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Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC4A8


Basic description
Gene Name SLC4A8
Protein Name Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)
Family SLC4
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 8 2 0 8 3 0 8 4 0 8 5 0 8 6 0 8 7 0 8 8 0 8 9 0 9 0 0 9 1 0 9 2 0 9 3 0 9 4 0 9 5 0 9 6 0 9 7 0 9 8 0 9 9 0 1 0 0 0 1 0 1 0 1 0 2 0 1 0 3 0 1 0 4 0 1 0 5 0 1 0 6 0 1 0 7 0 1 0 8 0 1 0 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890        900        910        920        930        940        950        960        970        980        990       1000       1010       1020       1030       1040       1050       1060       1070       1080       1090 
MPAAGSNEPD GVLSYQRPDE EAVVDQGGTS TILNIHYEKE ELEGHRTLYV GVRMPLGRQS HRHHRTHGQK HRRRGRGKGA SQGEEGLEAL AHDTPSQRVQ FILGTEEDEE HVPHELFTEL DEICMKEGED AEWKETARWL KFEEDVEDGG ERWSKPYVAT LSLHSLFELR SCLINGTVLL DMHANSIEEI SDLILDQQEL SSDLNDSMRV KVREALLKKH HHQNEKKRNN LIPIVRSFAE VGKKQSDPHL MDKHGQTVSP QSVPTTNLEV KNGVNCEHSP VDLSKVDLHF MKKIPTGAEA SNVLVGEVDI LDRPIVAFVR LSPAVLLSGL TEVPIPTRFL FILLGPVGKG QQYHEIGRSM ATIMTDEIFH DVAYKAKERD DLLAGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK MPGVPNGNVC HIEQEPHGGH SGPELQRTGR LFGGLVLDIK RKAPWYWSDY RDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT GIAYSLFAGQ ALTILGSTGP VLVFEKILFK FCKDYALSYL SLRACIGLWT AFLCIVLVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAI EKLIHLAETY PIHMHSQLDH LSLYYCRCTL PENPNNHTLQ YWKDHNIVTA EVHWANLTVS ECQEMHGEFM GSACGHHGPY TPDVLFWSCI LFFTTFILSS TLKTFKTSRY FPTRVRSMVS DFAVFLTIFT MVIIDFLIGV PSPKLQVPSV FKPTRDDRGW IINPIGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG YHLDLLMVAI MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP KFLGIREQRV TGLMIFVLMG CSVFMTAILK FIPMPVLYGV FLYMGVSSLQ GIQFFDRLKL FGMPAKHQPD FIYLRHVPLR KVHLFTLIQL TCLVLLWVIK ASPAAIVFPM MVLALVFVRK VMDLCFSKRE LSWLDDLMPE SKKKKLDDAK KKAKEEEEAE KMLEIGGDKF PLESRKLLSS PGKNISCRCD PSEINISDEM PKTTVWKALS MNSGNAKEKS LFN 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHCCCEEEEC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHCCCCCCC CCCCCCEEHH HHCCCCCCCC CCHHHHHHEE ECEEEECCCC CCCCCCCCCC CCHHHHHHHH HHHHCCCEEE CCCCCCHHHH HHHHHHHHHH CCCCCHHHHH HHHHHHHHHC CCCCCCCCCC CCCCCCCHHH CCCCCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHCCHHH HCCCCCCCCH HHHHCCCCCC CCCCEEHHHC CCCCEECCCC CCCCCCCEEE EEEECCCCCC CHHHHHHHCH HHHCCCHHHH HHHHHCCCHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHCCC CCEEEEECHH HCCCCEECCC HHHCCHHHHH HHHHHHHHHH CCHHHCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCHHHHHH HCHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCHHHC HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHHCCEEE CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC EECCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC HHHCCCCCCC HHHHHHHHHH HHHHCHHCCC HHHHCCCCCC CCHHHHCCCC CCCCCCCCCC CCCEEEEEEH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHCCC CCCHHHHHHH HCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HCHHHHHCCH HHHHHHHHHH HHHHCCCHHH HHHHHCCCCC CCCCCHHHHH HHCHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH CCCCCCCCCC CCC
[Overview] SLC4A1 SLC4A10 SLC4A11 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 
SLC4A1    --------------------------------MEELQD--D----------YEDMMEE-------------NLEQEEY-----------------------------------------------------EDPDIPE-------SQMEEPAAHDTE-------------------------------------------------------------------------------------------------------------------------------------------------ATATDYHTTSH-----PGT-----------------------------------------HKVYVELQELVMDEKNQELRWMEAA------------------------RWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------------AGELEALGGVKPAVLTRS---------------------------------------------------------GDP--SQPLL---------------------------------------------------------------PQ---------------------HSSLETQLFCEQGDGGT--------------EGHSPSGI------------LEKIPPDSEATLV----------LVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFLFVLLGP--EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRR--YQSSPAKP-----------DSSFYKGLDLNGG-----------------------------P-----DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAF------SPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY---------------------------N-------YNVLMVP-------------------------------KPQGP--------LPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRS--EFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGA-AAQIQEVKEQRISGLLVAVLVGLSILMEPI-LSRIPLAVLFGIFLYMGVTSLSGIQ----------------LFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTP---ASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKAT----FDEEEGRDEYDE-----------------------VAMPV--------------------------------------------------------
SLC4A10   MEIKDQGAQM------EP----------LLPTRNDEEAVVD-RGGTRSILKTH-----------------FEKEDLEGHRTLFIGVHVPLGGR-----KSHRRHRHRGHKHRKRD---------------------------------RERDSGL-EDGRES------PSFDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTELDEICWR-EGEDAEWRETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNA-----------------------------------------------------------------------------------------------------------------------------GQVVSPQSAPAC-VENK---------NDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQER----EVDLHFMKKIPPGAEASNI----------LVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGP--LGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKI------PAVPNGTAAHGEAEPH----------GGHSG---------------------------------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAF------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRE-------SNISASDII------WENL-TVSECKS--------LHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPTRDD-RGWFVTPLGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFILMGSSVFMTSI-LKFIPMPVLYGVFLYMGASSLKGIQ----------------FFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSR---AAIVFPMMVLALVFVRK-LMDLLFTKRELSWLDDLMPESK-KKKLEDAEK--EEEQ---SMLAMEDEGTVQLPLEGHY----------------RDDPSV-INIS--DEMSKTALWRNLLITADNSKDKESSFPSKSSPS
SLC4A11   MG------------VYGPQ------------DRSESEK-RD-------------VQRDPPPW--------HPRREGE------------------RPARARSLPLAAAGQGFLRK-TW---------------------------ISEHENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDE------AFDTANS--------------------------------------------------------------------------------------------------------------------------------------SIVSGE-----------------------SIRFFVNVNL-----EMQATNTENEATSGGCVLL------------HTSRKYLKLKNFKEE--------------IRAHRDLDGFLAQASIVLNETATSL----------------------DNVLRTMLRRFARDPDN-------------------------------------------------------------------------------------------NEP--------------------------------------------------------------------------------------------NCNLDLLMAMLFT--------------DAGAPMRGK--------VHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWG---ENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEP---------------------------------------------------------------PK----CKDFVPFGK---GIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLD-DYHTKRTSSLVSL-SGLGASLNASLH------------------TALNASFLASPTELPS----------ATHSGQA----------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSH--GFREIEM---SKFRYNPSE------SPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQ----------------LVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAEHR------------------------------------------P---------------------------------------------------------
SLC4A2    MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEE--DELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRR----------RPGASPTGETPTIEE-------GEEDEDEASEAEGARAL----TQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPA------PLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPL-PKAQPGHRSYNLQER----RRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK-----PHEVFVELNELLLD-KNQEPQWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHHHGQGAES----------------------------------------------------------DPHVTEPLMG---------------------------------------------------------G---VP--------------------------ETRLEVERERELP--------------PPAPPAGIT-RSKSKHELKLLEKIPENAEATVV----------LVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP--SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKR--EEQGRLLPTGAGLEPKSAQDKALLQMVEAAGA-----------------------------AE----DDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDAL------DPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS---------------------------A-------SNSSEVDGG--ENMTWAGA-RPTLGPGNRSLAGQSGQGKPRGQ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKS--PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPLAVLFGIFLYMGVTSLNGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPV----FDEREGVDEYNE-----------------------MPMPV--------------------------------------------------------
SLC4A3    MANGVIPPPGGASPL--PQVRVPLEEPPLSPDVEEEDD--D-LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKR-----KKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEP----VEPPPSGTPQKAKFSIGSD-------EDDSPGLPGRAAVTKPLP--SVGPHTDKSPQHSSSSPSPRARASRLA---------GEKSRPWSPSA-----SYDLRERLCPGSALGNPGGPEQ----QVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLD-RSQEPHWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG---------------------------------------------------------PDG--AVPTMADDL------------------------------------------------------G---EPAPLWPH---------------DPDAKEKPL-------------------------HMPGGDGHRGKS---LKLLEKIPEDAEATVV----------LVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGP--SHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPGKEL--SLELGGSEAT--------------------------PE----DDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDAL------HSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYP-------------PEGALEGSLDAGLE-------PNGSALP--------------PTEGPP-----------SPRNQ---------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSAR--PFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSGIQ----------------LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPN----FDE-DGQDEYNE-----------------------LHMPV--------------------------------------------------------
SLC4A4    ---------------------------------MEDEAVLD-RGASFLKHV-------------------CDEEEVEGHHTIYIGVHVPKSYR-----RRRRHKRKTGHKEKKEK----------------------ER------ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEE--------DDSPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------PPQLFTELDELLAV-DGQEMEWKETA------------------------RWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTVSSASRMFTNP----------------------------------------------------------DN--GSPAMTHR-----------------------------------------------------------NLTSSSLN------------------------DISD----------------------KPEKDQ------LKNKFMKKLPRDAEASNV----------LVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGP--KGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDT-----PHD----------GGHGGGGHGDC---------------------------EELQRTGRFCGGLIKDIKRKAPFFASDFYDAL------NIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPP-DPANISISNDTT-LAPEYLPTMSSTDMYHNTTFDWAFL-SKKECSK--------YGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN-----PWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGE-QPKFLGVREQRVTGTLVFILTGLSVFMAPI-LKFIPMPVLYGVFLYMGVASLNGVQ----------------FMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTV---AAIIFPVMILALVAVRK-GMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPS-----IKIPMDIMEQQPFLSDSKPSD--------------------------RERSPTFLERHTSC
SLC4A5    MK------------------------------VKEEKA-----GVGKLDHTNHR-------------RRFPDQKECP---PIHIGLPVP-TYP-----QRKTDQK--GHLSGLQKVHWGLR---------------PDQ------PQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEE--------DEAPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLFTEMDTLQH--DGDQMEWKESA------------------------RWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARS----------------------------------------------------------PG--AGPSLHHST--------------------------------EDL-------RMRQSANY----GRLCHAQSRSMN------------------------DISL----------------------TPNTDQ------RKNKFMKKIPKDSEASNV----------LVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGP--SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPG----------GGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGF------HIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAP-DTVNTTVFNASAPLAPD--TNASLYNLLNLTALDWSLL-SKKECLS--------YGGRLLGNSCK----FIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACF-GLETPKLHVPSVIKPTRPD-RGWFVAPFGKN-----PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGE-QPQFLGVREQRVTGIIVFILTGISVFLAPI-LKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTV---AAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDNILPEKE--KKETDKKRKRKKGA------HEDCDEEPQFPPPS--VIKIPMESVQ-------SDPQNGIHCI--------------------ARKRSSSWSYSL---
SLC4A7    ME-RFRLEKK------LP--------------GPDEEAVVD-LGKTSSTVNTK-----------------FEKEELESHRAVYIGVHVPF-SK-----ESRRRHRHRGHKHHHRR---------------------------------RKDKESDKEDGRES------PSYDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTEMDELCYR-DGEEYEWKETA------------------------RWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPP--SSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGN-LDNSKSGEIKGNGSGGSRENSTVDFSK----------------------------------VDMNFMRKIPTGAEASNV----------LVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGP--AGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKI------PVFHNGSTPTLGETPKE--------AAHHAG---------------------------------PELQRTGRLFGGLILDIKRKAPFFLSDFKDAL------SLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKK-------DNITAHNIS------WRNL-TVSECKK--------LRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV-GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN-----PWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGE-QPKFLGIREQRVTGLMIFILMGLSVFMTSV-LKFIPMPVLYGVFLYMGVSSLKGIQ----------------LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA---AAVVFPMMVLALVFVRK-LMDLCFTKRELSWLDDLMPESK-KKKEDDKKKKEKEEA---ERMLQDDDDTVHLPFEGGSLLQIPVKALK----YSPDKPVS-VKISFEDEPRKKYV------------DAETSL-------
SLC4A8    ---MPAAGSN------EPD-------GVLSYQRPDEEAVVD-QGGTSTILNIH-----------------YEKEELEGHRTLYVGVRMPL-GR-----QSHRHHRTHGQKHRRRG---------------------------------RGKGASQGEEGLEA------LAHDTPSQRVQFILGTE-------EDEEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHELFTELDEICMK-EGEDAEWKETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKH------------------------------------------------------------------------------------------------------------------------------GQTVSPQSVPTTNLEVK---------NGVNCEHSPVDLSK----------------------------------VDLHFMKKIPTGAEASNV----------LVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGP--VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKM------PGVPNGNVCHIEQEPH----------GGHSG---------------------------------PELQRTGRLFGGLVLDIKRKAPWYWSDYRDAL------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKD-------HNIVTAEVH------WANL-TVSECQE--------MHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSPKLQVPSVFKPTRDD-RGWIINPIGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFVLMGCSVFMTAI-LKFIPMPVLYGVFLYMGVSSLQGIQ----------------FFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASP---AAIVFPMMVLALVFVRK-VMDLCFSKRELSWLDDLMPESK-KKKLDDAKKKAKEEE---EAEKMLEIGGDKFPLESRKLLSSPGKNIS-----CRCDPSE-INIS--DEMPKTTVWKALSMNSGNAKEK-SLFN------
SLC4A9    MEMK----------------------------LPGQEG--------------------------------FEASSAP-----------------------------------------------------------------------RNIPSGELDSNPDPGTG---PSPDGPSDTESKELGVP-------KD------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLFIQLNELLG--WPQALEWRETGSSSASLLLDMGEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV--TRVES--LSPELRGQLQALLLQRPQHYNQT---------------------------------------------------------------------------------------TG--TRPCWGST-----------------------------------------------------------HPRKASDN------------------------------------------------EEAPLREQ------CQNPLRQKLPPGAEAGTV----------LAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGP--CMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLP----SQQREIRGPA-----VPRLTSAEDRHRHGPHAH--------------------------------SPELQRTGRLFGGLIQDVRRKVPWYPSDFLDAL------HLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS----SAYGCLCQYPGPGGNES--QWIR-TRPKDRDDIVSMDLG---LINASLL-PPPECTR--------QGGHPRGPGCH----TVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFKPTLPG-RGWLVSPFGAN-----PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGE-RPNFLGIREQRLTGLVVFILTGASIFLAPV-LKFIPMPVLYGIFLYMGVAALSSIQ----------------FTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTP---AAIIFPLMLLGLVGVRK-ALERVFSPQELLWLDELMPEEE---------------------------------------RSIPEKGLEPEHSFSGSDSED-------SELM--------------YQPKAPEINISVN--

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC4A8 18 R/Q 0.00013746 rs991944660
-- SLC4A8 21 P/A 0.00059324 rs78274064
-- SLC4A8 115 E/D 0.000111985 rs754944375
SLC4A8 394 T/M 0.00010062 rs200938638
-- SLC4A8 412 N/S 0.000913959 rs7308853
SLC4A8 507 R/H 0.000123786 rs200633626
SLC4A8 648 T/S 0.000103638 rs199981470
-- SLC4A8 704 A/T 0.000363357 rs776889477
-- SLC4A8 715 S/N 0.000173388 rs554947836
-- SLC4A8 718 G/R 0.00302792 rs146572503
SLC4A8 772 I/V 0.000111388 rs201905031
SLC4A8 898 I/V 0.000565062 rs12318785
-- SLC4A8 1080 S/I 0.000325725 rs556044018

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC4A8 SLC4A8 [plasma membrane] Bicarbonate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data