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Structure
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Variant
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Pathway
Disease

Detail Data SLC45A2


Basic description
Gene Name SLC45A2
Protein Name Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2)
Family SLC45
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530 
MGSNSGQAGR HIYKSLADDG PFDSVEPPKR PTSRLIMHSM AMFGREFCYA VEAAYVTPVL LSVGLPSSLY SIVWFLSPIL GFLLQPVVGS ASDHCRSRWG RRRPYILTLG VMMLVGMALY LNGATVVAAL IANPRRKLVW AISVTMIGVV LFDFAADFID GPIKAYLFDV CSHQDKEKGL HYHALFTGFG GALGYLLGAI DWAHLELGRL LGTEFQVMFF FSALVLTLCF TVHLCSISEA PLTEVAKGIP PQQTPQDPPL SSDGMYEYGS IEKVKNGYVN PELAMQGAKN KNHAEQTRRA MTLKSLLRAL VNMPPHYRYL CISHLIGWTA FLSNMLFFTD FMGQIVYRGD PYSAHNSTEF LIYERGVEVG CWGFCINSVF SSLYSYFQKV LVSYIGLKGL YFTGYLLFGL GTGFIGLFPN VYSTLVLCSL FGVMSSTLYT VPFNLITEYH REEEKERQQA PGGDPDNSVR GKGMDCATLT CMVQLAQILV GGGLGFLVNT AGTVVVVVIT ASAVALIGCC FVALFVRYVD  
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHCCHHHHH HCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHHHH HHHHHHHHCC CCEEEEEECC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCHHCCCCCC HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCEECCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CHHHHHHHCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHCCCCC
[Overview] SLC45A1 SLC45A2 SLC45A3 SLC45A4 
SLC45A1   MIPAASSTPPGDALFPSVAPQDFWRSQVTGYSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVL-----LQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGIAL-ADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQ-DRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLP--LPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSV----P--------RPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSK---PRSSGILKRP----QTL--------AIPDAAGGGGPETS-------------------RRRNVTFSQQV---------------------ANILLNGVKYESEL-----------------------TGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEK-LEEF-LSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYY-----QSKKFAGSSADGTR--------------------------------------------------------------RGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPP--SDAADEEH------------------RPLLLNV-------------------------------------------------------------------------------------------------
SLC45A2   ---------------------------MGSNSGQAGRHI-------------YKSLADDGPFDSVEP------------PKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL-----LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDK-EKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPL-----TEVAKGIP-------------PQQTPQD-------------------------------------------------------------------------------------PPLS------SDGMY-----------------------EYGSIEKVK---------------------------------NGYVNPE-------------------------------------------------------LAMQGAKNKNH---------------------------AEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFCINSVFSSLYSYFQKV-LVSY-IGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSV--------------------------------------------------------------RGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRY---------VD-----------------------------------------------------------------------------------------------------------------------------
SLC45A3   MV------------------QRLW----------VSRLLRHRK-----------------------------------------AQLLLVNLLTFGLEVCLAAGITYVPPLL-----LEVGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRAGWLAGLLCPDPR---PLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAAL-GPTE---------------------PAEGLSA-------------------------------------------------------------------------------------PSLS----------------------------------------------PH-----------------------CCP------------------------------CRARLAF---------------------------------RNLGAL-----------------------------------LPRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDR-LVQR-FGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDLAILDSAFLLSQVAPSLFMGSIVQLSQSVTAYMVSAAGLGLVAIYFATQVVFDK-----SDLAKYSA--------------------------------------------------------------------------------------------------------------------------
SLC45A4   ---------------------------MGKASPASGLSR----------------------------------------PK------------------------TLVSPLRSNQWSLQKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLAL-GDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQ-DMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQY-SPQQERSAEEPGALDGGEPHGVPAFPDEVQSE-------------------------------------HELA-------LDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIF------HDASY------------PATP-------RSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVP--NGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYH-----DIKQYIHHSPGNSK--------------------------------------------------------------RGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIY---PNVSEEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETERLQVLTSVRSRHIGWCRSCWRVFFFMIILEKKFSFPQCGSLRRMTYLLFLSELDTLCPGQPCPWAATAHQSWEEAGPGGLGRRQ

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC45A2 29 K/R 0.000167693 rs199882086
-- SLC45A2 135 R/G 0.000103617 rs768805504
-- SLC45A2 193 D/V 0.000449862 rs553073635
-- SLC45A2 202 W/C 0.000234813 rs146802593
-- SLC45A2 209 P/L 0.000175112 rs35990319
-- SLC45A2 220 D/E 0.00013534 rs140158799
-- SLC45A2 221 S/G 0.899393 rs2287949
-- SLC45A2 240 R/W 0.000111359 rs533984191
-- SLC45A2 267 E/K 0.000202841 rs140005143
-- SLC45A2 268 Y/C 0.000262505 rs201104968
-- SLC45A2 272 E/K 0.117899 rs26722
-- SLC45A2 297 W/S 0.000192278 rs775967282
-- SLC45A2 302 T/S 0.000449862 rs553073635
-- SLC45A2 318 R/L 0.000636856 rs142299109
-- SLC45A2 318 R/C 0.000175112 rs35990319
-- SLC45A2 329 T/R 0.00013534 rs140158799
-- SLC45A2 374 L/F 0.64504 rs16891982
-- SLC45A2 415 I/T 0.00014713 rs112249076
-- SLC45A2 451 R/H 0.000715757 rs142680641
-- SLC45A2 500 T/P 0.000103449 rs11568737
-- SLC45A2 504 V/I 0.000123365 rs149233226
-- SLC45A2 506 V/I 0.000171101 rs138338197
-- SLC45A2 507 V/L 0.000549096 rs3733808

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC45A2 SLC45A2 [melanosome membrane] Melanin biosynthesis

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data