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Variant
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Detail Data SLC38A1


Basic description
Gene Name SLC38A1
Protein Name Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)
Family SLC38
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name Glutamine transport from astrocytes
SLC38A1 (ATA1)-mediated uptake of neutral amino acids
Reaction 1 L-Gln [cytosol] --> 1 L-Gln [extracellular region]
1 ligands of SLC38A1 [extracellular region] + 1 Na+ [extracellular region] --> 1 ligands of SLC38A1 [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480 
MMHFKSGLEL TELQNMTVPE DDNISNDSND FTEVENGQIN SKFISDRESR RSLTNSHLEK KKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG ILLFLVLLTS VTLLSIYSIN LLLICSKETG CMVYEKLGEQ VFGTTGKFVI FGATSLQNTG AMLSYLFIVK NELPSAIKFL MGKEETFSAW YVDGRVLVVI VTFGIILPLC LLKNLGYLGY TSGFSLSCMV FFLIVVIYKK FQIPCIVPEL NSTISANSTN ADTCTPKYVT FNSKTVYALP TIAFAFVCHP SVLPIYSELK DRSQKKMQMV SNISFFAMFV MYFLTAIFGY LTFYDNVQSD LLHKYQSKDD ILILTVRLAV IVAVILTVPV LFFTVRSSLF ELAKKTKFNL CRHTVVTCIL LVVINLLVIF IPSMKDIFGV VGVTSANMLI FILPSSLYLK ITDQDGDKGT QRIWAALFLG LGVLFSLVSI PLVIYDWACS SSSDEGH 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH CCCCCCCHHH CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHCHHHHHHH HHHHHHHHHC CHHCCEEEEC CCCHHHHHHH CCCCCCCHHH HCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHCC CCHHHHHHHC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH CHHCCCHHHH HCHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCC
[Overview] SLC38A1 SLC38A10 SLC38A11 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A7 SLC38A8 SLC38A9 
SLC38A1   MMHFKS---GLELTELQ--------NMTV-PEDDNISNDSN-DFT-------EVENG-QINSKFIS-----------DRESRRSL----------------------TNSHLEKKK------CDEYIPG------TTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYS-INLLLICSKE-----TGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETF-------------------------------------------SAWYVDGRVLVVIVTFGIILPLCLLKN-LGYLGYTSGFSLSCMVFFLIVVIYKKFQIPC-------------------------IVP------ELN------------------------STISANSTN--ADTCTPKYVTFNSKTVY-ALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMF--VMYFLTAIFGYLTF------YDNVQSDLLHKYQS--KDDILILTVRLAVIVAVILTVPVLFFTVRSSLFE-LAKKTK-----------------------FNLCRHTVV-TCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKIT--DQDGDKGTQRIWAAL----FLGLGVLFSLVSIPL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIYDWACSSSSDEGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A10  ------------------------------------------------------MTA-AAAS---------------------------------------------------------------------------NWGL-ITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQS-CMFLVKSASL-----SKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVG--------------------------------------------GTFRM---FLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGL-----------------------------------------------------------------------FSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVT--TFYVMVGFFGYVSF------TEATAGNVLMHFPS----NLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQK----------DGTFA---AGGYMPPLRFKAL-TLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKI---HKNALSSQVVL--------WVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGPPEES
SLC38A11  -----------------------------------------------------------------------------------------------------------------------------------------------------------------MKQAGFPLGILLLFWVSYVTDFS-LVLLIKGGAL-----SGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPE---------------------------------------------NVFIGRHFIIGLSTVTFTLPLSLYRN-IAKLGKVSLISTGLTTLILGIVMARAISLGPHIP-----------------------------------------------------------------------KTEDAWVFAKPNAIQ-AVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISV--FICIFFATCGYLTF------TGFTQGDLFENYCR---NDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGN------------------------LSSVFHIVV-TVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKL---SEEPRTHSDKIMSCV----MLPIGAVVMVFGFVM---------------------------------------------------------------------------------------------------------------AITNTQD--------------------------------------------------------------------------------------------------CTH-----------------------------------------------------------------GQEMFYC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPDNFSLTNTSESHVQQTT-----------------------------------------------------------------------------------------------------------QLS----------------------TLNISIFQ------------------------
SLC38A2   ----------MKKAEMG--------RFSISPDEDSSSYSSNSDFNYSY----PTKQA-ALKSHYADV----------DPENQNFL----------------------LESNLGKKK-----YETEFHPG------TTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYS-VHLLLKTANE-----GGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKT-------------------------------------------GLWYLNGNYLVLLVSLVVILPLSLFRN-LGYLGYTSGLSLLCMVFFLIVVICKKFQVPC--PVEAALIINETINTTLT--QPTALVP----------------------------------ALSHNVTE--NDSCRPHYFIFNSQTVY-AVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMF--LMYLLAALFGYLTF------YEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKD-----------------------FSWWRHSLI-TVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLV--KKEPMKSVQKIGALF----FLLSGVLVMTGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVLDWVHNAPGGGH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A3   ------------------------------------------------------MEA-PLQTEMVELV-------PNGKHSEGLLPVI-TPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYS-IHLLLKSSGV-----VGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKT-------------------------------------------SDWYMNGNYLVILVSVTIILPLALMRQ-LGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLP--------PNFNNTTGNFSHVEIVK-------------------------------EKVQLQVEPEA--SAFCTPSYFTLNSQTAY-TIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMY--IMYFLAALFGYLTF------YNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQE-----------------------FSWLRHVLI-AVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALC----FAMLGFLLMTMSLSF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWASGTSRHGGNH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A4   ----------MDPMELR--------NVNIEPDDESSSGESAPD---SYIGIGNSEKA-AMSSQFANE----------DTESQKFL----------------------TNGFLGKKKLAD--YADEHHPG------TTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYS-VHLLLKTAKE-----GGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENT-------------------------------------------GEWYLNGNYLIIFVSVGIILPLSLLKN-LGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLP--MHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHS--DDKCEPKYFVFNSRTAY-AIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGML--VMYLLAALFGYLTF------YGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRP-----------------------FSWIRHFLI-AAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLV--KKETFRSPQKVGALI----FLVVGIFFMIGSMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIIDWIYDPPNSKHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A5   -------------MELQ-------------------------D---------PKMNG-ALPSDAVGY----------RQEREGFLPSR-GPAPGSKPVQ----------------------FMD--FEG------KTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYS-IHLLLTCAGI-----AGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPE--------------------------------------------GDWFLKGNLLIIIVSVLIILPLALMKH-LGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAI-------------------GHNETAM-------------------------------ESEALVGLPSQGLNSSCEAQMFTVDSQMSY-TVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMF--CMYGLTATFGYLTF------YSSVKAEMLHMYSQKDP---LILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKA-----------------------FSWPRHVAI-ALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALC----FGVLGVLFMAVSLGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFANWATGQSRMSGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A6   ------------------------------------------------------MEA-SWGSFNAERGWYVSVQQPEEAEAEELSPL--------------------LSNELHRQR----------SPG-------VSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS-VHLLLSMCIQ-----TAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYS--------------------------------------------RYWYLDGQTLLIIICVGIVFPLALLPK-IGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPL--------------------------------TLNY-----------------------VEKGFQISN-VTDDCKPKLFHFSKESAY-ALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSF--LIYFISALFGYLTF------YDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFP-----------------------FSWIRHFLI-TLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKL---SREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSS--------------------------------------------------------------------------------------------------NPPTSASRVAETTGRDT----------------------------------------------------ME------------------------------------------MCTQRKG-----------------------------------------------------------HARTQQEGNCLQAKGRG---------------------------------LRRTKRVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLILHFPTSRTVSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A7   ------------------------------------------------------MAQVSINNDYSEWDL-----STDAGERARLL-------------QSP------CVDTAPKSEWEA-------SPGGLDRGTTSTLGA-IFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQA-----SNERTYQEVVWAVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGA------------------------------------------SGPWYTDRKFTISLTAFLFILPLSIPRE-IGFQKYASFLSVVGTWYVTAIVIIK-YIWPDKEMTP----------------GNILTRP------------------------------------------------------ASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIAL--AVYMGTGICGFLTF------GAAVDPDVLLSYPS---EDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRY-------------QGVPVEEDVG--RERRRRVLQ-TLVWFLLTLLLALFIPDIGKVISVIGGLAA-CFIFVFPGLCLIQAKLSEMEEVKPASWW-------VLVSYGVLLVTLGAFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQTTANA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFVDLLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A8   ------------------------------------------------------MEG-----------------------------------------QTP------GSRGLPEKPHPA-------TAA----ATLSSMGA-VFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAV-----SGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPA------------------------------------------PQPWYADQRFTLPLLSVLVILPLSAPRE-IAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRE----------------SHPSLSP------------------------------------------------------ASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACC--LIYSLTGVYGFLTF------GTEVSADVLMSYPG---NDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWV------------RMPL-TILWVTVTLAMALFMPDLSEIVSIIGGISS-FFIFIFPGLCLICA--MGVEPIGPRVKC-------CLEVWGVVSVLVGTFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGQSTAAA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VWEMF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLC38A9   MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPT-NIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSP------LGSAYKLQS---------YTEG---YGKNTSLVT-IFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYC-CYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWW-DKSRTVPFYLVGLLLPLLNFKS-PSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFI-------------PTEFFVP----------------------------------EIRFQFPQ--------------------LTGVLTLAFFIHNCII----TLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPS---SDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDI------------------------YPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISL--HQEERLTWPKLIFHVF---IIILGVANLIVQFFM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC38A1 149 V/I 0.000108318 rs367932653
-- SLC38A1 258 S/A 0.000172421 rs199515149
-- SLC38A1 392 R/H 0.00157488 rs200881452
-- SLC38A1 395 V/M 0.00151856 rs114226133
-- SLC38A1 435 S/A 0.000138479 rs768949954
-- SLC38A1 473 I/N 0.000230899 rs879853551
-- SLC38A1 483 M/V 0.000968689 rs142103829
-- SLC38A1 485 E/K 0.000338404 rs202229349
-- SLC38A1 486 R/H 0.000246001 rs114140956
-- SLC38A1 486 R/C 0.000290702 rs541687865

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC38A1 SLC38A1 [plasma membrane] Amino acid transport across the plasma membrane
SLC38A1 SLC38A1 [plasma membrane] Astrocytic Glutamate-Glutamine Uptake And Metabolism

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data