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Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC34A2


Basic description
Gene Name SLC34A2
Protein Name Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Family SLC34
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690 
MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCGCPKCCR CSKCCEDLEE AQEGQDVPVK APETFDNITI SREAQGEVPA SDSKTECTAL  
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCHHHHH HHHHHHCCCC CCHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHCCCCCHHH HHHHHHHCCC CHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCH HHHHHHHHHC CHHHHHHHHH HHHHHHCCCC HHHCCHHHHE EECCCCCCCC CCCEECCCCC CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCHHHHHHHH HHCCCCCCCC HHHCCHHHHH HHHHHHHHHH HCHHHHHHCC CCCCCCCCCC HHHHHHHHHC CCCCHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCHHHCCC CCHHHHHHHH HHHHHCCCCC HHHHHCCEEH HHCCCCCCCC CCCCCCCHHH HHHHCCCCCC CCCHHCCHHH CHHHCCCCCC CCCCCCCCCC
[Overview] SLC34A1 SLC34A2 SLC34A3 
SLC34A1   MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRI--------PGTSAYAFPSLGPVALAEHT---------CPCGEVLERHEP--LPAKLALEE------EQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCH------------PDSLQAPT-SMSRAEANSSQTLGNAT----MEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRAT-------LCCARPEPRSPPL---PPRVF--------LEE------LPPATPS-------PRLA---LPAHHNATRL---
SLC34A2   MAPWPE-LGDAQPNP-----DKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLID---------------EPTEVDDPWNLP---TLQDSGIKWSERDTKGKILCFFQGIGRLI----LLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCGCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
SLC34A3   -----------MPSSL---------------------------------PGSQV-PHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDT-DPWTLP---QLKDTSQPWKELRVAGRL---RRVAGSVL-KACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGN--ATNSSLIKHWCGTTGQ--------PTQENSSC------GAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMVLAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTR---------CCPCNV--------CSPPKAT--------TKEA-----YCYENPE--------------ILASQQL------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC34A2 44 P/S 0.000119299 rs147129009
-- SLC34A2 45 V/A 0.00328869 rs35426730
-- SLC34A2 55 S/C 0.000107377 rs78068143
-- SLC34A2 56 T/M 0.000186917 rs114109706
-- SLC34A2 167 V/I 0.000107526 rs745908881
-- SLC34A2 177 T/A 0.000107428 rs748033823
-- SLC34A2 281 K/E 0.00308103 rs79937695
-- SLC34A2 312 I/M 0.00357873 rs112461275
-- SLC34A2 322 C/R 0.000226644 rs74775366
-- SLC34A2 325 P/L 0.000143143 rs142510757
-- SLC34A2 330 T/M 0.0269355 rs79450009
-- SLC34A2 403 I/V 0.000914452 rs141905062
-- SLC34A2 414 L/F 0.00300613 rs76404281
-- SLC34A2 430 V/I 0.00023062 rs201539404
-- SLC34A2 513 R/G 0.000827591 rs147732740
-- SLC34A2 609 K/R 0.000274741 rs116673562
-- SLC34A2 634 D/G 0.86192 rs6448389

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC34A2 SLC34A2 [plasma membrane] Type II Na+/Pi cotransporters
SLC34A2 SLC34A2 [plasma membrane] Surfactant metabolism

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC34A2 SLC34A2 K304* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 Q76* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 N38Tfs*8 [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 G106R [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 Q486* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 Q76* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 G106R [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 K304* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SLC34A2 SLC34A2 V448* [plasma membrane] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)