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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC30A7


Basic description
Gene Name SLC30A7
Protein Name Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) (Znt-like transporter 2)
Family SLC30
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name ZnT7 transports zinc into the golgi apparatus
Reaction 1 Zn2+ [cytosol] --> 1 Zn2+ [Golgi lumen]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370 
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN GALDQAHGHV DHCHSHEVKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW ILSQTHNIFT QAGVRQLYVQ IDFAAM 
CCCCCCCCCC CCCCCCCCCC HHCHHHHHHC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH CHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHHHHHHCHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCHHHHH HHHHHHHHHH CHHHHHHHHH HHHHHCCCCC CCCCHHHHHH HHHCCCCCCE EEEEEEEEEC CCEEEEEEEE EECCCCCHHH HHHHHHHHHH HCCCCCEEEE ECCCCC
[Overview] SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 
SLC30A1   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGC-----------------------------------WGRNRGR--------------LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDV----------------------------------------LALVVALVAERFAR-RTHATQKNTFGWIRAEVMGALVNAIFLTGL-CFAILLEAIERFIEPH---------EMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGF--------------SQDSGHGHSHG-GHGHGHGLPKGPR--VKSTRPGS-SDINVAPGEQGPDQE-ETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFL-----HVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFP----DPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQID--IRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKC---------EDPTSYMEVAKTIKDVFHNH-GIHATTIQPEFASVG-----------------------------SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIK---------------------------------------NMPNKQPESSL-------
SLC30A10  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGR-----------------------------------YSGKTCR--------------LLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDL----------------------------------------ISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTAL-CFTIFVEAVLRLARPE---------RIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPG-AFGGPQG-AEDPRRAADPTAPGSDSAVTLRGTSVERKRE-KGATVFANV-----------------AGDSFNTQ------NEPEDMMKKEKKSEALNIRGVLL-----HVMGDALGSVVVVITAIIFY---------------VLPLKSEDPCN-------------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVN--MEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKY---------PKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPL-------------------------EQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYG-SDGLSRRDAR-------EVAIEVSL--------------DSCLSD----------------HGQSLNKTQEDQCYVNRTHF
SLC30A2   ME---------------------------------------------------------AKEKQHLLDARPAIRS------------------------------------------------------YTGS----L----------------------------------------------------------WQE----------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------AGWIPLPRPGLD---------LQAIELAAQSNHHCHAQKGPDSHCDP------------------KKGKAQRQ-------------LYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDF----------------------------------------ASMLISLFSLWMSSRPATKTMN--FGWQRAEILGALVSVLSIWVV-TGVLVYLAVERLISGD--------YEIDGGTMLI-TSGCAVAVNIIMGLTLHQ---------------------SGHGHSHG-TTNQQEE---------------------------------------------------------------------------------------NPSVRAAFI-----HVIGDFMQSMGVLVAAYILY----------F-----------KP---------------------EYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVD--FTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAI---------AQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSED------------------------------MKDCQACQGPSD----------------------------------------------------------------------------------------------------------------------
SLC30A3   MEPS---------------------------------------------------PAAGGLETTRLVSPRDR-GG------------------------------------------------------AGGS----LRL--------------------------------------------------KSLFTEPSE--------------------------------------------------------------------------------------------PLP----------------------------------------------------------------------------------------------------------EESKPVEMPF----------------------HHCHRDPLPPPGLTP------------------ERLHARRQ-------------LYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADV----------------------------------------GSMMGSLFSLWLSTRPATRTMT--FGWHRSETLGALASVVSLWMV-TGILLYLAFVRLLHSD--------YHIEGGAMLL-TASIAVCANLLMAFVLHQ---------------------AGPPHSHG-SRGAEYAPLE--------------------------------------------------------EGPEEPLP------------------LGNTSVRAAFV-----HVLGDLLQSFGVLAASILIY----------F-----------KP---------------------QYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVG--FEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAI---------DSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPE------------------------------MAQCLRCQEPPQA---------------------------------------------------------------------------------------------------------------------
SLC30A4   MAGSGA-------------------------------------WKRLKSML-RKDDAPLFLNDTSAFDFSDEAGD------------------------------------------------------EGLSRFNKLRVV------------------------------------------------VADDGSEAPER-------------------------------------------------------------------------------------------PVNG-----------------------------AHP---------------TLQADDD------------------------------------------------SLLDQDLPLTNSQL--------------SLKVDSCDNCSKQRE-----IL------------------KQRKVKAR-------------LTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDL----------------------------------------SAIILTLLALWLSSKSPTKRFT--FGFHRLEVLSAMISVLLVYIL-MGFLLYEAVQRTIHMN--------YEINGDIMLI-TAAVGVAVNVIMGFLLNQ---------------------SGHRHSHS-HSLPSNSPTRG-------------------------------------------------------SGCERNHG------------------QDSLAVRAAFV-----HALGDLVQSVGVLIAAYIIR----------F-----------KP---------------------EYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLN--VDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLI-------PGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQE-----------------------------VDRTCANCQSSSP----------------------------------------------------------------------------------------------------------------------
SLC30A5   MEEKYGGDV-----------LAGPGGGGGLGPVD-------VPSARLTKYI-VLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFI---SALLFGNFWTHPITDQL----RAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLY--------------NFMGDAFQHSSQS-------IPR--------FIKESLKQILEESDSRQ-------------IFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDC----------------------------------------SALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVI-AFFVFMESVARLIDPP---------ELDTHMLTP-VSVGGLIVNLIGICAFSH----------------------AHSHAHGASQGSCHS------------SDHSHSH-------HMHGHSDHGHGHSHGS-----------------AGGGMNAN-----------------------MRGVFL-----HVLADTLGSIGVIVSTVLIE---------QF----------------------------------GWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQV---------TSDVLEQRIVQQVTGILKDA-GVNNLTIQVEKEAYF------------------------------------------------------------------QHMSGLSTGFHD------------------VLAMTKQM--------------ESM-------------------------KYCKDGTYIM----
SLC30A6   ------------------------------------------------------------MGTIHLFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQR--------------SFFGK---------------------------LLREFRLVAADRRSWK-------------ILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFRDGVSPFWLGWSQTPDLKWSTHLGLPKCWDNRRELPCLSNSLMTCLISYWVTLRKPSPVYS--FGFERLEVLAVFASTVLAQLG-ALFILKESAERFLEQP---------EIHTGRLLV-GTFVALCFNLFTMLSIRNKPFAYV------------------------SEAASTSWLQE-----------------------------HVADLSRSL-----------------CG------------IIP-------------GLSSIFLPRMNPFVLIDLAGAFALCITYMLIE-------------------------------IN------------NYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRI---------RRDANEQMVLAHVTNRLYTL--VSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAK---------------PSSPPPEFSFNTPGKNVN--------------------PVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP-
SLC30A7   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPLS---------------------------------------------------IKDD----------------------------------------------------EYKP---PKF--------------NLFGK---------------------------ISGWFRSILSDKTSRN-------------LFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDS----------------------------------------TAILAGLAASVISKWRDNDAFS--YGYVRAEVLAGFVNGLFLIFT-AFFIFSEGVERALAPP---------DVHHERLLL-VSILGFVVNLIGIFVFKH---------------------GGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSH-----------------DGPSLKET------TGPSRQ----------ILQGVFL-----HILADTLGSIGVIASAIMMQ---------NF----------------------------------GLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIV---------APDADARWILSQTHNIFTQA-GVRQLYVQI-----------------------------------------------------------------------------------D------------------FAAM------------------------------------------------------------
SLC30A8   ME---------------------------------------------------------FLERTYLVNDKAA-KM------------------------------------------------------YAFT----LE------------------------------------------------------SVELQQK-------------------------------------------------------------------------------------------PVN----------------------------------------------------------------------------------------------------------KDQCPRERPE---------------ELESGGMYHCHSGSKPTEKGAN------------------EYAYAKWK-------------LCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDL----------------------------------------TSFLLSLFSLWLSSKPPSKRLT--FGWHRAEILGALLSILCIWVV-TGVLVYLACERLLYPD--------YQIQATVMII-VSSCAVAANIVLTVVLHQ---------------------RCLGHNH----KEVQA---------------------------------------------------------------------------------------NASVRAAFV-----HALGDLFQSISVLISALIIY----------F-----------KP---------------------EYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLN--YSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVAT---------AASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQ------------------------------DPDCLFCEDPCD----------------------------------------------------------------------------------------------------------------------
SLC30A9   MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEG------------------------------------------------------QGSQ---TLRV-------------------------------------------------EKVPSFETAEG----------------------------------------------------------------------------IGTELKA--------PLK------------------------------QEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINE---------------------FCLKSSDLE------QLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT----------------------------C--NQ------------GLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNEL--------------------RRN--------------ARAKGMSFYKYVM---------------------------ESRDPSTNV-----------------------------------------------------------ILLEDTAAVLGVIIAATCMGLT-------SI---------TGNP--------------LYDSL--GSLGVGTLLGMVSAFLIYTNTEALLGRSIQ------PEQVQ----RLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPE--------ELETFMLK-------------------H------------------------------------------GENIIDTLGAEVDRLE--KELKKRNPE-----VRHVDLEIL---------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC30A7 3 P/T 0.000119296 rs529720665
-- SLC30A7 13 P/L 0.000218728 rs140152448
-- SLC30A7 169 G/D 0.00516298 rs145252614
-- SLC30A7 186 A/T 0.000270903 rs141366201
-- SLC30A7 189 H/R 0.000199165 rs111335585
-- SLC30A7 258 M/I 0.000199041 rs200864607

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC30A7 SLC30A7 [Golgi membrane] Zinc efflux and compartmentalization by the SLC30 family
SLC30A7 SLC30A7 [Golgi membrane] Insulin processing

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data