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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC44A1


Basic description
Gene Name SLC44A1
Protein Name Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)
Family SLC44
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name SLC44A1 transports Cho from cytosol to mitochondrial matrix
Reaction 1 Cho [cytosol] --> 1 Cho [mitochondrial matrix]

Network
No data
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650 
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA 
CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCEEEEC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC EEEECCCCCH HHHCCCCCCC CEECCCCCCH HHHCHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC EEHHCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHCCCHHE EECCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCHHHCCC CCCCCCCCCH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCC
[Overview] SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 
SLC44A1   MGC----CSS---ASSAAQSSKREWK---PLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLD--PCNLDLI-------NRKIKSVALCVAACPRQELKTLSDVQKFAEINGSA-------LCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSV---------LHRLISG------VMTSKE---------------IILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKE------TVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKIS-----GP--------------------------------------------LQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKEN-ACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLN----------YQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRK---AMKEAGKGGVADSR--ELKPMASGASSA
SLC44A2   MGD-----ERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQK----------GTKNENKPYLFYFNIVKCASPLVLLE-----FQCPTPQICVEKCPDRYLTY-------LNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSK---PLARRCFPA----IHAYKGVL-MVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVI-AMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAV--------YKIFD---DSP---CPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAEN-KFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQD--TAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTN------KKAAES--------------------
SLC44A3   MHC----LGAEYLVSAEGAPRQREWR---PQIYRKCTDTAWLFLFFLFWTGLVFIMGYSVVAGAAGRLLFGYDSFGNMCGKKNSPVEGAPLSGQDMTLKKHVFFMN--SCNLEVK-------GTQLNRMALCVSNCPEEQLDSLEEVQFFANTSGSF-------LCVYSLNSFNYTHSPKADSLCPRLPVPPSKSFPLFNRCVPQTPECYSLFASVLI---NDVDT---------LHRILSG------IMSGRD---------------TILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCGVLWWLYYDYTND-----------LSIELDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELFQITNKAISSAPFLLFQPLWTFAILIFFWVLWVAVLLSLGTAGAAQVMEGGQVEYKPL-----SG--------------------------------------------IRYMWSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRSK-NDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALKEQQHGALSRYLFRCCYCCFWCLDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVLVVCFTVFGGLMAFN----------YNRAFQVWAVPLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARAQQDKHSLRNEEGTELQAIVR-----
SLC44A4   MGG----KQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCGM------------GENKDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSCPEDPWTVGK--NEFSQTVGEVFYTKNRNFCLPGVPWNMTVITSLQQELCPSFLLPSA---PALGRCFPW----TNVTPPALPGITNDTTIQQG------ISGLIDS-------LNARDISVKIFEDFAQSWYWILVALGV-ALVLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYCWEEYRVLRDKGAS---ISQLGFTTNLSAYQSVQETWLAALIVLAVLEAILLLMLIFLRQRIRIAIALLKEASKAVGQMMSTMFYPLVTFVLLLICIAYWAMTALYLATSGQPQ--------YVLWASNISSPGCEKVPINTSCNPT---AHLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYGVLGLFWTLNWVLALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQN-PVARCIMCCFKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIPGLGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFGMCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK---------------------
SLC44A5   MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQK----------GTPNENKTILFYFNLLRCTSPSVLLN-----LQCPTTQICVSKCPEKFLTYVE--MQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSK---PFLQRCFPD----FSTKNGTL-TIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTI-AMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPV--------YKVI-----APGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQN-TLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQ--GPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVP---QKQKE---------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC44A1 8 S/T 0.00306748 rs1018350024
-- SLC44A1 105 R/Q 0.000438502 rs117349601
-- SLC44A1 146 P/S 0.000489813 rs74511615
-- SLC44A1 193 T/A 0.0105869 rs41306484
-- SLC44A1 227 M/I 0.000123707 rs777213213
-- SLC44A1 342 F/S 0.000234989 rs145882369
-- SLC44A1 361 T/S 0.000219309 rs138697456
-- SLC44A1 436 I/V 0.000179137 rs149543662
-- SLC44A1 502 T/A 0.000885996 rs148518626
-- SLC44A1 509 T/A 0.000151234 rs751434052
-- SLC44A1 575 V/I 0.000119396 rs767290859
-- SLC44A1 644 S/A 0.107529 rs3199966

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC44A1 SLC44A1 [plasma membrane] Transport of bile salts and organic acids, metal ions and amine compounds
SLC44A1 SLC44A1 [plasma membrane] Synthesis of PC
SLC44A1 SLC44A1 [mitochondrial outer membrane] Choline catabolism

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data