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Detail Data SLC35A2


Basic description
Gene Name SLC35A2
Protein Name UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT)
Family SLC35
Category Transport of vitamins, nucleosides, and related molecules
Reaction name SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP
Reaction 1 uridine 5'-monophosphate [Golgi lumen] + 1 UDP-Gal, UDP-GalNAc [cytosol] --> 1 UMP [cytosol] + 1 UDP-Gal, UDP-GalNAc [Golgi lumen]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390 
MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGG GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS ASASASGPCV HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHCEE EEECCCCCCC CCCCCCCCCH HHHEEHHHHH HHHHCHHCHH HHHHHCCCCC HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHCCCCCHH HHHHHHHHCC CCHHHHHHHC CCCCHHHHHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHCCC
[Overview] SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35D4 SLC35E1 SLC35E2 SLC35E3 SLC35E4 SLC35F1 SLC35F2 SLC35F3 SLC35F4 SLC35F5 SLC35F6 SLC35G1 SLC35G2 SLC35G3 SLC35G4 SLC35G5 SLC35G6 
SLC35A1   -------------------MAA---------------------------------------------------------------------------------------------------------------------------------------------PR---------------DNVTL------------------------LFKLYCLAVMTLMAAVYTIALRYTRTS-----------DKELYFSTTAVCITEVIKLL----------------------------LS----------------VGI------LAKET-GS-----------------------------------------LGRFKASLRENVLGSPKELLKLSVP-----SLVYAVQNNMAFLALSNL--DAAVYQVT-------YQLKIPCTALCTV------------LMLNRTL-----SKLQWVSVFMLC---------------------AGVTLVQ--------------------------------------------WKP------AQATKVV----VEQNPLLGFGAIAIAVLCSGFAG--------VYFEKVLKSSDT---------------SLWVRNIQ-MYLSGIIVT---------------LAGVYLSDGA-EIK-----------------EKGFFYGYTYYVWFVIFLA-----------------------------SVGGLYTSVVVKYTDN----------IMKG---------------------FSAAAAIV-----------LSTIAS-VMLFGLQITLT-------------------------------------------FALGTLLVCVS-----------IYL--YGL--------------PRQDTTSIQQGETASK--------------------------------------------------------------------------ERVIGV---------------
SLC35A2   -------------------MAAV----------------------------------------------------------------------------------------------------------GAG--------------------------GSTAAPG---------------PGAVSAGAL-------EPGTASA--A-HRRLKYISLAVLVVQNASLILSIRYARTL-----------PGDRFFATTAVVMAEVLKGL----------------------------TC----------------LLL------LFAQKRGN-----------------------------------------VKHLVLFLHEAVLVQYVDTLKLAVP-----SLIYTLQNNLQYVAISNL--PAATFQVT-------YQLKILTTALFSV------------LMLNRSL-----SRLQWASLLLLF---------------------TGVAIVQ-----------------------------------------------------AQQAGGGGPRPLDQNPGAGLAAVVASCLSSGFAG--------VYFEKILKGSSG---------------SVWLRNLQ-LGLFGTALG---------------LVGLWWAEGT-AVA-----------------TRGFFFGYTPAVWGVVLNQ-----------------------------AFGGLLVAVVVKYADN----------ILKG---------------------FATSLSIV-----------LSTVAS-IRLFGFHVDPL-------------------------------------------FALGAGLVIGA-----------VYL--YSL--------------PRGAAKAIASASASASG----PCV------------HQQPPGQPP-------------PPQLSSHRGDLITEPF---------LPK--LLTKVKGS---------------
SLC35A3   -------------------MFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLKYVSLGILVFQTTSLVLTMRYSRTLK---------EEGPRYLSSTAVVVAELLKIM----------------------------AC----------------ILL------VYKDSKCS-----------------------------------------LRALNRVLHDEILNKPMETLKLAIP-----SGIYTLQNNLLYVALSNL--DAATYQVT-------YQLKILTTALFSV------------SMLSKKL-----GVYQWLSLVILM---------------------TGVAFVQ--------------------------------------------WPSDSQL-DSKELSAG-------SQFVGLMAVLTACFSSGFAG--------VYFEKILKETKQ---------------SVWIRNIQ-LGFFGSIFG---------------LMGVYIYDGE-LVS-----------------KNGFFQGYNRLTWIVVVLQ-----------------------------ALGGLVIAAVIKYADN----------ILKG---------------------FATSLSII-----------LSTLISYFWLQDFVPTSV-------------------------------------------FFLGAILVITA-----------TFL--YGYD-------------PK-------------------------------------PAGNP----------------------------------------------TKA------------------
SLC35A4   -------------------MSV-----------------------------------------------------------------------------------------------------------EDG--------------------------GMPGLGR---------------P--------------------RQ--ARWTLMLLLSTAMYGAHAPLLALCHVDGRVP---------------FRPSSAVLLTELTKLL----------------------------LCAFS-------------LLVGW---------------------------------------------------------------QAWPQGPPPWRQAAPFAL-SALLYGANNNLVIYLQRYM--DPSTYQVL-------SNLKIGSTAVLYC------------LCLRHRL-----SVRQGLALLLLM--------------------AAGACYAAGGLQ----------VPGN--------------------TLP---SPPP-----AAAASPM---PLH-ITPLGLLLLILYCLISGLSS--------VYTELLMKRQRL---------------PLALQNLF-LYTFGVLLN----------------LGLHAGGGS---------------------GPGLLEGFSGWAALVVLSQ-----------------------------ALNGLLMSAVMKHGSS----------ITRL---------------------FVVSCSLV-----------VNAVLS-AVLLRLQLTAA-------------------------------------------FFLATLLIGLA-----------MRL--Y--------------YGSR-------------------------------------------------------------------------------------------------------------
SLC35A5   -------------------MEK------------------------------------------------------------------------------------------------------------------------------------------QCCSH---------------PVICSLST---------------------MYTFLLGAIFIALSSSRILLVKYSANE----------ENKYDYLPTTVNVCSELVKLV----------------------------FC----------------VLVSF---CVIKKD----------------------------------------------HQSRNLKYASWKEFSDFMKWSIP-----AFLYFLDNLIVFYVLSYL--QPAMAVIF-------SNFSIITTALLFR------------IVLKRRL-----NWIQWASLLTLFLSIVA--------------LTAGTKTLQHNLAGRGFHHDAFFSPSNSCLLFRSECPRKDNCTAKEWTFPEAKWNTT-----ARVFSHI-------RLGMGHVLIIVQCFISSMAN--------IYNEKILKEGNQL------------TESIFIQNSK-LYFFGILFNG-------------LTLGLQRSNRD-QIK-----------------NCGFFYGHSAFSVALIFVT-----------------------------AFQGLSVAFILKFLDN----------MFHV---------------------LMAQVTTV-----------IITTVS-VLVFDFRPSLE-------------------------------------------FFLEAPSVLLS-----------IFI--YNASKPQVPE-----YAPRQERIRDLSGNLWER-----------------------SSGDG---------------EELER-------------------------LTKPKSDESDEDTF--------
SLC35B1   ------------------------------------------------------------------------------------------------------------------------------MASSSSLVPDR-----------------------------------------LR-----------------------------------------------------------------------------------------------------------------LPLC-------------FLGVFVCYFYYGILQEKITR----GKYGEGAKQETFTFALTLVFI---------QCVINAVFAKILIQFFDTARVDRTRSWLYAAC---SISYLGAMV--SSNSALQFVN---YPTQVL------GKSCKPIPVMLLGV------------TLLKKKY-----PLAKYLCVLLIV---------------------AGVALFM--------------------------------------------YKPKKVVGIEEHTVGY-----------GELLLLLSLTLDGLTG--------VSQDHMRAHYQTGSNHMMLN----------------INLWSTLLL---------------GMGILFTGEL-------------------WEFLSFAERYPAIIYNILLFG--------------------------LTSALGQSFIFMTVVY----------FGPLTCS---------------------IITTTR----------KF-FTILAS-VILFANPISPM-------------------------------------------QWVGTVLVFLG-----------L-----------------------------------------------------------GLDAKF------------GKGAKKTSH----------------------------------------------
SLC35B2   -------------------MDARWWAVVVLAAF--PSL-------------------GAGGETPEAP--------------------PESWTQLWFFRFVV-----------------------NAAGYASFMVPGY-----------LLVQY-FRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAP---RTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGL------SCV-------------------LCKQPRHGAPMYRYSFA-----------------------------------------------------------------------------------------SLSNVLSSWCQYEALKFV--SFPTQVLA-------KASKVIPVMLMGK------------LVSRRSY-----EHWEYLTATLIS---------------------IGVSMFLL---------------------------------------------SSGP---EPRSSP-------ATTLSGLILLAGYIAFDSFTS--------NWQD-ALFAYKMSSVQMMFGVN--------------F--FSCLFTVGSLLEQGALLEGTRFMG---------------------------------RHSEFAAHALLLS---------------------------ICSACGQLFIFYTIGQ----------FGAAVFT---------------------IIMTLRQA-----------FAILLS-CLLYGHTVTVVGG-------------------------------------------LGVAVVFAA-----------LLLRVYARGR--------LKQRGKK-----------------------------AVPVE-----SPVQKV---------------------------------------------------------------
SLC35B3   -------------------MDLTQQAKDIQ---------------------------------------------------NIT-VQETNKNN-------------------------------SESIECSKITMDLKFNNSRK------------YISITVPSKTQ----------TMSPHIKSVDD-----------------------VVVLGMNLSKFNKLT------------------------------------------------------------------QFFIC-------------VAGVFVFYLIYGYLQELIF---------SVEGFKSCGWYLTLVQF---------AFYSIFGLIELQLIQDKRRRIPGKTY--MI------IAFLTVGTMGLSNTSLGYLN---YPTQVI------FKCCKLIPVMLGGV------------FIQGKRY-----NVADVSAAICMS---------------------LGLIWFT--------------------------------------------L-------ADSTTAPN-------FNLTGVVLISLALCADAVIG--------NVQEKAMKLHNASNSEMVLY----------------SYSIGFVYI---------------LLGLTCTSGL-------------------GPAVTFCAKNPVRTYGYAFLFS-------------------------LTGYFGISFVLALIKI----------FGALIAV---------------------TVTTGR----------KA-MTIVLS-FIFFAKPFTFQ-------------------------------------------YVWSGLLVVLG-----------IFLNVYSKNMDKIRL----------------------------PSL-----------YDLINKSVE------------ARKSRTLAQTV--------------------------------------------
SLC35B4   ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRP--------------------------------ALAVGLV-------------------------------------------------------------------------FAGC-------------CSNVIFLELL-------------------ARKHPGCGNIVTFAQF---------LFIAVEGFLFEADLGRKPPAIPIRYYAIMV------TMFFTVSV--VNNYALN-LN-IAMPLHMI------FRSGSLIANMILGI------------IILKKRY-----SIFKYTSIALVS---------------------VGIFICT--------------------------------------------FMSAKQVTSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMG--------IFQETLYKRFGKHSKEALFY----------------NHALPL------------------------------------------------PGFVFLASD---IYDHAVLFNKSELYEIPVIGVTLPIMWFYLLMNIITQYVCIRGVFILTTE----------CASLTVT---------------------LVVTLR----------KF-VSLIFS-ILYFQNPFTLW-------------------------------------------HWLGTLFVFIG-----------TLM--YTEVWNNLG----------------------------------------------TTKSEP------------QKDSKKN------------------------------------------------
SLC35C1   --MNRAPLKRSR--ILH--MALTG---------------------------------------------------------------------------------------------------------ASDP-------------------------SAEA------------EANGEKPFLLRALQ----------------IALVVSLYWVTSISMVFLNK-------YLL--------------DS---PSLRLDTPIFVTFY----------------------------QCLVTTL------------------------------------------------------------------------------------------------LCKGLSALAACCPGAVDFPSLRLDLRVARSV-------LPLSVVFIGMITFNNLCLKYVGVAFYNVGRSLTTVFNVLLSYLLLKQTT-SFYA-------------LLTCGIIIGGFWLG----------------------------------------VDQEGA---EGTLSWL-----------GTVFGVLASLCVSLNA--------IYTTKVLPAVDGSIWRLTFYNNVNAC----------ILFLPLLLL--------------------LGELQ-ALRDF--------------AQLG-----SAHFWGMMTLG-----------------------------GLFGFAIGYVTGLQIKF------TSPLTHN---------------------VSGTAKAC-----------AQTVLA-VLYYEETKSFLWW------------------------------------T-SNMMVLG------G-----------SSA--YTWV--------------RGWEM-------------------------------KKTPEEPS-----------PKDSEKSAM--GV------------------------------------------
SLC35C2   --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRWALDVAF--LWK----AVLTLGLVLLYYCFSIGITFYNKWLTKSFHFP--L----------FMTMLHLAVIFLFSALSRALV----------------------------QCSSH-------------------------------------------------------------------------------RARVVLSWADYLRRVAPTALATAL------DVGLSNWSFLYVTVSLYTMT-------KSSAVLFILIFSL------------IFKLEEL-----RAALVLVVLLIA---------------------GGLFMFTYK---------------------------------------------------STQFNVE-----------GFALVLGASFIGGIRW--------TLTQMLLQKAELGLQ------------NPI--DTM-FHLQPLMFLGLF-------PLFAVFEGLHLSTSE-KIFRF--------------QDTGLL---LRVLGSLFLGG--------------------------ILAFGLGFSEFLLVSRTSS----------LTLS---------------------IAGIFKEV-----------CTLLLA-AHLLGDQI-SL------------------------------------------LNWLGFALCLSG-----------ISL--HVALK----A-----LHSRGDGGPKALKGLGSS-----PDL--------ELLLRSSQREEG--------------DNEEEE-----------------------YFVAQGQQ----------------
SLC35D1   -------------------MAEVHRR---------------------------------------------------------------------------------------------------QHARVKG--------------------------EAPAKSSTL--------RDEEELGMASAETLTVF-----------LKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSL----------CVGLGQMVATVAVLWVGKAL--------------------------------------------------------------------------------------------------------------------RVVKFPDLDRNVPRKTFPLPLLYFGNQITGLFSTKKL--NLPMFTVL-------RRFSILFTMFAEG------------VLLKKTF-----SWGIKMTVFAMI---------------------IGAFVAASS---------------------------------------------------DLAFDLE-----------GYAFILINDVLTAANG--------AYVKQKLDSKELGKY------------GLLYYNAL-FMILPTLAI-------------AYFTG-DAQKAV-EFEGW--------------ADTLFL---LQFTLSCVMG------------------------------FILMYATVLCTQYNSA----------LTTT---------------------IVGCIKNI-----------LITYIG-MVFGGDYIFTW------------------------------------------TNFIGLNISIAG------------SL--VYSY----------------------------------------------ITFTEEQLSKQ---------------SEANN-----------------------KLDIKGKGAV--------------
SLC35D2   -------------------------------------------------------------------------------------------------------------------------------MTAGG--------------------------QAEAEGAG------------GEPGAARLPSRVA-------------RLLSALFYGTCSFLIVLVNKALLTTYGFPSPI----------FLGIGQMAATIMILYVSKLN--------------------------------------------------------------------------------------------------------------------KIIHFPDFDKKIPVKLFPLPLLYVGNHISGLSSTSKL--SLPMFTVL-------RKFTIPLTLLLET------------IILGKQY-----SLNIILSVFAII---------------------LGAFIAAGS---------------------------------------------------DLAFNLE-----------GYIFVFLNDIFTAANG--------VYTKQKMDPKELGKY------------GVLFYNAC-FMIIPTLII-------------SVSTG-DLQQAT-EFNQW--------------KNVVFI---LQFLLSCFLG------------------------------FLLMYSTVLCSYYNSA----------LTTA---------------------VVGAIKNV-----------SVAYIG-ILIGGDYIFSL------------------------------------------LNFVGLNICMAG------------GL--RYSF----------------------------------------------LTLSSQLKPKP--------------VGEENI-----------------------CLDLKS------------------
SLC35D3   ------------------------------------------------------------------------------------------MRQLCRGRVLG-----------------------ISVAIAHGVFSGS-----------L---------NIL------------------------------------------------LKFLISRYQFSFLT--LVQ--CLTSSTAALS------------LELLRR-LGLIAV----------------------------------PPFGLSLAR-SFAGVAV--------------------------------------------L---------------------------------------STLQSSLTLW----SLRGL--SLPMYVVF-------KRCLPLVTMLIGV------------LVLKNGA-----PSPGVLAAVLIT-TCGAALAGAGDLTGDPIGYVTGVLAVLVHAA----------------YLVL--------------------IQKASA---DTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAW----TFPGWKDPAMVCIFVACILIGCAMN--------------FTTLHCTYINSAV--------TTSFVGVVKSIAT--------------------ITVGMVAFSDVEPTSLFIAG-------------------------VVVNTLGS--IIYCVAK----------F----------------------------METRKQS-----------NYEDLE-AQPRGEEAQLSGDQLPFVMEELPGEGGNGRSEGGEAAGGPAQESRQEVRG----SPRGVPLVAGSSEEGSRRSLKDAYLEVWRLVR--------GTRYMKK-----------------------------DYLIENEELPSP-------------------------------------------------------------------
SLC35D4   -------------------MCVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQG---WQTLIGGLLLHVSWKLGWVEINSS------------------------------------------SRSHVLV--------------------------------------------W-------------------------------------LPASVLFVGIIYAGSRALSRL--AIPVFLTL---------HNVAEVIICGYQK----------CFQKEKT-----SPAKICSALLLL-------------------AAAGCLPFN-----------------------------------------------------DSQFNPD-----------GYFWAIIHLLCVGAYK--------ILQKSQKPSA----------------LSDIDQQYL-NYIFSVVLLAFA----------SHPTGDLFSVLDFPFLYF-----------------------------------------------------YRFHGSCCASGFLGFFLMFSTVKLKN-----------------------------------LLAPGQCAAWIFFA--KI-ITAGLS-ILLFDAILTSA------------------------------------TTGCLLLGALGEALLVFS-----------------------------------------------------------------------------------------ERKSS--------------------------------------------------
SLC35E1   -------------------MAAA------------------------------------------------------------------------------------------------------AVGAGHG-----------------------------AGG----------------PGAASSS----------------------------GGAREGARVAALCLLWYALSA-----------GGNVVNKVILSAFPFPVTVS----------------------------LCHILALCAGLPP-----LLRAW---RVPPAPPVS-----------------------------------------GPGPSPHPSSGPLLPPRFYPRYVLPL----AFGKYFASVSAHVSIWKV--PVSYAHTV-------KATMPIWVVLLSR------------IIMKEKQ-----STKVYLSLIPII---------------------SGVLLA----------------------------------------------TVT-----ELSFDMW-----------GLVSALAATLCFSLQN--------IFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVL-VDLSAFLVS---------------SDLTYVYQWP---------------------------------WTLLLLAVS---------------GFCNFAQNVIAFSILNLVS------------------PLSYS---------------------VANATKRI-----------MVITVS-LIMLRNPVTST-------------------------------------------NVLGMMTAILG-----------VFL--YNKTK-YDAN-----QQARKHLLPVTTADLSSKERHRSPL---------------EKPHNGLL---------FPQHGDYQYGRNNILTDHFQYSR---QSYPNSYSLNRYDV----------------
SLC35E2   -------------------MSSSVKT---------PALEEL------------------------VP---------------------------------------------------------GSEEKPKGRSPLS--------------------WGSLFGHRSEK-------------------------------------------------------------IVFAKSDGGTD-----------------------------------------------------------------------ENVLT----------------V----------------------------------------------------------------------------------------TITETTVIESDLGVWSSRALLYLTLWFFFSFC--------TLFLNKY------------ILSLL-------------GGEP--SMLGAVQML------------------------------------------------------------------STTVIGCVKTLVPCCLYQHKARLSYPP--------------------------------------NFLMTMLFVGLM---------------------------------------------------------------------------------------RFATVVLGLVSLKNVAVSFAE----------------------------------TVKSSAPI-----------FTVIMS------------------------------------------------------------------------R----MILGEYTGRP--------SDREERE-----------------------------------ELQLQP------------GRGAAASDRRSPVPPSERHGVRPHGENLPGDFQVPQALHRVALSMALPCPMLPAS
SLC35E3   ----------------------------------------------------------------------------------------------------------------------------------MALLVDR-----------------------------------------VRGHW------------------------------RIAAGLL-FNLL--------------------------------------------------------------------VSICI-----------VFLNKWI-YVYHGFP----------------------NMSLTLVHF---------VVTWLGLYICQKLDIFAPKSLPPSRLLLLA------LSFCGFVV--FTNLSLQ--------NNTI------G------------------------------TY-----QLAKAMTTPVII---------------------A-IQTFC--------------------------------------------YQKTFSTRIQ--------------------LTLIPITL----G--------VI---LNSYYD-------VK----------------FNFLGMVFA---------------ALGVLVT-SL-------------------YQVWVGAKQHELQVNSMQLLY--------------------------YQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALLMVLLSGVIAFMVNLSIYWIIGNTSPVTYNMFGHFKFCITLFGG-YVLFKDPLSIN-------------------------------------------QALGILCTLFG-----------ILA--YTH---------------------------------------------------FKLSEQE------------GSRSKLAQRP---------------------------------------------
SLC35E4   --MCRCPPEHH-----DGRMTSA------------------------------------------------------------------------------------------------------EVGAAAG--------------------------GAQAAGP---------------PEWPPGSPQAL----RQPGRARV--AMAALVWLLAGASMSSLNKWIFTVHGFGRPL-------------------LLSALHMLVAAL----------------------------ACHRGAR-RPMPGGTRCRVLL------LSLTFGTS-----------------------------------------MACGNVGLR-------------AVP----------------------L--DLA-------------QLVTTTTPLFTLA--------LSALLLGRRH-----HPLQLAAMGPLC---------------------LGAACSL-----------------------------------------------------AGEFR---------TPPTGCGFLLAATCLRG-----------------LKSVQQ---------------SALLQEER-LDAVTLLYATSL-------PSFCLLAGAALVLEA-GVAPP--------------PTAG-----DSRLWACILLSC-----------------LLSVLYNLASFSLLALTSALTVHVLGN---------------------------------------LTVV-----------GNLILS-RLLFGSRLSAL-------------------------------------------SYVGIALTLSG-----------MFL--YHNCE-FVAS-----WAARR--------GLWRR----------------------DQPSKG---------------------------------------------L---------------------
SLC35F1   ----MIPPEQP--------QQQLQPPSPA------------------------------------PPNHVVT------TI---------------------------------------------ENLPAEGS---------GGGG------------SLSASSRAGV---------------------------RQRIR-KV-LNREMLISVALGQVLSLLICGIGLTSKYLSEDFHA-------NTPVFQSFLNYILLFLVYTTT----------------------------LAVRQGE---------ENLLA------ILRRR--------------------------------------------------------------WWKYMIL-----GLIDLEANYLVVKAYQYT--TLTSIQLL-------DCFVIPVVILLSW------------FFLLIRY-----KAVHFIGIVVCI-------------------LGMGCMVGADVLVGR--------------------------------------HQGAGE-----------------NKLVGDLLVLGGATLYGISN--------VWEEYIIRTLSRVEF---------------------LGMIGLFGA--------------FFSGIQLAIME---------------------HKELLK--VPWDWQIGLLYV------------------------GFSACMFGLYSFMPVVIKKT--------SATSVN---------------------LSLLTADL-----------YSLFCG-LFLFHYKFSGL-------------------------------------------YLLSFFTILIG-----------LVL--YSSTSTYIAQDPRVYKQFRNPSGPV-------------------------VDLPTTAQVEP--SVT-----YTSLGQETEE---------------------------EPHVRVA-------------
SLC35F2   -------------------MEADSPAGPG------------------------------------APEPL-----------------------------------------------------------AEG----------------------------AAAEFSSL---------------------------LRRIKGKL-FTWNILKTIALGQMLSLCICGTAITSQYLAERYKV-------NTPMLQSFINYCLLFLIYTVM----------------------------LAFRSGS---------DNLLV------ILKRK--------------------------------------------------------------WWKYILL-----GLADVEANYVIVRAYQYT--TLTSVQLL-------DCFGIPVLMALSW------------FILHARY-----RVIHFIAVAVCL-------------------LGVGTMVGADILAGR--------------------------------------EDNSGS-----------------DVLIGDILVLLGASLYAISN--------VCEEYIVKKLSRQEF---------------------LGMVGLFGT--------------IISGIQLLIVE---------------------YKDIAS--IHWDWKIALLFV------------------------AFALCMFCLYSFMPLVIKVT--------SATSVN---------------------LGILTADL-----------YSLFVG-LFLFGYKFSGL-------------------------------------------YILSFTVIMVG-----------FIL--YCSTPTRTAE-------------------------------------------PAESSVPPVTSIG-----IDNLGLKLEEN------------------------LQETHSAVL-------------
SLC35F3   MGIREFPSGAPRGKSIAVGMRRSPDVSPRRLSDISPQLRQLKYLVVDEAIKEDLKWSRSVEDLTSGPVGLTSIEERILRITGYYGYQPWAAS-----------CK-------------REERP----RDSPGP---AEAQAP---------------AGVEAGGRASR--------------------------RCWTCSRAQLKKIFWGVAVVLCVCSSWAGSTQLAKLTFRKFDA---------PFTLTWFATNWNFLFFPLYYV--------------GH------------VCKSTEK----------------------------------QSVKQRYRECCRF------------------------------FGDNGLTLKVFFTKAAPF----GVLWTLTNYLYLHAIKKI--NTTDVSVL-------FCCNKAFVFLLSW------------IVLRDRF-----MGVRIVAAILAI---------------------AGIVMMTYADG------------------------------------------------------------FHSHSVIGIALVVASASMSALYK--------VLFKLLLGSAKFGEAALFLSI---------------LGVFNILFITCI-------P---------------IILYF--------------TKVEYWSSFDDIPWGNLCGF-----------------------------SVLLLTFNIVLNFGIAV------TYPTLMS-------LGIV----------LSIPVNAV-----------IDHYTS-QIVFN-----------------------------------------------GVRVIAIIIIGLG-----------FLL-------------------------------------LLLPEEWDVWLIKLLTRLKVRKKEEPAEGAADLS---SGPQSKNRRARPSFAR----------------------------------------
SLC35F4   ------------------------------------------------------------MDVKAAPNGVATIEDRILRITGYYGYYPGYSSQKSTSRSSVTRCKPGANCPSSHSGISRQLSPLSVTEDSSAPILELQNQGS---------------SGV-CGHRVERQ---NRSDDGTQTHSENSSQENRIKARCLSCTSMVLKGI-WGLLIILSVSSSWVGTTQIVKITYKNFYC---------PFFMTWFSTNWNIMFFPVYYS--------------GH------------LATAQEK----------------------------------QSPMKKFRECSRI------------------------------FGEDGLTLKLFLKRTAPF----SILWTLTNYLYLLALKKL--TATDVSAL-------FCCNKAFVFLLSW------------IVLKDRF-----MGVRIVAAIMAI---------------------TGIVMMAYADN------------------------------------------------------------FHADSIIGVAFAVGSASTSALYK--------VLFKMFLGSANFGEAAHFVST---------------LGFFNLIFISFT-------P---------------VILYF--------------TKVEHWSSFAALPWGCLCGM-----------------------------AGLWLAFNILVNVGVVL------TYPILIS-------IGTV----------LSVPGNAA-----------VDLLKQ-EVIFN-----------------------------------------------VVRLAATIIICIG-----------FLL-------------------------------------MLLPEEWDEITLRFINSLKEKKSEEHVDDVTDPSIHLRGRGRANGTVSIPLA-----------------------------------------
SLC35F5   ----MVPPRRHRGAGRPGVLSSS------------------------------------------PPFRL-------------------------------------------------------RSAKFSGIALED-LRRALKTRLQMVCVFVMNRMNSQNSGFTQR------------------------------------RRMALGIVILLLVDVIWVASSELTSYVFTQYNK---------PFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGLRGKHAAFFADAEGYFAACTTDTT---MNSSLSEPLYVPVKFHDLPSEKPESTNIDTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPVKEQESILKTVGKLTATQVAKISFFF----CFVWFLANLSYQEALSDT--QVAIVNIL-------SSTSGLFTLILAA---------VFPSNSGDRF-----TLSKLLAVILSI---------------------GGVVLVN---------------------L-------------------------------AGSEKPAG------RDTVGSIWSLAGAMLYAVYI--------VMIKRKVDREDKLDIPMFFGF---------------VGLFNLLLL---------------WPGFFLLHYT-GFEDFEFPNKVVLMCIIINGLIGTVLSEFLWLWGCFLTSS------------------------------------------------------LIGT---------------------LALSLTIP-----------LSIIAD-MCMQKVQFSWL-------------------------------------------FFAGAIPVFFS-----------FFI--VTLLCHYNNWDP-VMVGIRRIFAFICRKHRIQR---------------------------------------VPEDSEQCESLISM------------------HSVSQEDGAS--------------
SLC35F6   ----MAWTKYQL--FLAGLMLVTGSINTL------------------------------------------------------------------------------------------------SAKWADNF-------------------------MAEGCGGSK-------EHSFQHPFL-------------------------------QAVGM-FLGEFSCLAAFYLLRCRAA------GQSDSSVDPQQPFNPLLFLPPA----------------------------LCDMTG---------------------------------------------------------------------------------------------------TSLMYVALNMTSASSFQMLR-----------------GAVIIFTGLFS----------VAF--LGRRL-----VLSQWLGILATI-A--------------------GLVVVGLADL----------------------------------------LSKHDS---QHKLSEVI---------TGDLLIIMAQIIVAIQM--------VLEEK-----------FVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYY-----IPA-GSFSGNPRGTLEDALDAF--------------CQVG-----QQPLIAVALLG-----------------------------NISSIAFFNFAGISV------------TKE---------------------LSATTRMV-----------LDSLRT-VVIWALSLALGWE------------------------------------AFHALQILGFLILLIG-----------TAL--YNGLHRPLLG-----RLSRG---------------------------------------RPL-----------AEESEQERLLGGTRTP-----------------INDAS-----------------
SLC35G1   -------------------MRPQDSTGVAELQE--PGL----------------------PLTDDAP--------------------PGATEE-------------------------------PAAAEAAG--------APDRGRCWLC-------LSSPCCSRTE-------------PEAKKKAP----------------CPGLGLFYTLLSAFLFS--------------------------VGSLFVKKVQDVHAVEISAF----------------------------RCVFQML-----------VVIPC---LIY-------------------------------------------------------RKTGFIGPKGQRIFLILR----GVLGSTAMMLIYYAYQTM--SLADATVI-------TFSSPVFTSIFAW------------ICLKEKY-----SP--WDALFTVF-TI------------------TGVILIV--------------RPPF---LFG--------------------SDTSGM---EESYSGH----LK-----GTFAAIGSAVFAASTL--------VILRKMGKSVDYFL-------------SIWYYVVL-GLVESVIILS--------------VLG---------------------------------------EWSLPYCGLD---------------RLF-----LIFIGLFGLGGQIFITKALQI------EKAGPVA---------------------IMKTMDVV-----------FAFIFQ-IIFFNNVPT--------------------------------------------WWTVGGALCVVA-----------SNV-----------G-----AAIRK----------------------------------WYQSSK--------------------------------------------------------------------
SLC35G2   -------------------MDTSPSR-----KY--PVK----------------------KRVKIHPNTVMV------KYTSHY-PQPGDDGY-------------------------------EEINEGYGNFME---ENPKKG---LL-------SEMKKKGRAFF-----GTMDTLPPPTEDPMINEIG--QFQSFAEKNIFQSRKMWIVLFGSALAHGCVALITRLVSDRSK-----------VPSLELIFIRSVFQVLSVLV----------------------------VCY---------------------------------------------------------------------------------YQEAPFGPSGYRLRLFFY----GVCNVISITCAYTSFSIV--PPSNGTTM------WRATTTVFSAILAF------------LLVDEKM-----AYVDMATVVCSI---------------------LGVCLVM--------------IPNI--------------------------VDED-----NSLLNAW-------KEAFGYTMTVMAGLTTALSM--------IVYRSI-----------------KEKISMWTALFT-FGWTGTIWG---------------ISTMFILQEP-IIPL------------------------DGETWSY-----------------------------LIAICVCSTAAFLGVYYALDK------FHPALVS---------------------TVQHLEIV-----------VAMVLQ-LLVLH--IFPSI-----------------------------------------YDVFGGVIIMIS-----------VFV--------------------------LAGYKLYWRN---------------------------------------LRKQDYQEILDSPIK----------------------------------------
SLC35G3   -------------------MAGS------------------------------------------HP----------------Y-FNQPDSTH-------------------------------PS------------------------------------------------------PPSAPPSLRWYQ--RCQPSDATS-----GLLVALLGGGLPAGFVGPLSRMAYQASN-----------LPSLELLIWRCLFHLPIALL----------------------------LKL---------------------------------------------------------------------------------RGDPLLGTPDIRSRAFFC----ALLNILSIGCAYSAVQVV--PAGNAATV------RKGSSTVCSAVLTL------------CLESQGL-----SGYDWCGLLGCI---------------------LGLIIIV--------------GPGL--------------------------WTLQ-----EGTTGVY--------TALGYVEAFLGGLALSLRL--------LVYRSL-----------------HFPPCLPTVAFL-SGLVGLLGS---------------VPGLFVLQAP-VLPS------------------------DLLSWSC-----------------------------VGAVGILALVSFTCVGYAVTK------AHPALVC---------------------AVLHSEVV-----------VALILQ-YYMLHETVAPS-------------------------------------------DIVAAGVVLGS-----------IAI--------------------------ITAQNLSCE-----------------------------------------RTGRVEE-----------------------------------------------
SLC35G4   -------------------MAGS------------------------------------------HP----------------Y-FNLPDSTH-------------------------------PS------------------------------------------------------PPSTPPSLHWHQ--RCQPSDATN-----GLLVALLGGGLPAGFVGPLSRMAYQASN-----------LPSLELVICRCLFHLPIALL----------------------------LKL---------------------------------------------------------------------------------RGDPLLGPPDIRGRTCFC----ALLNVLNIGCAYSAVQVV--PTGNAATV------RKHSSTVCSAILTL------------CLESQVL-----SGYDWCGLLGSI---------------------LGLIIIV--------------GPGL--------------------------WTLQ-----EGTTGVY--------TGLGYVQAFLGGLALSLGL--------LVYRSL-----------------HFPSCLPTVAFL-SGLVGLLGS---------------VPGLFVLQSP-VLPS------------------------DLLSWSC-----------------------------VGAVGILTLVSFTCVGYAVTK------AHPALVC---------------------AVLHSEVV-----------MALILQ-YFMLHETVAPS-------------------------------------------DIMGAGVVLGS-----------IAI--------------------------ITARNLICE-----------------------------------------RTGKVEE-----------------------------------------------
SLC35G5   -------------------MAGS------------------------------------------HP----------------Y-FNLPDSTH-------------------------------PS------------------------------------------------------PPSAPPSLRWHQ--RCQPSGATN-----GLLVALLGGGLPAGFVGPLSRMAYQGSN-----------LPSLELLICRCLFHLPIALL----------------------------LKL---------------------------------------------------------------------------------RGDPLLGPPDIRGWACFC----ALLNVLSIGCAYSAVQVV--PAGNAATV------RKGSSTVCSAVLTL------------CLESQGL-----GGYEWCGLLGSI---------------------LGLIIIL--------------GPGL--------------------------WTLQ-----EGTTGVY--------TTLGYVQAFLGGLALSLGL--------LVYRSL-----------------HFPSCLPTVAFL-SGLVGLLGC---------------VPGLFVLQTP-VLPS------------------------DLLSWSC-----------------------------VGAEGILALVSFTCVGYAVTK------AHPALVC---------------------AVLHSEVV-----------VALILQ-YYMLHETVALS-------------------------------------------DIMGAGVVLGS-----------IAI--------------------------ITARNLSCE-----------------------------------------RTGKVEE-----------------------------------------------
SLC35G6   -------------------MAGS------------------------------------------HP----------------Y-LNPPDSTH-------------------------------PS------------------------------------------------------PPSAPPSLRWHQ--CCQPSDATN-----GLLVALLGGGLPAGFVGPLSHMAYQASN-----------LPSLELLICRCLFHLPIALL----------------------------LKL---------------------------------------------------------------------------------RGDPLLGPPDIRGRAYFY----ALLNVLSIGCAYSAVQVV--PAGNAATV------RKGSSTVCSAVLTL------------CLESQGL-----SGYDWCGLLGSI---------------------LGLIIIV--------------GPGL--------------------------WTLQ-----EGITGVY--------TALGYGQAFVGGLALSLGL--------LVYRSL-----------------HFPSCLPTVAFL-SGLVGLLGS---------------VPGLFVLQPP-VLPS------------------------DLPSWSC-----------------------------VGAVGILALVSFTCVSYAVTK------AHPALVC---------------------AVLHSEVV-----------VALILQ-YYMLHETVAPS-------------------------------------------DIVGAGVVLGS-----------IAI--------------------------ITAWNLSCE-----------------------------------------REGKVEE-----------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC35A2 2 K/N 0.000291891 rs782406865
-- SLC35A2 15 P/T 0.0161196 rs55719932
-- SLC35A2 24 E/D 0.000167518 rs374961453
-- SLC35A2 132 C/R 0.00073782 rs56111636
-- SLC35A2 139 R/H 0.000259192 rs138190020
-- SLC35A2 360 V/I 0.000259192 rs138190020

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC35A2 SLC35A2 [Golgi membrane] Transport of nucleotide sugars

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC35A2 SLC35A2 F324Lfs*25 [Golgi membrane] Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
SLC35A2 SLC35A2 V331I [Golgi membrane] Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
SLC35A2 SLC35A2 M1? [Golgi membrane] Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
SLC35A2 SLC35A2 G8Sfs*9 [Golgi membrane] Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
SLC35A2 SLC35A2 Y145Pfs*76 [Golgi membrane] Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)