Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC39A8


Basic description
Gene Name SLC39A8
Protein Name Zinc transporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)
Family SLC39
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460 
MAPGRAVAGL LLLAAAGLGG VAEGPGLAFS EDVLSVFGAN LSLSAAQLQH LLEQMGAASR VGVPEPGQLH FNQCLTAEEI FSLHGFSNAT QITSSKFSVI CPAVLQQLNF HPCEDRPKHK TRPSHSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTFFVGLAI GTLFSNAIFQ LIPEAFGFDP KVDSYVEKAV AVFGGFYLLF FFERMLKMLL KTYGQNGHTH FGNDNFGPQE KTHQPKALPA INGVTCYANP AVTEANGHIH FDNVSVVSLQ DGKKEPSSCT CLKGPKLSEI GTIAWMITLC DALHNFIDGL AIGASCTLSL LQGLSTSIAI LCEEFPHELG DFVILLNAGM STRQALLFNF LSACSCYVGL AFGILVGNNF APNIIFALAG GMFLYISLAD MFPEMNDMLR EKVTGRKTDF TFFMIQNAGM LTGFTAILLI TLYAGEIELE  
CCHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHCCC CCCCHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCHHHH HHHCCCCCCC CCCHHHHHHH CHHHHHHHHC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC HHCHHHHHHH HHHHHHHHHH HCHHHHCCCC CCCHHHHHHH HHHCCCCHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCE EECCCEECCC CCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHCCCC HHHHHHHCCH HHHHHHHHHH HHHCCCCCCC HHHHHHHHCH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHHHHH HCHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHCHHCCCC
[Overview] SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 
SLC39A1   ------------------------------------------------------------------MGP-------------------------------------WGEPELLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WRPEAVASEPPV---------------------------------------------------------------------------------------------------------------PV--------------------------------------------------------------------------------GLEVKLGALVLLLVLTLLCSLVPICV----LRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYL--------AAIDE-----------------ALAALHVT------------------------LQFPLQEFILAMGFFLVLVM-------EQITLAY-----------KEQSGPS-----------PLEETRALLGTVNGG----------PQHW-------------------HDGPGVPQAS--------------GAPA-------------------------------------------------------------------TPSALRACVLVFSLALHSVFEGLAVG-----LQRDRAR-AME----LCLALLLHKGILAVSLSLRLLQSHLR---AQVVAGCGILFSCMTPL-GIGLGAAL--AESAGPLH--QLAQSVLE---GMAAGTFLYITFLEILPQE---LASSEQ-----------RILKVILLLAGFALLTGLLFIQI------------
SLC39A10  ----MKVHMHT------------KFCLIC----LLTFIFHHCNHCHEEHDHG-PEALHRQHRGMTELEP---SKFSKQAAENEKKYYIEKLFERYGENG----RLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHL----DILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVS-------TKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKT---------QEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPD---RVHNPGHSHVHLPER-NGHDPGRGH-QDLDPDNEGELRHTRK--RE-------APHVKNNAIISLRKDL----NEDDHHHE--------------------------CLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGAS-AWICGIISITVISLLSLLGVI----LVPII-------------N-QGCFKFLLTFLVALAVGTMSGDALLHLLPHSQ---------GGHDHS------------------HQHAH-----GHGHSHGHESNKFLEE---YDAVLKGLVALGGIYLLFII-------EHCIR-MFKHYKQQRGK-QKWFMKQNTEESTIGRKLSDHKLNNTP---DSDWLQLKPL-AGTDDSVVSEDRLNETELT----DLEGQQESPPKN--YLCIEEEKIIDHSHSDGLHTIH-----EHDLHAAAHN----------HHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIG---AAFSAGLTG-GIS----TSIAVFCHELPHELGDFAVLLKAGMT---VKQAIVYNLLSAMMAYI-GMLIGTAV--G---------QYANNITLWIFAVTAGMFLYVALVDMLPEM---LHGDGDNEEHGFCPVGQFILQNLGLLFGFAIML---VIALYEDKIVFDIQF-
SLC39A11  ---------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGHSSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQALLGTFFTWGMTAAGAALVFVFS---------------SGQRRILDGSLGFAAGVMLAASYWSLLAPAV--------EMATSSGGF------------GAFAFFPVA------------------------VGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGST------LMKKKSDPEGPALLFPESELSIRIGRA--GLLSDKS-------ENGEAYQR---KKA--AAT----GLPEGPAVPVPSRGNL----------AQPG-------------------------------------------------------------------GSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA-TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFS---TWRAFWYGQLSGMVEPLAGVFGAFAVV------------LAEPILPYALAFAAGAMVYVVMDDIIPEA---QISGNG-----------KLASWASIL-GFVVMMSL-DVGLG-----------
SLC39A12  --MCFRTKLSVS-----------WVPLFL----LLSRVFST--------ETDKPSAQDSRSRGSS-GQP-------------------ADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRN--------GMQGDCNLCFEPDALLLIAGGNFED----------QLREEVVQRVSLLLLYYIIHQEEIC------------SSKLNMSNKEYKF----YLH-------------SLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGA-------------------NESTLPQLAAMIITLSLQGVCLGQG-NLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQ---NNIITHDQDYSNFSS----SMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSC---------HLPKDQQAKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTA----LVLFH-------------SCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---------GLHKQEA-------------PEFGHFHESK----------GH--------------IWKLMGLIGGIHGFFLI-------EKCFI-LLVSPNDKQGLSLV----------------------------NGHVGHSHHL-ALNSELSDQAGRGKSASTI----QLKSPEDSQAA---------EMPIG---------------------------------------------------------------SMTASNRKCKAISLLAIMILVGDSLHNFADGLAIG---AAFSSSSES-GVT----TTIAILCHEIPHEMGDFAVLLSSGLS---MKTAILMNFISSLTAFM-GLYIGLSV--S----------ADPCVQDWIFTVTAGMFLYLSLVEMLPEM---THVQTQ------RPWMMFLLQNFGLILGWLSLL---LLAIYEQNIKI-----
SLC39A13  ----------------------------------------------------MPGCP---CPGCGMAGPR---------------------------------LLFLTALALELLGRAGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQP---------------------------ALRSRGTAT-----------------------------------------------ACRLDNKES--------------------------------------ESWGALLSGERLDT---------------------------------------------WICSLLGSLMVGLSGVFPLL----VIPLEM-------GTMLRSEAGAWR--LKQLLSFALGGLLGNVFLHLLPEAW------------AYTCS----------ASPG------GE----------GQSLQ---------QQQQLGLWVIAGILTFLAL-------EKMF-------------------------------LDSKEEGTSQ--------------APNKDPTAAAAALNGGHCL-------AQPAAEPG-----------------------------------------LGAVV----------------------------------------RSIKVSGYLNLLANTIDNFTHGLAVA---ASFLVSKKI-GLL----TTMAILLHEIPHEVGDFAILLRAGFD---RWSAAKLQLSTALGGLL-GAGFAICT--QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL---LEEEDP---------WRSLQQLLLLCAGIVVMV---LFSLFVD---------
SLC39A14  ---MKLLLLHP------------AFQSCL----LLTLL------------------------GLWRTTP-EAHASSLGAPAISAASFLQDLIHRYGEGD----SLTLQQLKALLNHLDVGVGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVTQHVQGH-RNLST----------------------------------------------------------------------------CFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQE---NEENEQTEEGRPSAVEV-----WGYGLLCVTVISLCSLLGAS----VVPFM-------------K-KTFYKRLLLYFIALAIGTLYSNALFQLIPEAF---------GFNPLE------------------DYYVS-----------------------------KSAVVFGGFYLFFFT-------EKILKILLKQKNEH----HH--GHSHYASESL-PSKKDQEEGVMEKLQNGDLDHMIPQHCSSE--LDGKAPMVDEKVIVGSLSVQDLQASQSA-----------------------------------------------------------------------------CYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIG---ASFTVSVFQ-GIS----TSVAILCEEFPHELGDFVILLNAGMS---IQQALFFNFLSACCCYL-GLAFGILA--GS--------HFSAN---WIFALAGGMFLYISLADMFPEMNEVCQED----ERKGSILIPFIIQNLGLLTGFTIMV---VLTMYSGQIQIG----
SLC39A2   -------------------------------------------------------------------------------------------------------------MEQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHH------RLVLRLLGCISAGVFLGAGFMHMTAEAL--------EEIES-----------------QIQKFMVQN-RSASERNSSGDADS------AHMEYPYGELIISLGFFFVFFL-------ESLAL---------------QCCP---------------------GAAGGST-------VQDEEW-----GGA--HIF----ELHSHGHLPSPS--------------KGP------------------------------------------------------------------------LRALVLLLSLSFHSVFEGLAVG-----LQPTVAA-TVQ----LCLAVLAHKGLVVFGVGMRLVHLGTS---SRWAVFSILLLALMSPL-GLAVGLAVTGGDSEGG-R--GLAQAVLE---GVAAGTFLYVTFLEILPRE---LASPEA-----------PLAKWSCVAAGFAFMA---FIALWA----------
SLC39A3   -------------------------------------------------------------------------------------------------------------MVKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAKILCMVGVFFFMLLGSLLPVKI--IETDFEKAHRS-----KKILSLCNTFGGGVFLATCFNALLPAVR--------EKLQK-----------------VLSLGHIS------------------------TDYPLAETILLLGFFMTVFL-------EQLILTF-----------R-KEKPSF---------IDLETFNA--GSDVGS----------DSEYESPFMGGARGHAL----YVEPHGHGPSLSVQGLS--------RASP------------------------------------------------------------------------VRLLSLAFALSAHSVFEGLALG-----LQEEGEK-VVS----LFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPL-GIGLGLGI--ESAQGVPG--SVASVLLQ---GLAGGTFLFITFLEILAKE---LEEKSD-----------RLLKVLFLVLGYTVLAGMVFLKW------------
SLC39A4   --MVDVVGLERETGPRGSPWPGLPLPSLVGPAPLLTCLCPQCLSVEDALGLGEPE-------GSG-LPP----------GPVLEARYVA--------------RLSAAAVLYLSNPEGTCEDARAGLWAS-------------------------HA----------------------------------------------------------------------DHLLALLESPKALTPGLSWLLQRMQARAAGQT---------PKTACVDIPQLLEEAVGAGA------------PGSAGG------------VLAALLDHVRSGSCFH---ALPSPQYFVDFVFQQHSSEVPMTLAELSAL------------------MQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSV-WDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACT--------------SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLL----LLTCT-------------GCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVL---------GLHTHS------------------EEGLSP------------------------QPTWRLLAMLAGLYAFFLF-------ENLFNLLLPR------------DPEDLEDGPCGHSSHSHGGHS-----HGVSLQLAPS------------------------ELRQPKPPHEGSRADLVAEESPELLNPEPRRLS----P------------------------------------------------------------ELRLLPYMITLGDAVHNFADGLAVG---AAFASSWKT-GLA----TSLAVFCHELPHELGDFAALLHAGLS---VRQALLLNLASALTAFA-GLYVALAV--G----------VSEESEAWILAVATGLFLYVALCDMLPAM---LKVRDP------RPWLLFLLHNVGLLGGWTVLL---LLSLYEDDITF-----
SLC39A5   MMGSPVSHLLA------------GFCVWV----VLGWV-----------GGSVPN-----------LGP----------AEQEQNHYLAQLFGLYGENG----TLTAGGLARLLHSLGLGRVQGLRLGQ--------------------------HG---------------PLTG-------------------------------------------------------------RAASPAADNSTHR--------------------------PQNPELSVDVWAGM----------PLGPSGWGDLEE---------------SKAPHLP---RGPAPSG---LDL-----------------------------------LHRLLLLDHSLADHLNE-------------------------DCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCI--------------GAPAPAPPGDL-LS-ALLQSALAVLLLSLPSPLSLL----LLRLL-------------G-PRLLRPLLGFLGALAVGTLCGDALLHLLPHAQ---------EG-----------------------RHAGP----------GGLPEKDLGP---------GLSVLGGLFLLFVL-------ENMLG-LLRHRGLRPRCCRR--KRRNLETRNLDPE-------------NGSGMALQPLQAAPEPGAQGQREKNSQHPP----AL-----APPG------------------------------------------------------------------HQGHSHGHQ------------GGTDITWMVLLGDGLHNLTDGLAIG---AAFSDGFSS-GLS----TTLAVFCHELPHELGDFAMLLQSGLS---FRRLLLLSLVSGALGLG-GAVLGVGL--S---------LGPVPLTPWVFGVTAGVFLYVALVDMLPAL---LRPPEP------LPTPHVLLQGLGLLLGGGLML---AITLLEERLLPVTTEG
SLC39A6   --------MAR------------KLSVIL----ILTFALSVTNPLHELKAAAFPQTTEK-------ISPNWESGINVDLAISTRQYHLQQLFYRYGENN----SLSVEGFRKLLQNIGIDKIKRIHIHHD---HDH-------------------HS-DHEHHSDH---------------------ERH--------------SDHEHHSDHEHHSDHDHHSHH--NHAASGKNKRKALCPDHDSDSSG---------------------------KDPRNSQGKGAHR----------PEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL-------AGRKTNESVSEPRKGFMYSRNTNENPQE--------------------------CFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIH--------TSEKKAEIPPKTYSL-QI-AWVGGFIAISIISFLSLLGVI----LVPLM-------------N-RVFFKFLLSFLVALAVGTLSGDAFLHLLPHSH---------ASHHHS------------------HSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLV-------EHVLT-LIKQFKDKKKKNQK--KPENDDDVEIKKQLSKYESQLST---NEEKVD-------TDDRTEGYLRADSQEPS----HFDSQQPA-------VLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQR---YSREELKDAGVATLAWMVIMGDGLHNFSDGLAIG---AAFTEGLSS-GLS----TSVAVFCHELPHELGDFAVLLKAGMT---VKQAVLYNALSAMLAYL-GMATGIFI--G---------HYAENVSMWIFALTAGLFMYVALVDMVPEM---LHNDA--SDHGCSRWGYFFLQNAGMLLGFGIML---LISIFEHKIVFRINF-
SLC39A7   -------------------------------------------------------------MARGLGAPHWVA----------------------------VGLLTWATLGLLVAGLGGHDDLHDDLQED------------------------FHGHSHRHSHED-------------------FHHGH---------------SHAHGHGHTHESIWHGHTHDH-DHGHSHED---------------------------------------------------------------LHHGHSHGYSHE---------------------------SLYHRGHGH---------------------------------------------------DHEHSHGG---------------------------------YGES-GAPGIKQDLDAVT------------------------------------------LWAYALGATVLISAAPFFVLF----LIPVE-------------SNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL---------EPHSHHTL----------EQPGHGHSHSGQ----------GPIL-------------SVGLWVLSGIVAFLVV-------EKFVRHVKGGHGHSHGHGHA-HSHTRGSHGHGRQERSTKEKQSSE--------------EEEKE-TRGVQKRRGGSTVPKDGPVRPQNAEEEK-----------------------------------------RGL-------------------------------------------DLRVSGYLNLAADLAHNFTDGLAIG---ASFRGGRGL-GIL----TTMTVLLHEVPHEVGDFAILVQSGCS---KKQAMRLQLLTAVGALA-GTACALLT--EG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL---LREASP---------LQSLLEVLGLLGGVIMMV---LIAHLE----------
SLC39A8   --------MAPG----------RAVAGLL----LLAAA------------------------GLG------------GVAEGPGLAFSEDVLSVFGANL----SLSAAQLQHLLEQMG-AASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEPGQLH-FN--Q----------------------------------------------------------------------------CLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPC-----------EDRPKHKTRPSHSEV-----WGYGFLSVTIINLASLLGLI----LTPLI-------------K-KSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF---------GFDPKV------------------DSYVE-----------------------------KAVAVFGGFYLLFFF-------ERMLKMLLKTYGQ------N--GHTHFGNDNFGPQEKTHQPKALPAI-NGVTCYANP--AVTE--ANGHIHFDNVSVV----SLQDGKKEPSS-----------------------------------------------------------------------------CTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIG---ASCTLSLLQ-GLS----TSIAILCEEFPHELGDFVILLNAGMS---TRQALLFNFLSACSCYV-GLAFGILV--GN--------NFAPN---IIFALAGGMFLYISLADMFPEMNDMLREKV--TGRKTDFTF-FMIQNAGMLTGFTAIL---LITLYAGEIELE----
SLC39A9   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDFISISLLSLAMLVGCYV-AGIIPLA---------------VNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHS---------HDHTQ----------LHAYIGVSLVLGFVFMLLV-------DQIGN-----------------SHVH--------------------------------------------------------STDDPEAARSSN-------------------------------------------------------------------------------------SKITT-----TLGLVVHAAADGVALG---AAASTSQTSVQLI----VFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSM-VTYLGLSK--SSKEA-----LSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKP---DATGGRGLSRLEVAALVLGCLIPL---ILSVGHQH--------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC39A8 33 V/M 0.000641662 rs373562040
-- SLC39A8 64 P/S 0.00135644 rs556309213
-- SLC39A8 249 P/A 0.00172995 rs147912552
-- SLC39A8 365 A/T 0.000183879 rs528395987
-- SLC39A8 389 N/S 0.000370654 rs146759817
-- SLC39A8 391 A/T 0.0454346 rs13107325
-- SLC39A8 423 V/L 0.000103548 rs145529199
-- SLC39A8 449 L/F 0.0106924 rs112519623

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC39A8 SLC39A8 [plasma membrane] Zinc influx into cells by the SLC39 gene family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data