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Basic
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Variant
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Pathway
Disease

Detail Data SLC30A1


Basic description
Gene Name SLC30A1
Protein Name Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1)
Family SLC30
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name ZnT1 mediates the efflux of zinc from the cell
Reaction 1 Zn2+ [cytosol] --> 1 Zn2+ [extracellular region]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500 
MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP RRTKAENIPA VVIEIKNMPN KQPESSL 
CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHCCCCCCC HHHHCHHHCC CCCCCHHHHH HHHHHHHCCC EEEEEEEEEC CCCCCCCCCC CCCCCCCCCC CCCCHHCCCC CCCHHHHCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCHHHHHHHH HCCCCCCEEE EEEEEEECCC EEEEEEEEEE CCCCCHHHHH HHHHHHHHHC CCCEEEEEEE ECCCCCCCCC CCCCCCCCCC CCHHCCCCCC CCCCCCCCCC CCCCCCCCHH HHCCCCCCCC CCCCCCCCCC EEEECCCCCC CCCCCCC
[Overview] SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 
SLC30A1   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGC-----------------------------------WGRNRGR--------------LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDV----------------------------------------LALVVALVAERFAR-RTHATQKNTFGWIRAEVMGALVNAIFLTGL-CFAILLEAIERFIEPH---------EMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGF--------------SQDSGHGHSHG-GHGHGHGLPKGPR--VKSTRPGS-SDINVAPGEQGPDQE-ETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFL-----HVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFP----DPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQID--IRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKC---------EDPTSYMEVAKTIKDVFHNH-GIHATTIQPEFASVG-----------------------------SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIK---------------------------------------NMPNKQPESSL-------
SLC30A10  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGR-----------------------------------YSGKTCR--------------LLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDL----------------------------------------ISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTAL-CFTIFVEAVLRLARPE---------RIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPG-AFGGPQG-AEDPRRAADPTAPGSDSAVTLRGTSVERKRE-KGATVFANV-----------------AGDSFNTQ------NEPEDMMKKEKKSEALNIRGVLL-----HVMGDALGSVVVVITAIIFY---------------VLPLKSEDPCN-------------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVN--MEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKY---------PKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPL-------------------------EQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYG-SDGLSRRDAR-------EVAIEVSL--------------DSCLSD----------------HGQSLNKTQEDQCYVNRTHF
SLC30A2   ME---------------------------------------------------------AKEKQHLLDARPAIRS------------------------------------------------------YTGS----L----------------------------------------------------------WQE----------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------AGWIPLPRPGLD---------LQAIELAAQSNHHCHAQKGPDSHCDP------------------KKGKAQRQ-------------LYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDF----------------------------------------ASMLISLFSLWMSSRPATKTMN--FGWQRAEILGALVSVLSIWVV-TGVLVYLAVERLISGD--------YEIDGGTMLI-TSGCAVAVNIIMGLTLHQ---------------------SGHGHSHG-TTNQQEE---------------------------------------------------------------------------------------NPSVRAAFI-----HVIGDFMQSMGVLVAAYILY----------F-----------KP---------------------EYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVD--FTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAI---------AQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSED------------------------------MKDCQACQGPSD----------------------------------------------------------------------------------------------------------------------
SLC30A3   MEPS---------------------------------------------------PAAGGLETTRLVSPRDR-GG------------------------------------------------------AGGS----LRL--------------------------------------------------KSLFTEPSE--------------------------------------------------------------------------------------------PLP----------------------------------------------------------------------------------------------------------EESKPVEMPF----------------------HHCHRDPLPPPGLTP------------------ERLHARRQ-------------LYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADV----------------------------------------GSMMGSLFSLWLSTRPATRTMT--FGWHRSETLGALASVVSLWMV-TGILLYLAFVRLLHSD--------YHIEGGAMLL-TASIAVCANLLMAFVLHQ---------------------AGPPHSHG-SRGAEYAPLE--------------------------------------------------------EGPEEPLP------------------LGNTSVRAAFV-----HVLGDLLQSFGVLAASILIY----------F-----------KP---------------------QYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVG--FEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAI---------DSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPE------------------------------MAQCLRCQEPPQA---------------------------------------------------------------------------------------------------------------------
SLC30A4   MAGSGA-------------------------------------WKRLKSML-RKDDAPLFLNDTSAFDFSDEAGD------------------------------------------------------EGLSRFNKLRVV------------------------------------------------VADDGSEAPER-------------------------------------------------------------------------------------------PVNG-----------------------------AHP---------------TLQADDD------------------------------------------------SLLDQDLPLTNSQL--------------SLKVDSCDNCSKQRE-----IL------------------KQRKVKAR-------------LTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDL----------------------------------------SAIILTLLALWLSSKSPTKRFT--FGFHRLEVLSAMISVLLVYIL-MGFLLYEAVQRTIHMN--------YEINGDIMLI-TAAVGVAVNVIMGFLLNQ---------------------SGHRHSHS-HSLPSNSPTRG-------------------------------------------------------SGCERNHG------------------QDSLAVRAAFV-----HALGDLVQSVGVLIAAYIIR----------F-----------KP---------------------EYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLN--VDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLI-------PGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQE-----------------------------VDRTCANCQSSSP----------------------------------------------------------------------------------------------------------------------
SLC30A5   MEEKYGGDV-----------LAGPGGGGGLGPVD-------VPSARLTKYI-VLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFI---SALLFGNFWTHPITDQL----RAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLY--------------NFMGDAFQHSSQS-------IPR--------FIKESLKQILEESDSRQ-------------IFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDC----------------------------------------SALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVI-AFFVFMESVARLIDPP---------ELDTHMLTP-VSVGGLIVNLIGICAFSH----------------------AHSHAHGASQGSCHS------------SDHSHSH-------HMHGHSDHGHGHSHGS-----------------AGGGMNAN-----------------------MRGVFL-----HVLADTLGSIGVIVSTVLIE---------QF----------------------------------GWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQV---------TSDVLEQRIVQQVTGILKDA-GVNNLTIQVEKEAYF------------------------------------------------------------------QHMSGLSTGFHD------------------VLAMTKQM--------------ESM-------------------------KYCKDGTYIM----
SLC30A6   ------------------------------------------------------------MGTIHLFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQR--------------SFFGK---------------------------LLREFRLVAADRRSWK-------------ILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFRDGVSPFWLGWSQTPDLKWSTHLGLPKCWDNRRELPCLSNSLMTCLISYWVTLRKPSPVYS--FGFERLEVLAVFASTVLAQLG-ALFILKESAERFLEQP---------EIHTGRLLV-GTFVALCFNLFTMLSIRNKPFAYV------------------------SEAASTSWLQE-----------------------------HVADLSRSL-----------------CG------------IIP-------------GLSSIFLPRMNPFVLIDLAGAFALCITYMLIE-------------------------------IN------------NYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRI---------RRDANEQMVLAHVTNRLYTL--VSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAK---------------PSSPPPEFSFNTPGKNVN--------------------PVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP-
SLC30A7   -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPLS---------------------------------------------------IKDD----------------------------------------------------EYKP---PKF--------------NLFGK---------------------------ISGWFRSILSDKTSRN-------------LFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDS----------------------------------------TAILAGLAASVISKWRDNDAFS--YGYVRAEVLAGFVNGLFLIFT-AFFIFSEGVERALAPP---------DVHHERLLL-VSILGFVVNLIGIFVFKH---------------------GGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSH-----------------DGPSLKET------TGPSRQ----------ILQGVFL-----HILADTLGSIGVIASAIMMQ---------NF----------------------------------GLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIV---------APDADARWILSQTHNIFTQA-GVRQLYVQI-----------------------------------------------------------------------------------D------------------FAAM------------------------------------------------------------
SLC30A8   ME---------------------------------------------------------FLERTYLVNDKAA-KM------------------------------------------------------YAFT----LE------------------------------------------------------SVELQQK-------------------------------------------------------------------------------------------PVN----------------------------------------------------------------------------------------------------------KDQCPRERPE---------------ELESGGMYHCHSGSKPTEKGAN------------------EYAYAKWK-------------LCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDL----------------------------------------TSFLLSLFSLWLSSKPPSKRLT--FGWHRAEILGALLSILCIWVV-TGVLVYLACERLLYPD--------YQIQATVMII-VSSCAVAANIVLTVVLHQ---------------------RCLGHNH----KEVQA---------------------------------------------------------------------------------------NASVRAAFV-----HALGDLFQSISVLISALIIY----------F-----------KP---------------------EYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLN--YSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVAT---------AASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQ------------------------------DPDCLFCEDPCD----------------------------------------------------------------------------------------------------------------------
SLC30A9   MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEG------------------------------------------------------QGSQ---TLRV-------------------------------------------------EKVPSFETAEG----------------------------------------------------------------------------IGTELKA--------PLK------------------------------QEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINE---------------------FCLKSSDLE------QLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT----------------------------C--NQ------------GLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNEL--------------------RRN--------------ARAKGMSFYKYVM---------------------------ESRDPSTNV-----------------------------------------------------------ILLEDTAAVLGVIIAATCMGLT-------SI---------TGNP--------------LYDSL--GSLGVGTLLGMVSAFLIYTNTEALLGRSIQ------PEQVQ----RLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPE--------ELETFMLK-------------------H------------------------------------------GENIIDTLGAEVDRLE--KELKKRNPE-----VRHVDLEIL---------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC30A1 164 R/L 0.000241985 rs116730493

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC30A1 SLC30A1 [plasma membrane] Zinc efflux and compartmentalization by the SLC30 family

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data