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Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC38A3


Basic description
Gene Name SLC38A3
Protein Name Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)
Family SLC38
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
Reaction 1 ligands of SLC38A3 [extracellular region] + 1 H+ [cytosol] + 2 Na+ [extracellular region] --> 1 H+ [extracellular region] + 1 ligands of SLC38A3 [cytosol] + 2 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500 
MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH GGNH 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCHHHHCC EEEHEHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCEEEE CCEEEEECCC CCCCCCCCHH CCCCHHHHHH HHHHHHHHCC HHHHHHHHCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHCCHHCH HHHHCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHCCH HHHHHHHHHH HHHHHCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCC
[Overview] SLC38A1 SLC38A10 SLC38A11 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A7 SLC38A8 SLC38A9 
SLC38A1   MMHFKS---GLELTELQ--------NMTV-PEDDNISNDSN-DFT-------EVENG-QINSKFIS-----------DRESRRSL----------------------TNSHLEKKK------CDEYIPG------TTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYS-INLLLICSKE-----TGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETF-------------------------------------------SAWYVDGRVLVVIVTFGIILPLCLLKN-LGYLGYTSGFSLSCMVFFLIVVIYKKFQIPC-------------------------IVP------ELN------------------------STISANSTN--ADTCTPKYVTFNSKTVY-ALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMF--VMYFLTAIFGYLTF------YDNVQSDLLHKYQS--KDDILILTVRLAVIVAVILTVPVLFFTVRSSLFE-LAKKTK-----------------------FNLCRHTVV-TCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKIT--DQDGDKGTQRIWAAL----FLGLGVLFSLVSIPL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIYDWACSSSSDEGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A10  ------------------------------------------------------MTA-AAAS---------------------------------------------------------------------------NWGL-ITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQS-CMFLVKSASL-----SKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVG--------------------------------------------GTFRM---FLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGL-----------------------------------------------------------------------FSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVT--TFYVMVGFFGYVSF------TEATAGNVLMHFPS----NLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQK----------DGTFA---AGGYMPPLRFKAL-TLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKI---HKNALSSQVVL--------WVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGPPEES
SLC38A11  -----------------------------------------------------------------------------------------------------------------------------------------------------------------MKQAGFPLGILLLFWVSYVTDFS-LVLLIKGGAL-----SGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPE---------------------------------------------NVFIGRHFIIGLSTVTFTLPLSLYRN-IAKLGKVSLISTGLTTLILGIVMARAISLGPHIP-----------------------------------------------------------------------KTEDAWVFAKPNAIQ-AVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISV--FICIFFATCGYLTF------TGFTQGDLFENYCR---NDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGN------------------------LSSVFHIVV-TVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKL---SEEPRTHSDKIMSCV----MLPIGAVVMVFGFVM---------------------------------------------------------------------------------------------------------------AITNTQD--------------------------------------------------------------------------------------------------CTH-----------------------------------------------------------------GQEMFYC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPDNFSLTNTSESHVQQTT-----------------------------------------------------------------------------------------------------------QLS----------------------TLNISIFQ------------------------
SLC38A2   ----------MKKAEMG--------RFSISPDEDSSSYSSNSDFNYSY----PTKQA-ALKSHYADV----------DPENQNFL----------------------LESNLGKKK-----YETEFHPG------TTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYS-VHLLLKTANE-----GGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKT-------------------------------------------GLWYLNGNYLVLLVSLVVILPLSLFRN-LGYLGYTSGLSLLCMVFFLIVVICKKFQVPC--PVEAALIINETINTTLT--QPTALVP----------------------------------ALSHNVTE--NDSCRPHYFIFNSQTVY-AVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMF--LMYLLAALFGYLTF------YEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKD-----------------------FSWWRHSLI-TVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLV--KKEPMKSVQKIGALF----FLLSGVLVMTGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVLDWVHNAPGGGH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A3   ------------------------------------------------------MEA-PLQTEMVELV-------PNGKHSEGLLPVI-TPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYS-IHLLLKSSGV-----VGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKT-------------------------------------------SDWYMNGNYLVILVSVTIILPLALMRQ-LGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLP--------PNFNNTTGNFSHVEIVK-------------------------------EKVQLQVEPEA--SAFCTPSYFTLNSQTAY-TIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMY--IMYFLAALFGYLTF------YNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQE-----------------------FSWLRHVLI-AVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALC----FAMLGFLLMTMSLSF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWASGTSRHGGNH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A4   ----------MDPMELR--------NVNIEPDDESSSGESAPD---SYIGIGNSEKA-AMSSQFANE----------DTESQKFL----------------------TNGFLGKKKLAD--YADEHHPG------TTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYS-VHLLLKTAKE-----GGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENT-------------------------------------------GEWYLNGNYLIIFVSVGIILPLSLLKN-LGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLP--MHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHS--DDKCEPKYFVFNSRTAY-AIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGML--VMYLLAALFGYLTF------YGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRP-----------------------FSWIRHFLI-AAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLV--KKETFRSPQKVGALI----FLVVGIFFMIGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWIYDPPNSKHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A5   -------------MELQ-------------------------D---------PKMNG-ALPSDAVGY----------RQEREGFLPSR-GPAPGSKPVQ----------------------FMD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYS-IHLLLTCAGI-----AGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPE--------------------------------------------GDWFLKGNLLIIIVSVLIILPLALMKH-LGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAI-------------------GHNETAM-------------------------------ESEALVGLPSQGLNSSCEAQMFTVDSQMSY-TVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMF--CMYGLTATFGYLTF------YSSVKAEMLHMYSQKDP---LILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKA-----------------------FSWPRHVAI-ALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALC----FGVLGVLFMAVSLGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFANWATGQSRMSGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A6   ------------------------------------------------------MEA-SWGSFNAERGWYVSVQQPEEAEAEELSPL--------------------LSNELHRQR----------SPG-------VSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS-VHLLLSMCIQ-----TAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYS--------------------------------------------RYWYLDGQTLLIIICVGIVFPLALLPK-IGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPL--------------------------------TLNY-----------------------VEKGFQISN-VTDDCKPKLFHFSKESAY-ALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSF--LIYFISALFGYLTF------YDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFP-----------------------FSWIRHFLI-TLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKL---SREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSS--------------------------------------------------------------------------------------------------NPPTSASRVAETTGRDT----------------------------------------------------ME------------------------------------------MCTQRKG-----------------------------------------------------------HARTQQEGNCLQAKGRG---------------------------------LRRTKRVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLILHFPTSRTVSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A7   ------------------------------------------------------MAQVSINNDYSEWDL-----STDAGERARLL-------------QSP------CVDTAPKSEWEA-------SPGGLDRGTTSTLGA-IFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQA-----SNERTYQEVVWAVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGA------------------------------------------SGPWYTDRKFTISLTAFLFILPLSIPRE-IGFQKYASFLSVVGTWYVTAIVIIK-YIWPDKEMTP----------------GNILTRP------------------------------------------------------ASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIAL--AVYMGTGICGFLTF------GAAVDPDVLLSYPS---EDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRY-------------QGVPVEEDVG--RERRRRVLQ-TLVWFLLTLLLALFIPDIGKVISVIGGLAA-CFIFVFPGLCLIQAKLSEMEEVKPASWW-------VLVSYGVLLVTLGAFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQTTANA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFVDLLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A8   ------------------------------------------------------MEG-----------------------------------------QTP------GSRGLPEKPHPA-------TAA----ATLSSMGA-VFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAV-----SGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPA------------------------------------------PQPWYADQRFTLPLLSVLVILPLSAPRE-IAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRE----------------SHPSLSP------------------------------------------------------ASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACC--LIYSLTGVYGFLTF------GTEVSADVLMSYPG---NDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWV------------RMPL-TILWVTVTLAMALFMPDLSEIVSIIGGISS-FFIFIFPGLCLICA--MGVEPIGPRVKC-------CLEVWGVVSVLVGTFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQSTAAA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VWEMF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A9   MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPT-NIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSP------LGSAYKLQS---------YTEG---YGKNTSLVT-IFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYC-CYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWW-DKSRTVPFYLVGLLLPLLNFKS-PSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFI-------------PTEFFVP----------------------------------EIRFQFPQ--------------------LTGVLTLAFFIHNCII----TLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPS---SDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDI------------------------YPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISL--HQEERLTWPKLIFHVF---IIILGVANLIVQFFM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
No data

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC38A3 SLC38A3 [plasma membrane] Amino acid transport across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data