Detail Data SLC4A11

Basic description

Gene Name	SLC4A11
Protein Name	Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11)
Family	SLC4
Category	-
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890        900        910 
MGVYGPQDRS ESEKRDVQRD PPPWHPRREG ERPARARSLP LAAAGQGFLR KTWISEHENS PTMSQNGYFE DSSYYKCDTD DTFEAREEIL GDEAFDTANS SIVSGESIRF FVNVNLEMQA TNTENEATSG GCVLLHTSRK YLKLKNFKEE IRAHRDLDGF LAQASIVLNE TATSLDNVLR TMLRRFARDP DNNEPNCNLD LLMAMLFTDA GAPMRGKVHL LSDTIQGVTA TVTGVRYQQS WLCIICTMKA LQKRHVCISR LVRPQNWGEN SCEVRFVILV LAPPKMKSTK TAMEVARTFA TMFSDIAFRQ KLLETRTEEE FKEALVHQRQ LLTMVSHGPV APRTKERSTV SLPAHRHPEP PKCKDFVPFG KGIREDIARR FPLYPLDFTD GIIGKNKAVG KYITTTLFLY FACLLPTIAF GSLNDENTDG AIDVQKTIAG QSIGGLLYAL FSGQPLVILL TTAPLALYIQ VIRVICDDYD LDFNSFYAWT GLWNSFFLAL YAFFNLSLVM SLFKRSTEEI IALFISITFV LDAVKGTVKI FWKYYYGHYL DDYHTKRTSS LVSLSGLGAS LNASLHTALN ASFLASPTEL PSATHSGQAT AVLSLLIMLG TLWLGYTLYQ FKKSPYLHPC VREILSDCAL PIAVLAFSLI SSHGFREIEM SKFRYNPSES PFAMAQIQSL SLRAVSGAMG LGFLLSMLFF IEQNLVAALV NAPENRLVKG TAYHWDLLLL AIINTGLSLF GLPWIHAAYP HSPLHVRALA LVEERVENGH IYDTIVNVKE TRLTSLGASV LVGLSLLLLP VPLQWIPKPV LYGLFLYIAL TSLDGNQLVQ RVALLLKEQT AYPPTHYIRR VPQRKIHYFT GLQVLQLLLL CAFGMSSLPY MKMIFPLIMI AMIPIRYILL PRIIEAKYLD VMDAEHRP 
CCCCCCCCHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHCCCCCC CCCEECCCCC CCCCCCCCCC CCCCCCCCCC CCCHHCCHHC CCCCCCCCCC CCCCCCHHHH HHHCCHHHCC CCCCCCCCCC CEEEEEECCC CCCCCCHHHH HHHHHHHHHH HHHCHHHCCC CCCCHHHHHH HHHHHHHCCC CCCCCCCCHH HHHHHHCCCC CCCCCCCEEE CCCCCCCCCC CCCCCCCCEE EEEEEEECCH HHCCEEEEEE CCCCCCCCCC CCCEEEEEEE ECCCCCCCHH HHHHHHHHHH HHHCHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CEEEEECEEC CCHHHHHHHH HCCCCEEEEE CCCCHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHCHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC EECCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHCHH HHHHHHHHHH HHHCCCHHHC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHCCCC CCHHHHHHHH HHHHHCCHHH CCHHHHCCCC CCCCHHHHHH HHCCCCCCCC EEEEEEEEEC HHHHHHHHHH HHHHHHHCCC CCCCCCCHHH HCHHHHHHHH HHCCCCHHHH HHHHHHHCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHCCCCC

Family alignment

[Overview]

SLC4A1    --------------------------------MEELQD--D----------YEDMMEE-------------NLEQEEY-----------------------------------------------------EDPDIPE-------SQMEEPAAHDTE-------------------------------------------------------------------------------------------------------------------------------------------------ATATDYHTTSH-----PGT-----------------------------------------HKVYVELQELVMDEKNQELRWMEAA------------------------RWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------------AGELEALGGVKPAVLTRS---------------------------------------------------------GDP--SQPLL---------------------------------------------------------------PQ---------------------HSSLETQLFCEQGDGGT--------------EGHSPSGI------------LEKIPPDSEATLV----------LVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFLFVLLGP--EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRR--YQSSPAKP-----------DSSFYKGLDLNGG-----------------------------P-----DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAF------SPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY---------------------------N-------YNVLMVP-------------------------------KPQGP--------LPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRS--EFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGA-AAQIQEVKEQRISGLLVAVLVGLSILMEPI-LSRIPLAVLFGIFLYMGVTSLSGIQ----------------LFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTP---ASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKAT----FDEEEGRDEYDE-----------------------VAMPV--------------------------------------------------------
SLC4A10   MEIKDQGAQM------EP----------LLPTRNDEEAVVD-RGGTRSILKTH-----------------FEKEDLEGHRTLFIGVHVPLGGR-----KSHRRHRHRGHKHRKRD---------------------------------RERDSGL-EDGRES------PSFDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTELDEICWR-EGEDAEWRETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNA-----------------------------------------------------------------------------------------------------------------------------GQVVSPQSAPAC-VENK---------NDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQER----EVDLHFMKKIPPGAEASNI----------LVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGP--LGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKI------PAVPNGTAAHGEAEPH----------GGHSG---------------------------------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAF------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRE-------SNISASDII------WENL-TVSECKS--------LHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPTRDD-RGWFVTPLGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFILMGSSVFMTSI-LKFIPMPVLYGVFLYMGASSLKGIQ----------------FFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSR---AAIVFPMMVLALVFVRK-LMDLLFTKRELSWLDDLMPESK-KKKLEDAEK--EEEQ---SMLAMEDEGTVQLPLEGHY----------------RDDPSV-INIS--DEMSKTALWRNLLITADNSKDKESSFPSKSSPS
SLC4A11   MG------------VYGPQ------------DRSESEK-RD-------------VQRDPPPW--------HPRREGE------------------RPARARSLPLAAAGQGFLRK-TW---------------------------ISEHENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDE------AFDTANS--------------------------------------------------------------------------------------------------------------------------------------SIVSGE-----------------------SIRFFVNVNL-----EMQATNTENEATSGGCVLL------------HTSRKYLKLKNFKEE--------------IRAHRDLDGFLAQASIVLNETATSL----------------------DNVLRTMLRRFARDPDN-------------------------------------------------------------------------------------------NEP--------------------------------------------------------------------------------------------NCNLDLLMAMLFT--------------DAGAPMRGK--------VHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWG---ENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEP---------------------------------------------------------------PK----CKDFVPFGK---GIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLD-DYHTKRTSSLVSL-SGLGASLNASLH------------------TALNASFLASPTELPS----------ATHSGQA----------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSH--GFREIEM---SKFRYNPSE------SPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQ----------------LVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAEHR------------------------------------------P---------------------------------------------------------
SLC4A2    MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEE--DELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRR----------RPGASPTGETPTIEE-------GEEDEDEASEAEGARAL----TQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPA------PLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPL-PKAQPGHRSYNLQER----RRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK-----PHEVFVELNELLLD-KNQEPQWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHHHGQGAES----------------------------------------------------------DPHVTEPLMG---------------------------------------------------------G---VP--------------------------ETRLEVERERELP--------------PPAPPAGIT-RSKSKHELKLLEKIPENAEATVV----------LVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP--SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKR--EEQGRLLPTGAGLEPKSAQDKALLQMVEAAGA-----------------------------AE----DDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDAL------DPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS---------------------------A-------SNSSEVDGG--ENMTWAGA-RPTLGPGNRSLAGQSGQGKPRGQ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKS--PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPLAVLFGIFLYMGVTSLNGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPV----FDEREGVDEYNE-----------------------MPMPV--------------------------------------------------------
SLC4A3    MANGVIPPPGGASPL--PQVRVPLEEPPLSPDVEEEDD--D-LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKR-----KKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEP----VEPPPSGTPQKAKFSIGSD-------EDDSPGLPGRAAVTKPLP--SVGPHTDKSPQHSSSSPSPRARASRLA---------GEKSRPWSPSA-----SYDLRERLCPGSALGNPGGPEQ----QVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLD-RSQEPHWRETA------------------------RWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG---------------------------------------------------------PDG--AVPTMADDL------------------------------------------------------G---EPAPLWPH---------------DPDAKEKPL-------------------------HMPGGDGHRGKS---LKLLEKIPEDAEATVV----------LVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGP--SHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPGKEL--SLELGGSEAT--------------------------PE----DDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDAL------HSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYP-------------PEGALEGSLDAGLE-------PNGSALP--------------PTEGPP-----------SPRNQ---------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSAR--PFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSGIQ----------------LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPN----FDE-DGQDEYNE-----------------------LHMPV--------------------------------------------------------
SLC4A4    ---------------------------------MEDEAVLD-RGASFLKHV-------------------CDEEEVEGHHTIYIGVHVPKSYR-----RRRRHKRKTGHKEKKEK----------------------ER------ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEE--------DDSPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------PPQLFTELDELLAV-DGQEMEWKETA------------------------RWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTVSSASRMFTNP----------------------------------------------------------DN--GSPAMTHR-----------------------------------------------------------NLTSSSLN------------------------DISD----------------------KPEKDQ------LKNKFMKKLPRDAEASNV----------LVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGP--KGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDT-----PHD----------GGHGGGGHGDC---------------------------EELQRTGRFCGGLIKDIKRKAPFFASDFYDAL------NIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPP-DPANISISNDTT-LAPEYLPTMSSTDMYHNTTFDWAFL-SKKECSK--------YGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN-----PWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGE-QPKFLGVREQRVTGTLVFILTGLSVFMAPI-LKFIPMPVLYGVFLYMGVASLNGVQ----------------FMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTV---AAIIFPVMILALVAVRK-GMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPS-----IKIPMDIMEQQPFLSDSKPSD--------------------------RERSPTFLERHTSC
SLC4A5    MK------------------------------VKEEKA-----GVGKLDHTNHR-------------RRFPDQKECP---PIHIGLPVP-TYP-----QRKTDQK--GHLSGLQKVHWGLR---------------PDQ------PQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEE--------DEAPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLFTEMDTLQH--DGDQMEWKESA------------------------RWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARS----------------------------------------------------------PG--AGPSLHHST--------------------------------EDL-------RMRQSANY----GRLCHAQSRSMN------------------------DISL----------------------TPNTDQ------RKNKFMKKIPKDSEASNV----------LVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGP--SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPG----------GGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGF------HIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAP-DTVNTTVFNASAPLAPD--TNASLYNLLNLTALDWSLL-SKKECLS--------YGGRLLGNSCK----FIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACF-GLETPKLHVPSVIKPTRPD-RGWFVAPFGKN-----PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGE-QPQFLGVREQRVTGIIVFILTGISVFLAPI-LKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTV---AAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDNILPEKE--KKETDKKRKRKKGA------HEDCDEEPQFPPPS--VIKIPMESVQ-------SDPQNGIHCI--------------------ARKRSSSWSYSL---
SLC4A7    ME-RFRLEKK------LP--------------GPDEEAVVD-LGKTSSTVNTK-----------------FEKEELESHRAVYIGVHVPF-SK-----ESRRRHRHRGHKHHHRR---------------------------------RKDKESDKEDGRES------PSYDTPSQRVQFILGTED------DDEEHI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLFTEMDELCYR-DGEEYEWKETA------------------------RWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPP--SSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGN-LDNSKSGEIKGNGSGGSRENSTVDFSK----------------------------------VDMNFMRKIPTGAEASNV----------LVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGP--AGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKI------PVFHNGSTPTLGETPKE--------AAHHAG---------------------------------PELQRTGRLFGGLILDIKRKAPFFLSDFKDAL------SLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKK-------DNITAHNIS------WRNL-TVSECKK--------LRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV-GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN-----PWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGE-QPKFLGIREQRVTGLMIFILMGLSVFMTSV-LKFIPMPVLYGVFLYMGVSSLKGIQ----------------LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA---AAVVFPMMVLALVFVRK-LMDLCFTKRELSWLDDLMPESK-KKKEDDKKKKEKEEA---ERMLQDDDDTVHLPFEGGSLLQIPVKALK----YSPDKPVS-VKISFEDEPRKKYV------------DAETSL-------
SLC4A8    ---MPAAGSN------EPD-------GVLSYQRPDEEAVVD-QGGTSTILNIH-----------------YEKEELEGHRTLYVGVRMPL-GR-----QSHRHHRTHGQKHRRRG---------------------------------RGKGASQGEEGLEA------LAHDTPSQRVQFILGTE-------EDEEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------PHELFTELDEICMK-EGEDAEWKETA------------------------RWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKH------------------------------------------------------------------------------------------------------------------------------GQTVSPQSVPTTNLEVK---------NGVNCEHSPVDLSK----------------------------------VDLHFMKKIPTGAEASNV----------LVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGP--VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKM------PGVPNGNVCHIEQEPH----------GGHSG---------------------------------PELQRTGRLFGGLVLDIKRKAPWYWSDYRDAL------SLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKD-------HNIVTAEVH------WANL-TVSECQE--------MHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSPKLQVPSVFKPTRDD-RGWIINPIGPN-----PWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGE-QPKFLGIREQRVTGLMIFVLMGCSVFMTAI-LKFIPMPVLYGVFLYMGVSSLQGIQ----------------FFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASP---AAIVFPMMVLALVFVRK-VMDLCFSKRELSWLDDLMPESK-KKKLDDAKKKAKEEE---EAEKMLEIGGDKFPLESRKLLSSPGKNIS-----CRCDPSE-INIS--DEMPKTTVWKALSMNSGNAKEK-SLFN------
SLC4A9    MEMK----------------------------LPGQEG--------------------------------FEASSAP-----------------------------------------------------------------------RNIPSGELDSNPDPGTG---PSPDGPSDTESKELGVP-------KD------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLFIQLNELLG--WPQALEWRETGSSSASLLLDMGEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV--TRVES--LSPELRGQLQALLLQRPQHYNQT---------------------------------------------------------------------------------------TG--TRPCWGST-----------------------------------------------------------HPRKASDN------------------------------------------------EEAPLREQ------CQNPLRQKLPPGAEAGTV----------LAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGP--CMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLP----SQQREIRGPA-----VPRLTSAEDRHRHGPHAH--------------------------------SPELQRTGRLFGGLIQDVRRKVPWYPSDFLDAL------HLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS----SAYGCLCQYPGPGGNES--QWIR-TRPKDRDDIVSMDLG---LINASLL-PPPECTR--------QGGHPRGPGCH----TVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFKPTLPG-RGWLVSPFGAN-----PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGE-RPNFLGIREQRLTGLVVFILTGASIFLAPV-LKFIPMPVLYGIFLYMGVAALSSIQ----------------FTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTP---AAIIFPLMLLGLVGVRK-ALERVFSPQELLWLDELMPEEE---------------------------------------RSIPEKGLEPEHSFSGSDSED-------SELM--------------YQPKAPEINISVN--

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC4A11	7	R/W	0.000382111	rs200343026
--	SLC4A11	26	P/R	0.601429	rs3810562
--	SLC4A11	29	E/D	0.000127826	rs529397954
--	SLC4A11	37	R/W	0.000309573	rs182446041
--	SLC4A11	50	R/G	0.0723019	rs79057061
--	SLC4A11	109	R/L	0.000119311	rs200106947
--	SLC4A11	118	M/V	0.000123299	rs200940928
--	SLC4A11	127	A/V	0.000330177	rs145115400
--	SLC4A11	151	I/V	0.000103558	rs773078769
--	SLC4A11	159	G/S	0.000119395	rs201619917
--	SLC4A11	177	N/S	0.00308379	rs34520315
--	SLC4A11	184	R/H	0.000127335	rs146233650
--	SLC4A11	194	E/D	0.000401821	rs141836046
--	SLC4A11	215	R/P	0.000123476	rs149016022
--	SLC4A11	215	R/Q	0.000585517	rs149016022
--	SLC4A11	338	G/S	0.000167082	rs146274937
--	SLC4A11	341	A/V	0.00138428	rs141705330
--	SLC4A11	344	T/M	0.000135249	rs139941321
--	SLC4A11	349	T/A	0.000107423	rs144285319
--	SLC4A11	374	R/Q	0.000568738	rs112163941
--	SLC4A11	374	R/W	0.00112159	rs138137682
--	SLC4A11	602	V/M	0.000128933	rs144734280
--	SLC4A11	610	G/D	0.000248706	rs139078082
--	SLC4A11	646	A/T	0.00041875	rs138262189
--	SLC4A11	769	G/R	0.000319107	rs143965185
--	SLC4A11	772	Y/C	0.000115671	rs140689149
--	SLC4A11	861	G/S	0.000151318	rs144586846
--	SLC4A11	875	M/I	0.00249779	rs34224785

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
No data

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data