Detail Data SLC49A3

Basic description

Gene Name	SLC49A3
Protein Name	Solute carrier family 49 member A3 (Major facilitator superfamily domain-containing protein 7) (Myosin light polypeptide 5 regulatory protein) (MYL5)
Family	SLC49
Category	-
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MAGPTEAETG LAEPRALCAQ RGHRTYARRW VFLLAISLLN CSNATLWLSF APVADVIAED LVLSMEQINW LSLVYLVVST PFGVAAIWIL DSVGLRAATI LGAWLNFAGS VLRMVPCMVV GTQNPFAFLM GGQSLCALAQ SLVIFSPAKL AALWFPEHQR ATANMLATMS NPLGVLVANV LSPVLVKKGE DIPLMLGVYT IPAGVVCLLS TICLWESVPP TPPSAGAASS TSEKFLDGLK LLMWNKAYVI LAVCLGGMIG ISASFSALLE QILCASGHSS GFSGLCGALF ITFGILGALA LGPYVDRTKH FTEATKIGLC LFSLACVPFA LVSQLQGQTL ALAATCSLLG LFGFSVGPVA MELAVECSFP VGEGAATGMI FVLGQAEGIL IMLAMTALTV RRSEPSLSTC QQGEDPLDWT VSLLLMAGLC TFFSCILAVF FHTPYRRLQA ESGEPPSTRN AVGGADSGPG VDRGGAGRAG VLGPSTATPE CTARGASLED PRGPGSPHPA CHRATPRAQG PAATDAPSRP GRLAGRVQAS RFIDPAGSHS SFSSPWVIT 
CCCCCCCCCC CCCCCHHHCC CCCCCCHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHCCH HHHHCCHHCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHCC CCCCCCHHHH CHHHHHHCCC CCCCCCHHHH CCHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HCHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHCHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCC

Family alignment

[Overview]

SLC49A1   --MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKAGTFPVNGAPRDSLAAASGVLGGPQTPLAPEEETQARLLPAGAGAETPGAESSP--LPLTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGS--VQQHLFWVTML--GQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDTNLLACN---------ISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQA---ALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFT--------FTL----DLRYIIIVFVTGGV----LGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIF-GIL-------FTLAQGK---LTSDYGPKAGNIFLCVWMFIGII------LTALIKSDLRRHNINIGITNVDVKAI----------------------------------------------------------PADSPTDQEPKTVMLSKQSESAI----------------
SLC49A2   MVNEGPNQEESDDT-----------PVPESA--------LQADPSVSVHP-------SVSVHPSVSINPSVSVHPSSSAHPSALAQPSGLAHP-SSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGS--LKPHLFPVTVV--GQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIE-DRDELAYH---------ISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALT-SP--DASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYT--------FTL----NLGHLWVVFITAGT----MGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVF-GII-------FTISQGQ---IIDNYGTKPGNIFLCVFLTLGAA------LTAFIKADLRRQKANKETLENKLQEE----------------------------------------------------------EEESNTSKVPTAV-----SEDHL----------------
SLC49A3   --MAGPTEAE-----------------------------------------------------------------------------TGLAEPRALCAQRGH---RTYARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGE-DIPL-------------MLGVYTIPAGVVCLL--STICLWESVPPTPPSAGAA-------SS-TSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGF-SGLCGALFITFGILGALALGPYVDRTKHFTEATK-------IGLCLFS---LACVPFAL-----VSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAE-GILIMLAMTALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSCILAVFFHTPYRRLQAESGEPPSTRNAVGGADSGPGVDRGGAGRAGVLGPSTATPECTARGASLEDPRGPGSPHPACHRATPRAQGPAATDAPSRPGRLAGRVQASRFIDPAGSHSSFSSPWVIT
SLC49A4   MGSRWSSEEERQ-------------PL------------L--GPGLG--PGLGASWRSREA--------------------------AAAALPAAVPGPG-----RVYGRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLP-CFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIP--ISDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAA-------SQ--RLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVLD-LILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRG---------MLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLF----FLTFYHTE---LSWFNWCLPGSCLLSLLLILCF-----------------RESYDRLYLDVVVSV--------------------------------------------------------------------------------------------------

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC49A3	13	E/K	0.0101434	rs200792845
--	SLC49A3	96	R/H	0.000221214	rs200227958
--	SLC49A3	129	L/F	0.00080586	rs146109331
--	SLC49A3	164	N/D	0.000384825	rs141742124
--	SLC49A3	205	V/I	0.000105462	rs140444703
--	SLC49A3	273	L/F	0.000123629	rs144201570
--	SLC49A3	277	G/R	0.000135711	rs201056671
--	SLC49A3	307	R/Q	0.00133486	rs139230183
--	SLC49A3	364	A/V	0.000140622	rs201373487
--	SLC49A3	371	V/M	0.000583835	rs149031633
--	SLC49A3	405	P/L	0.000283323	rs146716957
--	SLC49A3	406	S/F	0.000332723	rs372313639
--	SLC49A3	414	E/K	0.000571097	rs187312561
--	SLC49A3	434	S/R	0.00265808	rs111874868
--	SLC49A3	484	P/L	0.000419425	rs756315376
--	SLC49A3	493	A/V	0.00732706	rs183765686
--	SLC49A3	552	F/S	0.000766605	rs139852524

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
No data

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data