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Seq./Align.
Variant
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Detail Data SLC3A2


Basic description
Gene Name SLC3A2
Protein Name 4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
Family SLC3
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630 
MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSETG SDCVTQAGLQ LLASSDPPAL ASKNAEVTVE TGFHHVSQAD IEFLTSIDPT ASASGSAGIT GTMSQDTEVD MKEVELNELE PEKQPMNAAS GAAMSLAGAE KNGLVKIKVA EDEAEAAAAA KFTGLSKEEL LKVAGSPGWV RTRWALLLLF WLGWLGMLAG AVVIIVRAPR CRELPAQKWW HTGALYRIGD LQAFQGHGAG NLAGLKGRLD YLSSLKVKGL VLGPIHKNQK DDVAQTDLLQ IDPNFGSKED FDSLLQSAKK KSIRVILDLT PNYRGENSWF STQVDTVATK VKDALEFWLQ AGVDGFQVRD IENLKDASSF LAEWQNITKG FSEDRLLIAG TNSSDLQQIL SLLESNKDLL LTSSYLSDSG STGEHTKSLV TQYLNATGNR WCSWSLSQAR LLTSFLPAQL LRLYQLMLFT LPGTPVFSYG DEIGLDAAAL PGQPMEAPVM LWDESSFPDI PGAVSANMTV KGQSEDPGSL LSLFRRLSDQ RSKERSLLHG DFHAFSAGPG LFSYIRHWDQ NERFLVVLNF GDVGLSAGLQ ASDLPASASL PAKADLLLST QPGREEGSPL ELERLKLEPH EGLLLRFPYA A 
CCCCCCCCCC CEEEECCCCC CCCCCCCCEE CCCCCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCCCEEEE ECCCCCCCCC EEECCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHCCCC CCCCCCCCCC CCHHCCCCHH HCCCEEEEEC CHHHHHHHHH CCCCCCHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC EEEEEEEECC HHHHCCCCCC CHHHHHHHHH HHHHCCCCEE EECCCCCCCC CCCCCCCCCE ECCCCCCHHH HHHHHHHHHH CCCCEEEECC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH CCCCCCCCCC HHHHHCCHHH HHHHHCHHCC CCCCCEEEEE CCCCHHHHHH HHHCCCCCEE EEEECCCCCC CCHHHHHHHH HHHHHHCCCC CCEECCCCCH HHHHCCHHHH HHHHHHHHHH CCCCCEECCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHCCH HHHHCCCCHH HHHHHHHHHH HHHCHHHHEE EEEEEECCCC EEEEEEEECC CCEEEEEEEC CCCCEEEECC HHCCCCCCCC CCCCEEEEEC CCCCCCCCCC CCCCEEECCC EEEEEECCCC C
[Overview] SLC3A1 SLC3A2 
SLC3A1    -------------------------------MAEDKSKRDSIEMSMKGCQ------------------TNNGFVH--NEDILEQTP-DPGSSTDNLKHSTRGILGS----QEPDFKGV---------QP------------------------------------YAGMPKEVLFQFSGQ---ARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLD-----WWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSL-------DAVKFLLEAKHL-----RDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVS-GNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQ-----WDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTL---LNLHNM--ISGLPAKMRIRLSTNSA-DKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
SLC3A2    MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSETGSDCVTQAGLQLLASSDPPALASKNAEVTVETGFHHVSQADIEFLTSIDPTASAS----GSAGITGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWL---GWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRI--GDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDV--AQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGE----------------------------------NSWFSTQVDT-----------------------------VATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSD------------------LQQILSLLESNKDLLLT------------------------------------SSYLS--DSGSTGEHTKSLVTQYL-NATGNRWCSWSLS--QARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLD---AAAL----------PGQPMEAPVMLWDESSFPDIPGAVSA---------NMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNER-FLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLL----------------------RFPYAA---------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC3A2 8 A/V 0.00015523 rs149843549
-- SLC3A2 12 V/F 0.000119404 rs144685406
-- SLC3A2 27 A/S 0.000225364 rs757945289
-- SLC3A2 87 I/T 0.000183756 rs190424203
SLC3A2 248 R/C 0.000202862 rs542576739
SLC3A2 263 G/C 0.0010219 rs145066571
SLC3A2 265 I/V 0.000397624 rs78298849
SLC3A2 277 D/N 0.000695842 rs80190679
SLC3A2 287 S/C 0.000170981 rs546675254
SLC3A2 314 R/W 0.000103383 rs142988967
SLC3A2 318 S/L 0.000143146 rs148341364
SLC3A2 343 V/M 0.000282317 rs372435716
SLC3A2 440 R/M 0.0028511 rs116829615
SLC3A2 452 R/Q 0.000131227 rs148443520
SLC3A2 517 P/S 0.00102903 rs7944051
SLC3A2 544 A/V 0.000198867 rs150311954
SLC3A2 563 R/H 0.00046128 rs143377797
SLC3A2 585 P/S 0.000211511 rs115479416
SLC3A2 593 K/Q 0.0109955 rs141470222
SLC3A2 595 D/N 0.000315697 rs574427142
SLC3A2 630 A/V 0.000311155 rs201220940

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC3A2 SLC3A2 [plasma membrane] Amino acid transport across the plasma membrane
SLC3A2 SLC3A2 [plasma membrane] Basigin interactions
SLC3A2 SLC3A2 [plasma membrane] Tryptophan catabolism

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC3A2 SLC3A2 [plasma membrane] Defective SLC7A7 causes lysinuric protein intolerance (LPI)