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Detail Data SLC3A1
Basic description
Gene Name | SLC3A1 |
---|---|
Protein Name | Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) |
Family | SLC3 |
Category | Transport of inorganic cations/anions and amino acids/oligopeptides |
Reaction name | - |
Reaction | - |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 MAEDKSKRDS IEMSMKGCQT NNGFVHNEDI LEQTPDPGSS TDNLKHSTRG ILGSQEPDFK GVQPYAGMPK EVLFQFSGQA RYRIPREILF WLTVASVLVL IAATIAIIAL SPKCLDWWQE GPMYQIYPRS FKDSNKDGNG DLKGIQDKLD YITALNIKTV WITSFYKSSL KDFRYGVEDF REVDPIFGTM EDFENLVAAI HDKGLKLIID FIPNHTSDKH IWFQLSRTRT GKYTDYYIWH DCTHENGKTI PPNNWLSVYG NSSWHFDEVR NQCYFHQFMK EQPDLNFRNP DVQEEIKEIL RFWLTKGVDG FSLDAVKFLL EAKHLRDEIQ VNKTQIPDTV TQYSELYHDF TTTQVGMHDI VRSFRQTMDQ YSTEPGRYRF MGTEAYAESI DRTVMYYGLP FIQEADFPFN NYLSMLDTVS GNSVYEVITS WMENMPEGKW PNWMIGGPDS SRLTSRLGNQ YVNVMNMLLF TLPGTPITYY GEEIGMGNIV AANLNESYDI NTLRSKSPMQ WDNSSNAGFS EASNTWLPTN SDYHTVNVDV QKTQPRSALK LYQDLSLLHA NELLLNRGWF CHLRNDSHYV VYTRELDGID RIFIVVLNFG ESTLLNLHNM ISGLPAKMRI RLSTNSADKG SKVDTSGIFL DKGEGLIFEH NTKNLLHRQT AFRDRCFVSN RACYSSVLNI LYTSC CCCCCCCCCC CCCHHCCCCC CCCCCCCHHH HCCCCCCCCC CHHCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCHHHC CCEEEECCHH HCCCCCCCCC CHHHHHHHCH HHHHCCCCEE EECCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHCCCEEEEE ECCCCCCCCC HHHHHHCCCC CCCCCEEEEE CCCCCCCCCC CCCCCCCCCC CCCCEEECCC CEEEEECCCC CCCCCCCCCH HHHHHHHHHH HHHHHCCCCE EEEHHHHHEE ECCCCCCCCC CCCCCCCCCC CCCHHHCCCC CCCCCCHHHH HHHHHHHHHH CCCCCCCCCE EEEEEECCCH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHCCCCCCC CEEEECCCCC CCHHHHCCCH HHHHHHHHHH HCCCCEEEEC CCCCCCCCCC CCCHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHCCHHH HCCCCCCHHH HHHHHHHHHH HCCCCCCCEE EEEECCCCEE EEEEEECCCC EEEEEEEECC CCCEEECHHH CCCCCCCCEE EEECCCCCCC CCCCCCCEEE CCCCEEEEEE CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHCC
[Overview]
SLC3A1 -------------------------------MAEDKSKRDSIEMSMKGCQ------------------TNNGFVH--NEDILEQTP-DPGSSTDNLKHSTRGILGS----QEPDFKGV---------QP------------------------------------YAGMPKEVLFQFSGQ---ARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLD-----WWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSL-------DAVKFLLEAKHL-----RDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVS-GNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQ-----WDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTL---LNLHNM--ISGLPAKMRIRLSTNSA-DKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC SLC3A2 MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSETGSDCVTQAGLQLLASSDPPALASKNAEVTVETGFHHVSQADIEFLTSIDPTASAS----GSAGITGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWL---GWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRI--GDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDV--AQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGE----------------------------------NSWFSTQVDT-----------------------------VATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSD------------------LQQILSLLESNKDLLLT------------------------------------SSYLS--DSGSTGEHTKSLVTQYL-NATGNRWCSWSLS--QARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLD---AAAL----------PGQPMEAPVMLWDESSFPDIPGAVSA---------NMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNER-FLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLL----------------------RFPYAA---------
Variant
check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
---|---|---|---|---|---|
-- | SLC3A1 | 3 | E/G | 0.000223104 | rs138311995 |
-- | SLC3A1 | 4 | N/K | 0.000131558 | rs371320502 |
-- | SLC3A1 | 7 | S/P | 0.0138012 | rs74997007 |
-- | SLC3A1 | 34 | T/A | 0.000175143 | rs748553507 |
SLC3A1 | 81 | R/C | 0.000262524 | rs149813423 | |
SLC3A1 | 95 | A/T | 0.000171052 | rs763040449 | |
SLC3A1 | 105 | I/V | 0.000127282 | rs200093674 | |
SLC3A1 | 108 | I/V | 0.000262482 | rs138597262 | |
SLC3A1 | 157 | I/T | 0.000171346 | rs749406831 | |
SLC3A1 | 182 | E/K | 0.000274439 | rs549909989 | |
SLC3A1 | 185 | P/H | 0.000103407 | rs569856127 | |
SLC3A1 | 189 | T/M | 0.0027362 | rs140317484 | |
SLC3A1 | 191 | E/G | 0.000127268 | rs534054965 | |
SLC3A1 | 227 | R/Q | 0.000186941 | rs142469446 | |
SLC3A1 | 229 | R/Q | 0.000163078 | rs138395881 | |
SLC3A1 | 229 | R/W | 0.000107389 | rs758636942 | |
SLC3A1 | 263 | S/T | 0.000190896 | rs139310305 | |
SLC3A1 | 266 | F/S | 0.00343218 | rs141587158 | |
SLC3A1 | 376 | G/S | 0.000551832 | rs143068960 | |
SLC3A1 | 423 | S/G | 0.000115367 | rs200016706 | |
SLC3A1 | 461 | Y/H | 0.000823986 | rs144162964 | |
SLC3A1 | 464 | V/M | 0.000195064 | rs561079654 | |
SLC3A1 | 467 | M/T | 0.00249646 | rs121912691 | |
SLC3A1 | 492 | A/T | 0.000271158 | rs201989712 | |
-- | SLC3A1 | 551 | R/C | 0.000106076 | rs547206473 |
-- | SLC3A1 | 559 | E/Q | 0.000509387 | rs202086252 |
SLC3A1 | 590 | D/N | 0.000111483 | rs200436145 | |
SLC3A1 | 609 | N/S | 0.000159783 | rs200592320 | |
SLC3A1 | 616 | A/T | 0.000156296 | rs143740561 | |
SLC3A1 | 618 | M/I | 0.593819 | rs698761 | |
SLC3A1 | 630 | G/D | 0.000289496 | rs150557210 | |
SLC3A1 | 658 | R/H | 0.000148891 | rs370262167 |
Phylogenetic tree
Pathway
Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
---|---|---|---|
main | SLC3A1 | SLC3A1 [plasma membrane] | Amino acid transport across the plasma membrane |
Disease