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Seq./Align.
Variant
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Disease

Detail Data SLC43A1


Basic description
Gene Name SLC43A1
Protein Name Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1)
Family SLC43
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC43A1 (LAT3)-mediated uptake of large neutral amino acids
Reaction 1 ligands of SLC43A1 and SLC43A2 [extracellular region] --> 1 ligands of SLC43A1 and SLC43A2 [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK VLSGSEVTA 
CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHCCCHHCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHCCCHHH CCHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHCCCCCHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHCCCCHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCC
[Overview] SLC43A1 SLC43A2 SLC43A3 
SLC43A1   MA--------PTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTC-P-AESSTNTT--------QDE---QRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIE-----------AFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLS--------QKAPSLEDGSDAFMSPQDVRGTSENLPERSV-----PLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQ--LLCLLTCPLIGYIMDWRIKDCVDA---PTQGTVLGDARD-GVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQ---QEYAANGMGPLKVLSGSEVTA--
SLC43A2   MA--------PTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTE-PENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLE-----------PFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQ--PDAAVA---PSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQ------------KTVGLYTSIFGVLQ--LLCLLTAPVIGYIMDWRLKECEDASEEPEE----KDANQ-GEKKKKKRDR--QIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
SLC43A3   MAGQGLPLHVATL-----------LTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNAT-------GQAD---------CKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGS---AVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISL---------RASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYG-----------------------------LCPGNGTTKEEKETAEHENRE--LQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDM------------ARVSTYTNAFAFTQFGVLC---APWNGLLMD-RLKQ-------KYQ----KEARKTGSSTLAV--------ALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHP-FLVYRECRTWKE----------------SPSAIA--

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC43A1 4 T/R 0.000136467 rs116713079
-- SLC43A1 13 W/C 0.000122031 rs150647715
-- SLC43A1 40 L/M 0.000917249 rs116007354
-- SLC43A1 119 T/I 0.000691929 rs115146548
-- SLC43A1 146 T/I 0.00122883 rs34746107
-- SLC43A1 171 M/V 0.000147196 rs200312455
-- SLC43A1 172 C/F 0.000210777 rs201763475
-- SLC43A1 219 I/V 0.000191048 rs202001356
-- SLC43A1 272 S/L 0.00115327 rs141990229
-- SLC43A1 293 V/L 0.000135892 rs200433921
-- SLC43A1 338 E/D 0.00213966 rs35730224
-- SLC43A1 387 A/T 0.00217172 rs114947771
-- SLC43A1 443 H/Y 0.00122883 rs34746107
-- SLC43A1 469 A/S 0.000210777 rs201763475

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC43A1 SLC43A1 [plasma membrane] Amino acid transport across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data