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Detail Data SLC30A3


Basic description
Gene Name SLC30A3
Protein Name Zinc transporter 3 (ZnT-3) (Solute carrier family 30 member 3)
Family SLC30
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380 
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA 
CCCCCCCCCC CCEECCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CHHHHHHHHH CCCCCEEEEE EEEEEECCCC EEEEEEEEEC CCCCHHHHHH HHHHHHHHHH CCCEEEEEEE CCCCCCCCCC CCCCCCCC
[Overview] SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 
SLC30A1   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGC-----------------------------------WGRNRGR--------------LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDV----------------------------------------LALVVALVAERFAR-RTHATQKNTFGWIRAEVMGALVNAIFLTGL-CFAILLEAIERFIEPH---------EMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGF--------------SQDSGHGHSHG-GHGHGHGLPKGPR--VKSTRPGS-SDINVAPGEQGPDQE-ETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFL-----HVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFP----DPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQID--IRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKC---------EDPTSYMEVAKTIKDVFHNH-GIHATTIQPEFASVG-----------------------------SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIK---------------------------------------NMPNKQPESSL-------
SLC30A10  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGR-----------------------------------YSGKTCR--------------LLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDL----------------------------------------ISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTAL-CFTIFVEAVLRLARPE---------RIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPG-AFGGPQG-AEDPRRAADPTAPGSDSAVTLRGTSVERKRE-KGATVFANV-----------------AGDSFNTQ------NEPEDMMKKEKKSEALNIRGVLL-----HVMGDALGSVVVVITAIIFY---------------VLPLKSEDPCN-------------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVN--MEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKY---------PKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPL-------------------------EQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYG-SDGLSRRDAR-------EVAIEVSL--------------DSCLSD----------------HGQSLNKTQEDQCYVNRTHF
SLC30A2   ME---------------------------------------------------------AKEKQHLLDARPAIRS------------------------------------------------------YTGS----L----------------------------------------------------------WQE----------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------AGWIPLPRPGLD---------LQAIELAAQSNHHCHAQKGPDSHCDP------------------KKGKAQRQ-------------LYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDF----------------------------------------ASMLISLFSLWMSSRPATKTMN--FGWQRAEILGALVSVLSIWVV-TGVLVYLAVERLISGD--------YEIDGGTMLI-TSGCAVAVNIIMGLTLHQ---------------------SGHGHSHG-TTNQQEE---------------------------------------------------------------------------------------NPSVRAAFI-----HVIGDFMQSMGVLVAAYILY----------F-----------KP---------------------EYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVD--FTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAI---------AQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSED------------------------------MKDCQACQGPSD----------------------------------------------------------------------------------------------------------------------
SLC30A3   MEPS---------------------------------------------------PAAGGLETTRLVSPRDR-GG------------------------------------------------------AGGS----LRL--------------------------------------------------KSLFTEPSE--------------------------------------------------------------------------------------------PLP----------------------------------------------------------------------------------------------------------EESKPVEMPF----------------------HHCHRDPLPPPGLTP------------------ERLHARRQ-------------LYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADV----------------------------------------GSMMGSLFSLWLSTRPATRTMT--FGWHRSETLGALASVVSLWMV-TGILLYLAFVRLLHSD--------YHIEGGAMLL-TASIAVCANLLMAFVLHQ---------------------AGPPHSHG-SRGAEYAPLE--------------------------------------------------------EGPEEPLP------------------LGNTSVRAAFV-----HVLGDLLQSFGVLAASILIY----------F-----------KP---------------------QYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVG--FEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAI---------DSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPE------------------------------MAQCLRCQEPPQA---------------------------------------------------------------------------------------------------------------------
SLC30A4   MAGSGA-------------------------------------WKRLKSML-RKDDAPLFLNDTSAFDFSDEAGD------------------------------------------------------EGLSRFNKLRVV------------------------------------------------VADDGSEAPER-------------------------------------------------------------------------------------------PVNG-----------------------------AHP---------------TLQADDD------------------------------------------------SLLDQDLPLTNSQL--------------SLKVDSCDNCSKQRE-----IL------------------KQRKVKAR-------------LTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDL----------------------------------------SAIILTLLALWLSSKSPTKRFT--FGFHRLEVLSAMISVLLVYIL-MGFLLYEAVQRTIHMN--------YEINGDIMLI-TAAVGVAVNVIMGFLLNQ---------------------SGHRHSHS-HSLPSNSPTRG-------------------------------------------------------SGCERNHG------------------QDSLAVRAAFV-----HALGDLVQSVGVLIAAYIIR----------F-----------KP---------------------EYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLN--VDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLI-------PGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQE-----------------------------VDRTCANCQSSSP----------------------------------------------------------------------------------------------------------------------
SLC30A5   MEEKYGGDV-----------LAGPGGGGGLGPVD-------VPSARLTKYI-VLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFI---SALLFGNFWTHPITDQL----RAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLY--------------NFMGDAFQHSSQS-------IPR--------FIKESLKQILEESDSRQ-------------IFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDC----------------------------------------SALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVI-AFFVFMESVARLIDPP---------ELDTHMLTP-VSVGGLIVNLIGICAFSH----------------------AHSHAHGASQGSCHS------------SDHSHSH-------HMHGHSDHGHGHSHGS-----------------AGGGMNAN-----------------------MRGVFL-----HVLADTLGSIGVIVSTVLIE---------QF----------------------------------GWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQV---------TSDVLEQRIVQQVTGILKDA-GVNNLTIQVEKEAYF------------------------------------------------------------------QHMSGLSTGFHD------------------VLAMTKQM--------------ESM-------------------------KYCKDGTYIM----
SLC30A6   ------------------------------------------------------------MGTIHLFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQR--------------SFFGK---------------------------LLREFRLVAADRRSWK-------------ILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFRDGVSPFWLGWSQTPDLKWSTHLGLPKCWDNRRELPCLSNSLMTCLISYWVTLRKPSPVYS--FGFERLEVLAVFASTVLAQLG-ALFILKESAERFLEQP---------EIHTGRLLV-GTFVALCFNLFTMLSIRNKPFAYV------------------------SEAASTSWLQE-----------------------------HVADLSRSL-----------------CG------------IIP-------------GLSSIFLPRMNPFVLIDLAGAFALCITYMLIE-------------------------------IN------------NYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRI---------RRDANEQMVLAHVTNRLYTL--VSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAK---------------PSSPPPEFSFNTPGKNVN--------------------PVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP-
SLC30A7   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPLS---------------------------------------------------IKDD----------------------------------------------------EYKP---PKF--------------NLFGK---------------------------ISGWFRSILSDKTSRN-------------LFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDS----------------------------------------TAILAGLAASVISKWRDNDAFS--YGYVRAEVLAGFVNGLFLIFT-AFFIFSEGVERALAPP---------DVHHERLLL-VSILGFVVNLIGIFVFKH---------------------GGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSH-----------------DGPSLKET------TGPSRQ----------ILQGVFL-----HILADTLGSIGVIASAIMMQ---------NF----------------------------------GLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIV---------APDADARWILSQTHNIFTQA-GVRQLYVQI-----------------------------------------------------------------------------------D------------------FAAM------------------------------------------------------------
SLC30A8   ME---------------------------------------------------------FLERTYLVNDKAA-KM------------------------------------------------------YAFT----LE------------------------------------------------------SVELQQK-------------------------------------------------------------------------------------------PVN----------------------------------------------------------------------------------------------------------KDQCPRERPE---------------ELESGGMYHCHSGSKPTEKGAN------------------EYAYAKWK-------------LCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDL----------------------------------------TSFLLSLFSLWLSSKPPSKRLT--FGWHRAEILGALLSILCIWVV-TGVLVYLACERLLYPD--------YQIQATVMII-VSSCAVAANIVLTVVLHQ---------------------RCLGHNH----KEVQA---------------------------------------------------------------------------------------NASVRAAFV-----HALGDLFQSISVLISALIIY----------F-----------KP---------------------EYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLN--YSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVAT---------AASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQ------------------------------DPDCLFCEDPCD----------------------------------------------------------------------------------------------------------------------
SLC30A9   MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEG------------------------------------------------------QGSQ---TLRV-------------------------------------------------EKVPSFETAEG----------------------------------------------------------------------------IGTELKA--------PLK------------------------------QEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINE---------------------FCLKSSDLE------QLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT----------------------------C--NQ------------GLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNEL--------------------RRN--------------ARAKGMSFYKYVM---------------------------ESRDPSTNV-----------------------------------------------------------ILLEDTAAVLGVIIAATCMGLT-------SI---------TGNP--------------LYDSL--GSLGVGTLLGMVSAFLIYTNTEALLGRSIQ------PEQVQ----RLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPE--------ELETFMLK-------------------H------------------------------------------GENIIDTLGAEVDRLE--KELKKRNPE-----VRHVDLEIL---------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC30A3 19 R/W 0.000684594 rs149400133
-- SLC30A3 22 R/W 0.00278777 rs78170515
-- SLC30A3 73 R/Q 0.000143277 rs200038718
-- SLC30A3 142 P/L 0.000252991 rs142470130
-- SLC30A3 154 R/C 0.000132329 rs771149305
-- SLC30A3 172 R/Q 0.000143625 rs114763573
-- SLC30A3 203 P/L 0.000127352 rs114829262
-- SLC30A3 205 H/N 0.000106261 rs148758588
-- SLC30A3 216 P/L 0.000132329 rs771149305
-- SLC30A3 240 S/L 0.000210871 rs371140945
-- SLC30A3 259 C/Y 0.000537065 rs151129800
-- SLC30A3 268 T/I 0.000620698 rs199876300
-- SLC30A3 295 T/I 0.000163596 rs373184365
-- SLC30A3 295 T/A 0.00116934 rs78882128
-- SLC30A3 298 R/C 0.000577459 rs146572471
-- SLC30A3 303 E/K 0.00020688 rs199912676
-- SLC30A3 348 V/I 0.000124396 rs200925410
-- SLC30A3 357 Y/C 0.00116934 rs78882128
-- SLC30A3 374 P/S 0.000223095 rs138075294
-- SLC30A3 383 Q/P 0.00015157 rs200797694
-- SLC30A3 387 Q/K 0.000184199 rs200706586

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC30A3 SLC30A3 [synaptic vesicle membrane] Zinc efflux and compartmentalization by the SLC30 family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data