Detail Data SLC4A4

Basic description

Gene Name	SLC4A4
Protein Name	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)
Family	SLC4
Category	Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

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MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKTG HKEKKEKERI SENYSDKSDI ENADESSSSI LKPLISPAAE RIRFILGEED DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIVDHQ IETGLLKPEL KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFTN PDNGSPAMTH RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDNNFDY LEFRLWIGLW SAFLCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA FKKMIKLADY YPINSNFKVG YNTLFSCTCV PPDPANISIS NDTTLAPEYL PTMSSTDMYH NTTFDWAFLS KKECSKYGGN LVGNNCNFVP DITLMSFILF LGTYTSSMAL KKFKTSPYFP TTARKLISDF AIILSILIFC VIDALVGVDT PKLIVPSEFK PTSPNRGWFV PPFGENPWWV CLAAAIPALL VTILIFMDQQ ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VICSLMALPW YVAATVISIA HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD IMEQQPFLSD SKPSDRERSP TFLERHTSC 
CCCCCCCCCC CCCCCCCCCH HHHCCCEEEE EEEECCCCCC CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHCCCCC CCCCCCCCCC HHHHEEEECC CCCCEEECCC EEECEEECCC CCCCCCCCCC CCCCHHHHHH HHHHHHHCCE EECCCCCCHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHCCCCC CCCCCCEEEE EECCCCCCEE EEEEECCCCH HHCCCCCCCC CCEEEEEECC CCCCCCHHHH HHHHHHHCCH HHHHHHHHHC CCHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC CHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHCC CCCCCCHHCH HHHCCCCCCC HHHHHCHHHH HHHHHHHHHH HCHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHHHHHC CHHHHHHCCC CHHHHHHHHC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCEEEECC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHCC HHHHHHHCCE EEECCCCCCC CHHHCHHHHH HHHHHHHHHH HHHCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCEECCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCHH HCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCEEEEECH HHHHHHHHHH HHCCCHHHCC CCCCEEHHHH HHHHHHHCCC CHHHHHHCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHCH HHHHHCHHHH HHHHHHHHHH CCCCCHHHHH HHCCCCCCCC CCCCHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHCCCCCCCC CCCCCCCCCC CHHHCCCCC

Family alignment

[Overview]

SLC4A1    --------------------------------MEELQD--D----------YEDMMEE-------------NLEQEEY-----------------------------------------------------EDPDIPE-------SQMEEPAAHDTE-------------------------------------------------------------------------------------------------------------------------------------------------ATATDYHTTSH-----PGT-----------------------------------------HKVYVELQELVMDEKNQELRWMEAA------------------------RWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------------AGELEALGGVKPAVLTRS---------------------------------------------------------GDP--SQPLL---------------------------------------------------------------PQ---------------------HSSLETQLFCEQGDGGT--------------EGHSPSGI------------LEKIPPDSEATLV----------LVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFLFVLLGP--EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRR--YQSSPAKP-----------DSSFYKGLDLNGG-----------------------------P-----DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAF------SPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY---------------------------N-------YNVLMVP-------------------------------KPQGP--------LPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRS--EFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGA-AAQIQEVKEQRISGLLVAVLVGLSILMEPI-LSRIPLAVLFGIFLYMGVTSLSGIQ----------------LFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTP---ASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKAT----FDEEEGRDEYDE-----------------------VAMPV--------------------------------------------------------
SLC4A10   MEIKDQGAQM------EP----------LLPTRNDEEAVVD-RGGTRSILKTH-----------------FEKEDLEGHRTLFIGVHVPLGGR-----KSHRRHRHRGHKHRKRD---------------------------------RERDSGL-EDGRES------PSFDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTELDEICWR-EGEDAEWRETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNA-----------------------------------------------------------------------------------------------------------------------------GQVVSPQSAPAC-VENK---------NDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQER----EVDLHFMKKIPPGAEASNI----------LVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGP--LGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKI------PAVPNGTAAHGEAEPH----------GGHSG---------------------------------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAF------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRE-------SNISASDII------WENL-TVSECKS--------LHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPTRDD-RGWFVTPLGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFILMGSSVFMTSI-LKFIPMPVLYGVFLYMGASSLKGIQ----------------FFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSR---AAIVFPMMVLALVFVRK-LMDLLFTKRELSWLDDLMPESK-KKKLEDAEK--EEEQ---SMLAMEDEGTVQLPLEGHY----------------RDDPSV-INIS--DEMSKTALWRNLLITADNSKDKESSFPSKSSPS
SLC4A11   MG------------VYGPQ------------DRSESEK-RD-------------VQRDPPPW--------HPRREGE------------------RPARARSLPLAAAGQGFLRK-TW---------------------------ISEHENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDE------AFDTANS--------------------------------------------------------------------------------------------------------------------------------------SIVSGE-----------------------SIRFFVNVNL-----EMQATNTENEATSGGCVLL------------HTSRKYLKLKNFKEE--------------IRAHRDLDGFLAQASIVLNETATSL----------------------DNVLRTMLRRFARDPDN-------------------------------------------------------------------------------------------NEP--------------------------------------------------------------------------------------------NCNLDLLMAMLFT--------------DAGAPMRGK--------VHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWG---ENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEP---------------------------------------------------------------PK----CKDFVPFGK---GIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLD-DYHTKRTSSLVSL-SGLGASLNASLH------------------TALNASFLASPTELPS----------ATHSGQA----------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSH--GFREIEM---SKFRYNPSE------SPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQ----------------LVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAEHR------------------------------------------P---------------------------------------------------------
SLC4A2    MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEE--DELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRR----------RPGASPTGETPTIEE-------GEEDEDEASEAEGARAL----TQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPA------PLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPL-PKAQPGHRSYNLQER----RRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK-----PHEVFVELNELLLD-KNQEPQWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHHHGQGAES----------------------------------------------------------DPHVTEPLMG---------------------------------------------------------G---VP--------------------------ETRLEVERERELP--------------PPAPPAGIT-RSKSKHELKLLEKIPENAEATVV----------LVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP--SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKR--EEQGRLLPTGAGLEPKSAQDKALLQMVEAAGA-----------------------------AE----DDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDAL------DPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS---------------------------A-------SNSSEVDGG--ENMTWAGA-RPTLGPGNRSLAGQSGQGKPRGQ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKS--PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPLAVLFGIFLYMGVTSLNGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPV----FDEREGVDEYNE-----------------------MPMPV--------------------------------------------------------
SLC4A3    MANGVIPPPGGASPL--PQVRVPLEEPPLSPDVEEEDD--D-LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKR-----KKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEP----VEPPPSGTPQKAKFSIGSD-------EDDSPGLPGRAAVTKPLP--SVGPHTDKSPQHSSSSPSPRARASRLA---------GEKSRPWSPSA-----SYDLRERLCPGSALGNPGGPEQ----QVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLD-RSQEPHWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG---------------------------------------------------------PDG--AVPTMADDL------------------------------------------------------G---EPAPLWPH---------------DPDAKEKPL-------------------------HMPGGDGHRGKS---LKLLEKIPEDAEATVV----------LVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGP--SHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPGKEL--SLELGGSEAT--------------------------PE----DDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDAL------HSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYP-------------PEGALEGSLDAGLE-------PNGSALP--------------PTEGPP-----------SPRNQ---------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSAR--PFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSGIQ----------------LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPN----FDE-DGQDEYNE-----------------------LHMPV--------------------------------------------------------
SLC4A4    ---------------------------------MEDEAVLD-RGASFLKHV-------------------CDEEEVEGHHTIYIGVHVPKSYR-----RRRRHKRKTGHKEKKEK----------------------ER------ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEE--------DDSPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------PPQLFTELDELLAV-DGQEMEWKETA------------------------RWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTVSSASRMFTNP----------------------------------------------------------DN--GSPAMTHR-----------------------------------------------------------NLTSSSLN------------------------DISD----------------------KPEKDQ------LKNKFMKKLPRDAEASNV----------LVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGP--KGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDT-----PHD----------GGHGGGGHGDC---------------------------EELQRTGRFCGGLIKDIKRKAPFFASDFYDAL------NIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPP-DPANISISNDTT-LAPEYLPTMSSTDMYHNTTFDWAFL-SKKECSK--------YGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN-----PWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGE-QPKFLGVREQRVTGTLVFILTGLSVFMAPI-LKFIPMPVLYGVFLYMGVASLNGVQ----------------FMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTV---AAIIFPVMILALVAVRK-GMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPS-----IKIPMDIMEQQPFLSDSKPSD--------------------------RERSPTFLERHTSC
SLC4A5    MK------------------------------VKEEKA-----GVGKLDHTNHR-------------RRFPDQKECP---PIHIGLPVP-TYP-----QRKTDQK--GHLSGLQKVHWGLR---------------PDQ------PQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEE--------DEAPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLFTEMDTLQH--DGDQMEWKESA------------------------RWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARS----------------------------------------------------------PG--AGPSLHHST--------------------------------EDL-------RMRQSANY----GRLCHAQSRSMN------------------------DISL----------------------TPNTDQ------RKNKFMKKIPKDSEASNV----------LVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGP--SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPG----------GGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGF------HIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAP-DTVNTTVFNASAPLAPD--TNASLYNLLNLTALDWSLL-SKKECLS--------YGGRLLGNSCK----FIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACF-GLETPKLHVPSVIKPTRPD-RGWFVAPFGKN-----PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGE-QPQFLGVREQRVTGIIVFILTGISVFLAPI-LKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTV---AAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDNILPEKE--KKETDKKRKRKKGA------HEDCDEEPQFPPPS--VIKIPMESVQ-------SDPQNGIHCI--------------------ARKRSSSWSYSL---
SLC4A7    ME-RFRLEKK------LP--------------GPDEEAVVD-LGKTSSTVNTK-----------------FEKEELESHRAVYIGVHVPF-SK-----ESRRRHRHRGHKHHHRR---------------------------------RKDKESDKEDGRES------PSYDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTEMDELCYR-DGEEYEWKETA------------------------RWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPP--SSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGN-LDNSKSGEIKGNGSGGSRENSTVDFSK----------------------------------VDMNFMRKIPTGAEASNV----------LVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGP--AGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKI------PVFHNGSTPTLGETPKE--------AAHHAG---------------------------------PELQRTGRLFGGLILDIKRKAPFFLSDFKDAL------SLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKK-------DNITAHNIS------WRNL-TVSECKK--------LRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV-GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN-----PWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGE-QPKFLGIREQRVTGLMIFILMGLSVFMTSV-LKFIPMPVLYGVFLYMGVSSLKGIQ----------------LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA---AAVVFPMMVLALVFVRK-LMDLCFTKRELSWLDDLMPESK-KKKEDDKKKKEKEEA---ERMLQDDDDTVHLPFEGGSLLQIPVKALK----YSPDKPVS-VKISFEDEPRKKYV------------DAETSL-------
SLC4A8    ---MPAAGSN------EPD-------GVLSYQRPDEEAVVD-QGGTSTILNIH-----------------YEKEELEGHRTLYVGVRMPL-GR-----QSHRHHRTHGQKHRRRG---------------------------------RGKGASQGEEGLEA------LAHDTPSQRVQFILGTE-------EDEEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHELFTELDEICMK-EGEDAEWKETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKH------------------------------------------------------------------------------------------------------------------------------GQTVSPQSVPTTNLEVK---------NGVNCEHSPVDLSK----------------------------------VDLHFMKKIPTGAEASNV----------LVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGP--VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKM------PGVPNGNVCHIEQEPH----------GGHSG---------------------------------PELQRTGRLFGGLVLDIKRKAPWYWSDYRDAL------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKD-------HNIVTAEVH------WANL-TVSECQE--------MHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSPKLQVPSVFKPTRDD-RGWIINPIGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFVLMGCSVFMTAI-LKFIPMPVLYGVFLYMGVSSLQGIQ----------------FFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASP---AAIVFPMMVLALVFVRK-VMDLCFSKRELSWLDDLMPESK-KKKLDDAKKKAKEEE---EAEKMLEIGGDKFPLESRKLLSSPGKNIS-----CRCDPSE-INIS--DEMPKTTVWKALSMNSGNAKEK-SLFN------
SLC4A9    MEMK----------------------------LPGQEG--------------------------------FEASSAP-----------------------------------------------------------------------RNIPSGELDSNPDPGTG---PSPDGPSDTESKELGVP-------KD------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLFIQLNELLG--WPQALEWRETGSSSASLLLDMGEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV--TRVES--LSPELRGQLQALLLQRPQHYNQT---------------------------------------------------------------------------------------TG--TRPCWGST-----------------------------------------------------------HPRKASDN------------------------------------------------EEAPLREQ------CQNPLRQKLPPGAEAGTV----------LAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGP--CMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLP----SQQREIRGPA-----VPRLTSAEDRHRHGPHAH--------------------------------SPELQRTGRLFGGLIQDVRRKVPWYPSDFLDAL------HLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS----SAYGCLCQYPGPGGNES--QWIR-TRPKDRDDIVSMDLG---LINASLL-PPPECTR--------QGGHPRGPGCH----TVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFKPTLPG-RGWLVSPFGAN-----PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGE-RPNFLGIREQRLTGLVVFILTGASIFLAPV-LKFIPMPVLYGIFLYMGVAALSSIQ----------------FTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTP---AAIIFPLMLLGLVGVRK-ALERVFSPQELLWLDELMPEEE---------------------------------------RSIPEKGLEPEHSFSGSDSED-------SELM--------------YQPKAPEINISVN--

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC4A4	24	F/I	0.000123274	rs200944017
--	SLC4A4	50	G/A	0.00156551	rs41265669
--	SLC4A4	174	R/W	0.00105825	rs149802590
--	SLC4A4	280	R/H	0.000103432	rs376230462
--	SLC4A4	424	G/D	0.00383519	rs148635969
	SLC4A4	454	A/V	0.000183006	rs138493429
	SLC4A4	567	I/V	0.000135573	rs761573966
	SLC4A4	602	K/R	0.00211416	rs72650362
--	SLC4A4	619	C/Y	0.000245026	rs548144688
--	SLC4A4	648	E/K	0.000736991	rs145378038
--	SLC4A4	680	N/K	0.00016746	rs201133749
	SLC4A4	682	V/I	0.000147543	rs773341183
	SLC4A4	684	N/I	0.00159871	rs35891845
	SLC4A4	748	V/A	0.000318487	rs148889712
--	SLC4A4	758	E/Q	0.00122251	rs140846842
--	SLC4A4	771	P/S	0.00149035	rs140882617
	SLC4A4	829	L/I	0.000346542	rs201643562
	SLC4A4	892	F/L	0.000889382	rs138942006
--	SLC4A4	1057	G/C	0.000124604	rs200777620
--	SLC4A4	1074	I/L	0.203869	rs1062677
--	SLC4A4	1074	I/M	0.000156914	rs199878909

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC4A4	SLC4A4 [plasma membrane]	Bicarbonate transporters

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
SLC4A4	SLC4A4 A799V [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 R298S [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 R510H [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 L522P [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 T485S [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 W516* [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 S427L [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 S982Nfs*4 [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
SLC4A4	SLC4A4 Q29* [plasma membrane]	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)