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Basic
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Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC4A7


Basic description
Gene Name SLC4A7
Protein Name Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)
Family SLC4
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 8 2 0 8 3 0 8 4 0 8 5 0 8 6 0 8 7 0 8 8 0 8 9 0 9 0 0 9 1 0 9 2 0 9 3 0 9 4 0 9 5 0 9 6 0 9 7 0 9 8 0 9 9 0 1 0 0 0 1 0 1 0 1 0 2 0 1 0 3 0 1 0 4 0 1 0 5 0 1 0 6 0 1 0 7 0 1 0 8 0 1 0 9 0 1 1 0 0 1 1 1 0 1 1 2 0 1 1 3 0 1 1 4 0 1 1 5 0 1 1 6 0 1 1 7 0 1 1 8 0 1 1 9 0 1 2 0 0 1 2 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890        900        910        920        930        940        950        960        970        980        990       1000       1010       1020       1030       1040       1050       1060       1070       1080       1090       1100       1110       1120       1130       1140       1150       1160       1170       1180       1190       1200       1210 
MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP FSKESRRRHR HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT EDDDEEHIPH DLFTEMDELC YRDGEEYEWK ETARWLKFEE DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK HSDPHLLERN GEGLSASRHS LRTGLSASNL SLRGESPLSL LLGHLLPSSR AGTPAGSRCT TPVPTPQNSP PSSPSISRLT SRSSQESQRQ APELLVSPAS DDIPTVVIHP PEEDLEAALK GEEQKNEENV DLTPGILASP QSAPGNLDNS KSGEIKGNGS GGSRENSTVD FSKVDMNFMR KIPTGAEASN VLVGEVDFLE RPIIAFVRLA PAVLLTGLTE VPVPTRFLFL LLGPAGKAPQ YHEIGRSIAT LMTDEIFHDV AYKAKDRNDL LSGIDEFLDQ VTVLPPGEWD PSIRIEPPKS VPSQEKRKIP VFHNGSTPTL GETPKEAAHH AGPELQRTGR LFGGLILDIK RKAPFFLSDF KDALSLQCLA SILFLYCACM SPVITFGGLL GEATEGRISA IESLFGASLT GIAYSLFAGQ PLTILGSTGP VLVFEKILYK FCRDYQLSYL SLRTSIGLWT SFLCIVLVAT DASSLVCYIT RFTEEAFAAL ICIIFIYEAL EKLFDLGETY AFNMHNNLDK LTSYSCVCTE PPNPSNETLA QWKKDNITAH NISWRNLTVS ECKKLRGVFL GSACGHHGPY IPDVLFWCVI LFFTTFFLSS FLKQFKTKRY FPTKVRSTIS DFAVFLTIVI MVTIDYLVGV PSPKLHVPEK FEPTHPERGW IISPLGDNPW WTLLIAAIPA LLCTILIFMD QQITAVIINR KEHKLKKGAG YHLDLLMVGV MLGVCSVMGL PWFVAATVLS ISHVNSLKVE SECSAPGEQP KFLGIREQRV TGLMIFILMG LSVFMTSVLK FIPMPVLYGV FLYMGVSSLK GIQLFDRIKL FGMPAKHQPD LIYLRYVPLW KVHIFTVIQL TCLVLLWVIK VSAAAVVFPM MVLALVFVRK LMDLCFTKRE LSWLDDLMPE SKKKKEDDKK KKEKEEAERM LQDDDDTVHL PFEGGSLLQI PVKALKYSPD KPVSVKISFE DEPRKKYVDA ETSL 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH CCEEEECCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCEEECCC CCCCCCCCCC CCEEECCEEC CCCCCEEEEE EHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHCCC CCCEEECCCC CCHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHCCCCCC CCCCCCCCCH HCHHHHCCCC CCCHHHHHCC CCCCCHHCCC HHHCCCCCCC HHCCCCCCHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHCC CCCCHHHHHC CCCCCCCCCC CCCCCEECCC CHHHHCHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHCHHHHH CCCCCCCCCE EEEEECCCCC CCEEEEEEEC CCEECCCCCC CCCCHHHHHH HHCCCCCCCC HHHHHHHHHH HCCCHHHHHH HHHCCCHHHH HHHCHHHHCC CEECCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHCCC CCCCCCCEEC CCCHHHHHHH HHCCCCCCHH HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHCCHHHHHH HHHHHHHCCC CCEEECCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCHH CCCHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCHHC CCCCEECCCC CCCCCCCHHH HHHHHCCCCC CCCHHCCCHH HHHHHCCEEE ECCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCE EECCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC HHHHCCCCCC CHHHHHHHHH HHHHHHHHCC HHHHCCCCCC CCHHCCCCCC CCCCCCCCCC CEEEEEEEEC HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHHHHHHC CCCHHHHHHH HCCCCCCCCC CCHHHCCCHH HHHHHHHHHH HHHHHHHHCC CHHHHHHCHH HHHHHHHHHH HHHHCCCHHH HHHHHCCCCC CCCCHHHHHH HHHHHHHHHH CCCCCCCEEC CCCCCCCCCC CHHHCCCCCC CCCCCCCCCC CCCCCCCCCC HHCC
[Overview] SLC4A1 SLC4A10 SLC4A11 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9 
SLC4A1    --------------------------------MEELQD--D----------YEDMMEE-------------NLEQEEY-----------------------------------------------------EDPDIPE-------SQMEEPAAHDTE-------------------------------------------------------------------------------------------------------------------------------------------------ATATDYHTTSH-----PGT-----------------------------------------HKVYVELQELVMDEKNQELRWMEAA------------------------RWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------------AGELEALGGVKPAVLTRS---------------------------------------------------------GDP--SQPLL---------------------------------------------------------------PQ---------------------HSSLETQLFCEQGDGGT--------------EGHSPSGI------------LEKIPPDSEATLV----------LVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFLFVLLGP--EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRR--YQSSPAKP-----------DSSFYKGLDLNGG-----------------------------P-----DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAF------SPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY---------------------------N-------YNVLMVP-------------------------------KPQGP--------LPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRS--EFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGA-AAQIQEVKEQRISGLLVAVLVGLSILMEPI-LSRIPLAVLFGIFLYMGVTSLSGIQ----------------LFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTP---ASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKAT----FDEEEGRDEYDE-----------------------VAMPV--------------------------------------------------------
SLC4A10   MEIKDQGAQM------EP----------LLPTRNDEEAVVD-RGGTRSILKTH-----------------FEKEDLEGHRTLFIGVHVPLGGR-----KSHRRHRHRGHKHRKRD---------------------------------RERDSGL-EDGRES------PSFDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTELDEICWR-EGEDAEWRETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNA-----------------------------------------------------------------------------------------------------------------------------GQVVSPQSAPAC-VENK---------NDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQER----EVDLHFMKKIPPGAEASNI----------LVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGP--LGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKI------PAVPNGTAAHGEAEPH----------GGHSG---------------------------------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAF------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRE-------SNISASDII------WENL-TVSECKS--------LHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPTRDD-RGWFVTPLGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFILMGSSVFMTSI-LKFIPMPVLYGVFLYMGASSLKGIQ----------------FFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSR---AAIVFPMMVLALVFVRK-LMDLLFTKRELSWLDDLMPESK-KKKLEDAEK--EEEQ---SMLAMEDEGTVQLPLEGHY----------------RDDPSV-INIS--DEMSKTALWRNLLITADNSKDKESSFPSKSSPS
SLC4A11   MG------------VYGPQ------------DRSESEK-RD-------------VQRDPPPW--------HPRREGE------------------RPARARSLPLAAAGQGFLRK-TW---------------------------ISEHENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDE------AFDTANS--------------------------------------------------------------------------------------------------------------------------------------SIVSGE-----------------------SIRFFVNVNL-----EMQATNTENEATSGGCVLL------------HTSRKYLKLKNFKEE--------------IRAHRDLDGFLAQASIVLNETATSL----------------------DNVLRTMLRRFARDPDN-------------------------------------------------------------------------------------------NEP--------------------------------------------------------------------------------------------NCNLDLLMAMLFT--------------DAGAPMRGK--------VHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWG---ENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEP---------------------------------------------------------------PK----CKDFVPFGK---GIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLD-DYHTKRTSSLVSL-SGLGASLNASLH------------------TALNASFLASPTELPS----------ATHSGQA----------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSH--GFREIEM---SKFRYNPSE------SPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQ----------------LVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAEHR------------------------------------------P---------------------------------------------------------
SLC4A2    MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEE--DELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRR----------RPGASPTGETPTIEE-------GEEDEDEASEAEGARAL----TQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPA------PLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPL-PKAQPGHRSYNLQER----RRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK-----PHEVFVELNELLLD-KNQEPQWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHHHGQGAES----------------------------------------------------------DPHVTEPLMG---------------------------------------------------------G---VP--------------------------ETRLEVERERELP--------------PPAPPAGIT-RSKSKHELKLLEKIPENAEATVV----------LVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP--SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKR--EEQGRLLPTGAGLEPKSAQDKALLQMVEAAGA-----------------------------AE----DDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDAL------DPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS---------------------------A-------SNSSEVDGG--ENMTWAGA-RPTLGPGNRSLAGQSGQGKPRGQ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKS--PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPLAVLFGIFLYMGVTSLNGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPV----FDEREGVDEYNE-----------------------MPMPV--------------------------------------------------------
SLC4A3    MANGVIPPPGGASPL--PQVRVPLEEPPLSPDVEEEDD--D-LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKR-----KKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEP----VEPPPSGTPQKAKFSIGSD-------EDDSPGLPGRAAVTKPLP--SVGPHTDKSPQHSSSSPSPRARASRLA---------GEKSRPWSPSA-----SYDLRERLCPGSALGNPGGPEQ----QVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLD-RSQEPHWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG---------------------------------------------------------PDG--AVPTMADDL------------------------------------------------------G---EPAPLWPH---------------DPDAKEKPL-------------------------HMPGGDGHRGKS---LKLLEKIPEDAEATVV----------LVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGP--SHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPGKEL--SLELGGSEAT--------------------------PE----DDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDAL------HSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYP-------------PEGALEGSLDAGLE-------PNGSALP--------------PTEGPP-----------SPRNQ---------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSAR--PFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSGIQ----------------LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPN----FDE-DGQDEYNE-----------------------LHMPV--------------------------------------------------------
SLC4A4    ---------------------------------MEDEAVLD-RGASFLKHV-------------------CDEEEVEGHHTIYIGVHVPKSYR-----RRRRHKRKTGHKEKKEK----------------------ER------ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEE--------DDSPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------PPQLFTELDELLAV-DGQEMEWKETA------------------------RWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTVSSASRMFTNP----------------------------------------------------------DN--GSPAMTHR-----------------------------------------------------------NLTSSSLN------------------------DISD----------------------KPEKDQ------LKNKFMKKLPRDAEASNV----------LVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGP--KGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDT-----PHD----------GGHGGGGHGDC---------------------------EELQRTGRFCGGLIKDIKRKAPFFASDFYDAL------NIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPP-DPANISISNDTT-LAPEYLPTMSSTDMYHNTTFDWAFL-SKKECSK--------YGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN-----PWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGE-QPKFLGVREQRVTGTLVFILTGLSVFMAPI-LKFIPMPVLYGVFLYMGVASLNGVQ----------------FMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTV---AAIIFPVMILALVAVRK-GMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPS-----IKIPMDIMEQQPFLSDSKPSD--------------------------RERSPTFLERHTSC
SLC4A5    MK------------------------------VKEEKA-----GVGKLDHTNHR-------------RRFPDQKECP---PIHIGLPVP-TYP-----QRKTDQK--GHLSGLQKVHWGLR---------------PDQ------PQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEE--------DEAPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLFTEMDTLQH--DGDQMEWKESA------------------------RWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARS----------------------------------------------------------PG--AGPSLHHST--------------------------------EDL-------RMRQSANY----GRLCHAQSRSMN------------------------DISL----------------------TPNTDQ------RKNKFMKKIPKDSEASNV----------LVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGP--SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPG----------GGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGF------HIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAP-DTVNTTVFNASAPLAPD--TNASLYNLLNLTALDWSLL-SKKECLS--------YGGRLLGNSCK----FIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACF-GLETPKLHVPSVIKPTRPD-RGWFVAPFGKN-----PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGE-QPQFLGVREQRVTGIIVFILTGISVFLAPI-LKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTV---AAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDNILPEKE--KKETDKKRKRKKGA------HEDCDEEPQFPPPS--VIKIPMESVQ-------SDPQNGIHCI--------------------ARKRSSSWSYSL---
SLC4A7    ME-RFRLEKK------LP--------------GPDEEAVVD-LGKTSSTVNTK-----------------FEKEELESHRAVYIGVHVPF-SK-----ESRRRHRHRGHKHHHRR---------------------------------RKDKESDKEDGRES------PSYDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTEMDELCYR-DGEEYEWKETA------------------------RWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPP--SSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGN-LDNSKSGEIKGNGSGGSRENSTVDFSK----------------------------------VDMNFMRKIPTGAEASNV----------LVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGP--AGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKI------PVFHNGSTPTLGETPKE--------AAHHAG---------------------------------PELQRTGRLFGGLILDIKRKAPFFLSDFKDAL------SLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKK-------DNITAHNIS------WRNL-TVSECKK--------LRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV-GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN-----PWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGE-QPKFLGIREQRVTGLMIFILMGLSVFMTSV-LKFIPMPVLYGVFLYMGVSSLKGIQ----------------LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA---AAVVFPMMVLALVFVRK-LMDLCFTKRELSWLDDLMPESK-KKKEDDKKKKEKEEA---ERMLQDDDDTVHLPFEGGSLLQIPVKALK----YSPDKPVS-VKISFEDEPRKKYV------------DAETSL-------
SLC4A8    ---MPAAGSN------EPD-------GVLSYQRPDEEAVVD-QGGTSTILNIH-----------------YEKEELEGHRTLYVGVRMPL-GR-----QSHRHHRTHGQKHRRRG---------------------------------RGKGASQGEEGLEA------LAHDTPSQRVQFILGTE-------EDEEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHELFTELDEICMK-EGEDAEWKETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKH------------------------------------------------------------------------------------------------------------------------------GQTVSPQSVPTTNLEVK---------NGVNCEHSPVDLSK----------------------------------VDLHFMKKIPTGAEASNV----------LVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGP--VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKM------PGVPNGNVCHIEQEPH----------GGHSG---------------------------------PELQRTGRLFGGLVLDIKRKAPWYWSDYRDAL------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKD-------HNIVTAEVH------WANL-TVSECQE--------MHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSPKLQVPSVFKPTRDD-RGWIINPIGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFVLMGCSVFMTAI-LKFIPMPVLYGVFLYMGVSSLQGIQ----------------FFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASP---AAIVFPMMVLALVFVRK-VMDLCFSKRELSWLDDLMPESK-KKKLDDAKKKAKEEE---EAEKMLEIGGDKFPLESRKLLSSPGKNIS-----CRCDPSE-INIS--DEMPKTTVWKALSMNSGNAKEK-SLFN------
SLC4A9    MEMK----------------------------LPGQEG--------------------------------FEASSAP-----------------------------------------------------------------------RNIPSGELDSNPDPGTG---PSPDGPSDTESKELGVP-------KD------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLFIQLNELLG--WPQALEWRETGSSSASLLLDMGEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV--TRVES--LSPELRGQLQALLLQRPQHYNQT---------------------------------------------------------------------------------------TG--TRPCWGST-----------------------------------------------------------HPRKASDN------------------------------------------------EEAPLREQ------CQNPLRQKLPPGAEAGTV----------LAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGP--CMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLP----SQQREIRGPA-----VPRLTSAEDRHRHGPHAH--------------------------------SPELQRTGRLFGGLIQDVRRKVPWYPSDFLDAL------HLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS----SAYGCLCQYPGPGGNES--QWIR-TRPKDRDDIVSMDLG---LINASLL-PPPECTR--------QGGHPRGPGCH----TVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFKPTLPG-RGWLVSPFGAN-----PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGE-RPNFLGIREQRLTGLVVFILTGASIFLAPV-LKFIPMPVLYGIFLYMGVAALSSIQ----------------FTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTP---AAIIFPLMLLGLVGVRK-ALERVFSPQELLWLDELMPEEE---------------------------------------RSIPEKGLEPEHSFSGSDSED-------SELM--------------YQPKAPEINISVN--

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC4A7 4 D/E 0.00192848 rs540556299
-- SLC4A7 5 R/H 0.000116331 rs372621060
-- SLC4A7 58 R/H 0.000302844 rs148308402
-- SLC4A7 82 R/Q 0.000188413 rs142072563
-- SLC4A7 252 E/D 0.00885698 rs73824931
-- SLC4A7 262 R/Q 0.000766086 rs139463553
-- SLC4A7 303 V/M 0.00147669 rs12491265
-- SLC4A7 307 R/W 0.000236309 rs749240402
-- SLC4A7 326 E/K 0.199192 rs3755652
-- SLC4A7 356 E/K 0.000957601 rs149030403
-- SLC4A7 563 T/A 0.000639821 rs140822700
SLC4A7 754 M/R 0.0002118 rs369445403
SLC4A7 756 N/S 0.00558525 rs75615379
SLC4A7 819 P/A 0.000107682 rs143008404
SLC4A7 824 V/L 0.000155271 rs149034907
SLC4A7 835 T/A 0.000203029 rs145395117
SLC4A7 895 H/Y 0.00115933 rs146857770
SLC4A7 896 P/S 0.0117798 rs114662202
SLC4A7 918 I/V 0.000783386 rs535493807

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC4A7 SLC4A7 [plasma membrane] Bicarbonate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data