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Seq./Align.
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Detail Data SLC36A1


Basic description
Gene Name SLC36A1
Protein Name Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1)
Family SLC36
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC36A1-mediated uptake of glycine, proline, and alanine
Reaction 1 H+ [extracellular region] + 1 ligands of SLC36A1 [extracellular region] --> 1 H+ [cytosol] + 1 ligands of SLC36A1 [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470 
MSTQRLRNED YHDYSSTDVS PEESPSEGLN NLSSPGSYQR FGQSNSTTWF QTLIHLLKGN IGTGLLGLPL AVKNAGIVMG PISLLIIGIV AVHCMGILVK CAHHFCRRLN KSFVDYGDTV MYGLESSPCS WLRNHAHWGR RVVDFFLIVT QLGFCCVYFV FLADNFKQVI EAANGTTNNC HNNETVILTP TMDSRLYMLS FLPFLVLLVF IRNLRALSIF SLLANITMLV SLVMIYQFIV QRIPDPSHLP LVAPWKTYPL FFGTAIFSFE GIGMVLPLEN KMKDPRKFPL ILYLGMVIVT ILYISLGCLG YLQFGANIQG SITLNLPNCW LYQSVKLLYS IGIFFTYALQ FYVPAEIIIP FFVSRAPEHC ELVVDLFVRT VLVCLTCILA ILIPRLDLVI SLVGSVSSSA LALIIPPLLE VTTFYSEGMS PLTIFKDALI SILGFVGFVV GTYEALYELI QPSNAPIFIN STCAFI 
CCCHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HCCHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CEECCCHHHH HHCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHH HHHCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCHHHH HHHHHHHHHC CCCCCCCHHH CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC HHHHCCCCCC HHHHHHHHHH HHHHHHHHHH HCHHHHHHHH HHHCCCCCCC HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCC
[Overview] SLC36A1 SLC36A2 SLC36A3 SLC36A4 
SLC36A1   -------------------MSTQRLRNEDYH-DYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNST------------------TWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWG-----------------------------------------RRVVDFFLIVTQLGFCCVYFVFLADNFKQV----------IEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLP-NCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFI----------NSTCAFI---
SLC36A2   -------------------MSVTK-----------STE-GPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWG-----------------------------------------RHIVSFFLIITQLGFCCVYIVFLADNLKQV----------VEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLP-NCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFS----------NST-TFVR--
SLC36A3   -------------------MSLLG---RDYNSELNSLDNGPQ----------SPSESSSSITSENVH-----PAGEAGL------SMMQTLIHLLKCNIGTGLLGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGLETCPNTWLRAHAVWGRWNLALSPRLECSGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLVITQLGFCSVYFMFMADNLQQM----------VEKAHVTSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMALIFEYIMEGIPYPSNLPLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQFSFVLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLP-NCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPFAISQVSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIAKDIMISIVGLLGCIFGTYQALYELPQPI-SHSMA----------NSTGVHA---
SLC36A4   MEAAATPAAAGAARREELDMDVMRPLINEQNFDGTSDEEHEQE--------LLPVQKHYQLDDQEGI------------------SFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWG-----------------------------------------RSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISNSTNSSNPCERRSV-------DLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEIIYPT-PKVVAGTPQSPFLNLNSTCLTSGLK

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC36A1 195 R/Q 0.000298237 rs538839843
-- SLC36A1 333 Q/L 0.000390112 rs140884226
-- SLC36A1 354 P/L 0.000425525 rs140356275
-- SLC36A1 362 F/L 0.00372232 rs9687945
-- SLC36A1 379 R/H 0.000139262 rs183131678
-- SLC36A1 385 L/V 0.000227716 rs372327626
-- SLC36A1 453 Y/C 0.000155104 rs150913271
-- SLC36A1 470 N/S 0.000282634 rs140057648

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC36A1 SLC36A1 [plasma membrane] Amino acid transport across the plasma membrane
main SLC36A1 SLC36A1 [plasma membrane] Proton-coupled neutral amino acid transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data