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Variant
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Pathway
Disease

Detail Data SLC39A1


Basic description
Gene Name SLC39A1
Protein Name Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)
Family SLC39
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320 
MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE QRILKVILLL AGFALLTGLL FIQI 
CCCCCCCCCC EECCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH CHHHHHHHCH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHHHCC HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HCHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHC
[Overview] SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 
SLC39A1   ------------------------------------------------------------------MGP-------------------------------------WGEPELLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WRPEAVASEPPV---------------------------------------------------------------------------------------------------------------PV--------------------------------------------------------------------------------GLEVKLGALVLLLVLTLLCSLVPICV----LRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYL--------AAIDE-----------------ALAALHVT------------------------LQFPLQEFILAMGFFLVLVM-------EQITLAY-----------KEQSGPS-----------PLEETRALLGTVNGG----------PQHW-------------------HDGPGVPQAS--------------GAPA-------------------------------------------------------------------TPSALRACVLVFSLALHSVFEGLAVG-----LQRDRAR-AME----LCLALLLHKGILAVSLSLRLLQSHLR---AQVVAGCGILFSCMTPL-GIGLGAAL--AESAGPLH--QLAQSVLE---GMAAGTFLYITFLEILPQE---LASSEQ-----------RILKVILLLAGFALLTGLLFIQI------------
SLC39A10  ----MKVHMHT------------KFCLIC----LLTFIFHHCNHCHEEHDHG-PEALHRQHRGMTELEP---SKFSKQAAENEKKYYIEKLFERYGENG----RLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHL----DILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVS-------TKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKT---------QEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPD---RVHNPGHSHVHLPER-NGHDPGRGH-QDLDPDNEGELRHTRK--RE-------APHVKNNAIISLRKDL----NEDDHHHE--------------------------CLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGAS-AWICGIISITVISLLSLLGVI----LVPII-------------N-QGCFKFLLTFLVALAVGTMSGDALLHLLPHSQ---------GGHDHS------------------HQHAH-----GHGHSHGHESNKFLEE---YDAVLKGLVALGGIYLLFII-------EHCIR-MFKHYKQQRGK-QKWFMKQNTEESTIGRKLSDHKLNNTP---DSDWLQLKPL-AGTDDSVVSEDRLNETELT----DLEGQQESPPKN--YLCIEEEKIIDHSHSDGLHTIH-----EHDLHAAAHN----------HHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIG---AAFSAGLTG-GIS----TSIAVFCHELPHELGDFAVLLKAGMT---VKQAIVYNLLSAMMAYI-GMLIGTAV--G---------QYANNITLWIFAVTAGMFLYVALVDMLPEM---LHGDGDNEEHGFCPVGQFILQNLGLLFGFAIML---VIALYEDKIVFDIQF-
SLC39A11  ---------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGHSSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQALLGTFFTWGMTAAGAALVFVFS---------------SGQRRILDGSLGFAAGVMLAASYWSLLAPAV--------EMATSSGGF------------GAFAFFPVA------------------------VGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGST------LMKKKSDPEGPALLFPESELSIRIGRA--GLLSDKS-------ENGEAYQR---KKA--AAT----GLPEGPAVPVPSRGNL----------AQPG-------------------------------------------------------------------GSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA-TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFS---TWRAFWYGQLSGMVEPLAGVFGAFAVV------------LAEPILPYALAFAAGAMVYVVMDDIIPEA---QISGNG-----------KLASWASIL-GFVVMMSL-DVGLG-----------
SLC39A12  --MCFRTKLSVS-----------WVPLFL----LLSRVFST--------ETDKPSAQDSRSRGSS-GQP-------------------ADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRN--------GMQGDCNLCFEPDALLLIAGGNFED----------QLREEVVQRVSLLLLYYIIHQEEIC------------SSKLNMSNKEYKF----YLH-------------SLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGA-------------------NESTLPQLAAMIITLSLQGVCLGQG-NLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQ---NNIITHDQDYSNFSS----SMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSC---------HLPKDQQAKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTA----LVLFH-------------SCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---------GLHKQEA-------------PEFGHFHESK----------GH--------------IWKLMGLIGGIHGFFLI-------EKCFI-LLVSPNDKQGLSLV----------------------------NGHVGHSHHL-ALNSELSDQAGRGKSASTI----QLKSPEDSQAA---------EMPIG---------------------------------------------------------------SMTASNRKCKAISLLAIMILVGDSLHNFADGLAIG---AAFSSSSES-GVT----TTIAILCHEIPHEMGDFAVLLSSGLS---MKTAILMNFISSLTAFM-GLYIGLSV--S----------ADPCVQDWIFTVTAGMFLYLSLVEMLPEM---THVQTQ------RPWMMFLLQNFGLILGWLSLL---LLAIYEQNIKI-----
SLC39A13  ----------------------------------------------------MPGCP---CPGCGMAGPR---------------------------------LLFLTALALELLGRAGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQP---------------------------ALRSRGTAT-----------------------------------------------ACRLDNKES--------------------------------------ESWGALLSGERLDT---------------------------------------------WICSLLGSLMVGLSGVFPLL----VIPLEM-------GTMLRSEAGAWR--LKQLLSFALGGLLGNVFLHLLPEAW------------AYTCS----------ASPG------GE----------GQSLQ---------QQQQLGLWVIAGILTFLAL-------EKMF-------------------------------LDSKEEGTSQ--------------APNKDPTAAAAALNGGHCL-------AQPAAEPG-----------------------------------------LGAVV----------------------------------------RSIKVSGYLNLLANTIDNFTHGLAVA---ASFLVSKKI-GLL----TTMAILLHEIPHEVGDFAILLRAGFD---RWSAAKLQLSTALGGLL-GAGFAICT--QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDL---LEEEDP---------WRSLQQLLLLCAGIVVMV---LFSLFVD---------
SLC39A14  ---MKLLLLHP------------AFQSCL----LLTLL------------------------GLWRTTP-EAHASSLGAPAISAASFLQDLIHRYGEGD----SLTLQQLKALLNHLDVGVGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVTQHVQGH-RNLST----------------------------------------------------------------------------CFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQE---NEENEQTEEGRPSAVEV-----WGYGLLCVTVISLCSLLGAS----VVPFM-------------K-KTFYKRLLLYFIALAIGTLYSNALFQLIPEAF---------GFNPLE------------------DYYVS-----------------------------KSAVVFGGFYLFFFT-------EKILKILLKQKNEH----HH--GHSHYASESL-PSKKDQEEGVMEKLQNGDLDHMIPQHCSSE--LDGKAPMVDEKVIVGSLSVQDLQASQSA-----------------------------------------------------------------------------CYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIG---ASFTVSVFQ-GIS----TSVAILCEEFPHELGDFVILLNAGMS---IQQALFFNFLSACCCYL-GLAFGILA--GS--------HFSAN---WIFALAGGMFLYISLADMFPEMNEVCQED----ERKGSILIPFIIQNLGLLTGFTIMV---VLTMYSGQIQIG----
SLC39A2   -------------------------------------------------------------------------------------------------------------MEQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHH------RLVLRLLGCISAGVFLGAGFMHMTAEAL--------EEIES-----------------QIQKFMVQN-RSASERNSSGDADS------AHMEYPYGELIISLGFFFVFFL-------ESLAL---------------QCCP---------------------GAAGGST-------VQDEEW-----GGA--HIF----ELHSHGHLPSPS--------------KGP------------------------------------------------------------------------LRALVLLLSLSFHSVFEGLAVG-----LQPTVAA-TVQ----LCLAVLAHKGLVVFGVGMRLVHLGTS---SRWAVFSILLLALMSPL-GLAVGLAVTGGDSEGG-R--GLAQAVLE---GVAAGTFLYVTFLEILPRE---LASPEA-----------PLAKWSCVAAGFAFMA---FIALWA----------
SLC39A3   -------------------------------------------------------------------------------------------------------------MVKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAKILCMVGVFFFMLLGSLLPVKI--IETDFEKAHRS-----KKILSLCNTFGGGVFLATCFNALLPAVR--------EKLQK-----------------VLSLGHIS------------------------TDYPLAETILLLGFFMTVFL-------EQLILTF-----------R-KEKPSF---------IDLETFNA--GSDVGS----------DSEYESPFMGGARGHAL----YVEPHGHGPSLSVQGLS--------RASP------------------------------------------------------------------------VRLLSLAFALSAHSVFEGLALG-----LQEEGEK-VVS----LFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPL-GIGLGLGI--ESAQGVPG--SVASVLLQ---GLAGGTFLFITFLEILAKE---LEEKSD-----------RLLKVLFLVLGYTVLAGMVFLKW------------
SLC39A4   --MVDVVGLERETGPRGSPWPGLPLPSLVGPAPLLTCLCPQCLSVEDALGLGEPE-------GSG-LPP----------GPVLEARYVA--------------RLSAAAVLYLSNPEGTCEDARAGLWAS-------------------------HA----------------------------------------------------------------------DHLLALLESPKALTPGLSWLLQRMQARAAGQT---------PKTACVDIPQLLEEAVGAGA------------PGSAGG------------VLAALLDHVRSGSCFH---ALPSPQYFVDFVFQQHSSEVPMTLAELSAL------------------MQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSV-WDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACT--------------SQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLL----LLTCT-------------GCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVL---------GLHTHS------------------EEGLSP------------------------QPTWRLLAMLAGLYAFFLF-------ENLFNLLLPR------------DPEDLEDGPCGHSSHSHGGHS-----HGVSLQLAPS------------------------ELRQPKPPHEGSRADLVAEESPELLNPEPRRLS----P------------------------------------------------------------ELRLLPYMITLGDAVHNFADGLAVG---AAFASSWKT-GLA----TSLAVFCHELPHELGDFAALLHAGLS---VRQALLLNLASALTAFA-GLYVALAV--G----------VSEESEAWILAVATGLFLYVALCDMLPAM---LKVRDP------RPWLLFLLHNVGLLGGWTVLL---LLSLYEDDITF-----
SLC39A5   MMGSPVSHLLA------------GFCVWV----VLGWV-----------GGSVPN-----------LGP----------AEQEQNHYLAQLFGLYGENG----TLTAGGLARLLHSLGLGRVQGLRLGQ--------------------------HG---------------PLTG-------------------------------------------------------------RAASPAADNSTHR--------------------------PQNPELSVDVWAGM----------PLGPSGWGDLEE---------------SKAPHLP---RGPAPSG---LDL-----------------------------------LHRLLLLDHSLADHLNE-------------------------DCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCI--------------GAPAPAPPGDL-LS-ALLQSALAVLLLSLPSPLSLL----LLRLL-------------G-PRLLRPLLGFLGALAVGTLCGDALLHLLPHAQ---------EG-----------------------RHAGP----------GGLPEKDLGP---------GLSVLGGLFLLFVL-------ENMLG-LLRHRGLRPRCCRR--KRRNLETRNLDPE-------------NGSGMALQPLQAAPEPGAQGQREKNSQHPP----AL-----APPG------------------------------------------------------------------HQGHSHGHQ------------GGTDITWMVLLGDGLHNLTDGLAIG---AAFSDGFSS-GLS----TTLAVFCHELPHELGDFAMLLQSGLS---FRRLLLLSLVSGALGLG-GAVLGVGL--S---------LGPVPLTPWVFGVTAGVFLYVALVDMLPAL---LRPPEP------LPTPHVLLQGLGLLLGGGLML---AITLLEERLLPVTTEG
SLC39A6   --------MAR------------KLSVIL----ILTFALSVTNPLHELKAAAFPQTTEK-------ISPNWESGINVDLAISTRQYHLQQLFYRYGENN----SLSVEGFRKLLQNIGIDKIKRIHIHHD---HDH-------------------HS-DHEHHSDH---------------------ERH--------------SDHEHHSDHEHHSDHDHHSHH--NHAASGKNKRKALCPDHDSDSSG---------------------------KDPRNSQGKGAHR----------PEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL-------AGRKTNESVSEPRKGFMYSRNTNENPQE--------------------------CFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIH--------TSEKKAEIPPKTYSL-QI-AWVGGFIAISIISFLSLLGVI----LVPLM-------------N-RVFFKFLLSFLVALAVGTLSGDAFLHLLPHSH---------ASHHHS------------------HSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLV-------EHVLT-LIKQFKDKKKKNQK--KPENDDDVEIKKQLSKYESQLST---NEEKVD-------TDDRTEGYLRADSQEPS----HFDSQQPA-------VLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQR---YSREELKDAGVATLAWMVIMGDGLHNFSDGLAIG---AAFTEGLSS-GLS----TSVAVFCHELPHELGDFAVLLKAGMT---VKQAVLYNALSAMLAYL-GMATGIFI--G---------HYAENVSMWIFALTAGLFMYVALVDMVPEM---LHNDA--SDHGCSRWGYFFLQNAGMLLGFGIML---LISIFEHKIVFRINF-
SLC39A7   -------------------------------------------------------------MARGLGAPHWVA----------------------------VGLLTWATLGLLVAGLGGHDDLHDDLQED------------------------FHGHSHRHSHED-------------------FHHGH---------------SHAHGHGHTHESIWHGHTHDH-DHGHSHED---------------------------------------------------------------LHHGHSHGYSHE---------------------------SLYHRGHGH---------------------------------------------------DHEHSHGG---------------------------------YGES-GAPGIKQDLDAVT------------------------------------------LWAYALGATVLISAAPFFVLF----LIPVE-------------SNSPRHRSLLQILLSFASGGLLGDAFLHLIPHAL---------EPHSHHTL----------EQPGHGHSHSGQ----------GPIL-------------SVGLWVLSGIVAFLVV-------EKFVRHVKGGHGHSHGHGHA-HSHTRGSHGHGRQERSTKEKQSSE--------------EEEKE-TRGVQKRRGGSTVPKDGPVRPQNAEEEK-----------------------------------------RGL-------------------------------------------DLRVSGYLNLAADLAHNFTDGLAIG---ASFRGGRGL-GIL----TTMTVLLHEVPHEVGDFAILVQSGCS---KKQAMRLQLLTAVGALA-GTACALLT--EG--GAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPEL---LREASP---------LQSLLEVLGLLGGVIMMV---LIAHLE----------
SLC39A8   --------MAPG----------RAVAGLL----LLAAA------------------------GLG------------GVAEGPGLAFSEDVLSVFGANL----SLSAAQLQHLLEQMG-AASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEPGQLH-FN--Q----------------------------------------------------------------------------CLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPC-----------EDRPKHKTRPSHSEV-----WGYGFLSVTIINLASLLGLI----LTPLI-------------K-KSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF---------GFDPKV------------------DSYVE-----------------------------KAVAVFGGFYLLFFF-------ERMLKMLLKTYGQ------N--GHTHFGNDNFGPQEKTHQPKALPAI-NGVTCYANP--AVTE--ANGHIHFDNVSVV----SLQDGKKEPSS-----------------------------------------------------------------------------CTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIG---ASCTLSLLQ-GLS----TSIAILCEEFPHELGDFVILLNAGMS---TRQALLFNFLSACSCYV-GLAFGILV--GN--------NFAPN---IIFALAGGMFLYISLADMFPEMNDMLREKV--TGRKTDFTF-FMIQNAGMLTGFTAIL---LITLYAGEIELE----
SLC39A9   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDFISISLLSLAMLVGCYV-AGIIPLA---------------VNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHS---------HDHTQ----------LHAYIGVSLVLGFVFMLLV-------DQIGN-----------------SHVH--------------------------------------------------------STDDPEAARSSN-------------------------------------------------------------------------------------SKITT-----TLGLVVHAAADGVALG---AAASTSQTSVQLI----VFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSM-VTYLGLSK--SSKEA-----LSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKP---DATGGRGLSRLEVAALVLGCLIPL---ILSVGHQH--------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC39A1 53 R/P 0.000148745 rs767605162
-- SLC39A1 65 R/H 0.00123134 rs61755890
-- SLC39A1 195 G/E 0.000119936 rs201735295
-- SLC39A1 202 R/Q 0.000103977 rs752283283
-- SLC39A1 206 R/Q 0.000651864 rs146586677
-- SLC39A1 265 G/R 0.000143541 rs368689023

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC39A1 SLC39A1 [plasma membrane] Zinc influx into cells by the SLC39 gene family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data