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Detail Data SLC3A1


Basic description
Gene Name SLC3A1
Protein Name Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)
Family SLC3
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 AA Pred
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680 
MAEDKSKRDS IEMSMKGCQT NNGFVHNEDI LEQTPDPGSS TDNLKHSTRG ILGSQEPDFK GVQPYAGMPK EVLFQFSGQA RYRIPREILF WLTVASVLVL IAATIAIIAL SPKCLDWWQE GPMYQIYPRS FKDSNKDGNG DLKGIQDKLD YITALNIKTV WITSFYKSSL KDFRYGVEDF REVDPIFGTM EDFENLVAAI HDKGLKLIID FIPNHTSDKH IWFQLSRTRT GKYTDYYIWH DCTHENGKTI PPNNWLSVYG NSSWHFDEVR NQCYFHQFMK EQPDLNFRNP DVQEEIKEIL RFWLTKGVDG FSLDAVKFLL EAKHLRDEIQ VNKTQIPDTV TQYSELYHDF TTTQVGMHDI VRSFRQTMDQ YSTEPGRYRF MGTEAYAESI DRTVMYYGLP FIQEADFPFN NYLSMLDTVS GNSVYEVITS WMENMPEGKW PNWMIGGPDS SRLTSRLGNQ YVNVMNMLLF TLPGTPITYY GEEIGMGNIV AANLNESYDI NTLRSKSPMQ WDNSSNAGFS EASNTWLPTN SDYHTVNVDV QKTQPRSALK LYQDLSLLHA NELLLNRGWF CHLRNDSHYV VYTRELDGID RIFIVVLNFG ESTLLNLHNM ISGLPAKMRI RLSTNSADKG SKVDTSGIFL DKGEGLIFEH NTKNLLHRQT AFRDRCFVSN RACYSSVLNI LYTSC 
CCCCCCCCCC CCCHHCCCCC CCCCCCCHHH HCCCCCCCCC CHHCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCHHHC CCEEEECCHH HCCCCCCCCC CHHHHHHHCH HHHHCCCCEE EECCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHCCCEEEEE ECCCCCCCCC HHHHHHCCCC CCCCCEEEEE CCCCCCCCCC CCCCCCCCCC CCCCEEECCC CEEEEECCCC CCCCCCCCCH HHHHHHHHHH HHHHHCCCCE EEEHHHHHEE ECCCCCCCCC CCCCCCCCCC CCCHHHCCCC CCCCCCHHHH HHHHHHHHHH CCCCCCCCCE EEEEEECCCH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHCCCCCCC CEEEECCCCC CCHHHHCCCH HHHHHHHHHH HCCCCEEEEC CCCCCCCCCC CCCHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHCCHHH HCCCCCCHHH HHHHHHHHHH HCCCCCCCEE EEEECCCCEE EEEEEECCCC EEEEEEEECC CCCEEECHHH CCCCCCCCEE EEECCCCCCC CCCCCCCEEE CCCCEEEEEE CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHCC 
                    
[Overview] SLC3A1 SLC3A2
SLC3A1    -------------------------------MAEDKSKRDSIEMSMKGCQ------------------TNNGFVH--NEDILEQTP-DPGSSTDNLKHSTRGILGS----QEPDFKGV---------QP------------------------------------YAGMPKEVLFQFSGQ---ARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLD-----WWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSL-------DAVKFLLEAKHL-----RDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVS-GNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQ-----WDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTL---LNLHNM--ISGLPAKMRIRLSTNSA-DKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
SLC3A2    MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSETGSDCVTQAGLQLLASSDPPALASKNAEVTVETGFHHVSQADIEFLTSIDPTASAS----GSAGITGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWL---GWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRI--GDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDV--AQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGE----------------------------------NSWFSTQVDT-----------------------------VATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSD------------------LQQILSLLESNKDLLLT------------------------------------SSYLS--DSGSTGEHTKSLVTQYL-NATGNRWCSWSLS--QARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLD---AAAL----------PGQPMEAPVMLWDESSFPDIPGAVSA---------NMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNER-FLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLL----------------------RFPYAA---------

                    

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC3A1 3 E/G 0.000223104 rs138311995
-- SLC3A1 4 N/K 0.000131558 rs371320502
-- SLC3A1 7 S/P 0.0138012 rs74997007
-- SLC3A1 34 T/A 0.000175143 rs748553507
SLC3A1 81 R/C 0.000262524 rs149813423
SLC3A1 95 A/T 0.000171052 rs763040449
SLC3A1 105 I/V 0.000127282 rs200093674
SLC3A1 108 I/V 0.000262482 rs138597262
SLC3A1 157 I/T 0.000171346 rs749406831
SLC3A1 182 E/K 0.000274439 rs549909989
SLC3A1 185 P/H 0.000103407 rs569856127
SLC3A1 189 T/M 0.0027362 rs140317484
SLC3A1 191 E/G 0.000127268 rs534054965
SLC3A1 227 R/Q 0.000186941 rs142469446
SLC3A1 229 R/Q 0.000163078 rs138395881
SLC3A1 229 R/W 0.000107389 rs758636942
SLC3A1 263 S/T 0.000190896 rs139310305
SLC3A1 266 F/S 0.00343218 rs141587158
SLC3A1 376 G/S 0.000551832 rs143068960
SLC3A1 423 S/G 0.000115367 rs200016706
SLC3A1 461 Y/H 0.000823986 rs144162964
SLC3A1 464 V/M 0.000195064 rs561079654
SLC3A1 467 M/T 0.00249646 rs121912691
SLC3A1 492 A/T 0.000271158 rs201989712
-- SLC3A1 551 R/C 0.000106076 rs547206473
-- SLC3A1 559 E/Q 0.000509387 rs202086252
SLC3A1 590 D/N 0.000111483 rs200436145
SLC3A1 609 N/S 0.000159783 rs200592320
SLC3A1 616 A/T 0.000156296 rs143740561
SLC3A1 618 M/I 0.593819 rs698761
SLC3A1 630 G/D 0.000289496 rs150557210
SLC3A1 658 R/H 0.000148891 rs370262167

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC3A1 SLC3A1 [plasma membrane] Amino acid transport across the plasma membrane