Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC44A3


Basic description
Gene Name SLC44A3
Protein Name Choline transporter-like protein 3 (Solute carrier family 44 member 3)
Family SLC44
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650 
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG YSVVAGAAGR LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS CNLEVKGTQL NRMALCVSNC PEEQLDSLEE VQFFANTSGS FLCVYSLNSF NYTHSPKADS LCPRLPVPPS KSFPLFNRCV PQTPECYSLF ASVLINDVDT LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL VHIFISLVIL GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV LLSLGTAGAA QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM TIAGAVVTCY FNRSKNDPPD HPILSSLSIL FFYHQGTVVK GSFLISVVRI PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC CFWCLDKYLL HLNQNAYTTT AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK VLVVCFTVFG GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA IVR 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHCCCCCE EECCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCEEECC CCCCCCCCCC CCCEEEECCC CHHHHHCHHH HHHHHCCCCC CEEEEECCCC CCCCCCCHHC CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCEEECCHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CHHCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCHHEEEE ECCCCCCCCC CHHHHHHHHH HHHCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH CCCCHHCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC HHHCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCC CCC
[Overview] SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 
SLC44A1   MGC----CSS---ASSAAQSSKREWK---PLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLD--PCNLDLI-------NRKIKSVALCVAACPRQELKTLSDVQKFAEINGSA-------LCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSV---------LHRLISG------VMTSKE---------------IILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKE------TVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKIS-----GP--------------------------------------------LQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKEN-ACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLN----------YQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRK---AMKEAGKGGVADSR--ELKPMASGASSA
SLC44A2   MGD-----ERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQK----------GTKNENKPYLFYFNIVKCASPLVLLE-----FQCPTPQICVEKCPDRYLTY-------LNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSK---PLARRCFPA----IHAYKGVL-MVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVI-AMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAV--------YKIFD---DSP---CPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAEN-KFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQD--TAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTN------KKAAES--------------------
SLC44A3   MHC----LGAEYLVSAEGAPRQREWR---PQIYRKCTDTAWLFLFFLFWTGLVFIMGYSVVAGAAGRLLFGYDSFGNMCGKKNSPVEGAPLSGQDMTLKKHVFFMN--SCNLEVK-------GTQLNRMALCVSNCPEEQLDSLEEVQFFANTSGSF-------LCVYSLNSFNYTHSPKADSLCPRLPVPPSKSFPLFNRCVPQTPECYSLFASVLI---NDVDT---------LHRILSG------IMSGRD---------------TILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCGVLWWLYYDYTND-----------LSIELDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELFQITNKAISSAPFLLFQPLWTFAILIFFWVLWVAVLLSLGTAGAAQVMEGGQVEYKPL-----SG--------------------------------------------IRYMWSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRSK-NDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALKEQQHGALSRYLFRCCYCCFWCLDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVLVVCFTVFGGLMAFN----------YNRAFQVWAVPLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARAQQDKHSLRNEEGTELQAIVR-----
SLC44A4   MGG----KQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCGM------------GENKDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSCPEDPWTVGK--NEFSQTVGEVFYTKNRNFCLPGVPWNMTVITSLQQELCPSFLLPSA---PALGRCFPW----TNVTPPALPGITNDTTIQQG------ISGLIDS-------LNARDISVKIFEDFAQSWYWILVALGV-ALVLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYCWEEYRVLRDKGAS---ISQLGFTTNLSAYQSVQETWLAALIVLAVLEAILLLMLIFLRQRIRIAIALLKEASKAVGQMMSTMFYPLVTFVLLLICIAYWAMTALYLATSGQPQ--------YVLWASNISSPGCEKVPINTSCNPT---AHLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYGVLGLFWTLNWVLALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQN-PVARCIMCCFKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIPGLGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFGMCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK---------------------
SLC44A5   MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQK----------GTPNENKTILFYFNLLRCTSPSVLLN-----LQCPTTQICVSKCPEKFLTYVE--MQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSK---PFLQRCFPD----FSTKNGTL-TIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTI-AMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPV--------YKVI-----APGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQN-TLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQ--GPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVP---QKQKE---------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC44A3 14 G/A 0.000517678 rs200690456
-- SLC44A3 51 Y/H 0.000260004 rs145608976
-- SLC44A3 69 G/D 0.000435324 rs148935541
-- SLC44A3 108 T/K 0.000111351 rs547531721
-- SLC44A3 178 R/Q 0.000316028 rs140889980
-- SLC44A3 220 I/T 0.000112744 rs377198581
-- SLC44A3 269 D/N 0.000590828 rs199881016
-- SLC44A3 281 M/V 0.000279426 rs118089857
-- SLC44A3 290 V/I 0.000126022 rs186467911
-- SLC44A3 297 V/M 0.00018733 rs556041690
-- SLC44A3 327 P/S 0.000119388 rs756785788
-- SLC44A3 362 V/I 0.000426548 rs143570687
-- SLC44A3 374 S/L 0.000251708 rs146768701
-- SLC44A3 425 S/L 0.00013138 rs756007310
-- SLC44A3 434 H/R 0.000270593 rs140072535
-- SLC44A3 438 V/I 0.780779 rs859098
-- SLC44A3 451 P/L 0.000362143 rs368373395
-- SLC44A3 472 R/M 0.0004309 rs181145758
-- SLC44A3 476 R/Q 0.000207749 rs142020864
-- SLC44A3 536 I/V 0.000197612 rs149434797
-- SLC44A3 545 C/R 0.00144115 rs115958260
-- SLC44A3 548 V/I 0.000489393 rs200876036
-- SLC44A3 579 A/V 0.000513033 rs139240340
-- SLC44A3 581 S/I 0.000167029 rs201552836
-- SLC44A3 607 S/L 0.000186962 rs34381000

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC44A3 SLC44A3 [plasma membrane] Transport of bile salts and organic acids, metal ions and amine compounds
SLC44A3 SLC44A3 [plasma membrane] Synthesis of PC

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data