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Detail Data SLC40A1
Basic description
| Gene Name | SLC40A1 |
|---|---|
| Protein Name | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) |
| Family | SLC40 |
| Category | Transport of bile salts and organic acids, metal ions and amine compounds |
| Reaction name | - |
| Reaction | - |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 MTRAGDHNRQ RGCCGSLADY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKHEL LTMYHGWVLT SCYILIITIA NIANLASTAT AITIQRDWIV VVAGEDRSKL ANMNATIRRI DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY VLLWKVYQKT PALAVKAGLK EEETELKQLN LHKDTEPKPL EGTHLMGVKD SNIHELEHEQ EPTCASQMAE PFRTFRDGWV SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF TWLRRKCGLV RTGLISGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFIQGESITP TKIPEITTEI YMSNGSNSAN IVPETSPESV PIISVSLLFA GVIAARIGLW SFDLTVTQLL QENVIESERG IINGVQNSMN YLLDLLHFIM VILAPNPEAF GLLVLISVSF VAMGHIMYFR FAQNTLGNKL FACGPDAKEV RKENQANTSV V CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCHHHH CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCEE EEECCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC HHHHHHCCCC HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHCHH HHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCEEEEE ECCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCHHHH CCHHCCCCCC C
[Overview]
SLC40A1 MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
Variant
| check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
|---|---|---|---|---|---|
| SLC40A1 | 209 | S/L | 0.000127287 | rs200018415 | |
| SLC40A1 | 230 | T/N | 0.000119332 | rs753603407 | |
| -- | SLC40A1 | 248 | Q/H | 0.00378336 | rs11568350 |
| -- | SLC40A1 | 259 | P/H | 0.000115383 | rs560312863 |
| SLC40A1 | 293 | R/C | 0.000124479 | rs149517113 | |
| SLC40A1 | 371 | R/W | 0.000119422 | rs146240138 | |
| -- | SLC40A1 | 418 | I/V | 0.000385793 | rs199629095 |
| -- | SLC40A1 | 432 | M/V | 0.000644345 | rs11568355 |
| -- | SLC40A1 | 443 | P/L | 0.00042564 | rs45606432 |
| SLC40A1 | 524 | V/I | 0.000151239 | rs142456282 | |
| -- | SLC40A1 | 552 | A/T | 0.000298429 | rs182470100 |
| -- | SLC40A1 | 561 | R/G | 0.00120576 | rs11568346 |
Phylogenetic tree
Pathway
| Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|---|
| main | SLC40A1 | SLC40A1 [plasma membrane] | Metal ion SLC transporters |
| SLC40A1 | SLC40A1 [plasma membrane] | Iron uptake and transport |
Disease