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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC30A8


Basic description
Gene Name SLC30A8
Protein Name Zinc transporter 8 (ZnT-8) (Solute carrier family 30 member 8)
Family SLC30
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name SLC30A8 transports Zn2+ from cytosol to secretory granule
Reaction 1 Zn2+ [cytosol] --> 1 Zn2+ [secretory granule lumen]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360 
MEFLERTYLV NDKAAKMYAF TLESVELQQK PVNKDQCPRE RPEELESGGM YHCHSGSKPT EKGANEYAYA KWKLCSASAI CFIFMIAEVV GGHIAGSLAV VTDAAHLLID LTSFLLSLFS LWLSSKPPSK RLTFGWHRAE ILGALLSILC IWVVTGVLVY LACERLLYPD YQIQATVMII VSSCAVAANI VLTVVLHQRC LGHNHKEVQA NASVRAAFVH ALGDLFQSIS VLISALIIYF KPEYKIADPI CTFIFSILVL ASTITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ MESPVDQDPD CLFCEDPCD 
CCCCCHHCCC CHHHCCCHHC CCCCCCCCCC CCCCCCCCCC CCHHHHCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCHHHHHHH HHCCCCCEEE EEEEEEEECC CEEEEEEEEE ECCCCCHHHH HHHHHHHHHH HCCCCEEEEE CCCCCCCCCC CCCCCCCCC
[Overview] SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 
SLC30A1   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGC-----------------------------------WGRNRGR--------------LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDV----------------------------------------LALVVALVAERFAR-RTHATQKNTFGWIRAEVMGALVNAIFLTGL-CFAILLEAIERFIEPH---------EMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGF--------------SQDSGHGHSHG-GHGHGHGLPKGPR--VKSTRPGS-SDINVAPGEQGPDQE-ETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFL-----HVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFP----DPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQID--IRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKC---------EDPTSYMEVAKTIKDVFHNH-GIHATTIQPEFASVG-----------------------------SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIK---------------------------------------NMPNKQPESSL-------
SLC30A10  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGR-----------------------------------YSGKTCR--------------LLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDL----------------------------------------ISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTAL-CFTIFVEAVLRLARPE---------RIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPG-AFGGPQG-AEDPRRAADPTAPGSDSAVTLRGTSVERKRE-KGATVFANV-----------------AGDSFNTQ------NEPEDMMKKEKKSEALNIRGVLL-----HVMGDALGSVVVVITAIIFY---------------VLPLKSEDPCN-------------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVN--MEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKY---------PKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPL-------------------------EQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYG-SDGLSRRDAR-------EVAIEVSL--------------DSCLSD----------------HGQSLNKTQEDQCYVNRTHF
SLC30A2   ME---------------------------------------------------------AKEKQHLLDARPAIRS------------------------------------------------------YTGS----L----------------------------------------------------------WQE----------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------AGWIPLPRPGLD---------LQAIELAAQSNHHCHAQKGPDSHCDP------------------KKGKAQRQ-------------LYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDF----------------------------------------ASMLISLFSLWMSSRPATKTMN--FGWQRAEILGALVSVLSIWVV-TGVLVYLAVERLISGD--------YEIDGGTMLI-TSGCAVAVNIIMGLTLHQ---------------------SGHGHSHG-TTNQQEE---------------------------------------------------------------------------------------NPSVRAAFI-----HVIGDFMQSMGVLVAAYILY----------F-----------KP---------------------EYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVD--FTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAI---------AQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSED------------------------------MKDCQACQGPSD----------------------------------------------------------------------------------------------------------------------
SLC30A3   MEPS---------------------------------------------------PAAGGLETTRLVSPRDR-GG------------------------------------------------------AGGS----LRL--------------------------------------------------KSLFTEPSE--------------------------------------------------------------------------------------------PLP----------------------------------------------------------------------------------------------------------EESKPVEMPF----------------------HHCHRDPLPPPGLTP------------------ERLHARRQ-------------LYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADV----------------------------------------GSMMGSLFSLWLSTRPATRTMT--FGWHRSETLGALASVVSLWMV-TGILLYLAFVRLLHSD--------YHIEGGAMLL-TASIAVCANLLMAFVLHQ---------------------AGPPHSHG-SRGAEYAPLE--------------------------------------------------------EGPEEPLP------------------LGNTSVRAAFV-----HVLGDLLQSFGVLAASILIY----------F-----------KP---------------------QYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVG--FEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAI---------DSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPE------------------------------MAQCLRCQEPPQA---------------------------------------------------------------------------------------------------------------------
SLC30A4   MAGSGA-------------------------------------WKRLKSML-RKDDAPLFLNDTSAFDFSDEAGD------------------------------------------------------EGLSRFNKLRVV------------------------------------------------VADDGSEAPER-------------------------------------------------------------------------------------------PVNG-----------------------------AHP---------------TLQADDD------------------------------------------------SLLDQDLPLTNSQL--------------SLKVDSCDNCSKQRE-----IL------------------KQRKVKAR-------------LTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDL----------------------------------------SAIILTLLALWLSSKSPTKRFT--FGFHRLEVLSAMISVLLVYIL-MGFLLYEAVQRTIHMN--------YEINGDIMLI-TAAVGVAVNVIMGFLLNQ---------------------SGHRHSHS-HSLPSNSPTRG-------------------------------------------------------SGCERNHG------------------QDSLAVRAAFV-----HALGDLVQSVGVLIAAYIIR----------F-----------KP---------------------EYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLN--VDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLI-------PGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQE-----------------------------VDRTCANCQSSSP----------------------------------------------------------------------------------------------------------------------
SLC30A5   MEEKYGGDV-----------LAGPGGGGGLGPVD-------VPSARLTKYI-VLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFI---SALLFGNFWTHPITDQL----RAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLY--------------NFMGDAFQHSSQS-------IPR--------FIKESLKQILEESDSRQ-------------IFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDC----------------------------------------SALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVI-AFFVFMESVARLIDPP---------ELDTHMLTP-VSVGGLIVNLIGICAFSH----------------------AHSHAHGASQGSCHS------------SDHSHSH-------HMHGHSDHGHGHSHGS-----------------AGGGMNAN-----------------------MRGVFL-----HVLADTLGSIGVIVSTVLIE---------QF----------------------------------GWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQV---------TSDVLEQRIVQQVTGILKDA-GVNNLTIQVEKEAYF------------------------------------------------------------------QHMSGLSTGFHD------------------VLAMTKQM--------------ESM-------------------------KYCKDGTYIM----
SLC30A6   ------------------------------------------------------------MGTIHLFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQR--------------SFFGK---------------------------LLREFRLVAADRRSWK-------------ILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFRDGVSPFWLGWSQTPDLKWSTHLGLPKCWDNRRELPCLSNSLMTCLISYWVTLRKPSPVYS--FGFERLEVLAVFASTVLAQLG-ALFILKESAERFLEQP---------EIHTGRLLV-GTFVALCFNLFTMLSIRNKPFAYV------------------------SEAASTSWLQE-----------------------------HVADLSRSL-----------------CG------------IIP-------------GLSSIFLPRMNPFVLIDLAGAFALCITYMLIE-------------------------------IN------------NYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRI---------RRDANEQMVLAHVTNRLYTL--VSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAK---------------PSSPPPEFSFNTPGKNVN--------------------PVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP-
SLC30A7   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPLS---------------------------------------------------IKDD----------------------------------------------------EYKP---PKF--------------NLFGK---------------------------ISGWFRSILSDKTSRN-------------LFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDS----------------------------------------TAILAGLAASVISKWRDNDAFS--YGYVRAEVLAGFVNGLFLIFT-AFFIFSEGVERALAPP---------DVHHERLLL-VSILGFVVNLIGIFVFKH---------------------GGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSH-----------------DGPSLKET------TGPSRQ----------ILQGVFL-----HILADTLGSIGVIASAIMMQ---------NF----------------------------------GLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIV---------APDADARWILSQTHNIFTQA-GVRQLYVQI-----------------------------------------------------------------------------------D------------------FAAM------------------------------------------------------------
SLC30A8   ME---------------------------------------------------------FLERTYLVNDKAA-KM------------------------------------------------------YAFT----LE------------------------------------------------------SVELQQK-------------------------------------------------------------------------------------------PVN----------------------------------------------------------------------------------------------------------KDQCPRERPE---------------ELESGGMYHCHSGSKPTEKGAN------------------EYAYAKWK-------------LCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDL----------------------------------------TSFLLSLFSLWLSSKPPSKRLT--FGWHRAEILGALLSILCIWVV-TGVLVYLACERLLYPD--------YQIQATVMII-VSSCAVAANIVLTVVLHQ---------------------RCLGHNH----KEVQA---------------------------------------------------------------------------------------NASVRAAFV-----HALGDLFQSISVLISALIIY----------F-----------KP---------------------EYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLN--YSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVAT---------AASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQ------------------------------DPDCLFCEDPCD----------------------------------------------------------------------------------------------------------------------
SLC30A9   MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEG------------------------------------------------------QGSQ---TLRV-------------------------------------------------EKVPSFETAEG----------------------------------------------------------------------------IGTELKA--------PLK------------------------------QEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINE---------------------FCLKSSDLE------QLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT----------------------------C--NQ------------GLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNEL--------------------RRN--------------ARAKGMSFYKYVM---------------------------ESRDPSTNV-----------------------------------------------------------ILLEDTAAVLGVIIAATCMGLT-------SI---------TGNP--------------LYDSL--GSLGVGTLLGMVSAFLIYTNTEALLGRSIQ------PEQVQ----RLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPE--------ELETFMLK-------------------H------------------------------------------GENIIDTLGAEVDRLE--KELKKRNPE-----VRHVDLEIL---------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC30A8 44 E/D 0.000365974 rs143592691
-- SLC30A8 45 L/M 0.000326192 rs148043363
SLC30A8 165 R/H 0.00025452 rs145677283
SLC30A8 165 R/C 0.000477221 rs73317647
SLC30A8 187 A/V 0.000123379 rs141202988
SLC30A8 286 G/S 0.000178756 rs548323063
SLC30A8 295 D/E 0.000272825 rs147372406
SLC30A8 295 D/N 0.000184518 rs774398640
SLC30A8 310 M/V 0.000267139 rs757010863
SLC30A8 325 R/W 0.287774 rs13266634
SLC30A8 325 R/Q 0.0145072 rs16889462

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC30A8 SLC30A8 [secretory granule membrane] Zinc efflux and compartmentalization by the SLC30 family
SLC30A8 SLC30A8 [secretory granule membrane] Insulin processing

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data