Detail Data SLC47A1

Basic description

Gene Name	SLC47A1
Protein Name	Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
Family	SLC47
Category	Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570 
MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL MVFLISFISS VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI SQTYGSQNLK HVGVILQRSA LVLLLCCFPC WALFLNTQHI LLLFRQDPDV SRLTQTYVTI FIPALPATFL YMLQVKYLLN QGIVLPQIVT GVAANLVNAL ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL HQATWGGWSL ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF SVLLLSCKDH VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR GSGNQKVGAI VNTIGYYVVG LPIGIALMFA TTLGVMGLWS GIIICTVFQA VCFLGFIIQL NWKKACQQAQ VHANLKVNNV PRSGNSALPQ DPLHPGCPEN LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK QLVLRRGLLL LGVFLILLVG ILVRFYVRIQ  
CCCCCCCCCC CCCCHHHCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHHHHH HHHHHHCCCC CHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCHHH HHHHHHHHHH HHHHHHHHHC CHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC

Family alignment

[Overview]

SLC47A1   MEAPEEPAPVRGGPEATLEVRGSRCLRLS-----AFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQG------------------------------------IVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPEN--LEGILTNDV-GKTGEPQSDQQ-----MRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
SLC47A2   MDSLQDTVALD---------HGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQ--RAESTA-----TRPG-PEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC47A1	10	V/L	0.000149421	rs555657341
--	SLC47A1	24	R/L	0.000105904	rs772367782
--	SLC47A1	46	V/A	0.000251188	rs567420887
--	SLC47A1	59	S/N	0.000172165	rs548651981
--	SLC47A1	64	G/D	0.000508065	rs77630697
--	SLC47A1	91	G/S	0.000115439	rs750584659
--	SLC47A1	122	V/I	0.000930943	rs150632967
--	SLC47A1	125	L/F	0.0209222	rs77474263
--	SLC47A1	156	T/A	0.000135213	rs541196872
--	SLC47A1	159	T/M	0.000119304	rs35646404
--	SLC47A1	204	R/W	0.0180254	rs16960203
--	SLC47A1	269	M/T	0.000107515	rs145720500
--	SLC47A1	279	V/D	0.00131067	rs141572615
--	SLC47A1	288	G/S	0.000449411	rs149604973
--	SLC47A1	294	A/T	0.000385809	rs563267554
--	SLC47A1	333	R/W	0.000119604	rs375236013
--	SLC47A1	338	V/I	0.00453936	rs35790011
--	SLC47A1	354	L/M	0.000103384	rs201011329
--	SLC47A1	414	I/T	0.000131218	rs374200449
--	SLC47A1	424	G/R	0.00065215	rs147768037
--	SLC47A1	427	S/L	0.000341962	rs139122064
--	SLC47A1	465	A/V	0.00639515	rs111653425
--	SLC47A1	482	R/W	0.000341962	rs139122064
--	SLC47A1	497	C/F	0.00246068	rs35395280
--	SLC47A1	552	G/E	0.00018293	rs201778540

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC47A1	SLC47A1 [plasma membrane]	Transport of bile salts and organic acids, metal ions and amine compounds

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data