Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC39A2


Basic description
Gene Name SLC39A2
Protein Name Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)
Family SLC39
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300 
MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA FMAFIALWA 
CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCHH CCCHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCCC CHHHHHHHHH HHHHCCHHHC HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHHHHC
[Overview] SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 
SLC39A1   ------------------------------------------------------------------MGP-------------------------------------WGEPELLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WRPEAVASEPPV---------------------------------------------------------------------------------------------------------------PV--------------------------------------------------------------------------------GLEVKLGALVLLLVLTLLCSLVPICV----LRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYL--------AAIDE-----------------ALAALHVT------------------------LQFPLQEFILAMGFFLVLVM-------EQITLAY-----------KEQSGPS-----------PLEETRALLGTVNGG----------PQHW-------------------HDGPGVPQAS--------------GAPA-------------------------------------------------------------------TPSALRACVLVFSLALHSVFEGLAVG-----LQRDRAR-AME----LCLALLLHKGILAVSLSLRLLQSHLR---AQVVAGCGILFSCMTPL-GIGLGAAL--AESAGPLH--QLAQSVLE---GMAAGTFLYITFLEILPQE---LASSEQ-----------RILKVILLLAGFALLTGLLFIQI------------
SLC39A10  ----MKVHMHT------------KFCLIC----LLTFIFHHCNHCHEEHDHG-PEALHRQHRGMTELEP---SKFSKQAAENEKKYYIEKLFERYGENG----RLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHL----DILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVS-------TKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKT---------QEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPD---RVHNPGHSHVHLPER-NGHDPGRGH-QDLDPDNEGELRHTRK--RE-------APHVKNNAIISLRKDL----NEDDHHHE--------------------------CLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGAS-AWICGIISITVISLLSLLGVI----LVPII-------------N-QGCFKFLLTFLVALAVGTMSGDALLHLLPHSQ---------GGHDHS------------------HQHAH-----GHGHSHGHESNKFLEE---YDAVLKGLVALGGIYLLFII-------EHCIR-MFKHYKQQRGK-QKWFMKQNTEESTIGRKLSDHKLNNTP---DSDWLQLKPL-AGTDDSVVSEDRLNETELT----DLEGQQESPPKN--YLCIEEEKIIDHSHSDGLHTIH-----EHDLHAAAHN----------HHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIG---AAFSAGLTG-GIS----TSIAVFCHELPHELGDFAVLLKAGMT---VKQAIVYNLLSAMMAYI-GMLIGTAV--G---------QYANNITLWIFAVTAGMFLYVALVDMLPEM---LHGDGDNEEHGFCPVGQFILQNLGLLFGFAIML---VIALYEDKIVFDIQF-
SLC39A11  ---------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGHSSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQALLGTFFTWGMTAAGAALVFVFS---------------SGQRRILDGSLGFAAGVMLAASYWSLLAPAV--------EMATSSGGF------------GAFAFFPVA------------------------VGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGST------LMKKKSDPEGPALLFPESELSIRIGRA--GLLSDKS-------ENGEAYQR---KKA--AAT----GLPEGPAVPVPSRGNL----------AQPG-------------------------------------------------------------------GSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA-TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFS---TWRAFWYGQLSGMVEPLAGVFGAFAVV------------LAEPILPYALAFAAGAMVYVVMDDIIPEA---QISGNG-----------KLASWASIL-GFVVMMSL-DVGLG-----------
SLC39A12  --MCFRTKLSVS-----------WVPLFL----LLSRVFST--------ETDKPSAQDSRSRGSS-GQP-------------------ADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRN--------GMQGDCNLCFEPDALLLIAGGNFED----------QLREEVVQRVSLLLLYYIIHQEEIC------------SSKLNMSNKEYKF----YLH-------------SLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGA-------------------NESTLPQLAAMIITLSLQGVCLGQG-NLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQ---NNIITHDQDYSNFSS----SMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSC---------HLPKDQQAKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTA----LVLFH-------------SCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---------GLHKQEA-------------PEFGHFHESK----------GH--------------IWKLMGLIGGIHGFFLI-------EKCFI-LLVSPNDKQGLSLV----------------------------NGHVGHSHHL-ALNSELSDQAGRGKSASTI----QLKSPEDSQAA---------EMPIG---------------------------------------------------------------SMTASNRKCKAISLLAIMILVGDSLHNFADGLAIG---AAFSSSSES-GVT----TTIAILCHEIPHEMGDFAVLLSSGLS---MKTAILMNFISSLTAFM-GLYIGLSV--S----------ADPCVQDWIFTVTAGMFLYLSLVEMLPEM---THVQTQ------RPWMMFLLQNFGLILGWLSLL---LLAIYEQNIKI-----
SLC39A13  ----------------------------------------------------MPGCP---CPGCGMAGPR---------------------------------LLFLTALALELLGRAGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQP---------------------------ALRSRGTAT-----------------------------------------------ACRLDNKES--------------------------------------ESWGALLSGERLDT---------------------------------------------WICSLLGSLMVGLSGVFPLL----VIPLEM-------GTMLRSEAGAWR--LKQLLSFALGGLLGNVFLHLLPEAW------------AYTCS----------ASPG------GE----------GQSLQ---------QQQQLGLWVIAGILTFLAL-------EKMF-------------------------------LDSKEEGTSQ--------------APNKDPTAAAAALNGGHCL-------AQPAAEPG-----------------------------------------LGAVV----------------------------------------RSIKVSGYLNLLANTIDNFTHGLAVA---ASFLVSKKI-GLL----TTMAILLHEIPHEVGDFAILLRAGFD---RWSAAKLQLSTALGGLL-GAGFAICT--QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL---LEEEDP---------WRSLQQLLLLCAGIVVMV---LFSLFVD---------
SLC39A14  ---MKLLLLHP------------AFQSCL----LLTLL------------------------GLWRTTP-EAHASSLGAPAISAASFLQDLIHRYGEGD----SLTLQQLKALLNHLDVGVGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVTQHVQGH-RNLST----------------------------------------------------------------------------CFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQE---NEENEQTEEGRPSAVEV-----WGYGLLCVTVISLCSLLGAS----VVPFM-------------K-KTFYKRLLLYFIALAIGTLYSNALFQLIPEAF---------GFNPLE------------------DYYVS-----------------------------KSAVVFGGFYLFFFT-------EKILKILLKQKNEH----HH--GHSHYASESL-PSKKDQEEGVMEKLQNGDLDHMIPQHCSSE--LDGKAPMVDEKVIVGSLSVQDLQASQSA-----------------------------------------------------------------------------CYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIG---ASFTVSVFQ-GIS----TSVAILCEEFPHELGDFVILLNAGMS---IQQALFFNFLSACCCYL-GLAFGILA--GS--------HFSAN---WIFALAGGMFLYISLADMFPEMNEVCQED----ERKGSILIPFIIQNLGLLTGFTIMV---VLTMYSGQIQIG----
SLC39A2   -------------------------------------------------------------------------------------------------------------MEQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHH------RLVLRLLGCISAGVFLGAGFMHMTAEAL--------EEIES-----------------QIQKFMVQN-RSASERNSSGDADS------AHMEYPYGELIISLGFFFVFFL-------ESLAL---------------QCCP---------------------GAAGGST-------VQDEEW-----GGA--HIF----ELHSHGHLPSPS--------------KGP------------------------------------------------------------------------LRALVLLLSLSFHSVFEGLAVG-----LQPTVAA-TVQ----LCLAVLAHKGLVVFGVGMRLVHLGTS---SRWAVFSILLLALMSPL-GLAVGLAVTGGDSEGG-R--GLAQAVLE---GVAAGTFLYVTFLEILPRE---LASPEA-----------PLAKWSCVAAGFAFMA---FIALWA----------
SLC39A3   -------------------------------------------------------------------------------------------------------------MVKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAKILCMVGVFFFMLLGSLLPVKI--IETDFEKAHRS-----KKILSLCNTFGGGVFLATCFNALLPAVR--------EKLQK-----------------VLSLGHIS------------------------TDYPLAETILLLGFFMTVFL-------EQLILTF-----------R-KEKPSF---------IDLETFNA--GSDVGS----------DSEYESPFMGGARGHAL----YVEPHGHGPSLSVQGLS--------RASP------------------------------------------------------------------------VRLLSLAFALSAHSVFEGLALG-----LQEEGEK-VVS----LFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPL-GIGLGLGI--ESAQGVPG--SVASVLLQ---GLAGGTFLFITFLEILAKE---LEEKSD-----------RLLKVLFLVLGYTVLAGMVFLKW------------
SLC39A4   --MVDVVGLERETGPRGSPWPGLPLPSLVGPAPLLTCLCPQCLSVEDALGLGEPE-------GSG-LPP----------GPVLEARYVA--------------RLSAAAVLYLSNPEGTCEDARAGLWAS-------------------------HA----------------------------------------------------------------------DHLLALLESPKALTPGLSWLLQRMQARAAGQT---------PKTACVDIPQLLEEAVGAGA------------PGSAGG------------VLAALLDHVRSGSCFH---ALPSPQYFVDFVFQQHSSEVPMTLAELSAL------------------MQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSV-WDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACT--------------SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLL----LLTCT-------------GCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVL---------GLHTHS------------------EEGLSP------------------------QPTWRLLAMLAGLYAFFLF-------ENLFNLLLPR------------DPEDLEDGPCGHSSHSHGGHS-----HGVSLQLAPS------------------------ELRQPKPPHEGSRADLVAEESPELLNPEPRRLS----P------------------------------------------------------------ELRLLPYMITLGDAVHNFADGLAVG---AAFASSWKT-GLA----TSLAVFCHELPHELGDFAALLHAGLS---VRQALLLNLASALTAFA-GLYVALAV--G----------VSEESEAWILAVATGLFLYVALCDMLPAM---LKVRDP------RPWLLFLLHNVGLLGGWTVLL---LLSLYEDDITF-----
SLC39A5   MMGSPVSHLLA------------GFCVWV----VLGWV-----------GGSVPN-----------LGP----------AEQEQNHYLAQLFGLYGENG----TLTAGGLARLLHSLGLGRVQGLRLGQ--------------------------HG---------------PLTG-------------------------------------------------------------RAASPAADNSTHR--------------------------PQNPELSVDVWAGM----------PLGPSGWGDLEE---------------SKAPHLP---RGPAPSG---LDL-----------------------------------LHRLLLLDHSLADHLNE-------------------------DCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCI--------------GAPAPAPPGDL-LS-ALLQSALAVLLLSLPSPLSLL----LLRLL-------------G-PRLLRPLLGFLGALAVGTLCGDALLHLLPHAQ---------EG-----------------------RHAGP----------GGLPEKDLGP---------GLSVLGGLFLLFVL-------ENMLG-LLRHRGLRPRCCRR--KRRNLETRNLDPE-------------NGSGMALQPLQAAPEPGAQGQREKNSQHPP----AL-----APPG------------------------------------------------------------------HQGHSHGHQ------------GGTDITWMVLLGDGLHNLTDGLAIG---AAFSDGFSS-GLS----TTLAVFCHELPHELGDFAMLLQSGLS---FRRLLLLSLVSGALGLG-GAVLGVGL--S---------LGPVPLTPWVFGVTAGVFLYVALVDMLPAL---LRPPEP------LPTPHVLLQGLGLLLGGGLML---AITLLEERLLPVTTEG
SLC39A6   --------MAR------------KLSVIL----ILTFALSVTNPLHELKAAAFPQTTEK-------ISPNWESGINVDLAISTRQYHLQQLFYRYGENN----SLSVEGFRKLLQNIGIDKIKRIHIHHD---HDH-------------------HS-DHEHHSDH---------------------ERH--------------SDHEHHSDHEHHSDHDHHSHH--NHAASGKNKRKALCPDHDSDSSG---------------------------KDPRNSQGKGAHR----------PEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL-------AGRKTNESVSEPRKGFMYSRNTNENPQE--------------------------CFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIH--------TSEKKAEIPPKTYSL-QI-AWVGGFIAISIISFLSLLGVI----LVPLM-------------N-RVFFKFLLSFLVALAVGTLSGDAFLHLLPHSH---------ASHHHS------------------HSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLV-------EHVLT-LIKQFKDKKKKNQK--KPENDDDVEIKKQLSKYESQLST---NEEKVD-------TDDRTEGYLRADSQEPS----HFDSQQPA-------VLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQR---YSREELKDAGVATLAWMVIMGDGLHNFSDGLAIG---AAFTEGLSS-GLS----TSVAVFCHELPHELGDFAVLLKAGMT---VKQAVLYNALSAMLAYL-GMATGIFI--G---------HYAENVSMWIFALTAGLFMYVALVDMVPEM---LHNDA--SDHGCSRWGYFFLQNAGMLLGFGIML---LISIFEHKIVFRINF-
SLC39A7   -------------------------------------------------------------MARGLGAPHWVA----------------------------VGLLTWATLGLLVAGLGGHDDLHDDLQED------------------------FHGHSHRHSHED-------------------FHHGH---------------SHAHGHGHTHESIWHGHTHDH-DHGHSHED---------------------------------------------------------------LHHGHSHGYSHE---------------------------SLYHRGHGH---------------------------------------------------DHEHSHGG---------------------------------YGES-GAPGIKQDLDAVT------------------------------------------LWAYALGATVLISAAPFFVLF----LIPVE-------------SNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL---------EPHSHHTL----------EQPGHGHSHSGQ----------GPIL-------------SVGLWVLSGIVAFLVV-------EKFVRHVKGGHGHSHGHGHA-HSHTRGSHGHGRQERSTKEKQSSE--------------EEEKE-TRGVQKRRGGSTVPKDGPVRPQNAEEEK-----------------------------------------RGL-------------------------------------------DLRVSGYLNLAADLAHNFTDGLAIG---ASFRGGRGL-GIL----TTMTVLLHEVPHEVGDFAILVQSGCS---KKQAMRLQLLTAVGALA-GTACALLT--EG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL---LREASP---------LQSLLEVLGLLGGVIMMV---LIAHLE----------
SLC39A8   --------MAPG----------RAVAGLL----LLAAA------------------------GLG------------GVAEGPGLAFSEDVLSVFGANL----SLSAAQLQHLLEQMG-AASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEPGQLH-FN--Q----------------------------------------------------------------------------CLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPC-----------EDRPKHKTRPSHSEV-----WGYGFLSVTIINLASLLGLI----LTPLI-------------K-KSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF---------GFDPKV------------------DSYVE-----------------------------KAVAVFGGFYLLFFF-------ERMLKMLLKTYGQ------N--GHTHFGNDNFGPQEKTHQPKALPAI-NGVTCYANP--AVTE--ANGHIHFDNVSVV----SLQDGKKEPSS-----------------------------------------------------------------------------CTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIG---ASCTLSLLQ-GLS----TSIAILCEEFPHELGDFVILLNAGMS---TRQALLFNFLSACSCYV-GLAFGILV--GN--------NFAPN---IIFALAGGMFLYISLADMFPEMNDMLREKV--TGRKTDFTF-FMIQNAGMLTGFTAIL---LITLYAGEIELE----
SLC39A9   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDFISISLLSLAMLVGCYV-AGIIPLA---------------VNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHS---------HDHTQ----------LHAYIGVSLVLGFVFMLLV-------DQIGN-----------------SHVH--------------------------------------------------------STDDPEAARSSN-------------------------------------------------------------------------------------SKITT-----TLGLVVHAAADGVALG---AAASTSQTSVQLI----VFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSM-VTYLGLSK--SSKEA-----LSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKP---DATGGRGLSRLEVAALVLGCLIPL---ILSVGHQH--------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC39A2 42 R/W 0.000350249 rs148284148
-- SLC39A2 43 L/Q 0.00209715 rs2234632
-- SLC39A2 43 L/R 0.701043 rs2234632
-- SLC39A2 48 L/P 0.0152818 rs2234633
-- SLC39A2 80 M/V 0.00451107 rs2234634
-- SLC39A2 110 S/T 0.00264165 rs72684072
-- SLC39A2 115 F/L 0.366552 rs2234636
-- SLC39A2 135 T/I 0.00029155 rs35516218
-- SLC39A2 139 E/K 0.000610017 rs144375696
-- SLC39A2 145 H/Y 0.000864235 rs142162000
-- SLC39A2 147 F/S 0.00223254 rs150879559
-- SLC39A2 150 H/R 0.000127508 rs180694682
-- SLC39A2 154 H/Y 0.00297384 rs2234637
-- SLC39A2 213 R/Q 0.000286405 rs145056031
-- SLC39A2 241 V/I 0.000390286 rs2234639
-- SLC39A2 272 V/I 0.000127505 rs751193511
-- SLC39A2 280 R/Q 0.000151732 rs140359641
-- SLC39A2 297 A/T 0.000131161 rs375310383

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC39A2 SLC39A2 [plasma membrane] Zinc influx into cells by the SLC39 gene family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data