| Menu |
| Basic |
| Network |
| Structure |
| Seq./Align. |
| Variant |
| Phylogenetic Tree |
| Pathway |
| Disease |
Detail Data SLC36A4
Basic description
| Gene Name | SLC36A4 |
|---|---|
| Protein Name | Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) |
| Family | SLC36 |
| Category | Transport of inorganic cations/anions and amino acids/oligopeptides |
| Reaction name |
SLC36A4 transports extracellular L-Pro to the cytosol SLC36A4 transports L-Trp from extracellular region to cytosol |
| Reaction |
1 L-Pro [extracellular region] --> 1 L-Pro [cytosol] 1 L-Trp [extracellular region] --> 1 L-Trp [cytosol] |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 MEAAATPAAA GAARREELDM DVMRPLINEQ NFDGTSDEEH EQELLPVQKH YQLDDQEGIS FVQTLMHLLK GNIGTGLLGL PLAIKNAGIV LGPISLVFIG IISVHCMHIL VRCSHFLCLR FKKSTLGYSD TVSFAMEVSP WSCLQKQAAW GRSVVDFFLV ITQLGFCSVY IVFLAENVKQ VHEGFLESKV FISNSTNSSN PCERRSVDLR IYMLCFLPFI ILLVFIRELK NLFVLSFLAN VSMAVSLVII YQYVVRNMPD PHNLPIVAGW KKYPLFFGTA VFAFEGIGVV LPLENQMKES KRFPQALNIG MGIVTTLYVT LATLGYMCFH DEIKGSITLN LPQDVWLYQS VKILYSFGIF VTYSIQFYVP AEIIIPGITS KFHTKWKQIC EFGIRSFLVS ITCAGAILIP RLDIVISFVG AVSSSTLALI LPPLVEILTF SKEHYNIWMV LKNISIAFTG VVGFLLGTYI TVEEIIYPTP KVVAGTPQSP FLNLNSTCLT SGLK CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHCCCCCC CCCCCCCCCC HHHHHHHHHH HHHCHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC EECCCCCCCC CCCHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHC CHHHHHCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCHHC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCHHHH HHCHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCC
[Overview]
SLC36A1 -------------------MSTQRLRNEDYH-DYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNST------------------TWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWG-----------------------------------------RRVVDFFLIVTQLGFCCVYFVFLADNFKQV----------IEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLP-NCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFI----------NSTCAFI--- SLC36A2 -------------------MSVTK-----------STE-GPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWG-----------------------------------------RHIVSFFLIITQLGFCCVYIVFLADNLKQV----------VEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLP-NCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFS----------NST-TFVR-- SLC36A3 -------------------MSLLG---RDYNSELNSLDNGPQ----------SPSESSSSITSENVH-----PAGEAGL------SMMQTLIHLLKCNIGTGLLGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGLETCPNTWLRAHAVWGRWNLALSPRLECSGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLVITQLGFCSVYFMFMADNLQQM----------VEKAHVTSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMALIFEYIMEGIPYPSNLPLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQFSFVLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLP-NCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPFAISQVSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIAKDIMISIVGLLGCIFGTYQALYELPQPI-SHSMA----------NSTGVHA--- SLC36A4 MEAAATPAAAGAARREELDMDVMRPLINEQNFDGTSDEEHEQE--------LLPVQKHYQLDDQEGI------------------SFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWG-----------------------------------------RSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISNSTNSSNPCERRSV-------DLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEIIYPT-PKVVAGTPQSPFLNLNSTCLTSGLK
Variant
| check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
|---|---|---|---|---|---|
| -- | SLC36A4 | 14 | R/S | 0.00019356 | rs769050426 |
| -- | SLC36A4 | 24 | R/S | 0.000108337 | rs544433678 |
| -- | SLC36A4 | 33 | D/V | 0.000300635 | rs750283537 |
| -- | SLC36A4 | 114 | S/R | 0.000228726 | rs141009557 |
| -- | SLC36A4 | 131 | T/P | 0.000266903 | rs767128226 |
| -- | SLC36A4 | 139 | S/G | 0.000109168 | rs139698991 |
| -- | SLC36A4 | 140 | P/A | 0.000207842 | rs762743236 |
| -- | SLC36A4 | 144 | L/P | 0.000364363 | rs146835691 |
| -- | SLC36A4 | 190 | V/G | 0.000136586 | rs200161055 |
| -- | SLC36A4 | 195 | S/N | 0.000435544 | rs143476889 |
| -- | SLC36A4 | 210 | R/T | 0.00218827 | rs143001920 |
| -- | SLC36A4 | 287 | I/V | 0.000100729 | rs200479590 |
| -- | SLC36A4 | 302 | R/C | 0.000147972 | rs117464224 |
| -- | SLC36A4 | 324 | L/S | 0.000279114 | rs149819804 |
| -- | SLC36A4 | 329 | F/C | 0.000211732 | rs139843467 |
| -- | SLC36A4 | 330 | H/R | 0.0537356 | rs78676517 |
| -- | SLC36A4 | 344 | D/Y | 0.000291151 | rs76610702 |
| -- | SLC36A4 | 405 | G/R | 0.000152975 | rs77563026 |
| -- | SLC36A4 | 441 | S/L | 0.000243494 | rs201279167 |
Phylogenetic tree
Pathway
| Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|---|
| main | SLC36A4 | SLC36A4 [plasma membrane] | Amino acid transport across the plasma membrane |
| SLC36A4 | SLC36A4 [plasma membrane] | Tryptophan catabolism |
Disease
| Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|
| No data | ||