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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC38A8


Basic description
Gene Name SLC38A8
Protein Name Putative sodium-coupled neutral amino acid transporter 8 (Solute carrier family 38 member 8)
Family SLC38
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430 
MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS KAGGVVPAFL VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI GKLCEACFLL NLLMISVAFL RVIGDQLEKL CDSLLSGTPP APQPWYADQR FTLPLLSVLV ILPLSAPREI AFQKYTSILG TLAACYLALV ITVQYYLWPQ GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC SMRKRSLSHW ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL TILWVTVTLA MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI GPRVKCCLEV WGVVSVLVGT FIFGQSTAAA VWEMF 
CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHC CCCCHHHCHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCHHHHCCCC CCHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHC
[Overview] SLC38A1 SLC38A10 SLC38A11 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A7 SLC38A8 SLC38A9 
SLC38A1   MMHFKS---GLELTELQ--------NMTV-PEDDNISNDSN-DFT-------EVENG-QINSKFIS-----------DRESRRSL----------------------TNSHLEKKK------CDEYIPG------TTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYS-INLLLICSKE-----TGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETF-------------------------------------------SAWYVDGRVLVVIVTFGIILPLCLLKN-LGYLGYTSGFSLSCMVFFLIVVIYKKFQIPC-------------------------IVP------ELN------------------------STISANSTN--ADTCTPKYVTFNSKTVY-ALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMF--VMYFLTAIFGYLTF------YDNVQSDLLHKYQS--KDDILILTVRLAVIVAVILTVPVLFFTVRSSLFE-LAKKTK-----------------------FNLCRHTVV-TCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKIT--DQDGDKGTQRIWAAL----FLGLGVLFSLVSIPL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIYDWACSSSSDEGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A10  ------------------------------------------------------MTA-AAAS---------------------------------------------------------------------------NWGL-ITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQS-CMFLVKSASL-----SKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVG--------------------------------------------GTFRM---FLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGL-----------------------------------------------------------------------FSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVT--TFYVMVGFFGYVSF------TEATAGNVLMHFPS----NLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQK----------DGTFA---AGGYMPPLRFKAL-TLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKI---HKNALSSQVVL--------WVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGPPEES
SLC38A11  -----------------------------------------------------------------------------------------------------------------------------------------------------------------MKQAGFPLGILLLFWVSYVTDFS-LVLLIKGGAL-----SGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPE---------------------------------------------NVFIGRHFIIGLSTVTFTLPLSLYRN-IAKLGKVSLISTGLTTLILGIVMARAISLGPHIP-----------------------------------------------------------------------KTEDAWVFAKPNAIQ-AVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISV--FICIFFATCGYLTF------TGFTQGDLFENYCR---NDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGN------------------------LSSVFHIVV-TVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKL---SEEPRTHSDKIMSCV----MLPIGAVVMVFGFVM---------------------------------------------------------------------------------------------------------------AITNTQD--------------------------------------------------------------------------------------------------CTH-----------------------------------------------------------------GQEMFYC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPDNFSLTNTSESHVQQTT-----------------------------------------------------------------------------------------------------------QLS----------------------TLNISIFQ------------------------
SLC38A2   ----------MKKAEMG--------RFSISPDEDSSSYSSNSDFNYSY----PTKQA-ALKSHYADV----------DPENQNFL----------------------LESNLGKKK-----YETEFHPG------TTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYS-VHLLLKTANE-----GGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKT-------------------------------------------GLWYLNGNYLVLLVSLVVILPLSLFRN-LGYLGYTSGLSLLCMVFFLIVVICKKFQVPC--PVEAALIINETINTTLT--QPTALVP----------------------------------ALSHNVTE--NDSCRPHYFIFNSQTVY-AVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMF--LMYLLAALFGYLTF------YEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKD-----------------------FSWWRHSLI-TVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLV--KKEPMKSVQKIGALF----FLLSGVLVMTGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVLDWVHNAPGGGH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A3   ------------------------------------------------------MEA-PLQTEMVELV-------PNGKHSEGLLPVI-TPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYS-IHLLLKSSGV-----VGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKT-------------------------------------------SDWYMNGNYLVILVSVTIILPLALMRQ-LGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLP--------PNFNNTTGNFSHVEIVK-------------------------------EKVQLQVEPEA--SAFCTPSYFTLNSQTAY-TIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMY--IMYFLAALFGYLTF------YNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQE-----------------------FSWLRHVLI-AVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALC----FAMLGFLLMTMSLSF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWASGTSRHGGNH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A4   ----------MDPMELR--------NVNIEPDDESSSGESAPD---SYIGIGNSEKA-AMSSQFANE----------DTESQKFL----------------------TNGFLGKKKLAD--YADEHHPG------TTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYS-VHLLLKTAKE-----GGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENT-------------------------------------------GEWYLNGNYLIIFVSVGIILPLSLLKN-LGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLP--MHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHS--DDKCEPKYFVFNSRTAY-AIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGML--VMYLLAALFGYLTF------YGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRP-----------------------FSWIRHFLI-AAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLV--KKETFRSPQKVGALI----FLVVGIFFMIGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWIYDPPNSKHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A5   -------------MELQ-------------------------D---------PKMNG-ALPSDAVGY----------RQEREGFLPSR-GPAPGSKPVQ----------------------FMD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYS-IHLLLTCAGI-----AGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPE--------------------------------------------GDWFLKGNLLIIIVSVLIILPLALMKH-LGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAI-------------------GHNETAM-------------------------------ESEALVGLPSQGLNSSCEAQMFTVDSQMSY-TVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMF--CMYGLTATFGYLTF------YSSVKAEMLHMYSQKDP---LILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKA-----------------------FSWPRHVAI-ALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALC----FGVLGVLFMAVSLGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFANWATGQSRMSGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A6   ------------------------------------------------------MEA-SWGSFNAERGWYVSVQQPEEAEAEELSPL--------------------LSNELHRQR----------SPG-------VSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS-VHLLLSMCIQ-----TAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYS--------------------------------------------RYWYLDGQTLLIIICVGIVFPLALLPK-IGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPL--------------------------------TLNY-----------------------VEKGFQISN-VTDDCKPKLFHFSKESAY-ALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSF--LIYFISALFGYLTF------YDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFP-----------------------FSWIRHFLI-TLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKL---SREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSS--------------------------------------------------------------------------------------------------NPPTSASRVAETTGRDT----------------------------------------------------ME------------------------------------------MCTQRKG-----------------------------------------------------------HARTQQEGNCLQAKGRG---------------------------------LRRTKRVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLILHFPTSRTVSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A7   ------------------------------------------------------MAQVSINNDYSEWDL-----STDAGERARLL-------------QSP------CVDTAPKSEWEA-------SPGGLDRGTTSTLGA-IFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQA-----SNERTYQEVVWAVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGA------------------------------------------SGPWYTDRKFTISLTAFLFILPLSIPRE-IGFQKYASFLSVVGTWYVTAIVIIK-YIWPDKEMTP----------------GNILTRP------------------------------------------------------ASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIAL--AVYMGTGICGFLTF------GAAVDPDVLLSYPS---EDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRY-------------QGVPVEEDVG--RERRRRVLQ-TLVWFLLTLLLALFIPDIGKVISVIGGLAA-CFIFVFPGLCLIQAKLSEMEEVKPASWW-------VLVSYGVLLVTLGAFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQTTANA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFVDLLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A8   ------------------------------------------------------MEG-----------------------------------------QTP------GSRGLPEKPHPA-------TAA----ATLSSMGA-VFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAV-----SGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPA------------------------------------------PQPWYADQRFTLPLLSVLVILPLSAPRE-IAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRE----------------SHPSLSP------------------------------------------------------ASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACC--LIYSLTGVYGFLTF------GTEVSADVLMSYPG---NDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWV------------RMPL-TILWVTVTLAMALFMPDLSEIVSIIGGISS-FFIFIFPGLCLICA--MGVEPIGPRVKC-------CLEVWGVVSVLVGTFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQSTAAA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VWEMF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A9   MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPT-NIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSP------LGSAYKLQS---------YTEG---YGKNTSLVT-IFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYC-CYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWW-DKSRTVPFYLVGLLLPLLNFKS-PSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFI-------------PTEFFVP----------------------------------EIRFQFPQ--------------------LTGVLTLAFFIHNCII----TLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPS---SDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDI------------------------YPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISL--HQEERLTWPKLIFHVF---IIILGVANLIVQFFM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC38A8 2 E/D 0.00017091 rs570795956
-- SLC38A8 5 T/I 0.000874105 rs73254348
-- SLC38A8 16 H/P 0.000899244 rs200455970
-- SLC38A8 20 A/D 0.000107598 rs150483726
-- SLC38A8 57 P/L 0.00144995 rs145119400
-- SLC38A8 107 C/G 0.000477696 rs554293529
-- SLC38A8 139 P/L 0.000130279 rs371968857
-- SLC38A8 140 P/A 0.000129864 rs199899823
-- SLC38A8 147 A/G 0.00787913 rs56802364
-- SLC38A8 197 L/F 0.000151217 rs763037826
-- SLC38A8 210 L/V 0.000740959 rs150844985
-- SLC38A8 220 S/T 0.0251184 rs11862366
-- SLC38A8 221 V/D 0.000206856 rs191193863
-- SLC38A8 227 F/Y 0.000186989 rs367775968
-- SLC38A8 236 V/I 0.000201381 rs576168838
-- SLC38A8 248 S/C 0.00830206 rs11861325
-- SLC38A8 265 Y/C 0.000251046 rs371168310
-- SLC38A8 283 D/A 0.000282452 rs139373929
-- SLC38A8 308 T/A 0.000481228 rs142821762
-- SLC38A8 321 M/L 0.000784582 rs144753514
-- SLC38A8 340 D/N 0.000232015 rs200459710
-- SLC38A8 341 P/S 0.00016796 rs138524338
-- SLC38A8 343 G/R 0.00377871 rs113733057
-- SLC38A8 347 R/W 0.000119841 rs202125219
-- SLC38A8 356 T/N 0.000283175 rs775786911
-- SLC38A8 358 T/M 0.000115647 rs573821154
-- SLC38A8 402 P/L 0.000509137 rs201194139
-- SLC38A8 427 T/M 0.00278693 rs114304006
-- SLC38A8 430 A/E 0.000107603 rs202082621
-- SLC38A8 431 V/I 0.000227081 rs144862027
-- SLC38A8 435 F/L 0.000506691 rs111765632

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data