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Detail Data SLC47A2


Basic description
Gene Name SLC47A2
Protein Name Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)
Family SLC47
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600 
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT RH 
CCCCCCCCCC CCCCCCCHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHHCCCC CCCHHHCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCEEE CCCCCCCCCC CCCCCHHHHC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CC
[Overview] SLC47A1 SLC47A2 
SLC47A1   MEAPEEPAPVRGGPEATLEVRGSRCLRLS-----AFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG------------------------------------IVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPEN--LEGILTNDV-GKTGEPQSDQQ-----MRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
SLC47A2   MDSLQDTVALD---------HGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQ--RAESTA-----TRPG-PEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC47A2 73 A/V 0.000955118 rs147915236
-- SLC47A2 81 G/R 0.000147264 rs148775490
-- SLC47A2 110 V/M 0.000107734 rs200639965
-- SLC47A2 199 P/S 0.000123268 rs201090632
-- SLC47A2 236 A/V 0.000202869 rs74454709
-- SLC47A2 261 V/I 0.000263563 rs143558800
-- SLC47A2 290 P/R 0.000145482 rs150225670
-- SLC47A2 327 Q/H 0.000317156 rs772143428
-- SLC47A2 328 A/S 0.000321143 rs748044622
-- SLC47A2 345 S/R 0.00017989 rs552694046
-- SLC47A2 366 R/H 0.000393075 rs376720627
-- SLC47A2 429 G/R 0.00599778 rs34399035
-- SLC47A2 454 P/T 0.00035393 rs139110700
-- SLC47A2 577 R/C 0.000206824 rs201004962
-- SLC47A2 577 R/H 0.000178985 rs201870806
-- SLC47A2 578 R/H 0.000262509 rs138244461
-- SLC47A2 584 A/V 0.00012336 rs374301491
-- SLC47A2 594 T/M 0.000107472 rs376316493

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC47A2 SLC47A2 [plasma membrane] Transport of bile salts and organic acids, metal ions and amine compounds

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data