VMGGVVQASL SIHGMCGGPM LGLFSLGIVF PFVNWKGALG GLLTGITLSF WVAIGAFIYP APASKTWPLP LSTDQCIKSN VTATGPPVLS SRPGIADTWY SISYLYYSAV GCLGCIVAGV IISLITGRQR GEDIQPLLIR PVCNLFCFWS KKYKTLCWCG VQHDSGTEQE NLENGSARKQ GAESVLQNGL RRESLVHVPG YDPKDKSYNN MAFETTHF 
CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCE EEECCCCCCC HHHHHHHHHC CCCCHHHHCC CCHHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC HHHHHCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHCCCC CCCEECCCCC CCCCHHHHHH HHHHHHHHHH HHHCCCHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHCH HHHHHHHHCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHCCCCCCC HHHHHHCCCC HHHCCHHCCC CCCCCCCCHH HCCCCCCCCC CCCCHHCCCC CCCHHCCCCC CCCCCCCCCC CCCCCCCC
[Overview] SLC5A1 SLC5A10 SLC5A11 SLC5A12 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 
SLC5A1    -----------MDSSTWSPKTTAVT---RPVETHELIRNAADISIIVIYFVVVMAVGLWAMFST-NRGTVGG----FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN-------------------------ALVLVVVLGWLFVPIYIKAGVVTMPEYLR----KRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIF------INLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVG----GYDAFMEKYMKAIPTIVS-------DGNT---TFQEKCYT-PRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIM----VMPGMISRILYT----------------EKIACVVPSECEKYCGTKVGCTNIAYPTLVVEL---MPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYA-KVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGI-----SRMITEFA------YGTGS------------CME----------------------PS-------NCPTIIC---GVHYLYFAIILFAISFITIVVISLL--------TKPIPDVH-------------------------------------------------------LYRLCWSLRNSKEERIDLDAEEEN---------------------IQEGPKETIEIETQVPEK-----------------------------------------------KKGIFRRAYDLFCGLEQHG---APKM-----TEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA-
SLC5A10   -------MAANSTSDLHTPGTQLSVA---------------DIIVITVYFALNVAVGIWSSCRA-SRNTVNG----YFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN-------------------------ATYVLLALAWVFVPIYISSEIVTLPEYIQ----KRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALF------VHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIG----GYGQLEAAYAQAIPSRTI-------ANTT--------CHL-PRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLI----IMPGMISRALFPGAHVYEERHQVSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMEL---MPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWR-RLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGA-----TRLVLEFL------NPAPP------------CGE----------------------PD-------TRPAVLG---SIHYLHFAVALFALSGAVVVAGSLL--------TPPPQSVQ-------------------------------------------------------IENLTWWTL-------------------------------AQDVPLGTKAGD----GQ--------------------------------------------------------------------------TPQK----------------------HAFWARVCGFNAILLMCVNIFFYAYFA-
SLC5A11   --------MESGTSSPQPPQLDPLDAF-PQKGLE-----PGDIAVLVLYFLFVLAVGLWSTVKT-KRDTVKG----YFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELN-------------------------GLFSVLMLAWIFLPIYIAGQVTTMPEYLR----KRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIF------IQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVG----GMEGLKEKYFLALASNRS-------ENSS--------CGL-PREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIM----VFPGMVSRILFP----------------DQVACADPEICQKICSNPSGCSDIAYPKLVLEL---LPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWN-HLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGL-----VRLVLDFI------YVQPR------------CDQ----------------------PD-------ERPVLVK---SIHYLYFSMILSTVTLITVSTVSWF--------TEPPSKEM-------------------------------------------------------VSHLTWFTRHDPVVQ-----KEQAPPAA-----------PLSLTLSQNGMPEASSSSSVQFEMVQ------------------------ENTSKTHSCDM--------TPKQSKVVKAILWLCGIQEKG------------KEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA-
SLC5A12   ---------ME---------------------VK--NFAVWDYVVFAALFFISSGIGVFFAIKERKKATSRE----FLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIA-------------------------YLFVILLTSELFLPVFYRSGITSTYEYLQ----LRFN--KPVRYAATVIYIVQTILYTGVVVYAPALA------LNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAG----GFHNVLEQ-----------------STNG------------SRLHIFDFDVDPLRRHTFWT-ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALY----FNLLGLWIILVCAVFSGLIMYSHFK----------------D---------CDPWTSGIISAPDQLMPYFVMEIFATMP-GLPGLFVACAFSGTLSTVASSINALATVTFEDFVK-SCFPHLSDKLSTWISKGLCLLFGVMCTS-MAVAASVM-GGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSF-----WVAIGAFI------YPAPASKTWPLPLSTDQCIK-SN-----VTATGPPVLSS-------------RPGIADTWYSISYLYYSAVGCLGCIVAGVIISLI--------T-GRQRGE-------------------------------------------DIQPLLIRP---VCNLFCFWSKK--------------------------YKTLCWCGVQH---DS-GTEQ---ENLEN------------------------------------------GSARKQGAESVL-QNGLRRESLVHVPGY--------DPKDKSYNNMAFETTHF-------------------------
SLC5A2    --------MEEHTEAGSAPEMGAQKA---------LIDNPADILVIAAYFLLVIGVGLWSMCRT-NRGTVGG----YFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN-------------------------ALFVVLLLGWLFAPVYLTAGVITMPQYLR----KRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVF------IQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVG----GYSGLFDKYLGAATSLTV-------SEDPAVGNISSFCYR-PRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLM----VMPGMISRILYP----------------DEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKL---MPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYT-RLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGL-----ARLIPEFS------FGSGS------------CVQ----------------------PS-------ACPAFLC---GVHYLYFAIVLFFCSGLLTLTVSLC--------TAPIPRKH-------------------------------------------------------LHRLVFSLRHSKEEREDLDADEQQ----------------GSSLPVQNGCPES-AMEMNEPQA----------------------------------------------PAPSLFRQCLLWFCGMSRGGVGSPPPL-----TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA-
SLC5A3    -----------------------MRA----------VLDTADIAIVALYFILVMCIGFFAMWKS-NRSTVSG----YFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN-------------------------ALLLLQLLGWVFIPIYIRSGVYTMPEYLS----KRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALF------IQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIG----GFEEVKRRYMLASPDVTSILLTYNLSNTNS-------CNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFII----VVPGMISRILFT----------------DDIACINPEHCMLVCGSRAGCSNIAYPRLVMKL---VPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYK-LIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGA-----VRLILAFA------YRAPE------------CDQ----------------------PD-------NRPGFIK---DIHYMYVATGLFWVTGLITVIVSLL--------TPPPTKEQ-------------------------------------------------------IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSED-SIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKS---LSKRSLRDLMEEEAVCLQM----LEETRQVKVILNIGLFAVCSLGIFMFVYFSL
SLC5A4    ------------MASTVSPSTIAETPEPPPLSDH--IRNAADISVIVIYFLVVMAVGLWAMLKT-NRGTIGG----FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT-------------------------SSVMLLILGWIFVPIYIKSGVMTMPEYLK----KRFGGERLQVYLSILSLFICVVLLISADIFAGAIF------IKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVG----GYESFTEKYVNATPSVVE-------GDNL---TISASCYT-PRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLM----VMPGMISRILYT----------------DMVACVVPSECVKHCGVDVGCTNYAYPTMVLEL---MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT-KMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL-----IRMITEFA------YGTGS------------CLA----------------------PS-------NCPKIIC---GVHYLYFSIVLFFGSMLVTLGISLL--------TKPIPDVH-------------------------------------------------------LYRLCWVLRNSTEERIDIDAEEKS---------------------QEETDD---GVEEDYPEK-----------------------------------------------SRGCLKKAYDLFCGLQK-----GPKL-----TKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA-
SLC5A5    ---------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAED----FFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLG-------------------------QLLNSVLTALLFMPVFYRLGLTSTYEYLE----MRFS--RAVRLCGTLQYIVATMLYTGIVIYAPALI------LNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVG----GPRQVLTL-----------------AQNH------------SRINLMDFNPDPRSRYTFWT-FVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALL----INQVGLFLIVSSAACCGIVMFVFYT----------------D---------CDPLLLGRISAPDQYMPLLVLDIFEDLP-GVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK-PRLRSLAPRKLVIISKGLSLIYGSACLT-VAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSL-----WVALGATL------YPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSS--GMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCL--------TGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNED-RL----FFLGQKEL----------------------EGAGSWTPC-VGH---DG-GRDQQE-TNL--------------------------------------------------------------------------------------------------------------------------
SLC5A6    ---------MSVGVSTSAPLSPTSGT---SVGMS--TFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGE----LLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCC-------------------------YFLGLLIPAHIFIPVFYRLHLTSAYEYLE----LRFN--KTVRVCGTVTFIFQMVIYMGVVLYAPSLA------LNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVG----GLGRVWAV-----------------ASQH------------GRISGFELDPDPFVRHTFWT-LAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCV----GCLIGLVMFAYYQ----------------E---------YPMSIQQAQAAPDQFVLYFVMDLLKGLP-GLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIR-PWFPEFSEARAIMLSRGLAFGYGLLCLG-MAYISSQM-GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAF-----WIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVA--------TVTTLMPLTTF------------SKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLL--------T-GRMRGR----------SLNPATIYPV----------------LPK----------------LLSLLPLSCQKRLH--------------------CRSYGQ------DH--LDT-GLFPEKPRNGVL------------------------------------------GDSRDKEAMAL---DGTAYQG--------------------SSSTCILQETSL-------------------------
SLC5A7    -----------------------------------MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAP-------------------IG----YSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGG------------LLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVD-------SSEVY-----------SWLDSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSF----LAAFGCLVMAIPAILIGAIGASTDW----------------NQTAYGLPD------PKTTEEADMILPIVLQYL---CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATA-MALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIF-----YPGYY-------------------------------------PDDNGIYNQKFP-------------FKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDV-------FD-----AVVARHSE-----ENM-------------DKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEA-------------FLDVDSSPEGSGTEDN------------------------------------------------------------------------------------------------------LQ-----------------------------
SLC5A8    ---------MDT------PR-----------GIG--TFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKD----FLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFT-------------------------YFFVVVISAEVFLPVFYKLGITSTYEYLE----LRFN--KCVRLCGTVLFIVQTILYTGIVIYAPALA------LNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQG----GISTILND-----------------AYDG------------GRLNFWNFNPNPLQRHTFWT-IIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLY----INLVGLWAILTCSVFCGLALYSRYH----------------D---------CDPWTAKKVSAPDQLMPYLVLDILQDYP-GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK-PYFRSLSERSLSWISQGMSVVYGALCIG-MAALASLM-GALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISL-----WVGIGAQI------YPPLPERTLPLHLDIQGCNS-TYNETNLMTTTEMPFTTSVFQI-----YNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLS--------TGGRKQNL-------------------------------------------DPRYILTKED-FLSNFDIFKKKKHV----------------------LSYKS-------HPVEDG-GTDNPAFNHIEL------------------------------------------NS--DQSGKS----NGTRL-----------------------------------------------------------
SLC5A9    MSKELAAMGPGASGDGVRTETAPHIALDSRVGLH-----AYDISVVVIYFVFVIAVGIWSSIRA-SRGTIGG----YFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLK----KRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALF------IQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG----WYPGLEQRYRQAIPNVTV-------PNTT--------CHL-PRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFI----VMPGMISRALFP----------------DEVGCVDPDVCQRICGARVGCSNIAYPKLVMAL---MPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQ-RFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGL-----LRMILEFS------YPAPA------------CGE----------------------VD-------RRPAVLK---DFHYLYFAILLCGLTAIVIVIVSLC--------TTPIPEEQ-------------------------------------------------------LTRLTWWTRNCPLSELEKEAHESTPEISE---------RPAGECPAGGGAAENSSLGQEQPEA----------------------------------------------PSRSWGKLLWSWFCGLSG-----TPEQA---LSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC5A12 8 V/I 0.00866906 rs113908376
-- SLC5A12 143 V/L 0.00328034 rs115137776
-- SLC5A12 247 F/L 0.000183229 rs201306863
-- SLC5A12 303 D/E 0.00011945 rs138192976
-- SLC5A12 330 M/I 0.000115406 rs141239567
-- SLC5A12 349 V/M 0.000131513 rs147808899
-- SLC5A12 390 V/M 0.000184543 rs199962510
-- SLC5A12 429 V/M 0.000189789 rs199554975
-- SLC5A12 496 A/V 0.000221588 rs769429865
-- SLC5A12 510 V/L 0.0554343 rs12278761
-- SLC5A12 577 A/T 0.000220257 rs75473290
-- SLC5A12 578 R/Q 0.000308259 rs151303131
-- SLC5A12 603 P/L 0.000105051 rs771466834

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC5A12 SLC5A12 [plasma membrane] Multifunctional anion exchangers

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data