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Detail Data SLC39A14


Basic description
Gene Name SLC39A14
Protein Name Zinc transporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Family SLC39
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490 
MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR YGEGDSLTLQ QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA HNFSEQSRIG SSELQEFCPT ILQQLDSRAC TSENQENEEN EQTEEGRPSA VEVWGYGLLC VTVISLCSLL GASVVPFMKK TFYKRLLLYF IALAIGTLYS NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI LKILLKQKNE HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI DGLAIGASFT VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF FNFLSACCCY LGLAFGILAG SHFSANWIFA LAGGMFLYIS LADMFPEMNE VCQEDERKGS ILIPFIIQNL GLLTGFTIMV VLTMYSGQIQ IG 
CCCCCCCHHH HHHHHHHHHH HHHHCHHHCC CCCCCCCCCH HHHHHHHHHH HCCCCCEEHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH CCCCCCCCCC HHHHHHHCHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHC CHHHHHCHHH HCCCCHHHHH HHHHHEEECC CHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCCEECCC CHHCHHCCCC CCCCCCCCCH HHHHHHHHHH HHHHCHHHHC CCCCHHHHCC CCHHHCHHHH HHHHHHCCCC HHCHHHHHHH HCHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CC
[Overview] SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 
SLC39A1   ------------------------------------------------------------------MGP-------------------------------------WGEPELLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WRPEAVASEPPV---------------------------------------------------------------------------------------------------------------PV--------------------------------------------------------------------------------GLEVKLGALVLLLVLTLLCSLVPICV----LRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYL--------AAIDE-----------------ALAALHVT------------------------LQFPLQEFILAMGFFLVLVM-------EQITLAY-----------KEQSGPS-----------PLEETRALLGTVNGG----------PQHW-------------------HDGPGVPQAS--------------GAPA-------------------------------------------------------------------TPSALRACVLVFSLALHSVFEGLAVG-----LQRDRAR-AME----LCLALLLHKGILAVSLSLRLLQSHLR---AQVVAGCGILFSCMTPL-GIGLGAAL--AESAGPLH--QLAQSVLE---GMAAGTFLYITFLEILPQE---LASSEQ-----------RILKVILLLAGFALLTGLLFIQI------------
SLC39A10  ----MKVHMHT------------KFCLIC----LLTFIFHHCNHCHEEHDHG-PEALHRQHRGMTELEP---SKFSKQAAENEKKYYIEKLFERYGENG----RLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHL----DILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVS-------TKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKT---------QEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPD---RVHNPGHSHVHLPER-NGHDPGRGH-QDLDPDNEGELRHTRK--RE-------APHVKNNAIISLRKDL----NEDDHHHE--------------------------CLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGAS-AWICGIISITVISLLSLLGVI----LVPII-------------N-QGCFKFLLTFLVALAVGTMSGDALLHLLPHSQ---------GGHDHS------------------HQHAH-----GHGHSHGHESNKFLEE---YDAVLKGLVALGGIYLLFII-------EHCIR-MFKHYKQQRGK-QKWFMKQNTEESTIGRKLSDHKLNNTP---DSDWLQLKPL-AGTDDSVVSEDRLNETELT----DLEGQQESPPKN--YLCIEEEKIIDHSHSDGLHTIH-----EHDLHAAAHN----------HHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIG---AAFSAGLTG-GIS----TSIAVFCHELPHELGDFAVLLKAGMT---VKQAIVYNLLSAMMAYI-GMLIGTAV--G---------QYANNITLWIFAVTAGMFLYVALVDMLPEM---LHGDGDNEEHGFCPVGQFILQNLGLLFGFAIML---VIALYEDKIVFDIQF-
SLC39A11  ---------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGHSSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQALLGTFFTWGMTAAGAALVFVFS---------------SGQRRILDGSLGFAAGVMLAASYWSLLAPAV--------EMATSSGGF------------GAFAFFPVA------------------------VGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGST------LMKKKSDPEGPALLFPESELSIRIGRA--GLLSDKS-------ENGEAYQR---KKA--AAT----GLPEGPAVPVPSRGNL----------AQPG-------------------------------------------------------------------GSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA-TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFS---TWRAFWYGQLSGMVEPLAGVFGAFAVV------------LAEPILPYALAFAAGAMVYVVMDDIIPEA---QISGNG-----------KLASWASIL-GFVVMMSL-DVGLG-----------
SLC39A12  --MCFRTKLSVS-----------WVPLFL----LLSRVFST--------ETDKPSAQDSRSRGSS-GQP-------------------ADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRN--------GMQGDCNLCFEPDALLLIAGGNFED----------QLREEVVQRVSLLLLYYIIHQEEIC------------SSKLNMSNKEYKF----YLH-------------SLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGA-------------------NESTLPQLAAMIITLSLQGVCLGQG-NLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQ---NNIITHDQDYSNFSS----SMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSC---------HLPKDQQAKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTA----LVLFH-------------SCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---------GLHKQEA-------------PEFGHFHESK----------GH--------------IWKLMGLIGGIHGFFLI-------EKCFI-LLVSPNDKQGLSLV----------------------------NGHVGHSHHL-ALNSELSDQAGRGKSASTI----QLKSPEDSQAA---------EMPIG---------------------------------------------------------------SMTASNRKCKAISLLAIMILVGDSLHNFADGLAIG---AAFSSSSES-GVT----TTIAILCHEIPHEMGDFAVLLSSGLS---MKTAILMNFISSLTAFM-GLYIGLSV--S----------ADPCVQDWIFTVTAGMFLYLSLVEMLPEM---THVQTQ------RPWMMFLLQNFGLILGWLSLL---LLAIYEQNIKI-----
SLC39A13  ----------------------------------------------------MPGCP---CPGCGMAGPR---------------------------------LLFLTALALELLGRAGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQP---------------------------ALRSRGTAT-----------------------------------------------ACRLDNKES--------------------------------------ESWGALLSGERLDT---------------------------------------------WICSLLGSLMVGLSGVFPLL----VIPLEM-------GTMLRSEAGAWR--LKQLLSFALGGLLGNVFLHLLPEAW------------AYTCS----------ASPG------GE----------GQSLQ---------QQQQLGLWVIAGILTFLAL-------EKMF-------------------------------LDSKEEGTSQ--------------APNKDPTAAAAALNGGHCL-------AQPAAEPG-----------------------------------------LGAVV----------------------------------------RSIKVSGYLNLLANTIDNFTHGLAVA---ASFLVSKKI-GLL----TTMAILLHEIPHEVGDFAILLRAGFD---RWSAAKLQLSTALGGLL-GAGFAICT--QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL---LEEEDP---------WRSLQQLLLLCAGIVVMV---LFSLFVD---------
SLC39A14  ---MKLLLLHP------------AFQSCL----LLTLL------------------------GLWRTTP-EAHASSLGAPAISAASFLQDLIHRYGEGD----SLTLQQLKALLNHLDVGVGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVTQHVQGH-RNLST----------------------------------------------------------------------------CFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQE---NEENEQTEEGRPSAVEV-----WGYGLLCVTVISLCSLLGAS----VVPFM-------------K-KTFYKRLLLYFIALAIGTLYSNALFQLIPEAF---------GFNPLE------------------DYYVS-----------------------------KSAVVFGGFYLFFFT-------EKILKILLKQKNEH----HH--GHSHYASESL-PSKKDQEEGVMEKLQNGDLDHMIPQHCSSE--LDGKAPMVDEKVIVGSLSVQDLQASQSA-----------------------------------------------------------------------------CYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIG---ASFTVSVFQ-GIS----TSVAILCEEFPHELGDFVILLNAGMS---IQQALFFNFLSACCCYL-GLAFGILA--GS--------HFSAN---WIFALAGGMFLYISLADMFPEMNEVCQED----ERKGSILIPFIIQNLGLLTGFTIMV---VLTMYSGQIQIG----
SLC39A2   -------------------------------------------------------------------------------------------------------------MEQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHH------RLVLRLLGCISAGVFLGAGFMHMTAEAL--------EEIES-----------------QIQKFMVQN-RSASERNSSGDADS------AHMEYPYGELIISLGFFFVFFL-------ESLAL---------------QCCP---------------------GAAGGST-------VQDEEW-----GGA--HIF----ELHSHGHLPSPS--------------KGP------------------------------------------------------------------------LRALVLLLSLSFHSVFEGLAVG-----LQPTVAA-TVQ----LCLAVLAHKGLVVFGVGMRLVHLGTS---SRWAVFSILLLALMSPL-GLAVGLAVTGGDSEGG-R--GLAQAVLE---GVAAGTFLYVTFLEILPRE---LASPEA-----------PLAKWSCVAAGFAFMA---FIALWA----------
SLC39A3   -------------------------------------------------------------------------------------------------------------MVKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAKILCMVGVFFFMLLGSLLPVKI--IETDFEKAHRS-----KKILSLCNTFGGGVFLATCFNALLPAVR--------EKLQK-----------------VLSLGHIS------------------------TDYPLAETILLLGFFMTVFL-------EQLILTF-----------R-KEKPSF---------IDLETFNA--GSDVGS----------DSEYESPFMGGARGHAL----YVEPHGHGPSLSVQGLS--------RASP------------------------------------------------------------------------VRLLSLAFALSAHSVFEGLALG-----LQEEGEK-VVS----LFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPL-GIGLGLGI--ESAQGVPG--SVASVLLQ---GLAGGTFLFITFLEILAKE---LEEKSD-----------RLLKVLFLVLGYTVLAGMVFLKW------------
SLC39A4   --MVDVVGLERETGPRGSPWPGLPLPSLVGPAPLLTCLCPQCLSVEDALGLGEPE-------GSG-LPP----------GPVLEARYVA--------------RLSAAAVLYLSNPEGTCEDARAGLWAS-------------------------HA----------------------------------------------------------------------DHLLALLESPKALTPGLSWLLQRMQARAAGQT---------PKTACVDIPQLLEEAVGAGA------------PGSAGG------------VLAALLDHVRSGSCFH---ALPSPQYFVDFVFQQHSSEVPMTLAELSAL------------------MQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSV-WDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACT--------------SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLL----LLTCT-------------GCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVL---------GLHTHS------------------EEGLSP------------------------QPTWRLLAMLAGLYAFFLF-------ENLFNLLLPR------------DPEDLEDGPCGHSSHSHGGHS-----HGVSLQLAPS------------------------ELRQPKPPHEGSRADLVAEESPELLNPEPRRLS----P------------------------------------------------------------ELRLLPYMITLGDAVHNFADGLAVG---AAFASSWKT-GLA----TSLAVFCHELPHELGDFAALLHAGLS---VRQALLLNLASALTAFA-GLYVALAV--G----------VSEESEAWILAVATGLFLYVALCDMLPAM---LKVRDP------RPWLLFLLHNVGLLGGWTVLL---LLSLYEDDITF-----
SLC39A5   MMGSPVSHLLA------------GFCVWV----VLGWV-----------GGSVPN-----------LGP----------AEQEQNHYLAQLFGLYGENG----TLTAGGLARLLHSLGLGRVQGLRLGQ--------------------------HG---------------PLTG-------------------------------------------------------------RAASPAADNSTHR--------------------------PQNPELSVDVWAGM----------PLGPSGWGDLEE---------------SKAPHLP---RGPAPSG---LDL-----------------------------------LHRLLLLDHSLADHLNE-------------------------DCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCI--------------GAPAPAPPGDL-LS-ALLQSALAVLLLSLPSPLSLL----LLRLL-------------G-PRLLRPLLGFLGALAVGTLCGDALLHLLPHAQ---------EG-----------------------RHAGP----------GGLPEKDLGP---------GLSVLGGLFLLFVL-------ENMLG-LLRHRGLRPRCCRR--KRRNLETRNLDPE-------------NGSGMALQPLQAAPEPGAQGQREKNSQHPP----AL-----APPG------------------------------------------------------------------HQGHSHGHQ------------GGTDITWMVLLGDGLHNLTDGLAIG---AAFSDGFSS-GLS----TTLAVFCHELPHELGDFAMLLQSGLS---FRRLLLLSLVSGALGLG-GAVLGVGL--S---------LGPVPLTPWVFGVTAGVFLYVALVDMLPAL---LRPPEP------LPTPHVLLQGLGLLLGGGLML---AITLLEERLLPVTTEG
SLC39A6   --------MAR------------KLSVIL----ILTFALSVTNPLHELKAAAFPQTTEK-------ISPNWESGINVDLAISTRQYHLQQLFYRYGENN----SLSVEGFRKLLQNIGIDKIKRIHIHHD---HDH-------------------HS-DHEHHSDH---------------------ERH--------------SDHEHHSDHEHHSDHDHHSHH--NHAASGKNKRKALCPDHDSDSSG---------------------------KDPRNSQGKGAHR----------PEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL-------AGRKTNESVSEPRKGFMYSRNTNENPQE--------------------------CFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIH--------TSEKKAEIPPKTYSL-QI-AWVGGFIAISIISFLSLLGVI----LVPLM-------------N-RVFFKFLLSFLVALAVGTLSGDAFLHLLPHSH---------ASHHHS------------------HSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLV-------EHVLT-LIKQFKDKKKKNQK--KPENDDDVEIKKQLSKYESQLST---NEEKVD-------TDDRTEGYLRADSQEPS----HFDSQQPA-------VLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQR---YSREELKDAGVATLAWMVIMGDGLHNFSDGLAIG---AAFTEGLSS-GLS----TSVAVFCHELPHELGDFAVLLKAGMT---VKQAVLYNALSAMLAYL-GMATGIFI--G---------HYAENVSMWIFALTAGLFMYVALVDMVPEM---LHNDA--SDHGCSRWGYFFLQNAGMLLGFGIML---LISIFEHKIVFRINF-
SLC39A7   -------------------------------------------------------------MARGLGAPHWVA----------------------------VGLLTWATLGLLVAGLGGHDDLHDDLQED------------------------FHGHSHRHSHED-------------------FHHGH---------------SHAHGHGHTHESIWHGHTHDH-DHGHSHED---------------------------------------------------------------LHHGHSHGYSHE---------------------------SLYHRGHGH---------------------------------------------------DHEHSHGG---------------------------------YGES-GAPGIKQDLDAVT------------------------------------------LWAYALGATVLISAAPFFVLF----LIPVE-------------SNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL---------EPHSHHTL----------EQPGHGHSHSGQ----------GPIL-------------SVGLWVLSGIVAFLVV-------EKFVRHVKGGHGHSHGHGHA-HSHTRGSHGHGRQERSTKEKQSSE--------------EEEKE-TRGVQKRRGGSTVPKDGPVRPQNAEEEK-----------------------------------------RGL-------------------------------------------DLRVSGYLNLAADLAHNFTDGLAIG---ASFRGGRGL-GIL----TTMTVLLHEVPHEVGDFAILVQSGCS---KKQAMRLQLLTAVGALA-GTACALLT--EG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL---LREASP---------LQSLLEVLGLLGGVIMMV---LIAHLE----------
SLC39A8   --------MAPG----------RAVAGLL----LLAAA------------------------GLG------------GVAEGPGLAFSEDVLSVFGANL----SLSAAQLQHLLEQMG-AASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEPGQLH-FN--Q----------------------------------------------------------------------------CLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPC-----------EDRPKHKTRPSHSEV-----WGYGFLSVTIINLASLLGLI----LTPLI-------------K-KSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF---------GFDPKV------------------DSYVE-----------------------------KAVAVFGGFYLLFFF-------ERMLKMLLKTYGQ------N--GHTHFGNDNFGPQEKTHQPKALPAI-NGVTCYANP--AVTE--ANGHIHFDNVSVV----SLQDGKKEPSS-----------------------------------------------------------------------------CTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIG---ASCTLSLLQ-GLS----TSIAILCEEFPHELGDFVILLNAGMS---TRQALLFNFLSACSCYV-GLAFGILV--GN--------NFAPN---IIFALAGGMFLYISLADMFPEMNDMLREKV--TGRKTDFTF-FMIQNAGMLTGFTAIL---LITLYAGEIELE----
SLC39A9   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDFISISLLSLAMLVGCYV-AGIIPLA---------------VNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHS---------HDHTQ----------LHAYIGVSLVLGFVFMLLV-------DQIGN-----------------SHVH--------------------------------------------------------STDDPEAARSSN-------------------------------------------------------------------------------------SKITT-----TLGLVVHAAADGVALG---AAASTSQTSVQLI----VFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSM-VTYLGLSK--SSKEA-----LSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKP---DATGGRGLSRLEVAALVLGCLIPL---ILSVGHQH--------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC39A14 8 P/R 0.000364172 rs34328787
-- SLC39A14 33 L/P 0.525721 rs896378
-- SLC39A14 82 V/M 0.000111575 rs150377639
-- SLC39A14 90 T/M 0.000224755 rs554100657
-- SLC39A14 132 S/L 0.000127359 rs143724214
-- SLC39A14 158 F/I 0.000310213 rs79856562
-- SLC39A14 280 G/R 0.000227492 rs111637707
-- SLC39A14 302 D/G 0.000157478 rs572471122
-- SLC39A14 420 G/A 0.000131525 rs748420118
-- SLC39A14 451 A/P 0.000374076 rs566298999
-- SLC39A14 492 G/E 0.000284509 rs142292859

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC39A14 SLC39A14 [plasma membrane] Zinc influx into cells by the SLC39 gene family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data