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Basic
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Variant
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Pathway
Disease

Detail Data SLC39A9


Basic description
Gene Name SLC39A9
Protein Name Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9)
Family SLC39
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300 
MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIVPEGVH ALYEDILEGK HHQASETHNV IASDKAAEKS VVHEHEHSHD HTQLHAYIGV SLVLGFVFML LVDQIGNSHV HSTDDPEAAR SSNSKITTTL GLVVHAAADG VALGAAASTS QTSVQLIVFV AIMLHKAPAA FGLVSFLMHA GLERNRIRKH LLVFALAAPV MSMVTYLGLS KSSKEALSEV NATGVAMLFS AGTFLYVATV HVLPEVGGIG HSHKPDATGG RGLSRLEVAA LVLGCLIPLI LSVGHQH 
CCHHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCEECC EEECCCHHHH HCCCCCCCCC CCCCCCCHHC CCCHHHHHHH HHHHHHCCCC CCHHHHHHCC CHHHHHHHHH HHHHHHCCHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHCCCCC
[Overview] SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 
SLC39A1   ------------------------------------------------------------------MGP-------------------------------------WGEPELLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WRPEAVASEPPV---------------------------------------------------------------------------------------------------------------PV--------------------------------------------------------------------------------GLEVKLGALVLLLVLTLLCSLVPICV----LRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYL--------AAIDE-----------------ALAALHVT------------------------LQFPLQEFILAMGFFLVLVM-------EQITLAY-----------KEQSGPS-----------PLEETRALLGTVNGG----------PQHW-------------------HDGPGVPQAS--------------GAPA-------------------------------------------------------------------TPSALRACVLVFSLALHSVFEGLAVG-----LQRDRAR-AME----LCLALLLHKGILAVSLSLRLLQSHLR---AQVVAGCGILFSCMTPL-GIGLGAAL--AESAGPLH--QLAQSVLE---GMAAGTFLYITFLEILPQE---LASSEQ-----------RILKVILLLAGFALLTGLLFIQI------------
SLC39A10  ----MKVHMHT------------KFCLIC----LLTFIFHHCNHCHEEHDHG-PEALHRQHRGMTELEP---SKFSKQAAENEKKYYIEKLFERYGENG----RLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHL----DILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVS-------TKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKT---------QEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPD---RVHNPGHSHVHLPER-NGHDPGRGH-QDLDPDNEGELRHTRK--RE-------APHVKNNAIISLRKDL----NEDDHHHE--------------------------CLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGAS-AWICGIISITVISLLSLLGVI----LVPII-------------N-QGCFKFLLTFLVALAVGTMSGDALLHLLPHSQ---------GGHDHS------------------HQHAH-----GHGHSHGHESNKFLEE---YDAVLKGLVALGGIYLLFII-------EHCIR-MFKHYKQQRGK-QKWFMKQNTEESTIGRKLSDHKLNNTP---DSDWLQLKPL-AGTDDSVVSEDRLNETELT----DLEGQQESPPKN--YLCIEEEKIIDHSHSDGLHTIH-----EHDLHAAAHN----------HHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIG---AAFSAGLTG-GIS----TSIAVFCHELPHELGDFAVLLKAGMT---VKQAIVYNLLSAMMAYI-GMLIGTAV--G---------QYANNITLWIFAVTAGMFLYVALVDMLPEM---LHGDGDNEEHGFCPVGQFILQNLGLLFGFAIML---VIALYEDKIVFDIQF-
SLC39A11  ---------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGHSSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQALLGTFFTWGMTAAGAALVFVFS---------------SGQRRILDGSLGFAAGVMLAASYWSLLAPAV--------EMATSSGGF------------GAFAFFPVA------------------------VGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGST------LMKKKSDPEGPALLFPESELSIRIGRA--GLLSDKS-------ENGEAYQR---KKA--AAT----GLPEGPAVPVPSRGNL----------AQPG-------------------------------------------------------------------GSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA-TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFS---TWRAFWYGQLSGMVEPLAGVFGAFAVV------------LAEPILPYALAFAAGAMVYVVMDDIIPEA---QISGNG-----------KLASWASIL-GFVVMMSL-DVGLG-----------
SLC39A12  --MCFRTKLSVS-----------WVPLFL----LLSRVFST--------ETDKPSAQDSRSRGSS-GQP-------------------ADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRN--------GMQGDCNLCFEPDALLLIAGGNFED----------QLREEVVQRVSLLLLYYIIHQEEIC------------SSKLNMSNKEYKF----YLH-------------SLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGA-------------------NESTLPQLAAMIITLSLQGVCLGQG-NLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQ---NNIITHDQDYSNFSS----SMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSC---------HLPKDQQAKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTA----LVLFH-------------SCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---------GLHKQEA-------------PEFGHFHESK----------GH--------------IWKLMGLIGGIHGFFLI-------EKCFI-LLVSPNDKQGLSLV----------------------------NGHVGHSHHL-ALNSELSDQAGRGKSASTI----QLKSPEDSQAA---------EMPIG---------------------------------------------------------------SMTASNRKCKAISLLAIMILVGDSLHNFADGLAIG---AAFSSSSES-GVT----TTIAILCHEIPHEMGDFAVLLSSGLS---MKTAILMNFISSLTAFM-GLYIGLSV--S----------ADPCVQDWIFTVTAGMFLYLSLVEMLPEM---THVQTQ------RPWMMFLLQNFGLILGWLSLL---LLAIYEQNIKI-----
SLC39A13  ----------------------------------------------------MPGCP---CPGCGMAGPR---------------------------------LLFLTALALELLGRAGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQP---------------------------ALRSRGTAT-----------------------------------------------ACRLDNKES--------------------------------------ESWGALLSGERLDT---------------------------------------------WICSLLGSLMVGLSGVFPLL----VIPLEM-------GTMLRSEAGAWR--LKQLLSFALGGLLGNVFLHLLPEAW------------AYTCS----------ASPG------GE----------GQSLQ---------QQQQLGLWVIAGILTFLAL-------EKMF-------------------------------LDSKEEGTSQ--------------APNKDPTAAAAALNGGHCL-------AQPAAEPG-----------------------------------------LGAVV----------------------------------------RSIKVSGYLNLLANTIDNFTHGLAVA---ASFLVSKKI-GLL----TTMAILLHEIPHEVGDFAILLRAGFD---RWSAAKLQLSTALGGLL-GAGFAICT--QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL---LEEEDP---------WRSLQQLLLLCAGIVVMV---LFSLFVD---------
SLC39A14  ---MKLLLLHP------------AFQSCL----LLTLL------------------------GLWRTTP-EAHASSLGAPAISAASFLQDLIHRYGEGD----SLTLQQLKALLNHLDVGVGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVTQHVQGH-RNLST----------------------------------------------------------------------------CFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQE---NEENEQTEEGRPSAVEV-----WGYGLLCVTVISLCSLLGAS----VVPFM-------------K-KTFYKRLLLYFIALAIGTLYSNALFQLIPEAF---------GFNPLE------------------DYYVS-----------------------------KSAVVFGGFYLFFFT-------EKILKILLKQKNEH----HH--GHSHYASESL-PSKKDQEEGVMEKLQNGDLDHMIPQHCSSE--LDGKAPMVDEKVIVGSLSVQDLQASQSA-----------------------------------------------------------------------------CYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIG---ASFTVSVFQ-GIS----TSVAILCEEFPHELGDFVILLNAGMS---IQQALFFNFLSACCCYL-GLAFGILA--GS--------HFSAN---WIFALAGGMFLYISLADMFPEMNEVCQED----ERKGSILIPFIIQNLGLLTGFTIMV---VLTMYSGQIQIG----
SLC39A2   -------------------------------------------------------------------------------------------------------------MEQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHH------RLVLRLLGCISAGVFLGAGFMHMTAEAL--------EEIES-----------------QIQKFMVQN-RSASERNSSGDADS------AHMEYPYGELIISLGFFFVFFL-------ESLAL---------------QCCP---------------------GAAGGST-------VQDEEW-----GGA--HIF----ELHSHGHLPSPS--------------KGP------------------------------------------------------------------------LRALVLLLSLSFHSVFEGLAVG-----LQPTVAA-TVQ----LCLAVLAHKGLVVFGVGMRLVHLGTS---SRWAVFSILLLALMSPL-GLAVGLAVTGGDSEGG-R--GLAQAVLE---GVAAGTFLYVTFLEILPRE---LASPEA-----------PLAKWSCVAAGFAFMA---FIALWA----------
SLC39A3   -------------------------------------------------------------------------------------------------------------MVKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAKILCMVGVFFFMLLGSLLPVKI--IETDFEKAHRS-----KKILSLCNTFGGGVFLATCFNALLPAVR--------EKLQK-----------------VLSLGHIS------------------------TDYPLAETILLLGFFMTVFL-------EQLILTF-----------R-KEKPSF---------IDLETFNA--GSDVGS----------DSEYESPFMGGARGHAL----YVEPHGHGPSLSVQGLS--------RASP------------------------------------------------------------------------VRLLSLAFALSAHSVFEGLALG-----LQEEGEK-VVS----LFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPL-GIGLGLGI--ESAQGVPG--SVASVLLQ---GLAGGTFLFITFLEILAKE---LEEKSD-----------RLLKVLFLVLGYTVLAGMVFLKW------------
SLC39A4   --MVDVVGLERETGPRGSPWPGLPLPSLVGPAPLLTCLCPQCLSVEDALGLGEPE-------GSG-LPP----------GPVLEARYVA--------------RLSAAAVLYLSNPEGTCEDARAGLWAS-------------------------HA----------------------------------------------------------------------DHLLALLESPKALTPGLSWLLQRMQARAAGQT---------PKTACVDIPQLLEEAVGAGA------------PGSAGG------------VLAALLDHVRSGSCFH---ALPSPQYFVDFVFQQHSSEVPMTLAELSAL------------------MQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSV-WDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACT--------------SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLL----LLTCT-------------GCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVL---------GLHTHS------------------EEGLSP------------------------QPTWRLLAMLAGLYAFFLF-------ENLFNLLLPR------------DPEDLEDGPCGHSSHSHGGHS-----HGVSLQLAPS------------------------ELRQPKPPHEGSRADLVAEESPELLNPEPRRLS----P------------------------------------------------------------ELRLLPYMITLGDAVHNFADGLAVG---AAFASSWKT-GLA----TSLAVFCHELPHELGDFAALLHAGLS---VRQALLLNLASALTAFA-GLYVALAV--G----------VSEESEAWILAVATGLFLYVALCDMLPAM---LKVRDP------RPWLLFLLHNVGLLGGWTVLL---LLSLYEDDITF-----
SLC39A5   MMGSPVSHLLA------------GFCVWV----VLGWV-----------GGSVPN-----------LGP----------AEQEQNHYLAQLFGLYGENG----TLTAGGLARLLHSLGLGRVQGLRLGQ--------------------------HG---------------PLTG-------------------------------------------------------------RAASPAADNSTHR--------------------------PQNPELSVDVWAGM----------PLGPSGWGDLEE---------------SKAPHLP---RGPAPSG---LDL-----------------------------------LHRLLLLDHSLADHLNE-------------------------DCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCI--------------GAPAPAPPGDL-LS-ALLQSALAVLLLSLPSPLSLL----LLRLL-------------G-PRLLRPLLGFLGALAVGTLCGDALLHLLPHAQ---------EG-----------------------RHAGP----------GGLPEKDLGP---------GLSVLGGLFLLFVL-------ENMLG-LLRHRGLRPRCCRR--KRRNLETRNLDPE-------------NGSGMALQPLQAAPEPGAQGQREKNSQHPP----AL-----APPG------------------------------------------------------------------HQGHSHGHQ------------GGTDITWMVLLGDGLHNLTDGLAIG---AAFSDGFSS-GLS----TTLAVFCHELPHELGDFAMLLQSGLS---FRRLLLLSLVSGALGLG-GAVLGVGL--S---------LGPVPLTPWVFGVTAGVFLYVALVDMLPAL---LRPPEP------LPTPHVLLQGLGLLLGGGLML---AITLLEERLLPVTTEG
SLC39A6   --------MAR------------KLSVIL----ILTFALSVTNPLHELKAAAFPQTTEK-------ISPNWESGINVDLAISTRQYHLQQLFYRYGENN----SLSVEGFRKLLQNIGIDKIKRIHIHHD---HDH-------------------HS-DHEHHSDH---------------------ERH--------------SDHEHHSDHEHHSDHDHHSHH--NHAASGKNKRKALCPDHDSDSSG---------------------------KDPRNSQGKGAHR----------PEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL-------AGRKTNESVSEPRKGFMYSRNTNENPQE--------------------------CFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIH--------TSEKKAEIPPKTYSL-QI-AWVGGFIAISIISFLSLLGVI----LVPLM-------------N-RVFFKFLLSFLVALAVGTLSGDAFLHLLPHSH---------ASHHHS------------------HSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLV-------EHVLT-LIKQFKDKKKKNQK--KPENDDDVEIKKQLSKYESQLST---NEEKVD-------TDDRTEGYLRADSQEPS----HFDSQQPA-------VLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQR---YSREELKDAGVATLAWMVIMGDGLHNFSDGLAIG---AAFTEGLSS-GLS----TSVAVFCHELPHELGDFAVLLKAGMT---VKQAVLYNALSAMLAYL-GMATGIFI--G---------HYAENVSMWIFALTAGLFMYVALVDMVPEM---LHNDA--SDHGCSRWGYFFLQNAGMLLGFGIML---LISIFEHKIVFRINF-
SLC39A7   -------------------------------------------------------------MARGLGAPHWVA----------------------------VGLLTWATLGLLVAGLGGHDDLHDDLQED------------------------FHGHSHRHSHED-------------------FHHGH---------------SHAHGHGHTHESIWHGHTHDH-DHGHSHED---------------------------------------------------------------LHHGHSHGYSHE---------------------------SLYHRGHGH---------------------------------------------------DHEHSHGG---------------------------------YGES-GAPGIKQDLDAVT------------------------------------------LWAYALGATVLISAAPFFVLF----LIPVE-------------SNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL---------EPHSHHTL----------EQPGHGHSHSGQ----------GPIL-------------SVGLWVLSGIVAFLVV-------EKFVRHVKGGHGHSHGHGHA-HSHTRGSHGHGRQERSTKEKQSSE--------------EEEKE-TRGVQKRRGGSTVPKDGPVRPQNAEEEK-----------------------------------------RGL-------------------------------------------DLRVSGYLNLAADLAHNFTDGLAIG---ASFRGGRGL-GIL----TTMTVLLHEVPHEVGDFAILVQSGCS---KKQAMRLQLLTAVGALA-GTACALLT--EG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL---LREASP---------LQSLLEVLGLLGGVIMMV---LIAHLE----------
SLC39A8   --------MAPG----------RAVAGLL----LLAAA------------------------GLG------------GVAEGPGLAFSEDVLSVFGANL----SLSAAQLQHLLEQMG-AASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEPGQLH-FN--Q----------------------------------------------------------------------------CLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPC-----------EDRPKHKTRPSHSEV-----WGYGFLSVTIINLASLLGLI----LTPLI-------------K-KSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF---------GFDPKV------------------DSYVE-----------------------------KAVAVFGGFYLLFFF-------ERMLKMLLKTYGQ------N--GHTHFGNDNFGPQEKTHQPKALPAI-NGVTCYANP--AVTE--ANGHIHFDNVSVV----SLQDGKKEPSS-----------------------------------------------------------------------------CTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIG---ASCTLSLLQ-GLS----TSIAILCEEFPHELGDFVILLNAGMS---TRQALLFNFLSACSCYV-GLAFGILV--GN--------NFAPN---IIFALAGGMFLYISLADMFPEMNDMLREKV--TGRKTDFTF-FMIQNAGMLTGFTAIL---LITLYAGEIELE----
SLC39A9   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDFISISLLSLAMLVGCYV-AGIIPLA---------------VNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHS---------HDHTQ----------LHAYIGVSLVLGFVFMLLV-------DQIGN-----------------SHVH--------------------------------------------------------STDDPEAARSSN-------------------------------------------------------------------------------------SKITT-----TLGLVVHAAADGVALG---AAASTSQTSVQLI----VFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSM-VTYLGLSK--SSKEA-----LSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKP---DATGGRGLSRLEVAALVLGCLIPL---ILSVGHQH--------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC39A9 64 E/D 0.000405938 rs2296723
-- SLC39A9 95 H/L 0.00125279 rs199978769
-- SLC39A9 153 V/I 0.000357907 rs77585484
-- SLC39A9 221 M/T 0.00988666 rs2232059
-- SLC39A9 282 G/A 0.000441657 rs2232061

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data