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Variant
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Detail Data SLC37A4


Basic description
Gene Name SLC37A4
Protein Name Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19)
Family SLC37
Category -
Reaction name Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4
Reaction 1 Pi [endoplasmic reticulum lumen] + 1 G6P [cytosol] --> 1 Pi [cytosol] + 1 G6P [endoplasmic reticulum lumen]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420 
MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAASTAA FFLLRNIRTK MGRVSKKAE 
CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHCCCHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHCCCC HHHCCCCCCC CCCCCCCCCC CCCCCCHHHH HCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCC
[Overview] SLC37A1 SLC37A2 SLC37A3 SLC37A4 
SLC37A1   --------MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEADVRFSSQNRKSGSAAPHQLPDNETD-------CGWAPFDKNNYQQL-LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFG-LGYFYNIHSFG-----FYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVS-TCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKNKPLDP-EMQCLLLSDGKGSI---------HPNHVVILPGDGGS--GTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRA-------STCGLMLLLAAPT-----LYIFSTVSKMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGL----LSPS-GWSNVFYM--LMFADACALLFLIRLIHKEL----SCPGSATGDQVPFKEQ------
SLC37A2   -------MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNC----------SEQIK----------PINDTHSLNDTMWCSWAPFDKDNYKEL-LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFG-LGYFWNIHELW-----YFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVN-GQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPP-QHHGEPAEN---------------QDNPEDPGNSPCSIRESGLETVAKCSKGPCEEP----------------AAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRA-------TTCCVMLILAAPM-----MFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGL----ISPT-GWNNVFYM--LISADVLACLLLCRLVYKEILAWKVSLSRGSGSSMVLTHQ------
SLC37A3   MAWPNVFQRGSL---------LSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVK--------------VSISEQWTPSAFNTSVELPVE--------IWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKW-----LYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGI-----EAEEN--------------FEEDSHRP------LINGGENEDEY-------EPNYSI---QDDSSVAQVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRA-------PVLALSLLLAVGS-----LIGYSRSPNDKSINALLM-TVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSL----IRDKLGWMWVFYF--FILMTSCTIVFISPLIVREIF------------SLVLRRQAHILRE
SLC37A4   -------------------MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSL-----------VE--------------EIPLDKDD----------------------LGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFA-----------WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNL------------------------------DP------MPSEGKKGSLK------EES-------------------TLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAIVGLM----------ANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMG------------RVSKKAE------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC37A4 24 Y/C 0.000104427 rs569831771
-- SLC37A4 34 V/I 0.000124539 rs782644732
-- SLC37A4 126 R/Q 0.000118855 rs78735156
-- SLC37A4 156 A/V 0.00165831 rs201036248
-- SLC37A4 164 S/R 0.000162143 rs369399624
-- SLC37A4 166 R/H 0.000510498 rs186476316
-- SLC37A4 185 L/F 0.000152884 rs538938823
-- SLC37A4 197 N/I 0.00362563 rs34203644
-- SLC37A4 202 P/T 0.000112435 rs534894133
-- SLC37A4 203 S/F 0.000252961 rs567419206
-- SLC37A4 260 V/I 0.000523442 rs561701030
-- SLC37A4 285 R/Q 0.00022307 rs548684318
-- SLC37A4 322 T/I 0.00344439 rs202209699
-- SLC37A4 334 L/V 0.000718579 rs201997939
-- SLC37A4 340 A/V 0.00287646 rs191545031
-- SLC37A4 352 I/V 0.00109209 rs201967384
-- SLC37A4 359 F/L 0.000426278 rs200662873
-- SLC37A4 377 S/T 0.00109123 rs547488738
-- SLC37A4 411 H/Y 0.000100322 rs199764888
-- SLC37A4 413 S/R 0.000140439 rs782552989
-- SLC37A4 450 E/A 0.000108737 rs149974794

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC37A4 SLC37A4 [endoplasmic reticulum membrane] Gluconeogenesis

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC37A4 SLC37A4 G20D [endoplasmic reticulum membrane] Glycogen storage disease type Ib (SLC37A4)
SLC37A4 SLC37A4 G88D [endoplasmic reticulum membrane] Glycogen storage disease type Ib (SLC37A4)