Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC43A2


Basic description
Gene Name SLC43A2
Protein Name Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Family SLC43
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC43A2 (LAT4)-mediated uptake of large neutral amino acids
Reaction 1 ligands of SLC43A1 and SLC43A2 [extracellular region] --> 1 ligands of SLC43A1 and SLC43A2 [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560 
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNGT VGGTAEPGHE EVSWMNGWLS CQAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL LGSACFAVSC LLIAYGASKP NALSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI ALMIGSYASS AVTFPGIKLI YDAGVSFIVV LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQVALQE GHKLCLSTVD LEVKCQPDAA VAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILK FLVSGDQKTV GLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANQGEKK KKKRDRQIQK ITNAMRAFAF TNLLLVGFGV TCLIPNLPLQ ILSFILHTIV RGFIHSAVGG LYAAVYPSTQ FGSLTGLQSL ISALFALLQQ PLFLAMMGPL QGDPLWVNVG LLLLSLLGFC LPLYLICYRR QLERQLQQRQ EDDKLFLKIN GSSNQEAFV 
CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHCCCEEEEC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHCCCHHHH HHHHHCCHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CHHHHHHHEE CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHCHHC CCCCEEHHCC CCCCCCCCCC CCCCHHHHHC CHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HCHHHCHHHH CCCCCCCCCH HHCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCC
[Overview] SLC43A1 SLC43A2 SLC43A3 
SLC43A1   MA--------PTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTC-P-AESSTNTT--------QDE---QRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIE-----------AFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLS--------QKAPSLEDGSDAFMSPQDVRGTSENLPERSV-----PLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQ--LLCLLTCPLIGYIMDWRIKDCVDA---PTQGTVLGDARD-GVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQ---QEYAANGMGPLKVLSGSEVTA--
SLC43A2   MA--------PTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTE-PENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLE-----------PFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQ--PDAAVA---PSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQ------------KTVGLYTSIFGVLQ--LLCLLTAPVIGYIMDWRLKECEDASEEPEE----KDANQ-GEKKKKKRDR--QIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
SLC43A3   MAGQGLPLHVATL-----------LTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNAT-------GQAD---------CKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGS---AVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISL---------RASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYG-----------------------------LCPGNGTTKEEKETAEHENRE--LQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDM------------ARVSTYTNAFAFTQFGVLC---APWNGLLMD-RLKQ-------KYQ----KEARKTGSSTLAV--------ALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHP-FLVYRECRTWKE----------------SPSAIA--

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC43A2 2 A/V 0.000168665 rs376843937
-- SLC43A2 70 E/K 0.000442122 rs149235737
-- SLC43A2 127 A/T 0.000123426 rs372188012
-- SLC43A2 210 V/I 0.000580199 rs140407415
-- SLC43A2 219 G/A 0.000117569 rs769260145
-- SLC43A2 309 A/V 0.000194591 rs146131991
-- SLC43A2 312 A/V 0.000172851 rs139418031
-- SLC43A2 397 E/K 0.000176178 rs200971388
-- SLC43A2 422 T/I 0.00022276 rs145630054
-- SLC43A2 464 I/T 0.00013548 rs375875239
-- SLC43A2 540 R/H 0.000185469 rs201032490
-- SLC43A2 544 R/W 0.000277984 rs34412033

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC43A2 SLC43A2 [plasma membrane] Amino acid transport across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data