Detail Data SLC32A1

Basic description

Gene Name	SLC32A1
Protein Name	Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT)
Family	SLC32
Category	Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name	Vesicular inhibitory amino acid transport Loading of GABA into clathrin sculpted GABA transport vesicle lumen
Reaction	1 Inhibitory amino acids [cytosol] + 1 H+ [synaptic vesicle] --> 1 Inhibitory amino acids [synaptic vesicle] + 1 H+ [cytosol] 1 GABA [cytosol] --> 1 GABA [clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen]

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520 
MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD QVGGGGEFGG HDKPKITAWE AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA CYSGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HCCCHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCHHHHH HHHCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCH HHHHHHHHHH HCHHHCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCH HHCCCCHHHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCC

Family alignment

[Overview]

SLC32A1   MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQMDILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVVRVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC32A1	39	E/G	0.000256507	rs201398803
--	SLC32A1	95	P/L	0.000191252	rs551108790
--	SLC32A1	193	C/F	0.000103629	rs140808070
--	SLC32A1	423	S/G	0.00366585	rs34517228
--	SLC32A1	489	Q/E	0.000128252	rs757122447
--	SLC32A1	521	T/N	0.0038328	rs140172143

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC32A1	SLC32A1 [synaptic vesicle membrane]	Transport of inorganic cations/anions and amino acids/oligopeptides
	SLC32A1	SLC32A1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]	GABA synthesis, release, reuptake and degradation
	SLC32A1	SLC32A1 [plasma membrane]	GABA synthesis, release, reuptake and degradation

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data